Cutaneous Adnexal Carcinoma with Apocrine Differentiation: A Challenging Diagnosis and Personalized Treatment with mTOR Inhibitor in a Very Rare Disease:
Cutaneous adnexal carcinoma with apocrine differentiation is a rare neoplasm arising from cutaneous adnexa, especially of the head and neck and trunk region. Because of its rarity, the diagnosis is challenging and often impossible to distinguish from metastatic cutaneous adenocarcinoma of the breast. The standard of care remains surgery for resectable disease. To date, univocal guidelines for metastatic disease are lacking, particularly regarding systemic therapy. We report a clinical case of a patient diagnosed with cutaneous adnexal adenocarcinoma with apocrine differentiation of the left axilla with lymph node and bone metastasis. We started with carboplatin and paclitaxel chemotherapy regimen, with good response. After progression, we performed a next-generation sequencing analysis (by the Foundation One CDx test) to identify genomic alteration in cancer-related genes. We found PIK3CA and KRAS mutations. Due to this result, the patient started a second-line treatment with a personalized therapy including an mTOR inhibitor, everolimus, and, to date, he is still under treatment. To our knowledge, this is the first case of a patient responding both to chemotherapy and to a personalized treatment with an mTOR inhibitor. It is important to support the value of genomic screening in this rare neoplasm.
Case Rep Oncol 2020;13:1091–1096
Medicine RSS-Feeds by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com
Πληροφορίες
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Αρχειοθήκη ιστολογίου
-
►
2023
(366)
- ► Φεβρουαρίου (184)
- ► Ιανουαρίου (182)
-
►
2022
(2814)
- ► Δεκεμβρίου (182)
- ► Σεπτεμβρίου (213)
- ► Φεβρουαρίου (264)
- ► Ιανουαρίου (262)
-
►
2021
(3815)
- ► Δεκεμβρίου (229)
- ► Σεπτεμβρίου (276)
- ► Φεβρουαρίου (64)
-
▼
2020
(5754)
- ► Δεκεμβρίου (401)
-
▼
Σεπτεμβρίου
(365)
-
▼
Σεπ 20
(102)
- Medicine by Alexandros G. Sfakianakis
- steroid refractory graft-versus-host disease
- migrants and refugees with posttraumatic stress di...
- Laryngeal polyp associated with reflux disease
- snoring and health problems
- Giant cell-rich extrapleural solitary fibrous tumor
- Malignant tumors in hernia sac
- Papillary-Cystic Neoplasms of the Middle Ear Are D...
- TMP3-NTRK1 rearranged uterine sarcoma
- Pediatric Suprasellar Germ Cell Tumors
- Penile angiomyxoma
- Colorectal non-invasive epithelial lesions
- a 37-year-old woman presented with headache that h...
- Multiple schwannoma of the seminal vesicle
- Thyroid-like low-grade nasopharyngeal papillary ad...
- HER2-positive pure mucinous breast carcinoma
- Resection of retroperitoneal leiomyosarcoma follow...
- Solitary fibrous tumor of pleura
- Wnt activation as a therapeutic strategy in medull...
- Transverse myelitis syndrom as a result of neuromy...
- Retroauricular teratoma with congenital microtia a...
- Renomedullary interstitial cell tumor: , these cel...
- Brit-Hogg-Dubé syndrome (BHD) . The disease-causin...
- incidental sporadic and tuberous sclerosis complex...
- Spinal metastasis of glioblastoma multiforme
- Mediastinal 99mTc-Methylene Diphosphonate Accumula...
- Primary Neuroendocrine Tumor of the Ileostomy Stom...
- Primary Pancreatic Yolk Sac Tumor Presenting as Di...
- Renal Medullary Carcinoma on Dual-Time Point FDG P...
- Colon Adenocarcinoma Associated With Clostridium S...
- Daratumumab demonstrated activity in the treatment...
- A 10-year-old boy presented with back pain. Tc-met...
- A knee stiffness .....Progressive unilateral knee ...
- Diffuse Metastases in Bilateral Penile Corpus Cave...
