Πέμπτη 9 Ιανουαρίου 2020

GSE


GSE143404 The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids [Rh123hi-lo RNA-Seq]
Contributors : M Chen ; M S SundrudSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCD4+ T cells are tightly regulated by microbiota in the intestine, but whether intestinal T cells interface with host-derived metabolites is less clear. Here, we show that CD4+ T effector (Teff) cells upregulated the xenobiotic transporter, Mdr1, in the ileum to maintain homeostasis in the presence of bile acids. Whereas wild-type Teff cells upregulated Mdr1 in the ileum, those...
GEO series published today
1h
GSE143342 Gene expression profile of ileum, jejunum and colon in hyperuricemia and wildtype mice
Contributors : Shichao Xing ; Qiulan lvSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculuswe detected the gen expression of ileum,jejunum and colon in hyperuricemia and wildtype mice
GEO series published today
1h
GSE143403 The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids [shMdr1 RNA-seq in vivo]
Contributors : M Chen ; M S SundrudSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCD4+ T cells are tightly regulated by microbiota in the intestine, but whether intestinal T cells interface with host-derived metabolites is less clear. Here, we show that CD4+ T effector (Teff) cells upregulated the xenobiotic transporter, Mdr1, in the ileum to maintain homeostasis in the presence of bile acids. Whereas wild-type Teff cells upregulated Mdr1 in the ileum, those...
GEO series published today
1h
GSE124875 Notch ligand Dll4 impairs the recruitment of hemogenic cells into intra-aortic clusters and limits hematopoietic stem cell production.
Contributors : Anna Bigas ; Cristina Porcheri ; Cristina Ruiz-Herguido ; Yolanda GuillénSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHematopoietic stem cells (HSCs) develop from the hemogenic endothelium in the embryonic aorta. In most vertebrates, hemogenic cells protrude into the aortic lumen forming clusters where the hematopoietic features are acquired. Although much is known about the molecular characteristics of the hematopoietic cells, we still...
GEO series published today
1h
GSE143396 Circadian analysis of the mouse retinal pigment epithelium transcriptome
Contributors : Christopher DeVera ; Gianluca TosiniSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPurpose: The presence of a phagocytic peak of photoreceptor outer segments by the retinal pigment epithelium (RPE) one or two hours after the onset of light has been reported for several diurnal and nocturnal species. This peak in phagocytic activity also persists under constant lighting conditions (i.e., constant light or dark) thus demonstrating that the...
GEO series published today
1h
GSE143336 MeDIP-Seq for ALV-J-susceptible and ALV-J-resistant chickens
Contributor : Yan YimingSeries Type : Methylation profiling by high throughput sequencingOrganism : Gallus gallusWe bed ALV-J-susceptible and ALV-J-resistant chickens. In this work, we find the difference DNA methylation states between ALV-J-susceptible and ALV-J-resistant chickens
GEO series published today
1h
GSE143394 Airway Smooth Muscle Differentiation is Essential for Promoting Airway Size, Tracheal Cartilage Segmentation, but Dispensable for Epithelial Branching
Contributors : Randee E Young ; Xin SunSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe goals of this study are to evalute the role of airway smooth muscle during mouse lung development. We have compared Tbx4rtTA;tetOcre;Mycocdf/f (MyocdCKO) mutants to control mice and generated next generation sequencing transcriptome profiling (RNA-seq) to compare the transcriptomes of each genotype.
GEO series published today
1h
GSE139559 Myeloid Dendritic Cells from People Living with HIV have Altered Gene Expression Not Restored by Anti-Retroviral Therapy
Contributors : Shannon M Murray ; Daniel C Douek ; Rafick P SekalySeries Type : Expression profiling by arrayOrganism : Homo sapiensMyeloid dendritic cells (mDC) were isolated from antiretroviral therapy (ARV)-treated and untreated people living with HIV (PLWH), and from HIV uninfected Individuals. The results indicate that mDC are altered in genes expression from PLWH. Some RNA transcriptional changes are not completely restored by ARV. This provides more data on myeloid cells, an understudied cell...
GEO series published today
1h
GSE143362 Profiling of APEX-NLS and APEX-PMLca associated regions
Contributors : Misuzu Kurihara ; Kagayaki Kato ; Chiaki Sanbo ; Shuji Shigenobu ; Yasuyuki Ohkawa ; Takeshi Fuchigami ; Yusuke MiyanariSeries Type : OtherOrganism : Mus musculusTo address specificity of ALaP-seq for PMLwt, we performed genome-wide profiling of genomic regions associated with NLS-APEX or PMLca-APEX. Cells were treated with H2O2 to trigger labeling of chromatin with biotin (H2O2+). Experimental negative control for PMLca (H2O2-), where the H2O2 treatment was omitted, was also...
GEO series published today
1h
GSE143405 The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids
Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.CD4+ T cells are tightly regulated by microbiota in the intestine, but whether intestinal T cells interface with host-derived metabolites is less clear. Here, we show that CD4+ T effector (Teff) cells upregulated the xenobiotic transporter, Mdr1, in the ileum to maintain homeostasis in the presence of bile acids. Whereas wild-type Teff cells upregulated...
GEO series published today
1h
GSE143361 ALaP-seq and RNA-seq analyses of paraquat treated mESCs
Contributors : Misuzu Kurihara ; Kagayaki Kato ; Chiaki Sanbo ; Shuji Shigenobu ; Yasuyuki Ohkawa ; Takeshi Fuchigami ; Yusuke MiyanariSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusTo address the roles of PML bodies in transcription under stress condition, we performed ALaP-seq and RNA-seq with paraquat treated mESCs.
GEO series published today
1h
GSE143340 Canonical Wnt pathway controls mESCs self-renewal through inhibition of spontaneous differentiation via β-catenin/TCF/LEF functions
Contributors : Francesco Aulicino ; Francesco Sottile ; Elisa Pedone ; Frederic Lluis ; Lucia Marucci ; Maria P CosmaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe Wnt/β-catenin signalling pathway is a key regulator of embryonic stem cell self-renewal and differentiation. Constitutive activation of this pathway has been shown to significantly increase mouse embryonic stem cell (mESC) self-renewal and pluripotency marker expression. In this study, we...
GEO series published today
1h
GSE143353 Single Cell RNA Sequencing of Monocyte Derived Endothelial Cells
Contributors : Randall J Smith Jr ; Julien V Kann ; Jonathan E Bard ; Donald Yergeau ; Stelios T AndreadisSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe examined the global transcriptome of individual cells in the three cell populations, starting MC from three donors after 1hr adherence to FN pooled, MC-derived EC subjected to shear stress, and HCAEC subjected to shear stress using single cell RNA-sequencing (scRNA-Seq). Analysis showed that the initial...
GEO series published today
1h
GSE142526 Single cell transcriptomic comparison of human fetal retina, hPSC-derived retinal organoids, and long-term retinal cultures.
Contributors : Akshayalakshmi Sridhar ; Akina Hoshino ; Connor Finkbeiner ; Thomas A RehSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo study the development of human retina, we used single cell RNAseq at key fetal stages and followed the development of the major cell types, as well as populations of transitional cells. We also analyzed stem cell (hPSC)-derived retinal organoids; although organoids have a very similar cellular composition at equivalent...
GEO series published today
1h
GSE143352 The changes of transcription profiles of tumor cells with the deletion of components of PRC1 complex, and of the infiltrated NK cells.
Contributors : Z Zhang ; J W Leavenworth ; E S YangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe report the changes in the transcription profiles of the 4T1 breast cancer cells (control, RNF2 knockout (KO), and RSF1 KO), isolated and enriched from the tumor implanted in the 4th mammary pads by Fluorescence activated cell sorting, and the changes in the infiltrated NK cells. The transcription profiles were measured by RNA sequencing. We found that upon...
GEO series published today
1h
GSE140066 Caco2 response to methotrexate, lactoferrin, and methotrexate-lactoferrin co-exposure
Contributors : Thomas Wallach ; Vasudha Srivastava ; Zev GartnerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensbulk sequencing outputs of Caco2 cells after exposure to permeability modifying and permeability rescuing agents.To identify the molecular drivers for methotrexate-induced barrier dysfunction, we conducted RNA sequencing on Caco2 spheroids treated with methotrexate and lactoferrin. Given our observation that barrier function was compromised as early...
GEO series published today
1h
GSE143349 Snail and Twist expression in HMLE and MCF10A cells
Contributors : Binhua P Zhou ; Ren XuSeries Type : Expression profiling by arrayOrganism : Homo sapiensSnail and Twist are two EMT inducer, expression of Snail or Twist will induce EMT in HMLE and MCF10A cells. By introducing Snail or Twist in HMLE and MCF10A cells, which lack the expression of these two proteins, will identify the genes are induced during EMT.We used microarray analysis to compare the gene expression profiles between the mammamry epithleial cells and the cells undergone EMT.
GEO series published today
1h
GSE124987 Bone marrow microenvironment mediated drug resistance in Acute promyelocytic leukemia
Contributors : Vikram Mathews ; Saravanan Ganesan ; Hamenth Kumar PalaniSeries Type : Expression profiling by arrayOrganism : Homo sapiensAbout 5-10% newly diagnosed and about 20-30% of relapsed acute promyelocytic leukemia (APL) patients will have disease recurrence after receiving currently accepted standards of care. While there are reports of micro-environment mediated drug resistance (EM-DR) in AML, there is no data on the effect of malignant promyelocyte and stromal interaction on Arsenic...
GEO series published today
1h
GSE143348 Mouse lung gene expression analysis after repetitive hyperbaric oxygen exposure based on RNA-seq
Contributors : Yuan Yuan ; Yilu Zhou ; Yali Li ; Zhenglin Jiang ; Yihua WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHyperbaric oxygen (HBO) is widely applied to treat a number of hypoxia-related diseases. Previous studies focused on the immediate effect of HBO-exposure induced oxidative stress on lungs, but knowledge regarding the chronic effects from repetitive HBO exposure is limited, especially at the gene expression level. We found that repetitive...
GEO series published today
1h
GSE93392 Gene-expression profiles of multi-stage hepatocellular carcinoma induced by diethylnitrosamine (DEN) in mouse model
Contributors : Jung-Woo Eun ; Suk-Woo NamSeries Type : Expression profiling by arrayOrganism : Mus musculusTo better characterize the pathogenesis of hepatocarcinogenesis, we established mouse HCC model by diethylnitrosamine (DEN) exposures and performed whole genome expression profiling.
GEO series published today
1h
GSE143270 An integrative view of the regulatory and transcriptional landscapes in mouse hematopoiesis [ATAC-seq]
Contributors : Guanjue Xiang ; Cheryl A Keller ; Elisabeth Heuston ; Belinda M Giardine ; Lin An ; Alexander Q Wixom ; Amber Miller ; April Cockburn ; Michael E Sauria ; Kathryn Weaver ; Jens Lichtenberg ; Berthold Göttgens ; Qunhua Li ; David Bodine ; Shaun Mahony ; James Taylor ; Gerd A Blobel ; Mitchell J Weiss ; Yong Cheng ; Feng Yue ; Jim Hughes ; Douglas R Higgs ; Yu Zhang ; Ross C HardisonSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism...
GEO series published today
5h
GSE143266 An integrative view of the regulatory and transcriptional landscapes in mouse hematopoiesis [ChIP-seq]
Contributors : Guanjue Xiang ; Cheryl A Keller ; Elisabeth Heuston ; Belinda M Giardine ; Lin An ; Alexander Q Wixom ; Amber Miller ; April Cockburn ; Michael E Sauria ; Kathryn Weaver ; Jens Lichtenberg ; Berthold Göttgens ; Qunhua Li ; David Bodine ; Shaun Mahony ; James Taylor ; Gerd A Blobel ; Mitchell J Weiss ; Yong Cheng ; Feng Yue ; Jim Hughes ; Douglas R Higgs ; Yu Zhang ; Ross C HardisonSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism...
GEO series published today
5h
GSE143265 An integrative view of the regulatory and transcriptional landscapes in mouse hematopoiesis [histones]
Contributors : Guanjue Xiang ; Cheryl A Keller ; Elisabeth Heuston ; Belinda M Giardine ; Lin An ; Alexander Q Wixom ; Amber Miller ; April Cockburn ; Michael E Sauria ; Kathryn Weaver ; Jens Lichtenberg ; Berthold Göttgens ; Qunhua Li ; David Bodine ; Shaun Mahony ; James Taylor ; Gerd A Blobel ; Mitchell J Weiss ; Yong Cheng ; Feng Yue ; Jim Hughes ; Douglas R Higgs ; Yu Zhang ; Ross C HardisonSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism...
GEO series published today
5h
GSE143261 An integrative view of the regulatory and transcriptional landscapes in mouse hematopoiesis [RNA-seq]
Contributors : Guanjue Xiang ; Cheryl A Keller ; Elisabeth Heuston ; Belinda M Giardine ; Lin An ; Alexander Q Wixom ; Amber Miller ; April Cockburn ; Michael E Sauria ; Kathryn Weaver ; Jens Lichtenberg ; Berthold Göttgens ; Qunhua Li ; David Bodine ; Shaun Mahony ; James Taylor ; Gerd A Blobel ; Mitchell J Weiss ; Yong Cheng ; Feng Yue ; Jim Hughes ; Douglas R Higgs ; Yu Zhang ; Ross C HardisonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThousands...
GEO series published today
5h
GSE142183 Two separate roles for the transcription coactivator SAGA and a set of genes redundantly regulated by TFIID and SAGA [ChIP-Seq]
Contributors : Rafal Donczew ; Linda Warfield ; Derek Pacheco ; Ariel Erijman ; Steven HahnSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeDeletions within genes coding for subunits of the transcription coactivator SAGA caused strong genome-wide defects in transcription and SAGA-mediated chromatin modifications. In contrast, rapid SAGA depletion produced only modest transcription defects at 13% of protein-coding genes – genes that...
GEO series published today
5h
GSE142182 Two separate roles for the transcription coactivator SAGA and a set of genes redundantly regulated by TFIID and SAGA [RNA-Seq]
Contributors : Rafal Donczew ; Linda Warfield ; Derek Pacheco ; Ariel Erijman ; Steven HahnSeries Type : Expression profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeDeletions within genes coding for subunits of the transcription coactivator SAGA caused strong genome-wide defects in transcription and SAGA-mediated chromatin modifications. In contrast, rapid SAGA depletion produced only modest transcription defects at 13% of protein-coding genes – genes that are generally...
GEO series published today
5h
GSE142120 Two separate roles for the transcription coactivator SAGA and a set of genes redundantly regulated by TFIID and SAGA [ChEC-Seq]
Contributors : Rafal Donczew ; Linda Warfield ; Derek Pacheco ; Ariel Erijman ; Steven HahnSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeDeletions within genes coding for subunits of the transcription coactivator SAGA caused strong genome-wide defects in transcription and SAGA-mediated chromatin modifications. In contrast, rapid SAGA depletion produced only modest transcription defects at 13% of protein-coding genes – genes that...
GEO series published today
5h
GSE140395 The taste receptor TAS1R3 regulates small intestinal tuft cell homeostasis
Contributors : Michael R Howitt ; Y G Cao ; Matthew Gologorsky ; Jessica Li ; Adam L Haber ; Moshe Biton ; Jessica Lang ; Monia Michaud ; Aviv Regev ; Wendy S GarrettSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTuft cells are an epithelial cell subset critical for initiating type 2 immune responses to parasites and protozoa in the small intestine. To respond to these stimuli, intestinal tuft cells use taste chemosensory signaling pathways, but the role...
GEO series published today
7h
GSE128958 TGF-β and RREB1 coordinate EMT programs in NMuMG cells
Contributors : Jie Su ; Joan MassagueSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEpithelial-to-mesenchymal transitions (EMT) play prominent roles during development, regeneration and tumor progression. EMTs are triggered by TGF-β, RAS and other signals that cooperatively induce the expression of master EMT transcription factors such as SNAIL. Here, we elucidate how the TGF-β and RAS pathways jointly trigger EMTs and tie them to broader developmental programs....
GEO series published today
10h
GSE118765 TGF-β and RREB1 coordinate EMT programs in development and cancer
Contributors : Jie Su ; Joan MassagueSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusEpithelial-to-mesenchymal transitions (EMT) play prominent roles during development, regeneration and tumor progression. EMTs are triggered by TGF-β, RAS and other signals that cooperatively induce the expression of master EMT transcription factors such as SNAIL. Here, we elucidate how the TGF-β and RAS pathways...
GEO series published today
10h
GSE137164 Abundant and diverse non-coding small RNAs identified in an extremophilic microbial community using metatranscriptomics
Contributors : Diego R Gelsinger ; Gherman Uritskiy ; Rahul Reddy ; Adam Munn ; Katie Farney ; Jocelyne DiRuggieroSeries Type : Expression profiling by high throughput sequencingOrganism : Regulatory small RNAs (sRNAs) represent a major class of regulatory molecules that play large-scale and essential roles in many cellular processes across all domains of life. Microbial sRNAs have been primarily investigated in a few model organisms and little is known about the dynamics of sRNA synthesis in...
GEO series published today
11h
GSE118111 Transcriptome profiling of influenza-specific memory CD8 T cells in the lung airways, lung parenchyma, and spleen
Contributors : C D Scharer ; J E KohlmeierSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo examine differences in the transcriptome of resident memory CD8 T cells in the lung, influenza nucleoprotein-specific CD8 T cells from the airways , lung parenchyma, and spleen were FACS sorted and RNA isolated for RNA-seq.
GEO series published today
12h
GSE135503 ATAC-seq profiling of influenza-specific memory CD8 T cells in the lung airways (BAL), lung interstitium (LR), lung vasculature (LV), and spleen
Contributors : C D Scharer ; J E KohlmeierSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusTo examine differences in chromatin accessibility of resident memory CD8 T cells in the lung, influenza nucleoprotein-specific CD8 T cells from the airways , lung interstitium, and spleen were FACS sorted and ATAC-seq performed.
GEO series published today
12h
GSE118109 Chormatin accessiblity of influenza-specific memory CD8 T cells in the lung airways, lung parenchyma, and spleen
Contributors : C D Scharer ; J E KohlmeierSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusTo examine differences in chromatin accessibility of resident memory CD8 T cells in the lung, influenza nucleoprotein-specific CD8 T cells from the airways , lung parenchyma, and spleen were FACS sorted and DNA isolated for ATAC-seq.
GEO series published today
12h
GSE135504 Transcriptome profiling of influenza-specific memory CD8 T cells in the lung airways (BAL), lung interstitium (LR), lung vasculature (LV), and spleen
Contributors : C D Scharer ; J E KohlmeierSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo examine differences in the transcriptome of resident memory CD8 T cells in the lung, influenza nucleoprotein-specific CD8 T cells from the airways , lung interstitium, and spleen were FACS sorted and RNA isolated for RNA-seq.
GEO series published today
12h
GSE118110 Lung airways reprogram circulating memory CD8 T cells
Contributors : C D Scharer ; J E KohlmeierSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo examine how the transcriptome of circulating memory CD8 T cells isolated from the spleen are reprogrammed in the lung airways, influenza nucleoprotein-specific CD8 T cells from the spleen were FACS sorted and RNA isolated for RNA-seq or the cells were transferred to the lung airways and allowed to rest for 2 days. Following 2 days, donor influenza nucleoprotein-specific...
GEO series published today
12h
GSE137370 Transcriptome profiling of influenza-specific memory CD8 T cells following transfer into the airways or in vitro culture
Contributors : C D Scharer ; J E KohlmeierSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo examine differences in the transcriptome of resident memory CD8 T cells in the lung, influenza nucleoprotein-specific CD8 T cells from the airways , lung interstitium, lung vasculature, and spleen were FACS sorted and RNA isolated for RNA-seq. In some experiments, FACS sorted cells were transferred into the airways, peritoneum, or in vitro culture before subsequent isolation...
GEO series published today
12h
GSE118112 The lung microenvironment results in unique gene expression and epigenomic programs in airway and parenchyma resident memory CD8 T cells
Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
GEO series published today
13h
GSE129284 Epigenetic Regulation in Activated Macrophages
Contributors : Vichaya Ruenjaiman ; Yu-Wei Leu ; Asada Leelahavanichkul ; Monnat Pongpanich ; Tanapat PalagaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusIn this study, we compared active histone marks (trimethylation on lysine 4 on histone 3 (H3K4me3)) in LPS-stimulated macrophages and LPS/IC-stimulated macrophages using bone marrow derived murine macrophages using ChIP-seq approach.
GEO series published today
14h

GSE134670 Characterization of Holstein and Normande whole milk miRNomes highlights breed specificities
Contributors : Sandrine Le Guillou ; Antoine Leduc ; Johann Laubier ; Sarah Barbey ; Marie-Noëlle Rossignol ; Rachel Lefebvre ; Sylvain Marthey ; Denis Laloë ; Fabienne Le Provost ; Diane EsquerreSeries Type : Expression profiling by high throughput sequencingOrganism : Bos taurusThe concept of milk as a healthy food has opened the way for studies on milk components, from nutrients to microRNAs, molecules with broad regulatory properties present in large quantities in milk. Characterization...
GEO series published today
15h
GSE131255 An extended PAXT connection is required for turnover of nuclear polyadenylated RNA in human cells
Contributors : Toomas Silla ; Manfred Schmid ; Yuhui Dou ; Miha Milek ; Koshi Imami ; Dennis Johnsen ; Patrik Polak ; Jens S Andersen ; Mathias Selbach ; Markus Landthaler ; Torben H JensenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRecruitment of the human ribonucleolytic RNA exosome to nuclear polyadenylated (pA+) RNA is facilitated by the Poly(A) Tail eXosome Targeting (PAXT) connection. Besides its core dimer, formed by the exosome co-factor...
GEO series published today
17h
GSE140943 Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis [blood array]
Contributors : Lucia Moreira-Teixeira ; Anne O'GarraSeries Type : Expression profiling by arrayOrganism : Mus musculusCharacterisation of blood and lung global transcriptional responses to Mycobacterium tuberculosis infection in distinct mouse models of Tuberculosis
GEO series published today
17h
GSE137092 Mouse transcriptome reveals novel signatures of protection and pathogenesis in human tuberculosis [blood]
Contributors : Lucia Moreira-Teixeira ; Anne O'GarraSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCharacterisation of blood and lung global transcriptional responses to Mycobacterium tuberculosis infection in distinct mouse models of Tuberculosis
GEO series published today
17h
GSE140945 Mouse transcriptome reveals signatures of protection and pathogenesis in human tuberculosis
Series Type : Expression profiling by array ; Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
GEO series published today
17h
GSE140944 Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis [lung array]
Contributors : Lucia Moreira-Teixeira ; Anne O'GarraSeries Type : Expression profiling by arrayOrganism : Mus musculusCharacterisation of blood and lung global transcriptional responses to Mycobacterium tuberculosis infection in distinct mouse models of Tuberculosis
GEO series published today
17h
GSE137093 Mouse transcriptome reveals novel signatures of protection and pathogenesis in human tuberculosis [lung]
Contributors : Lucia Moreira-Teixeira ; Anne O'GarraSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCharacterisation of blood and lung global transcriptional responses to Mycobacterium tuberculosis infection in distinct mouse models of Tuberculosis
GEO series published today
17h
GSE109436 Next Generation Sequencing Analysis of Wild Type (WT) and SRSF1 knockdown (KD) U87MG and U251 cells Transcriptomes
Contributor : Xuexia ZhouSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe generated the SRSF1 knockdown U87MG and U251 cells by infecting with shRNA virus. Then, we extracted RNAs and performed next generation sequencing. By comparing sequencing data from WT and KD samples in each cell type, we profiled the alternative splicing events and gene expression regulated by SRSF1 in GBM.
GEO series published today
18h
GSE140408 The influence of acetate in the medium to the global gene expression of C. glutamicum wild type (WT) and the C. glutamicum ΔcyaB mutant (ΔcyaB)
Contributors : Natalie Wolf ; Michael Bussmann ; Abigail Koch-Koerfges ; Nino Katcharava ; Julia Schulte ; Tino Polen ; Johannes Hartl ; Julia A Vorholt ; Meike Baumgart ; Michael BottSeries Type : Expression profiling by arrayOrganism : Corynebacterium glutamicum ATCC 13032The cAMP-dependent transcriptional regulator GlxR serves as a central hub in the regulatory network of the actinobacterial model organism Corynebacterium glutamicum and controls expression of ~10% of all genes. The consequences...
GEO series published today
19h
GSE108536 Systematic identification of silencers in human cells
Contributors : Baoxu Pang ; Michael SnyderSeries Type : OtherOrganism : The majority of the human genome does not encode proteins. Many of these noncoding regions contain important regulatory sequences that control gene expression. To date, most studies have focused on activators such as enhancers, but regions that repress gene expression⎯silencers⎯have not been systematically studied. We have developed a system that identifies silencer regions in a genome-wide fashion based on silencer-mediated...
GEO series published today
19h
GSE93810 The role of micro-ribonucleic acids and extracellular vesicles in In-Vitro Fertilization
Contributors : Masood Abu-Halima ; Nicole LudwigSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensBACKGROUND: Molecular signaling in in vitro fertilization procedures seems to play a crucial role for embryonic development. In a prospective blinded cohort study, we investigated the role of microRNAs (miRNA) and extracellular vesicles (EV) as potential carriers of miRNAs in embryonic culture media. METHODS: Embryonic culture media from 56 female partners undergoing infertility...
GEO series published today
20h
GSE139134 Transcriptomic profiling of LPS-induced adrenal inflammation in sorted adrenal endothelial cells from C576L6 mice
Contributors : Lan-Sun Chen ; Waldemar KanczkowskiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAltogether, this is the first study presenting the global changes of the transcriptome in the adrenal microvascular cells. The results of RNA sequencing and subsequent bioinformatics analysis revealed that adrenal vascular endothelial cells are active players not only involved in maintenance of the adrenal gland microenvironment, but also they play a key role...
GEO series published today
21h

Δεν υπάρχουν σχόλια:

Δημοσίευση σχολίου

Αρχειοθήκη ιστολογίου