- Splenogonadal Fusion in Children: A Rare Entity Mi...
- Rituximab for acute demyelinating myelopathy after...
- Inflammatory (acute and chronic specific dacryoade...
- Clinical Manifestations, Diagnosis, and Management...
- A rare association between true thymic hyperplasia...
- abscesses during treatment with pazopanib ...........
- Merkel Cell Carcinoma of the Head and Neck Compare...
- Unexpected vincristine-induced systemic capillary ...
- Outcomes of treatment of mammary analogue secretor...
- Castleman Disease of the Parotid Gland: Castleman ...
- Pheochromocytomatosis after adrenalectomy: metasta...
- Storiform collagenoma (sclerotic fibroma) of the o...
- Pediatric myeloid sarcoma
- haematemesis from a gastric submucosal lesion.
- Nasal Sebaceous Carcinoma
- Mixed epithelial and stromal tumor
- Metastatic epithelioid haemangioendothelioma masqu...
- Skin-directed radiation therapy for cutaneous lymp...
- Rituximab-induced serum sickness is more frequent ...
- Cytotoxic T Cells and their Activation Status are ...
- Paraneoplastic movement disorders: phenomenology,....
- The expression and clinical significance of an Epi...
- Stokes polarimetry-based second harmonic generatio...
- Robotic surgery for gastric cancer
- Semiautomatic morphometric analysis of skeletal mu...
- The role of the tumour microenvironment in the ang...
- multiparametric ultrasound criteria for the gradin...
- 3D multi-echo gradient-recalled echo (ME-GRE) can ...
- Diagnostic value of exosomal circMYC in radioresis...
- Middle Cranial Fossa Approach to Vestibular Schwan...
- Transimpedance Matrix (TIM) Measurement for the De...
- Cochlear Implantation in Cases of Inner Ear Malfor...
- Perilymphatic Fistula: Consideration Based on MRI ...
- Patency of Anterior Epitympanic Space and Surgical...
- Investigating the Electrical Properties of Differe...
- Tumor-treating field (TTF) therapy is a novel elec...
- circUSP42 Is Downregulated in Triple-Negative Brea...
- Comparison of Ultrasonography and CT for Determini...
- Two-Level Factorial Pre-TomoBreast Pilot Study of ...
- Association of APOE e2 genotype with Alzheimer’s a...
- a family with three girls presenting similar dysmo...
- Ophthalmological abnormalities in Down syndrome
- Removal of a Silicone Gel Breast Implant in a Mult...
- Giant Pulmonary Colloid Adenocarcinoma
- Cutaneous Adnexal Carcinoma with Apocrine Differen...
- A Rare Case of Neglected Rupture of Right Axillary...
- Endocranial anatomy of the ceratopsid dinosaur Tri...
- Isolated cranial nerve six palsy in two patients w...
- Axillary lymph node metastasis: Fine‐needle aspira...
- Alzheimer’s‐related cerebrovascular disease in Dow...
- New developments in respiratory medicine: a primar...
- Primary immune regulatory disorders: a growing uni...
- The Management of Foreign Body Displacement into t...
- Long noncoding RNA MCM3AP antisense RNA 1 is downr...
- Circular RNA circ-NCOR2 accelerates papillary thyr...
- Role of the Hippo signaling pathway in safflower y...
- schwannomatosis of the extremities
- Deferasirox, an iron-chelating agent, alleviates a...
- Giant axillary tumor resection using ultrasound-gu...
- Changes in global DNA methylation and hydroxymethy...
- Patterns of supraclavicular area failure after mas...
- Association of −344C/T polymorphism in the aldoste...
- mild cerebral hypothermia on oxidative factors and...
- Comparison of transradial coronary intervention fo...
- Labor after cesarean section (TOLAC) in women with...
- Potential COVID-19 papain-like protease PLpro inhi...
-
▼
Σεπ 20
(102)
- ► Φεβρουαρίου (754)
- ► Ιανουαρίου (894)
-
►
2019
(146)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου