"Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"

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1.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Nov;33(11):1113-1116. doi: 10.13201/j.issn.1001-1781.2019.11.027.
[The progress of narrow band imaging endoscopy in diagnosis of vocal cord leukoplakia].
[Article in Chinese]
Zhang BG, Ni XG.

Abstract


SummaryThe appearances of vocal cord leukoplakia are largely identical in the macroscopic examination even though the pathological character may differ. This makes it difficult for physicians to evaluate the extent of dysplasia of vocal cord leukoplakia and detect the occurrence of canceration using the conventional laryngoscopy, which might result in overtreatment or undertreatment of vocal cord leukoplakia in different patients. Therefore, an accurate preoperative assessment of the pathological character of vocal cord leukoplakia shows clinical significance in the selection of an appropriate treatment plan and predicting the prognosis of a patient. Recent studies have found that narrow band imaging（NBI） endoscopy can facilitate the early and differential diagnosis of head and neck cancers by observing the intraepithelial papillary capillary loop（IPCL） patterns at the mucosal surfaces. In this paper, the recent progress of NBI endoscopy in the diagnosis of vocal cord leukoplakia is reviewed.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

diagnosis; laryngoscope; narrow band imaging; vocal cord leukoplakia
PMID: 31914309 DOI: 10.13201/j.issn.1001-1781.2019.11.027



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Select item 319143082.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Nov;33(11):1113-1116. doi: 10.13201/j.issn.1001-1781.2019.11.026.
[Progress in studies on obstructive sleep apnea and intestinal microecological balance].
[Article in Chinese]
Chen QC, Wang HY, Zhang PP, Fu AS, Ge YL, Zhu XY, Zhang Q, Zhang X, Yu HL.

Abstract


SummaryObstructive sleep apnea （OSA） is closely related to the development of various diseases. Hypoxic perfusion caused by OSA can mediate the occurrence of inflammatory reactions or aggravate metabolic disorders to affect intestinal microecological balance. Intestinal bacteria can participate in the development of inflammatory reaction or metabolic disorder by itself or its components, and the oxidative stress reaction of the body develops in a vicious circle. The mechanism has not yet been fully elucidated, so we reviewed the research progress on OSA and intestinal microecological balance.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

insulin resistance; intestinal microecology; intestinal mucosal injury; metabolic syndrome; oxidative stress response; sleep apnea, obstructive
PMID: 31914308 DOI: 10.13201/j.issn.1001-1781.2019.11.026



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Select item 319143073.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Nov;33(11):1109-1112. doi: 10.13201/j.issn.1001-1781.2019.11.025.
[Research progress in the application of intralymphatic allergen immunotherapy in allergic diseases].
[Article in Chinese]
Cai ZM, Wen Z.

Abstract


SummaryAlthough subcutaneous immunotherapy （SCIT） and sublingual immunotherapy （SLIT） have a positive effect, there are drawbacks such as long treatment time period, frequent treatment times, and risk of adverse reactions. Peripheral superficial lymph node injection of allergen immunotherapy （ILIT） as an emerging specific immunotherapy method has the advantages of high safety, less adverse reactions, short treatment time, less treatment times, less patient pain, and exact curative effect. In recent years, more and more scholars have conducted extensive research on intra-lymphatic injection of immunotherapy for allergic diseases. This paper systematically summarizes the theoretical basis, method, safety, effectiveness and possible immune mechanism of ILIT.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

allergic disease; lymph node injection; specific immunotherapy
PMID: 31914307 DOI: 10.13201/j.issn.1001-1781.2019.11.025



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Select item 319143064.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Nov;33(11):1105-1108. doi: 10.13201/j.issn.1001-1781.2019.11.024.
[Primary Ewing's sarcoma of the temporal bone: a rare case].
[Article in Chinese]
Deng JH, Lai RS, Li W, Hu P, Xie DH, Yang XM.

Abstract


SummaryEwing's sarcoma is a malignant, round cell tumor arising from the bones and primarily affecting children and adolescent. Involvement of the skull bones is rarely reported, constituting 1%-6% of the total Ewing's sarcoma cases. We describe a 33 years old male patient having Ewing sarcoma of the mastoid and petrous parts of temporal bone, whose clinical presentation mimicked mastoiditis with facial nerve palsy. We discuss the clinical and therapeutic course of an extensive primary Ewing sarcoma of the temporal bone and review this entity's literature in detail. The etiopathology of an acute peripheral facial palsy is often hard to identify. If the facial weakness starts together with symptoms suggesting an inflammatory process, the differential diagnosis may be focused first on diseases like herpes zoster oticus and a severe course of acute purulent otitis media. As an uncommon tumor of the temporal bone, physicians should consider Ewing's sarcoma in the differential diagnosis of children and adolescents who present with facial nerve paralysis. And in the case of ambiguous clinical findings, a surgical exposure of the middle ear is recommended.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

facial nerve paralysis; osteosarcoma; temporal bone
PMID: 31914306 DOI: 10.13201/j.issn.1001-1781.2019.11.024



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Select item 319143055.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Nov;33(11):1099-1101. doi: 10.13201/j.issn.1001-1781.2019.11.023.
[Atlantoaxial dislocation after tonsillectomy: two cases report].
[Article in Chinese]
Zhao XH, Wang YS.

Abstract


SummaryThe necks of two young patient can't moved around the plane after tonsillectomy. CT of atlantoaxial bone showed that the anatomy of atlantoaxial joint had been turned upside down. It is an extremely rare entity and very few have been reported in the literature. The reasons and specific mechanisms of atlantoaxial dislocation are the result of the aspects of anatomy of atlantoaxial joint and surrounding structures, biomechanics and histology. The patients have been cured by the raise neck as pinned and gived Anti-inflammatory. Atlantoaxial dislocation is difficult to be distinguish in the complication. It may lead to serious consequences in sometimes. When the event occurs medical staff has to take effect way to treat immediately. This point should be considered by medical staff.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

atlantoaxial joion; dislocations; tonsillectomy
PMID: 31914305 DOI: 10.13201/j.issn.1001-1781.2019.11.023



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Select item 319143046.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Nov;33(11):1095-1098. doi: 10.13201/j.issn.1001-1781.2019.11.022.
[Analysis the features of familial benign paroxysmal positional vertigo].
[Article in Chinese; Abstract available in Chinese from the publisher]
Wang Q1, Yuan BM2, Jin P1, Mao TT1, Pang Y1, Yu H1.

Author information
1Department of Otolaryngology，the First Hospital of Jilin University，Changchun，130000，China.2Department of Otolaryngology，the Second Hospital of Jilin University.

Abstract


Objective:The family heredity of BPPV disease was preliminarily discussed in order to guide the clinical practice, prevent early and shorten the course of BPPV disease in the future. Method:Familial BPPV patients were enquired and registered in detail, including gender, age at first onset, occupation, inducing factors, symptoms, diagnosis, sleep status and clinical manifestations. Analysis of the clinical data. Result:Nine patients with idiopathic BPPV from four families had no definite pathogenic factors, accounting for 0.4% of the patients with idiopathic BPPV, including 3 males and 6 females; the age of first onset ranged from 31 to 66 years old. the course of disease ranged from 2 days to 8 years; the duration of nystagmus ranged from seconds to 1 minute. The main clinical symptoms were dizziness and visual rotation related to position transformation. Family 1, 3 and 4 patients had a history of fatigue. Family 2 patients had a predisposing factor of forced lateral decubitus due to lumbar discomfort. All patients had nystagmus lasting less than 1 minute and were single-tube involvement, all patients were canalithiasis. Different patients in the same family have different pathogenic locations. Conclusion:Familial BPPV is urgent to attract the attention of clinicians and the public. Early clinical test for suspected familial BPPV can play a role in early prevention and shorten the process of disease, so as to improve the life quality of patients.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

benign paroxysmal positional vertigo; clinical features; family
PMID: 31914304 DOI: 10.13201/j.issn.1001-1781.2019.11.022



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Select item 319143037.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Nov;33(11):1093-1094. doi: 10.13201/j.issn.1001-1781.2019.11.021.
[Distribution and drug resistance analysis of secretion pathogens in 90 children with acute otitis media].
[Article in Chinese; Abstract available in Chinese from the publisher]
Li GB1, Xu MB1.

Author information
1Department of Otolaryngology，Putuo District People's Hospital，Zhoushan，316100，China.

Abstract


Objective:To analyze the pathogenic bacteria distribution and drug resistance of secretion in 90 child patients with acute otitis media. Method:The clinical data of 90 cases of acute otitis media child patients were retrospectively analyzed. The distribution of pathogenic bacteria in all child patients were analyzed. The child patients were divided into A group（less than 1 year old, n=38）, B group （1 to 3 years old, n=27） and C group （more than 3 years old, n=25） according to the age. The streptococcus pneumoniae detection in each group and the streptococcus pneumoniae resistant to various antibacterial agents were compared. Result:The positive rate of pathogen detection in children was 75.6% （68/90）, and the highest proportion was streptococcus pneumoniae with 61.8% （42/68）. The detection rate of streptococcus pneumoniae in A and B group was significantly higher than that of C group （P<0.05）. The resistance rate of streptococcus pneumoniae to different antibacterial drugs is quite different. Conclusion:Streptococcus pneumoniae is the main pathogenic bacterium in child patients with acute otitis media less than 3 years old, and different types of antibacterial drugs have different drug resistance.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

child; drug resistance; otitis media; pathogenic bacteria
PMID: 31914303 DOI: 10.13201/j.issn.1001-1781.2019.11.021



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Select item 319143028.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Nov;33(11):1089-1092. doi: 10.13201/j.issn.1001-1781.2019.11.020.
[Hearing assessment and follow-up study of aeonatal deafness gene screening homozygous mutation infants].
[Article in Chinese; Abstract available in Chinese from the publisher]
Liu QM1, Tian Y1, Yu JJ1, He QQ1, Peng L1, Guo XQ1, Li DY1, Chen T1, Wang F1.

Author information
1Department of Otorhinolaryngology，Zhuhai Maternal and Child Health Care Hospital，Zhuhai，519001，China.

Abstract


Objective:To analyze the hearing assessment characteristics and follow-up of some deafness gene screening homozygous infants in Zhuhai. Method:The clinical data of 28 newborns with homozygous mutations transferred to Zhuhai Maternal and Child Health Hospital from Feb. 1, 2015 to Oct. 25, 2018 in hospitals of Zhuhai City were retrospectively analyzed. All the children were screened for hearing. The hearing characteristics and long-term follow-up results of homozygous mutations at different gene sites were analyzed by auditory diagnosis and behavioral follow-up from 1 to 3 years. Result:Fourteen cases of GJB2 c.109G>A with a homozygous mutation, 11 cases passed the hearing screening, the audiological diagnosis was normal, and the behavior test and follow-up were normal from 1 to 3 years. Hearing screening was not passed in 3 newborns, mild to moderate abnormalities of single or bilateral ears were diagnosed by audiology, 1 000 Hz without positive, and middle ear lesions were diagnosed. Eight cases of GJB2 c.235del C homozygous mutation were followed up by behavioral audiometry and follow-up from 1 to 3 years after cure. Among them, 5 cases were diagnosed as severe hearing impairment of bilateral ears and 3 cases as mild and moderate hearing impairment. One case of GJB3 547G>A homozygous mutation was followed up for 1-3 years, and all of them failed to pass the follow-up of behavioral audiometry and follow-up. Four cases of SLC26A4 IVS7-2A>G, 1 case of SLC26A4 1229C>T homozygous mutation, all of them failed to pass the neonatal hearing screening. All the patients were diagnosed as severe hearing impairment of binaural hearing, and the follow-up of 1-3 years' follow-up did not pass the follow-up tests. Conclusion:GJB2 C.235del C, SLC26A4 IVS7-2A>G locus homozygous mutation infant hearing impairment was mainly severe hearing impairment in bilateral ears, and there was no change in 1-3 years follow-up. GJB2 C.109G A homozygous mutant infants had normal hearing, and it was suggested that they should be followed up closely. It is very important to give correct and reasonable genetic counseling to parents with GJB2 C.109G A homozygous mutation without unnecessary panic.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

deafness gene screening; follow-up investigation; neonatal hearing screening
PMID: 31914302 DOI: 10.13201/j.issn.1001-1781.2019.11.020



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Select item 319143019.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Nov;33(11):1085-1088. doi: 10.13201/j.issn.1001-1781.2019.11.019.
[Clinical characteristics and treatment of myoepithelial carcinoma of head and neck].
[Article in Chinese; Abstract available in Chinese from the publisher]
Zhao DL1, Wang LZ1, Cao H1, Sang JZ1, Gao L1, Cao XD1, Cao S2, Chen L1.

Author information
1Department of Otolaryngology，the First Affiliated Hospital of Zhengzhou University，Zhengzhou，450052，China.2Department of Otorhinolaryngology Head and Neck Surgery，Henan Shenhuo Group General Hospital，Yongcheng.

Abstract


Objective:To investigate the clinical features, diagnosis, treatment and prognosis of myoepithelial carcinoma of the head and neck. Method:The clinical data of 59 patients with head and neck myoepithelial carcinoma admitted from January 2012 to October 2018 were analyzed retrospectively. The data was analyzed with SPSS 21.0 statistical software. Result:The follow-up period was 6 to 131 months. The mean follow-up time was 36 months. One patient（1.7%） was lost to follow-up, 17 patients（28.8%） had postoperative local recurrence, 8 patients（13.6%） had distant metastasis, and 5 patients（8.5%） had cervical lymph node metastasis; 14 patients（23.7%） died. The 1-, 3-, and 5-year cumulative survival rates were 92%, 73%, and 62%, respectively. Survival rate curves of different treatment methods were significantly different by Gehan method（P<0.05）. Compared between the two groups, there was significant difference between surgery alone and surgery plus radiotherapy than radiotherapy alone and chemotherapy alone（P<0.05）. There was no significant difference between the other two treatment methods. Multivariate logistic regression analysis showed that tumor location, clinical stage and survival status and local recurrence rate were significantly correlated（P<0.05）, but gender, age and survival status and local recurrence rate were not significantly correlated（P>0.05）. Conclusion:The incidence of myoepithelial carcinoma is low, and the clinical manifestations and imaging studies lack specificity. The tumor is prone to local recurrence, invasive, and has a high incidence of distant metastasis. It is a highly malignant tumor. Surgical treatment is preferred and the requirements for first surgery are high, and major salivary glands and advanced tumors（stage Ⅲ-Ⅳ） are risk factors for survival and local recurrence. Early diagnosis and early treatment can significantly improve the survival rate of patients, reduce the local recurrence rate of tumors, and improve the prognosis of patients.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

myoepithelial carcinoma; prognosis; salivary neoplasms; treatment
PMID: 31914301 DOI: 10.13201/j.issn.1001-1781.2019.11.019



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Select item 3191430010.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Nov;33(11):1081-1084. doi: 10.13201/j.issn.1001-1781.2019.11.018.
[Correlation between BRAP expression and prognosis of patients with laryngeal squamous cell carcinoma].
[Article in Chinese; Abstract available in Chinese from the publisher]
Yin WJ1, Li LM1, Wang L1, Huang A2, Qiao AX1, Jia YT3, Feng Y3.

Author information
1Department of Pathology，Shanxi Medical University，Taiyuan，030001，China.2Department of Otorhinolaryngology，the First People's Hospital of Jinzhong.3Department of Otorhinolaryngology Head and Neck Surgery，the First Hospital of Shanxi Medical University.

Abstract


Objective:To investigate the expression of BRCA1 associated protein（BRAP） and its correlations with clinicopathological features and prognosis of patients with laryngeal squamous cell carcinoma（LSCC）. Method:The protein expression of BRAP in LSCC tissues and normal laryngeal tissues were assessed by immunohistochemistry and Western blot, and their correlations with clinicopathological features and prognosis were statistically analyzed. Result:The expression of BRAP in LSCC was significantly higher than that in normal laryngeal tissues（P<0.05）. BRAP expression was significantly correlated with the TNM stage and lymph node metastasis（P<0.05）. Kaplan-Meier survival analysis showed that LSCC patients with high BRAP expression had worse overall survival than those with low BRAP expression（P<0.01）. Multivariate Cox proportional-hazards analysis showed that the high expression of BRAP protein was an important poor prognostic indicator of the patients. Conclusion:BRAP is related with the development of LSCC, and it may be used as an important prognostic biomarker for LSCC patients.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

BRAP; immunohistochemistry; laryngeal neoplasms; squamous cell carcinoma
PMID: 31914300 DOI: 10.13201/j.issn.1001-1781.2019.11.018



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Select item 3191429911.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Nov;33(11):1076-1080. doi: 10.13201/j.issn.1001-1781.2019.11.017.
[Treatment of parotid hemangioma in children].
[Article in Chinese; Abstract available in Chinese from the publisher]
Ming C1, Zhang TS1, Ma J1, Gao L1, Lou F1, Lin K1, Zeng WJ1, Xiao Y1.

Author information
1Department of Otolaryngology Head and Neck Surgery, Kunming Children's Hospital(Children's Hospital Affiliated to Kunming Medical University), Yunnan Key Laboratory of Children's Major Disease Research, Kunming, 650228, China.

Abstract


Objective:To summarize the treatment and effect of children with parotid hemangioma. Method:Thirty-three children with parotid hemangioma were treated with drug in 22 cases, 9 of which received propranolol orally, accounting for 27%; 13 cases underwent B-ultrasound guided bleomycin injection, accounting for 40%; another 11 cases were used. The treatment of surgical removal of hemangioma, accounting for 33%. Result:In 22 children with drug therapy, the evaluation criteria were evaluated by Achauer et al. 12 cases of grade Ⅳ, accounting for 54.5%; 7 cases of grade Ⅲ, accounting for 31.8%; 2 cases of grade Ⅱ, accounting for 9%. For example, accounted for 4.5%; 2 of them（1 in gradeⅠand Ⅱ） were treated with drug therapy for 6 months after surgical resection of hemangioma. Eleven children underwent surgical resection of hemangioma, and 8 patients underwent complete resection of the tumor, accounting for 73%. Among them, 3 patients had residual hemangiomas during operation, and the residual tumor was treated with bleomycin. This group of medications showed that children aged<12 months, after oral propranolol, the tumors were reduced to varying degrees, the most significant change within 1 week after administration, and then the tumor was further reduced until the end of treatment. Conclusion:B-ultrasoun lower bleomycin injection in children with parotid hemangioma is effective, and the incidence of adverse reactions is low, but multiple courses of treatment are required. For patients with poor drug treatment, recurrence or limited range, surgical resection of blood vessels can be selected. Tumor surgery should pay attention to the choice of indications and surgical operation skills, reduce the risk of facial nerve injury and postoperative facial scars. There are many different treatments for infantile hemangioma, but there is still no treatment for all children. The drug treatment of this group showed that after oral propranolol, the tumors were all reduced to varying degrees, the color became lighter, the texture became softer, and the change was most significant within 1 week after administration, and then the tumor was further reduced until the end of treatment. B-ultrasound guided bleomycin injection in children with parotid hemangioma is effective. After 1-2 courses of treatment, the tumor shrinks significantly and the incidence of adverse reactions is low. Drug treatment of parotid hemangioma in children is simple. A safe and effective method. For children with poor drug treatment, recurrence or limited range, surgical treatment of hemangioma can be selected. Surgery should pay attention to the choice of indications and surgical operation skills, reduce the risk of facial nerve injury and postoperative facial scars.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

children; parotid hemangioma; treatment
PMID: 31914299 DOI: 10.13201/j.issn.1001-1781.2019.11.017



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Select item 3191429812.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Nov;33(11):1072-1075;1080. doi: 10.13201/j.issn.1001-1781.2019.11.016.
[Therapeutic evaluation of modified supraglottoplasty for laryngomalacia].
[Article in Chinese; Abstract available in Chinese from the publisher]
Pu SL1, Li XY1.

Author information
1Department of Otolaryngology Head and Neck Surgery，Shanghai Children's Hospital，Shanghai Jiaotong University，Shanghai，226001，China.

Abstract


Objective:To evaluate the therapeutic effect of modified supraglottoplasty for laryngeal malacia in children. Method: All 22 children with laryngomalacia underwent modified supraglottoplasty were retrospectively analyzed. Surgical correction of type Ⅰ involved the ablation of redundant mucosal tissue over the arytenoids, keep the part below anesthetic intubation. Type Ⅱ was treated by ablation of the shortened aryepiglottic folds and/or ablation of the lateral edge of the epiglottis, separate the epiglottis with epiglottis to enlarge the laryngeal inlet. Type Ⅲ was corrected by ablating wound surfaces on the base of the tongue and epiglottic vallecula but no more than 1/2 area of lingual surface of epiglottis. All patients were kept intubated for 5 days after surgery in the intensive care unit （ICU）. Evaluate the severity of laryngomalacia before and after surgery （extubation）, 1 month after surgery, and 6 months after surgery. Visual analogue scale （VAS） was used to score the symptoms, including stridor, reflux or feeding difficulties, aspiration, dyspnea and frequency or severity of pneumonia. Clinical score was determined by the physician on the child's laryngeal obstruction, supraglottic morphology in laryngoscope, swallowing function, weight and the result of polysomnography. Result:All 22 children with laryngomalacia were followed up for 6 months after surgery, statistically significant differences in scores before, after, 1 month after and 6 months after surgery （P<0.01）. The symptoms of stridor, dyspnea and feeding difficulties were improved in different degrees. Conclusion:Modified supraglottoplasty for children with laryngomalacia simplified the surgical procedure, and the therapeutic effect is safe and reliable. The evaluation system designed in this study is more intuitive and objective to evaluate the severity of laryngomalacia and the operative effect, which may has certain reference value for the evaluation of the condition and the treatment process.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

evaluation; laryngomalacia; supraglottoplasty
PMID: 31914298 DOI: 10.13201/j.issn.1001-1781.2019.11.016



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Select item 3191429713.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Nov;33(11):1068-1071. doi: 10.13201/j.issn.1001-1781.2019.11.015.
[Diagnosis and treatment of cervical migratory foreign bodies caused by sharp esophageal foreign bodies].
[Article in Chinese; Abstract available in Chinese from the publisher]
Liu LF1, Qiu HT1, Jiang F1, Chen LH2, Li F1, Yao J1.

Author information
1Department of Otolaryngology Head and Neck Surgery，Affiliated Hospital of Guangdong Medical University，Zhanjiang，524001，China.2Department of Radiology，Affiliated Hospital of Guangdong Medical University.

Abstract


Objective:Imaging findings and treatment of sharp foreign bodies penetrating the esophagus to migrate in the neck were collected. Method:All of 9 cases were determined by CT imaging. The foreign bodies were removed in 8 cases through the lateral cervical approach. The last case was taken out by bronchoscope. Eight cases successfully removed the foreign bodies. No definite foreign body was found in 1 case. Result:There were no postoperative complications in 8 patients that successful removed of foreign bodies. All patients begin to eat normally after operation and were discharged from hospital in 7 days. Tracheoesophageal fistula occurred that happened to the patient that no foreign body was found in operation. So gastric tube was retained for 7 days. Conclusion:CT imaging should be performed to determine whether there is the possibility of foreign body penetrating out of the esophagus, for the patients who had explicit history but the foreignbodies could not be found by barium meal examination. If necessary, three-dimensional CT reconstruction of the neck should be performed to locate the foreign body. Surgical exploration should be done as soon as possible to avoid aimless migration of foreign bodies, and it is difficult to find it during operation.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

diagnosis treatment; esophageal perforation; foreign body
PMID: 31914297 DOI: 10.13201/j.issn.1001-1781.2019.11.015



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Select item 3191429614.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Nov;33(11):1065-1067. doi: 10.13201/j.issn.1001-1781.2019.11.014.
[Excision of thyroglossal cyst in children by transverse submentum incision].
[Article in Chinese; Abstract available in Chinese from the publisher]
Pan WJ1, Sun J1, Zhou J1, Sun DX1, Wu P1, Han Q1.

Author information
1Department of General Surgery，Children's Hospital of Nanjing Medical University，Nanjing，210029，China.

Abstract


Objective:To explore the application of transverse submentum incision in thyroglossal duct cyst surgery. Method:Submentum transverse incision for thyroglossal duct cyst removal in 14 children with thyroglossal duct cyst from January 2014 to December 2017. All cases were performed submentum dermatoglyphic incision, skin incision, subcutaneous tissue, platysma muscle incision, down lifting flap, along the white line incision and separation of banded muscle on both sides, see the mass along the wall of the capsule separated to the attachment of the hyoid bone, ablation of the mucosa of the capsule wall of the hyoid bone attachment, electrotome to break the hyoid bone. The cavity is indeed stopped after bleeding, and the skin is sutured continuously for continuous intradermal suture. The operation time, bleeding volume, severe complications, wound healing time and severe surgical scars were recorded. Close follow-up was performed to observe whether there was infection or recurrence of incisional wound. Parents were informed by telephone to go back to the outpatient clinic. RUTTER Children's Behavior Questionnaire was used to assess the children's psychological status. Vancouver Scar Rating Scale was used to evaluate the children's surgical scars, and to investigate whether parents satisfactory surgical methods. Result:Fourteen cases of thyroglossal duct cyst underwent transverse incision thyroglossal duct cyst excision successfully. The average operative time was 55 minutes, and the standard deviation was 10.5 min, bleeding was less than 10 ml, postoperative hoarseness and weakness of voice, silence became low, wound healing time averaged one week, no serious surgical scars, no wound infection and recurrence. Among the normal children of the same age group, 14 parents were satisfied with the operation. Conclusion:Excision of thyroglossal duct cyst under transverse incision is safe, reliable and satisfactory in appearance.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

sistrunk's operation; submentum transverse incision; thyroglossal duct cyst
PMID: 31914296 DOI: 10.13201/j.issn.1001-1781.2019.11.014



Conflict of interest statement


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Select item 3191429515.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Nov;33(11):1060-1064. doi: 10.13201/j.issn.1001-1781.2019.11.013.
[Evaluation of the role of melatonin in the metastasis of papillary thyroid carcinoma].
[Article in Chinese; Abstract available in Chinese from the publisher]
Fan L1, Xiong YP1, Liu HT1, Min X1, Tang YQ1, Zhang ZY1.

Author information
1Department of Otolaryngology Head and Neck Surgery，First Affiliated Hospital of Nanchang University，Nanchang，330006，China.

Abstract


Objective:To evaluate the level of melatonin and the role of melatonin in the metastasis of papillary thyroid carcinoma in patients with papillary thyroid carcinoma. Method:We measured serum melatonin levels in 81 patients with papillary thyroid carcinoma（PTC） ,20 patients with multinodular goiter（MNG） and 20 healthy adults using ELISA. The relationship between melatonin and clinicopathological features of PTC were analyzed.The expression of MT1 and MT2 in two subtypes of melatonin receptor in 81 cases of papillary thyroid carcinoma and adjacent tissues were detected by immunohistochemical SP method, and its the mean optical density（MOD） image was analyzed by Image Pro Plusversion（IPP） image processing software. Result:Serum melatonin concentration in patients with PTC was significantly higher than that in MNG patients and normal controls（P<0.05）. The level of melatonin in the primary tumor T≥2 cm group was significantly higher than that in the T<2 cm group. Patients with positive cervical lymph nodes（N≥1） had significantly higher melatonin levels than lymph node negatives（N=0）（P<0.05）. The MT1 and MT2 receptors were expressed in both PTC and paracancerous tissues, mainly in the cell membrane and cytoplasm. The expression of MT1 receptor was low in the two groups, and there was no statistical difference. The expression of MT2 receptor in PTC tissues Significantly higher than the adjacent tissues（P<0.05）, further studies showed that the expression of MT2 receptor in PTC tissues was associated with cervical lymph node metastasis, and the expression of MT2 receptor in PTC tissues with cervical lymph node metastasis was significantly lower than that without metastasis （P<0.05）. Conclusion:Serum melatonin levels in PTC patients were higher than those in MNG and control groups, which may be associated with low malignancy of PTC; melatonin inhibits PTC metastasis, which exerts anti-PTC metastasis mainly through MT2 receptors.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

lymphatic metastasis; melatonin; melatonin receptor; papillary thyroid cancer
PMID: 31914295 DOI: 10.13201/j.issn.1001-1781.2019.11.013



Conflict of interest statement


Publication type


Select item 3191429416.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Nov;33(11):1057-1059;1064. doi: 10.13201/j.issn.1001-1781.2019.11.012.
[The application of three-dimensional printing technique combined with three-dimensional reconstruction in mandibular fracture].
[Article in Chinese; Abstract available in Chinese from the publisher]
Lv JL1, Zhong KT1, Zheng YH1, Wang P2, Cai XQ1, Zhang R1.

Author information
1Department of Oral and Maxillofacial Surgery，Zhengzhou Central Hospital Affiliated to Zhengzhou University，Zhengzhou，450007，China.2Department of Orthopaedics，Zhengzhou Central Hospital Affiliated to Zhengzhou University.

Abstract


Objective:To explore the value and significance of the combination of 3D printing and spiral CT three-dimensional reconstruction in the diagnosis and treatment of common mandibular fractures. Method:Forty patients with mandibular fracture were collected. They were randomly divided into traditional operation group and 3D printing combined with three-dimensional reconstruction operation group. The differences between the two groups were compared according to the operation time and the recovery of fracture. Result:The operation time and trauma of 3D printing combined with three-dimensional reconstruction group were significantly better than those of traditional operation group, and the former was better than the latter （P<0.05）. Conclusion: 3D printing combined with three-dimensional reconstruction operation method realized the concept of individualized, precise and minimally invasive comprehensive treatment, which is worthy of clinical promotion.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

3D printing; mandibular fracture; three-dimensional reconstruction
PMID: 31914294 DOI: 10.13201/j.issn.1001-1781.2019.11.012



Conflict of interest statement


Publication type


Select item 3191429317.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Nov;33(11):1053-1056. doi: 10.13201/j.issn.1001-1781.2019.11.011.
[The ability of gap detection in patients with acoustic neuroma].
[Article in Chinese; Abstract available in Chinese from the publisher]
Lan L1, Shao LM2, Xiong F1, Xie LY1, Yu L1, Han B1, Wang QJ1.

Author information
1Department of Otorhinolaryngology Head and Neck Surgery，General Hospital of Chinese People's Liberation Army，Beijing，100853，China.2Otolaryngology Clinical Hearing Center，Shenzhen Hospital of Southern Medical University.

Abstract


Objective:We aimed to provide a basis for the clinical study of acoustic neuroma through investigating the ability of temporal gap detection in acoustic neuroma patients and comparing the abilities with those in people with normal and impaired hearing. Method:Twenty-two patients with confirmed acoustic neuroma, 30 normal hearing patients and 16 patients with sensorineural hearing loss were enrolled in this study, and the interval threshold for awareness of each group was tested. Result:The mean temporal gap detection test（TGDT） threshold of the normal hearing group was （3.56±0.82） ms; the sensorineural hearing loss group's was （3.91±1.46） ms; TGDT threshold of healthy side of acoustic neuroma patients was （4.01±1.86） ms; TGDT threshold of the impaired side of acoustic neuroma patients was （9.48±9.46）ms. After statistical analysis, we found that excepting for the test of phonetically balanced maximum （PBmax） and TGDT, other results in the sensorineural hearing loss group and normal hearing group is of no statistical difference. The difference between the affected side of the acoustic neuroma group and the other groups was statistically significant （P<0.05）. There was no linear correlation between the value of TGDT threshold and PBmax （P> 0.05）. TGDT value of normal people has no significant difference among people of different genders and ears of different individuals. Conclusion:The TGDT of the healthy ear of the patients with acoustic neuroma is not affected, and there is no significant change compared with normal people. The TGDT test has a good consistency with the PBmax results. The time interval response ability of the affected ear of the acoustic neuroma is significantly weaker than that of the normal person. The combined test of PBmax and TGDT will contribute to the diagnosis of retrocochlear disease.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

acoustic neuroma; auditory temporal gap detection thresholds test; sensorineural hearing loss
PMID: 31914293 DOI: 10.13201/j.issn.1001-1781.2019.11.011



Conflict of interest statement


Publication type


Select item 3191429218.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Nov;33(11):1049-1052. doi: 10.13201/j.issn.1001-1781.2019.11.010.
[Clinical observation of the relationship between the newborn hearing screening and ABO blood groups].
[Article in Chinese; Abstract available in Chinese from the publisher]
Li AF1, Gao GQ2, Niu YZ1, Fu T1, Zhang XW1, Ji CL1.

Author information
1Department of Otolaryngology Head and Neck Surgery，the Affiliated Hospital of Qingdao University，Qingdao，266000，China.2Department of Obstetrics，the Affiliated Hospital of Qingdao University.

Abstract


Objective:To analyze the relationship between ABO blood groups and otoacoustic emissions in full-term newborns, including the occurrence of SOAE and the amplitudes of DPOAE. Method:A total of eighty normal hearing female neonates were included in the study, with equal number of participants in each of the ABO blood group. Measurements of SOAE and DPOAE were collected from both ears of all participants. Result:The blood group O subjects showed significantly fewer SOAE occurrences and lower DPOAE amplitudes at 793 Hz, 1 257 Hz and 1 587 Hz than subjects with other three blood groups both in the left and right ears. Conclusion:The full-term neonates with blood group O have lower SOAE occurrence than other three blood group individual. The blood group O individuals have the lowest amplitude at 793 Hz, 1 257 Hz and 1 587 Hz of both ears.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

ABO blood-group system; distortion product otoacoustic emission; noise-induced hearing loss; spontaneous otoacoustic emission
PMID: 31914292 DOI: 10.13201/j.issn.1001-1781.2019.11.010



Conflict of interest statement


Publication type


Select item 3191429119.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Nov;33(11):1044-1048. doi: 10.13201/j.issn.1001-1781.2019.11.009.
[The curative effect of manual reduction combined with vestibular rehabilitation exercise in the treatment of benign paroxysmal positional vertigo].
[Article in Chinese; Abstract available in Chinese from the publisher]
Zou TM1, Chen JM1, Zhou XW1, Chen DP1, Liu QL1, Liu Z1, Yu YJ1.

Author information
1Department of Otolaryngology，the First People's Hospital of Foshan，Guangdong Hearing and Equilibrium Engineering and Technology Research Development Center，Foshan，528000，China.

Abstract


Objective:To investigate the effect of vestibular rehabilitation exercise combined with manual reduction in the treatment of benign paroxysmal positional vertigo（BPPV）. Method:A total of 186 patients with benign paroxysmal positional vertigo were selected and randomly divided into experimental group and control group . The control group was treated with manual reduction, while the experimental group was treated with manual reduction combined with vestibular rehabilitation exercises. Patients with posterior semicircular canal BPPV carried out Brandt-Daroff exercises, while patients with horizontal semicircular canal BPPV carried out Cawthorne-Cooksey exercises and position restriction. To analyze the clinical curative effect, DHI score, residual dizziness and recurrence of the two groups. Result:There was no significant difference in total efficiency rate and DHI score between the two groups at the first diagnosis（P>0.05）. After 1 week, 2 weeks and 1 month of follow-up, the total efficiency rate of the experimental group were 90.3%, 91.4% and 93.5% respectively, which were significantly higher than those of the control group（P<0.05）. Synchronously, the scores of DHI in experimental group were respectively 14.33±5.71, 12.25±4.98 and 9.45±3.70, which were significantly lower than the control group（P<0.05）. For the experimental group, in the first diagnosis, 1 week, 2 weeks and 1 month after follow-up, residual dizziness patients were 29 cases, 13 cases, 8 cases and 0 cases. The mean duration of residual dizziness was （5.86±4.71） days, which was significantly lower than that in the control group（P<0.05）. One month after follow-up, the recurrence of patients in the experimental group were 5 cases, while the control group were 11 cases, significant difference between the two groups（χ²=4.704, P=0.030）. Conclusion:Manual reduction combined with vestibular rehabilitation exercise can significantly improve the therapeutic effect of BPPV, ameliorate the residual dizziness symptoms and reduce the recurrence rate, meanwhile improve the balance function and quality life of patients.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

manual reduction; vertigo; vestibular rehabilitation exercises
PMID: 31914291 DOI: 10.13201/j.issn.1001-1781.2019.11.009



Conflict of interest statement


Publication type


Select item 3191429020.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Nov;33(11):1040-1043. doi: 10.13201/j.issn.1001-1781.2019.11.008.
[The value of laryngoscopy and MRI in diagnosis and management of pharyngolaryngeal venous malformations].
[Article in Chinese; Abstract available in Chinese from the publisher]
Kang Y1, Yao JJ1, Zhang ZH1, Wang ZY1, Wu H1, Shi J1.

Author information
1Department of Otolaryngology Head and Neck Surgery，Shanghai Ninth People's Hospital，Shanghai Jiao Tong University School of Medicine，Ear Institute，Shanghai Key Laboratory of Translational Medicine on Ear and Nose diseases，Shanghai Jiao Tong University School of Medicine，Shanghai，200092，China.

Abstract


Objective:To investigate the value of laryngoscopy and MRI in diagnosis and management of pharyngolaryngeal venous malformations（VMs）, and to provide reliable evidences for clinical application. Method:The clinical data of 73 patients with pharyngolaryngeal VMs was analyzed retrospectively. Laryngoscopy and MRI were detected before treatment. The involved anatomic sites and the volume of VMs were calculated by Mimics version 20.0. Result:No significant difference was found in the detection rate of VMs between laryngoscopy and MRI（P>0.05）. The most common sites involved in pharyngolaryngeal VMs were the tongue base（37.0%）, followed by epiglottis（35.6%） and pyriform sinus（32.9%）. The volume of pharyngolaryngeal VMs ranged from 0.75 cm³to 76.33 cm³, with an average volume of （17.43±6.28） cm³. Conclusion:Laryngoscopy and MRI have their own advantages in diagnosing of pharyngolaryngeal VMs. Thus a combination which provides more information to formulate reasonable treatment plan has great diagnosing value. When treating with facial and cervical VMs, routine laryngoscopy is recommended to screen and to evaluate the laryngopharyngeal involvement.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

MRI; laryngoscopy; vascular malformation; venous malformations
PMID: 31914290 DOI: 10.13201/j.issn.1001-1781.2019.11.008



Conflict of interest statement


Publication type


Select item 3191428921.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Nov;33(11):1036-1039. doi: 10.13201/j.issn.1001-1781.2019.11.007.
[The clinical study of modified transseptal suturing after septoplasty].
[Article in Chinese; Abstract available in Chinese from the publisher]
Yu Z1, Liu YL1, Jia HG1, Wei YX1.

Author information
1Capital Medical University Affiliated Beijing Anzhen Hospital Otorhinolaryngology Head and Neck Surgery，Beijing，100029，China.

Abstract


Objective:To study whether modified transseptal suturing could be an alternative to packing after septoplasty. Method:We conducted a prospective randomized controlled trial. The study involved 40 patients who underwent septoplasty. Patients were randomly divided into two groups, one with anterior nasal packing and the other with modified transseptal suturing. Patients were asked to record their subjective discomfort levels on a visual analogue scale（VAS） during 48 h postoperatively. Both groups were compared for VAS, postoperative complications 2 weeks after septoplasty through nasal endoscope, the datum of rhinomanometry before surgery and 2 weeks after surgery. Result:The differences of mean postoperative VAS score between two groups were statistically significant（P<0.05）. The patients of nasal packing group experienced more discomforts than the other group. No statistically significant between two groups in terms of the datum of rhinomanometry before surgery and 2 weeks after surgery（P>0.05）. There were no bleeding, septal hematoma, nasal septum perforation and local infection in all patients 2 weeks after septoplasty. During follow-up 1 case was found with postoperative nasal adhesion, nasal vestibular swelling and fester were seen in two patients and nasal peculiar smell was found in 1 case in nasal packing group. We can find that there were a lot of blood crust in silicone ventilation tube about in 14 patients in packing group. However, the suturing group could see none of the above questions. Conclusion:Modified transseptal suturing is more simple and convenient than nasal packing. In a word, the use of modified transseptal suturing could be an alternative topacking after septoplasty.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

nasal packing; rhinomanometry; septoplasty; transseptal suturing
PMID: 31914289 DOI: 10.13201/j.issn.1001-1781.2019.11.007



Conflict of interest statement


Publication type


Select item 3191428822.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Nov;33(11):1031-1035;1039. doi: 10.13201/j.issn.1001-1781.2019.11.006.
[Research on the effects of CPAP for OSA combined CHD long-term prognosis].
[Article in Chinese; Abstract available in Chinese from the publisher]
Wang JF1, Fang JR2, Xie YP1, Ma W1, Hui PL1, Su XY1, Guo B1, Liu Y1.

Author information
1Sleep Medicine Center，Gansu Provincial People Hospital，Lanzhou，730000，China.2Day care center，Gansu Provincial People Hospital.

Abstract


Objective:To investigate the effects of CPAP for obstructive sleep apnea（OSA） combined CHD（coronary heart disease） long-term prognosis. Method:One hundred and twenty cases of OSA combind CHD in gansu province people's hospital sleep center were randomly divided into two groups according to apnea hypopnea index（AHI）, group A（light, medium OSA and CHD） 60 cases, group B（severe OSA and CHD） 60 cases. Contrast analysis and comparison between two groups PSG（Polysomnography） parameters, and the differences between the degree of coronary artery lesions and CPAP therapy effect on coronary long-term prognosis. Result:Compared group B with A, AHI, BMI, LSaO2, Epworth sleepiness scale（ESS） score, the amino acid homocysteine, the prevalence of hypertension, type 2 diabetes, the prevalence of acute myocardial infarction（ami） and vascular lesions and SYNTAX score increased significantly（P<0.05）. The ejection fraction decreased significantly（P<0.05）. The BNP（Brain natriuretic peptide） and cTNT（cardiac troponin, cTn） concentration there was no significant difference between the two groups（P>0.05）. CPAP treatment（30.0±4.2） months later, Group B: CAPA + conventional treatment group, compared with the simple routine LSaO2, ejection fraction increased significantly（P<0.05）, AHI, cardiovascular adverse events, vascular lesions, SYNTAX score, the BNP and TNT concentration significantly reduced（P<0.05）; Group A: AHI, decreased significantly（P<0.05）, LSaO2increased significantly（P<0.05）, ejection fraction, cardiovascular adverse events, vascular lesions, SYNTAX score, there was no significant difference between the BNP and TNT concentration; Survival analysis showed that: Group A CPAP+conventional treatment group cumulative survival rate higher than the conventional treatment group, but there was no statistically significant difference（P=0.260）. Group B: CPAP+conventional treatment group total survival rate was significantly higher than that of the conventional treatment group（P<0.001）; Conclusion:With the increase of the severity of OSA, OSA merge CHD coronary artery pathological changes degree aggravating, CPAP therapeutic benefit the long-term prognosis of CHD.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

continuous positive airway pressure; coronary heart disease; obstructive sleep apnea syndrom
PMID: 31914288 DOI: 10.13201/j.issn.1001-1781.2019.11.006



Conflict of interest statement


Publication type


Select item 3191428723.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Nov;33(11):1027-1030. doi: 10.13201/j.issn.1001-1781.2019.11.005.
[The diagnostic value of eosinophilic and eosinophilic cationic proteins in blood and nasal secretions for allergic rhinitis].
[Article in Chinese; Abstract available in Chinese from the publisher]
Yu WT1, Zhou Y1, Tan HF1, Shi QM1, Wang YJ1, Zhu Y1, Kong WJ1, Chen JJ1.

Author information
1Department of Otolaryngology，Union Hospital of Tongji Medical College，Huazhong University of Science and Technology，Wuhan，430022，China.

Abstract


Objective:To compare the diagnostic value of eosinophil and eosinophil cationin protein（ECP） in blood and nasal secretions for allergic rhinitis（AR）. Method:Collecting the blood samples of 33 patients with AR （AR group） and 40 healthy people（control group）, and test the concentration of ECP in serum and the percentage of eosinophil in blood. At the same time, collecting the nasal secretions samples of 33 patients with AR and 24 healthy people, and test the concentration of ECP and the percentage of eosinophils in nasal secretions. Using receiver operating characteristic curve（ROC） analysis, calculate the area under the curve（AUC） for each parameter and determine their predictive capabilities, then analyzing the correlation between each indicator and clinical symptom scores. Result:Compared with the healthy control group, the concentration of ECP and the percentage of eosinophil in blood and nasal secretion increased significantly（P<0.001） in patients with AR. The AUG of ECP concentration in nasal secretions was 0.965 9, when the cut-off value was 3.634, 100% sensitivity and 88% specificity were obtained; the AUG of eosinophil percentage in blood was 0.9087, and when its cut-off value was 4.6, 95% sensitivity and 73% specificity were obtained; the ECP concentration in serum had an AUG of 0.903, and when the cut-off value was 0.866, 90% sensitivity and 76% specificity were obtained; the AUG of nasal secretion eosinophil's percentage was 0.863 6, when its cut-off value is 0.72, 100% sensitivity and 73% specificity were obtained. Conclusion:For allergic rhinitis, ECP concentrate in nasal secretions is the ideal auxiliary diagnosis marker, and has the best predictive capability.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

eosinophile cationic protein; eosnophils; rhinitis, allergic
PMID: 31914287 DOI: 10.13201/j.issn.1001-1781.2019.11.005



Conflict of interest statement


Publication type


Select item 3191428624.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Nov;33(11):1022-1026. doi: 10.13201/j.issn.1001-1781.2019.11.004.
[Interpretation of the guidelines for multidisciplinary treatment of epistaxis of the British Academy of Rhinology].
[Article in Chinese]
Liu YT, Sha JC, Zhu DD, Xie J, Meng CD.

Abstract


SummaryEpistaxis is a common condition that can be associated with significant morbidity, and it places a considerable burden on our healthcare system. In China, a draft guidelines for diagnosis and treatment of epistaxis was released in 2015. In UK, a national audit of management for epistaxis was promulgated in 2016, followed by multidisciplinary consensus recommendations on the hospital management of epistaxis in 2017. Here, we compared the management of diagnosis and treatment for epistaxis between China and UK in five clinical aspects, including initial assessment, cautery, intranasal agents, antithrombotic therapy and hematological factors, as well as surgery and radiological intervention. The results demonstrate that the management recommendations in UK combined a wide-ranging review of the relevant literature with established and rigorous methods of guideline generation, while the guidelines in China is more specific on the procedures of diagnosis and treatment for epistaxis. The current discussion provides perspectives to improve the guidelines for epistaxis in China.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

diagnosis; epistaxis; guideline; treatment
PMID: 31914286 DOI: 10.13201/j.issn.1001-1781.2019.11.004



Conflict of interest statement


Publication type


Select item 3191428525.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Nov;33(11):1017-1021. doi: 10.13201/j.issn.1001-1781.2019.11.003.
[The progress on diagnosis and treatment of larynx cancer].
[Article in Chinese]
Le HJ, Chen SY, Li Y, Xu Y, Lei WB.

Abstract


SummaryLaryngeal cancer remains one of the most common tumors of head and neck. While significant advancements have been made over the last several decades, diagnosis and treatment of laryngeal cancer presents an unique challenge given its complexity. It is essential to perform a thorough preoperative assessment by the dedicated multidisciplinary team（MDT）, including confirmed diagnosis, accurate staging, surgical selection, rehabilitation and reconstruction, supportive care and postoperative follow-up. Surgery has been the historical mainstay for localized disease and still is an integral part of treatment, while transoral CO2 laser microsurgery is being increasingly popularised in early stage tumors and occasionally in more advanced forms of the disease. Nonsurgical methods like radiation and systemic therapy have emerged as viable options in patients considered unfit for surgery or those who refuse it. In addition, novel targeted agents are showing promise for the population with metastases. Currently, a multimodal approach is preferred in advanced cases, but the optimal strategy remains under debate. Close follow-up is crucial in achieving early detection and being able to treat the recurrence with curative intention. In summary, all patients should have a comprehensive evaluation and treatment plan in a multidisciplinary setting. This highlights the need for further research and innovation in the field.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

complex treatment; diagnosis; individual therapy; laryngeal neoplasms
PMID: 31914285 DOI: 10.13201/j.issn.1001-1781.2019.11.003



Conflict of interest statement


Publication type


Select item 3191428426.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Nov;33(11):1014-1016. doi: 10.13201/j.issn.1001-1781.2019.11.002.
[The scheme of diagnosis and treatment on metastatic cervical carcinomas from an unknown primary].
[Article in Chinese]
Wen SX, Zhang QF, Wang X.

Abstract


SummaryMetastatic cervical carcinomas from unknown primary（MCCUP） are a group of metastatic carcinomas of cervical lymph nodes which could not be managed to find their origins. The diagnosis of MCCUP includes pathological diagnosis of metastatic cervical carcinomas, search of the primary cancer, the stage of（T₀） NM. For unknown primary, there are some uncertainties of treatment on MCCUP. The methods of diagnosis and treatment on MCCUP should be renewed with the development of clinical medicine.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

head and neck neoplasms; lymph node metastases; neoplasms unknown primary
PMID: 31914284 DOI: 10.13201/j.issn.1001-1781.2019.11.002



Conflict of interest statement


Publication type


Select item 3191428327.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Nov;33(11):1009-1013;1016. doi: 10.13201/j.issn.1001-1781.2019.11.001.
[Progress in the diagnosis and treatment of oropharyngeal cancer].
[Article in Chinese]
Liu LF, Yuan SQ.

Abstract


SummaryIn recent years，human papillomavirus has been proved to be closely related to the occurrence and prognosis of oropharyngeal cancer.The treatment of oropharyngeal cancer has evolved from the primary radiotherapy to the corresponding treatment according to different tumor stages.For patients with advanced oropharyngeal cancer，the treatment strategy is mostly surgery + postoperative concurrent chemoradiotherapy.Patients are often accompanied by large defects in the surgical area after surgery.With the improvement of head and neck surgical repair technology and the progress of free flap technology，various repair methods can be adopted to repair and reconstruct.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

human papillomavirus; oropharyngeal carcinoma; reconstruction
PMID: 31914283 DOI: 10.13201/j.issn.1001-1781.2019.11.001



Conflict of interest statement


Publication type


Select item 3191428228.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Dec;33(12):1221-1224. doi: 10.13201/j.issn.1001-1781.2019.12.028.
[Research progress on the relationship between electrode position and electrode impedance of artificial cochlea].
[Article in Chinese]
Huang JC, Chen P.

Abstract


Summary Since the first cochlear implant was developed and used in clinical practice, many patients with profound deafness have returned to the world of sound, with the development of modern large-scale integrated circuits and the in-depth study of the anatomical pathophysiology of cochlea, deaf patients have been continuously benefited from it. Electrode is one of the core parts of cochlea implants, the design of the electrode and the placement of the electrode are important factors for patients to benefit from cochlea implantation. Postoperative starting up and debugging are also crucial. Through debugging, the electric stimulation level of each channel can be optimized, which is of great significance for postoperative rehabilitation effect, the magnitude of electrode impedance plays an important role in starting up and debugging. At present, there is no unified conclusion about the relationship between the electrode position and the electrode impedance value. Only when the implanted position and the electrode impedance are normal, can the implanted electrode function be better played.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

cochlear implants; electrode impedance; electrode position
PMID: 31914282 DOI: 10.13201/j.issn.1001-1781.2019.12.028



Conflict of interest statement


Publication types


Select item 3191428129.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Dec;33(12):1217-1220. doi: 10.13201/j.issn.1001-1781.2019.12.027.
[Regenerative medicine: the research progress of cartilage tissue engineering in rhinology].
[Article in Chinese]
Li XS, Sun JJ.

Abstract


Summary In recent years, the cartilage tissue engineering technology has rapid development, and shows a bright prospect in the field of cartilage defect and repair. In this paper, the field of rhinology cartilage tissue engineering research progress were reviewed, with the purpose to understand the status quo, and determine the next step research direction. From the research in recent years, we found that although cartilage tissue engineering technique could play an important role in the field of rhinology, but the progress to date was still lagging behind. In the published literature, there were few basic and applied research about cartilage tissue engineering techniques for nasal diseases. There have a small amount of applied research report, mainly concentrated in the animal experiments. There are still quite a distance from a wide range of clinical application. Based on the existing research results, cartilage tissue engineering technique in nasal plastic and reconstruction surgery has great potential in clinic application and needs more further research.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

cartilage; regenerative medicine; rhinology; tissue engineering
PMID: 31914281 DOI: 10.13201/j.issn.1001-1781.2019.12.027



Conflict of interest statement


Publication types


Select item 3191428030.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Dec;33(12):1214-1216;1220. doi: 10.13201/j.issn.1001-1781.2019.12.026.
[Research progress of vertigo and sleep disorder].
[Article in Chinese]
Fei YP, Zheng Y.

Abstract


Summary Sleep disorders are commonly encountered in patients with vertigo. Comorbid of them is a major clinical challenge as the outcomes of both conditions are worsened by each other. The sleep and vertigo issues that are covered in this review are epidemiology, possible mechanisms and pathogenesis, and most recent clinical studies. In addition, treatment recommendations on vertigo patients with sleep disorders are discussed briefly. The multiple interactions between vertigo and sleep disorders underscore the need for improving the ability to deal with comorbidity.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

dizziness; sleep disorders; vertigo
PMID: 31914280 DOI: 10.13201/j.issn.1001-1781.2019.12.026



Conflict of interest statement


Publication types


Select item 3191427931.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Dec;33(12):1211-1213. doi: 10.13201/j.issn.1001-1781.2019.12.025.
[Canceration of inflammatory myofibroblastic tumor of the larynx:a case report].
[Article in Chinese]
Wang YB, Shi SJ, Qiao ZH, Zhang XL, Liu CB.

Abstract


Summary Inflammatory myofibroblastic tumor（IMT） is a rare spindle neoplasm with malignant potentials of local invasion, recurrence and metastasis. Here, we present an extremely unusual case of the larynx IMT that was recurred three times and transformed into laryngeal squamous cell carcinoma.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

inflammatory myofibroblastic tumor; laryngeal microsurgery; laryngeal neoplasms
PMID: 31914279 DOI: 10.13201/j.issn.1001-1781.2019.12.025



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Select item 3191427832.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Dec;33(12):1209-1211. doi: 10.13201/j.issn.1001-1781.2019.12.024.
[Three cases of head and neck carcinosarcoma].
[Article in Chinese]
Wang JW, Jia CL, Zhang H, Song XC.

Abstract


Summary Head and neck carcinosarcoma leads to kinds of manifestations because of different original tumor sites, such as hoarseness and dyspnea in larynx, pharyngalgia and dysphagia in pharynx and compression in neck. Imaging examinations show specific occupying tumor sites and sometimes discover peripheral invasion. Pathological examination reveals both malignant squamous epithelium and interstitial tissue in these tumors，and therefore we diagnose these tumors as carcinosarcoma.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

head and neck neoplasms; sarcoma; surgical procedures, operative
PMID: 31914278 DOI: 10.13201/j.issn.1001-1781.2019.12.024



Conflict of interest statement


Publication types


Select item 3191427733.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Dec;33(12):1207-1208. doi: 10.13201/j.issn.1001-1781.2019.12.023.
[External auditory canal osseous hamartoma: a case report].
[Article in Chinese]
Zhou LQ, Zhang K, Wang Y, Xiao HJ.

Abstract


Summary Hamartomas are non-neoplastic overgrowth of mature/differentiated tissue indigenous to the specific part of the body in which they develop. Most hamartomas are located in the liver, spleen, lungs, and pancreas. However, external auditory canal hamartoma is rare. We describe here an 18-year-old man who presented with aural fullness. Computed tomography revealed an equal low density mass without bony erosion, pathological examination showed that the mass was an osseous hamartoma. Although osseous hamartoma in the external auditory canal is extremely rare, it should be kept in mind during differential diagnosis.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

external auditory canal; hamartoma
PMID: 31914277 DOI: 10.13201/j.issn.1001-1781.2019.12.023



Conflict of interest statement


Publication types


Select item 3191427634.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Dec;33(12):1206-1206;1208. doi: 10.13201/j.issn.1001-1781.2019.12.022.
[Vocal cords myxoma misdiagnosed as vocal cord polyp：a case report].
[Article in Chinese]
Sha JC, Sun LW, Ma JS, Zhu DD, Zheng J.

KEYWORDS:

misdiagnosis; myxoma; vocal cords
PMID: 31914276 DOI: 10.13201/j.issn.1001-1781.2019.12.022



Conflict of interest statement


Select item 3191427535.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Dec;33(12):1203-1205. doi: 10.13201/j.issn.1001-1781.2019.12.021.
[The application of extended high frequency audiometry in detecting the early hearing loss for polycystic ovarian syndrome].
[Article in Chinese; Abstract available in Chinese from the publisher]
Chen RC1, Yang X2, Tang FZ1, Lu QT1, Liang JP1, Qu SH1.

Author information
1Department of Otolaryngology Head and Neck Surgery，People's Hospital of Guangxi Zhuang Autonomous Region，Nanning，530021，China.2Department of Obsterics and Gynecology，People's Hospital of Guangxi Zhuang Autonomous Region.

Abstract


Objective:To preliminarily explore the clinical significance of extended high frequency audiometry in evaluating the early hearing loss in patients with polycystic ovarian syndrome（PCOS）. The results were statistically analyzed. Method:The hearing threshold of forty young women diagnosed as PCOS and 20 healthy controls were obtained by using conventional audiometry（0.25-8.00 kHz） and extended high frequency（10-20 kHz） pure tone audiometry. Result:The hearing thresholds of the two groups were similar at conventional frequencies of 0.25，0.50，1.00，2.00 and 4.00 kHz（P>0.05）. The hearing threshold of PCOS group at 8-20 kHz frequency was significantly higher than that of the control group, and the difference was statistically significant（P<0.05）. The expanded high-frequency detectable rate was lower in PCOS group than that in control group, especially at 16 and 18 kHz （P<0.05） and the differences were statistically significant. Conclusion:The early hearing impairment of PCOS patients starts from the extended high frequency, which is more sensitive than the conventional pure tone audiometry in the early hearing impairment assessment of PCOS patients.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

extended high frequency; hearing loss; polycystic ovarian syndrome
PMID: 31914275 DOI: 10.13201/j.issn.1001-1781.2019.12.021



Conflict of interest statement


Publication type


Select item 3191427436.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Dec;33(12):1200-1202. doi: 10.13201/j.issn.1001-1781.2019.12.020.
[Analysis of related factors of secondary pulmonary infection in children with tracheobronchial foreign body].
[Article in Chinese; Abstract available in Chinese from the publisher]
Wen X1, Shi J2, Cui L1, Wang YF1, Huang AP1, Liu YY1, Song YL1.

Author information
1Department of Otolaryngology，Hebei Children' s Hospital Affiliated to Hebei Medical University，Shijiazhuang，050031，China.2Department of Anesthesiology，Hebei Children' s Hospital Affiliated to Hebei Medical University.

Abstract


Objective:To analyze the secondary pulmonary infection and the distribution of pathogenic bacteria in children with tracheobronchial foreign body, and to guide the clinical treatment. Method:The clinical data of 197 children with tracheobronchial foreign bodies confirmed by rigid bronchoscopy were reviewed. According to the clinical manifestations and signs, blood routine, chest CT and airway endocrine pathogen distribution, the secondary pulmonary infection was analyzed. Result:Seventy-five of 197 children with foreign bodies in tracheobronchial had secondary pulmonary infections. Among them, 32 cases of airway endocrine cultured pathogenic bacteria, mainly including Streptococcus pneumoniae and Haemophilus influenzae. Children with long preoperative history, fever, and with a history of using antibiotics are more likely to have secondary pulmonary infections. Conclusion:The duration of disease history, preoperative fever and the use of antibiotics are related to secondary pulmonary infection. The third generation of cephalosporins can effectively control the infection.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

foreign bodies; pulmonary infection; tracheobronchial
PMID: 31914274 DOI: 10.13201/j.issn.1001-1781.2019.12.020



Conflict of interest statement


Publication type


Select item 3191427337.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Dec;33(12):1196-1199. doi: 10.13201/j.issn.1001-1781.2019.12.019.
[First bite syndrome: clinical study of six cases and review of the literature].
[Article in Chinese; Abstract available in Chinese from the publisher]
Huang S1, Huang CP1, Shen CY2, Lin Y1, Wang Y1.

Author information
1Department of Otorhinolaryngology Head and Neck Surgery，the First Affiliated Hospital of Chengdu Medical College，Chengdu，610500，China.2Department of Gastrointestinal Surgery，West China Hospital，Sichuan University.

Abstract


Objective:The aim of this study is to explore the etiology, diagnosis and treatment of first bite syndrome（FBS）. Method:Clinical data of six patients with FBS were analyzed retrospectively. There were 4 cases of parapharyngeal space tumor resection complicated with FBS, 1 case of parotidectomy of deep lobe parotid gland tumor complicated with FBS, and 1 case of no definite cause. Analgesic treatments such as ibuprofen and tramadol capsules were given, in combination with carbamazepine （200 mg, 3 times a day） for four weeks. Result:The severity of symptoms decreased in five cases, 2-16 months after treatment. While another one had no amelioration during 10 months' follow-up. Conclusion:FBS is one of the possible complications of surgery of the upper cervical region, especially parotid deep lobe tumor resection, which should be distinguished from the usual postoperative pain. The cause of the disease may be related to intraoperative injury to the sympathetic plexus of the parotid gland. Currently, there is no standard treatment method, but the symptoms are usually relieved within a few months.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

complication; drug therapy; first bite syndrome
PMID: 31914273 DOI: 10.13201/j.issn.1001-1781.2019.12.019



Conflict of interest statement


Publication type


Select item 3191427238.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Dec;33(12):1189-1195;1199. doi: 10.13201/j.issn.1001-1781.2019.12.018.
[Clinical analysis of transnasal endoscopic repair of cerebrospinal fluid rhinorrhea].
[Article in Chinese; Abstract available in Chinese from the publisher]
Zhang SN1, Jiang Y1, Yu LG1, Zhao LJ1, Li LL1, Zhang CY1, Xu WR1, Li N1.

Author information
1Department of Otorhinolaryngology Head and Neck Surgery/Nasal Skull Base Surgery，the Affiliated Hospital of Qingdao University，Shandong Key Laboratory of Otorhinolaryngology Head and Neck Surgery，Qingdao，266000，China.

Abstract


Objective:To summarize the common clinical types of cerebrospinal fluid（CSF） rhinorrhea and key points of transnasal endoscopic repair of CSF rhinorrhea. To evaluate clinical effects. Method:In 29 patients with cerebrospinal fluid rhinorrhea, 9 patients with traumatic CSF rhinorrhea, 10 patients with spontaneous CSF rhinorrhea, 7 patients with CSF rhinorrhea after tumour excision, and 3 patients with iatrogenic CSF rhinorrhea. All the 29 patients were treated with transnasal endoscopic repair of CSF rhinorrhea. Result:There were 25 patients were successfully repaired at one time. Three patients developed intracranial infection and 2 patient developed pneumocephalus after surgery, all of them were cured with conservative treatment. All the patients who were followed-up for more than half a year had no recurrence. Conclusion:Transnasal endoscopic repair of CSF rhinorrhea is safe and effective, the success rate of operation is high, it is not easy to recur, and the complications are few. It can be used as the first choice for repairing of CSF rhinorrhea and effective prevention measures. Accurate location of leak, appropriate repair, effective reconstruction of the skull base, continuous drainage of the lumbar cistern when necessary and active prevention of intracranial infection are critical to the success of operation.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

cerebrospinal fluid rhinorrhea; endoscopic surgical procedures; intracranial infection; repair of skull base
PMID: 31914272 DOI: 10.13201/j.issn.1001-1781.2019.12.018



Conflict of interest statement


Publication type


Select item 3191427139.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Dec;33(12):1185-1188. doi: 10.13201/j.issn.1001-1781.2019.12.017.
[Clinical features and recurrence rate on benign paroxysmal positional vertigo].
[Article in Chinese; Abstract available in Chinese from the publisher]
Wang YQ1, Li JR1, Zou SZ1, Ding YL1.

Author information
1Department of Otolaryngology Head and Neck Surgery，People's Liberation Army General Hospital Sixth Medical Center，Beijing，100048，China.

Abstract


Objective:To study the characteristics and the recurrence rate of manual reduction of BPPV. Method:The clinical characteristics of 735 patients with BPPV were analyzed retrospectively. The posterior semicircular canal BPPV（PC-BPPV） was treated with the Epley maneuver therapy; the horizontal semicircular canal BPPV（HC-BPPV） was treated with the Barbecue therapy; the anterior semicircular canal BPPV（AC-BPPV） was treated with the Yacovino therapy; the combined semicircular canal was treated with the Epley and the Barbecue therapy; and for the bilateral lesions, first treat the more severe side with manual reduction then the lighter side was treated with manual reduction after the more severe side nystagmus or vertigo completely disappears. Result:①Of the 735 patients with BPPV, 455（61.90%） were PC-BPPV, 272（37.01%） were HC-BPPV, 3（0.41%） were AC-BPPV, and 5（0.68%） were combined BPPV. ②A total of 455 patients with BPPV were followed up by telephone. 51 patients recurred within 3 years, the recurrence rate was 11.21%; the male recurrence rate was 25.68%（38/148）, and the female recurrence rate was 28.66%（88/307）. The recurrence rate was the highest in 51-60 years old, and the recurrence rate was 29.67%. ③300 patients with PC-BPPV were followed up by telephone, 81 cases（27.00%） recurred, and the recurrence rates of one month, six months, one year, two years, and three years were 0.67%（2/300）, 3.33%（10/300）, 6.67%（20/300）, 9.33%（28/300） and 11.67%（35/300） respectively; 155 patients with HC-BPPV were followed up by telephone, 45 cases（29.03%） recurred, the recurrence rates of one months, six months, one year, two years, and three years were 0（0/155）, 2.58%（4/155）, 3.23%（5/155）, 7.10%（11/155） and 9.68%（15/155） respectively. Conclusion:PC-BPPV is the most common disease in BPPV patients. Manual recurrence can effectively treat the recurrence rate of BPPV, female patients is slightly higher than that of male patients. The long-term recurrence rate of PC-BPPV is consistent with that of HC-BPPV. The BPPV were most common in posterior semicircular canal. Manual reduction is effective to treat BPPV cases. BPPV recurrence was not correlated with age and gender. The long-term recurrence rate of PC-BPPV and HC-BPPV is consistent.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

manual reduction; recurrence; semicircular canals; vertigo
PMID: 31914271 DOI: 10.13201/j.issn.1001-1781.2019.12.017



Conflict of interest statement


Publication type


Select item 3191427040.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Dec;33(12):1181-1184. doi: 10.13201/j.issn.1001-1781.2019.12.016.
[Spectomycin B1 induces VEGFR2 de-SUMO modification to inhibit angiogenesis in nasopharyngeal carcinoma].
[Article in Chinese; Abstract available in Chinese from the publisher]
Ren Q1, Zhang CY2, Ma XF3, Cheng RZ2, Bian XY3, Xiao XL3, Liu XZ3, Zhou HF4.

Author information
1Department of Otorhinolaryngology，the Fifth Central Hospital of Tianjin，Tianjin，300450，China.2Department of Pharmacy，Tianjin Binhai New Area Hospital of Traditional Chinese Medicine.3Central Laboratory，the Fifth Central Hospital of Tianjin.4Department of Otorhinolaryngology，Tianjin Medical University General Hospital.

Abstract


Objective:To explore the new mechanism of spectomycin B1 in inhibiting angiogenesis of nasopharyngeal carcinoma and to provide a theoretical basis for targeted gene therapy of nasopharyngeal carcinoma. Method:Human nasopharyngeal carcinoma CNE1 cells were divided into two groups, the control group and spectomycin B1 group. Western blot was used to detect the expression levels of small ubiquitin-related modified protein（SUMO） 1 and vascular endothelial growth factor receptor 2（VEGFR2）. The angiogenesis assay was used to detect the angiogenic ability of CNE1 cells, and the apoptosis was detected by flow cytometry. The model of nasopharyngeal carcinoma-bearing mice was established, spectomycin B1 was administered, tumor volume and weight were measured, and protein expression of CD31 was detected by immunohistochemistry and microvessel density was compared. Result:Spectomycin B1 could reduce deSUMOylation of VEGFR2 protein by 4.05 times, significantly reduce the angiogenic ability of CNE1 cells, and increase the apoptosis rate by 20.68%. In the tumor-bearing mouse model, spectomycin B1 treatment could inhibit subcutaneous tumor growth rate and weight, and the blood vessel density decreased by 40.04%. Conclusion:Spectomycin B1 can inhibit neovascularization of nasopharyngeal carcinoma by inducing deSUMOylation of VEGFR2 protein.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

nasopharyngeal neoplasms; small ubiquitin-related modified protein; spectomycin B1; vascular endothelial growth factor receptor 2
PMID: 31914270 DOI: 10.13201/j.issn.1001-1781.2019.12.016



Conflict of interest statement


Publication type


Select item 3191426941.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Dec;33(12):1176-1180. doi: 10.13201/j.issn.1001-1781.2019.12.015.
[Spectrum analysis of pathological classification in 463 cases with nasal and paranasal sinuses malignant tumors].
[Article in Chinese; Abstract available in Chinese from the publisher]
Li J1,2, Yuan H1, Li Y2, Zhao XQ2, Chen L1, Han MK1, Liu CQ1, Liu Q1, Wang HT1, Zhong Q2, Feng B1.

Author information
1Department of Otorhinolaryngology Head and Neck Surgery，Hospital 301，PLA General Hospital，Beijing，100853，China.2Department of Otorhinolaryngology Head and Neck Surgery，the Second Affiliated Hospital of North Sichuan Medical College，Sichuan Mianyang 404 Hospital.

Abstract


Objective:The characteristics of pathological histological classification of nasal and paranasal sinuses malignant tumors in the past 10 years were analyzed, so as to provide possible basis, direction and ideas for the development of relevant effective treatment measures for nasal and paranasal sinuses malignant tumors in clinical practice. Method:The clinical data of patients with nasal and paranasal sinuses malignant tumors admitted to PLA general hospital from January 2009 to December 2018 were collected. Pathological types were retrospectively analyzed, and disease spectrum distribution, composition ratio and variation tendency of these patients were calculated. Result:Among the 463 patients, the overall pathological types in the top 5 were as follows: squamous cell carcinoma, adenoid cystadenocarcinoma, olfactory neuroblastoma, melanoma, adenocarcinoma. As for male patients, the pathological types in the top 5 were squamous cell carcinoma, adenoid cystic carcinoma, olfactory neuroblastoma, adenocarcinoma, neuroendocrine carcinoma and rhabdomyosarcoma were tied for fifth; the top 5 most common pathological types in female patients were squamous cell carcinoma, adenoid cystic carcinoma, melanoma, rhabdomyosarcoma, and adenocarcinoma. From 2009 to 2013, there were 183 patients with nasal and paranasal sinuses malignant tumors, the top 5 pathological types were squamous cell carcinoma, adenoid cystadenocarcinoma, olfactory neuroblastoma, melanoma, neuroendocrine carcinoma and rhabdomyosarcoma were tied for fifth; From 2014 to 2018, 280 patients with nasal and paranasal sinuses malignant tumors were diagnosed, the top 5 pathological types were squamous cell carcinoma, adenoid cystadenocarcinoma, melanoma, adenocarcinoma, and rhabdomyosarcoma. The ratio of the number of patients from 2009 to 2013 and 2014 to 2018 was about 0.65∶1. Malignant tumors of the nasal and paranasal sinuses tend to occur between the ages of 41 and 60, and the pathological types in the top 5 were squamous cell carcinoma,adenoid cystic carcinoma, adenocarcinoma, melanoma, neuroendocrine carcinoma. Conclusion:Malignant tumors of nasal cavity and sinus were more common in male, and the pathological types such as squamous cell carcinoma, adenoid cystic carcinoma, olfactory neuroblastoma were more common. All age groups have the disease, but the age group of 41-60 years old is the high-risk group of nasal and nasal sinus malignant tumors. However, the incidence rate of melanoma has gradually increased in the past five years, which needs to be paid more attention to.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

disease spectrum; nasal cavity; paranasal sinus neoplasms; pathology
PMID: 31914269 DOI: 10.13201/j.issn.1001-1781.2019.12.015



Conflict of interest statement


Publication type


Select item 3191426842.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Dec;33(12):1173-1175. doi: 10.13201/j.issn.1001-1781.2019.12.014.
[Application of ultrasonography in etiologic judgment of hoarseness after thyroidecomy].
[Article in Chinese; Abstract available in Chinese from the publisher]
Wang H1, Hou J2, Li XP1, Jiang J1, Sun L1, Zhou Q1.

Author information
1Department of Ultrosound，the Second Affiliated Hospital of Xi'an Jiaotong University，Xi'an，710004，China.2Department of Otolaryngology Head and Neck Surgery，the Second Affiliated Hospital of Xi'an Jiaotong University.

Abstract


Objective:To explore the application value of ultrasound in etiologic judgement of hoarseness after thyroidecomy. Method:Sixty-three cases of hoarseness after thyroidecomy were examed by laryngeal ultrasonography. Vocal cord, arytenoid cartilage, pyriform fossa, thyroid operation area and recurrent laryngeal nerve pathway were evaluated. Regard electronic laryngoscope results as gold standard and compare the differences between the two methods. Result:Sixty-three patients were detected by ultrasound, then, 29 cases were diagnosed with left vocal cord paralysis, 24 cases with right vocal cord paralysis, 2 cases with bilateral vocal cord paralysis, 1 case with right vocal cord polyp, 3 cases with left vocal cord polyp, 1 case with renke layer edema, and 3 cases has normal laryngeal imaging. The accuracy of ultrasonography in determining the etiology of hoarseness after thyroidecomy is 92.1%, the sensitivity is 93.3%, and the specificity is 66.7%. Conclusion:The ultrasonography can not only show laryngeal structures, but also display thyroid operation area and recurrent laryngeal nerve pathway. Moreover, as an non-invasive method, ultrasonography has high accuracy in etiologic judgement of hoarseness after thyroidecomy and certain clinical application values.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

hoarseness; thyroid diseases; ultrasonography
PMID: 31914268 DOI: 10.13201/j.issn.1001-1781.2019.12.014



Conflict of interest statement


Publication type


Select item 3191426743.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Dec;33(12):1168-1172. doi: 10.13201/j.issn.1001-1781.2019.12.013.
[Clinical value of intraoperative parathyroid hormone determination in secondary hyperparathyroidism operation].
[Article in Chinese; Abstract available in Chinese from the publisher]
Chen AJ1, Wang TT1, Bo SJ1, Li HY1, Zhang C1, Yang XQ1, Xu XF1.

Author information
1Department of Otolaryngology Head and Neck Surgery，Peking University Civil Aviation School of Clinical Medicine，Civil Aviation General Hospital，Beijing，100123，China.

Abstract


Objective:To investigate the clinical value of intraoperative parathyroid hormone monitoring in operation of patients with secondary hyperparathyroidism（SHPT）. Method:A retrospective analysis was carried out and enrolled， including 100 primary surgery and 14 second surgery. The data of 100 patients with primary surgery and 14 patients with reoperation were retrospectively analyzed. The criterion, predicting the success of surgery, is that the measured iPTH level declines by more than 80% compared with that before surgery, 20 minutes after the last parathyroid gland removed. Serum calcium, serum phosphorus and iPTH tested pre-and post-operation were statistically analyzed. Result:112 cases（98 cases in the first operation and 14 cases in the second operation） were cured by operation and the cure rate is 98.2%. In 109 cases（97 cases of first operation and 12 cases of reoperation）, the intraoperative determination of parathyroid hormone was up to standard, and the sensitivity of predicting the success of surgery was 97.0% and 85.7%, respectively. Postoperative clinical symptoms such as joint pain and skin itching, etc. were significantly improved or disappeared. Postoperative iPTH, serum calcium and serum phosphorus were significantly different from those before surgery, and the difference was statistically significant（P<0.05）. Conclusion:Intraoperative parathyroid hormone monitoring has vital clinical guiding value for SHPT, and can improve the success rate significantly. A more than 80% reduction in iPTH at 20 min after the last parathyroidectomy was a good predictor of successful surgery.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

hyperparathyroidism; intact parathyroid hormone; sensitivity
PMID: 31914267 DOI: 10.13201/j.issn.1001-1781.2019.12.013



Conflict of interest statement


Publication type


Select item 3191426644.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Dec;33(12):1165-1167;1172. doi: 10.13201/j.issn.1001-1781.2019.12.012.
[Application of double skin island free forearm flap in the repair of large perforating defect of palate].
[Article in Chinese; Abstract available in Chinese from the publisher]
Song ZW1, Ji L2, Zhou HY1, Zhang L1, Xia DL1.

Author information
1Department of Oral and Maxillofacial Surgery，the Affiliated Stomatological Hospital of Southwest Medical University，Luzhou，646000，China.2Department of Oral and Maxillofacial Surgery，the Affiliated Hospital of Southwest Medical University.

Abstract


Objective:To explore the value of free forearm flap with double skin island in repairing large perforating defect of palate. Method:The free forearm flap with double skin island was used to repair 6 cases of large perforating palatal defect due to oral malignant tumor. Preoperative Allen test and ultrasound doppler examination were used to judge the forearm vessels. Result:All the free forearm flap with double skin island survived in 6 cases, followed up for 3 months to 24 months, the patients ate normally, swallowing without nasal regurgitation. The patients had mild to moderate nasal sounds, and the patients were satisfied with the effect of operation and the quality of life. Conclusion:The double skin island free forearm flap is a reliable method for repairing large perforating defect of palate, with satisfactory morphological function and good effect.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

double skin island forearm flap; palatal defect; reconstructive surgical procedures
PMID: 31914266 DOI: 10.13201/j.issn.1001-1781.2019.12.012



Conflict of interest statement


Publication type


Select item 3191426545.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Dec;33(12):1162-1164. doi: 10.13201/j.issn.1001-1781.2019.12.011.
[Curative effect observation of application of the snare in epiglottic cystectomy by arc-shaped laryngoscopy].
[Article in Chinese; Abstract available in Chinese from the publisher]
Sun SL1, Li LJ1, Wang L1, Yan Y1, Zeng J1, Du C1.

Author information
1Department of Otolaryngology Head and Neck Surgery，Peking University Third Hospital，Beijing，100191，China.

Abstract


Objective:To evaluate the effect of the epiglottic cystectomy by arc-shaped video laryngoscopy combined with snare. Method:The clinical data of 42 patients with epiglottic cysts were retrospectively analyzed. Forty-two patients with epiglottis cyst were treated by arc-shaped video laryngoscopy combined with snare. Result:All 42 cases were completely resected at one time without obvious complications and the cure rate was 100%. Moreover, the short operation time（5-20 min） and the minor hemorrhage（1-10 ml） were observe. There was no recurrence after 6 to 33 months follow-up. Conclusion:The epiglottic cystectomy by arc-shaped video laryngoscopy combined with snare has the advantages of broad vision, easy operation, minimal invasion, rapid recovery and good curative effect, it is worthy to be popularized in clinical application.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

epiglottis cysts; laryngoscopes; snare
PMID: 31914265 DOI: 10.13201/j.issn.1001-1781.2019.12.011



Conflict of interest statement


Publication type


Select item 3191426446.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Dec;33(12):1158-1162. doi: 10.13201/j.issn.1001-1781.2019.12.010.
[Clinical features of occult mastoiditis complicated with periphlcbitis of sigmoid sinus in children].
[Article in Chinese; Abstract available in Chinese from the publisher]
Zhang X1, Chen M2, Zhang J2, Yang Y2, Liu ZY2.

Author information
1Department of Otolaryngology，Children's Hospital of Shanxi Women Health Center of Shanxi，Taiyuan，030013，China.2Department of Otolaryngology Head and Neck Surgery，National Center for Children's Health，Beijing Children's Hospital，Capital Medical University.

Abstract


Objective:To investigate the clinical characteristics and principle of treatment of occult mastoiditis accompanied with periphlcbitis of sigmoid sinus in pediatrics. Result:Four cases, with a short-time acute otitis media history, complained of headache / retroauricular pain, with papillary swelling, diagnosed as occult mastoiditis accompanied with periphlcbitis of sigmoid sinus according to the results of the temporal bone CT and MR. All of them had normal tympanic membrane, normal pure tone threshold, but type B tympanogram. CT scan of temporal bone showed soft tissue shadow of mastoid process, bone destruction of sigmoid sinus wall, and nuclear magnetic enhancement suggested cystic lesion behind mastoid process. With the usage of sufficient amount and anti-inflammatory antibiotics of permeable brain barrier, mastoidectomy were performed as early as possible. All the postoperative pathology showed inflammatory granulation, and no recurrence happened during the follow-up periods of 12-18 months. Conclusion:Intracranial complications in occult mastoiditis should be taken into account, with contemporary acute otitis media history, headache/retroauricular pain, and papillary swelling. Temporal bone image examination and hearing test should be done timely. Once the diagnosis was confirmed, on the basis of anti-infection treatment, the operation should be done as early as possible to to open the mastoid and improve the ventilation drainage of middle ear.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

child; mastoiditis; periphlcbitis of sigmoid sinus
PMID: 31914264 DOI: 10.13201/j.issn.1001-1781.2019.12.010



Conflict of interest statement


Publication type


Select item 3191426347.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Dec;33(12):1153-1157. doi: 10.13201/j.issn.1001-1781.2019.12.009.
[Clinical assessment and related intervention of neonatal upper airway obstruction].
[Article in Chinese; Abstract available in Chinese from the publisher]
Wang H1, Wang GX1, Zhao J1, Jin F2, Xi Y1, Hei MY2, Zhang J1.

Author information
1National Center for Children's Health，Department of Otorhinolaryngology Head and Neck Surgery，Beijing Children's Hospital，Capital Medical University，Beijing Key Laboratory for Pediatric Diseases of Otolaryngology Head and Neck Surgery，Beijing Pediatric Research Institute，Beijing，100045，China.2Department of Neonatology，Beijing Children' s Hospital，Capital Medical University.

Abstract


Objective:To discuss the diagnosis and evaluation of upper airway obstruction in neonates, classify the possible causes of neonatal upper airway obstruction, establish a standardized diagnosis and treatment procedure to improve the of treatment efficacy. Method:Clinical data of 71 cases with upper airway obstruction history were retrospective analyzed, 38 cases were treated by combined medical and surgical treatment, 17 cases underwent medical treatment, 16 cases abandonment the treatment. The effectiveness of fibrolaryngoscope, CT, neck ultrasound, MRI and other results was evaluated, and to analyze the prognosis of the treatment, the outcomes and risk factors were also analysed, to evaluate risk factors associated with upper airway obstruction. Result:Fifty-five cases were cured or improved. The mortality rate of 16 children who gave up treatment and left hospital automatically was 81.25%（13/16）. The accuracy rate of flexible laryngoscope in detecting the level of upper airway obstruction was 100%, the coincidence rate of B-ultrasound for upper airway cystic occupation was 100%. Etiological order from high to low was congenital space-occupying lesions, congenital upper airway malformation, vocal cord paralysis, Pierre-Robin syndrome. The site of obstruction has a significant influence on the severity of upper airway obstruction（P<0.05）. The cure rate of the non-endotracheal intubation group was higher than that of the endotracheal intubation group（P<0.05）. Conclusion:The obstruction site of upper airway significantly affects the outcome and the severity of the disease. Upper airway space occupying lesions are the primary causes of upper airway obstruction in neonates. Early assessment and timely treatment can improve the cure rate and improve the prognosis. Internal medicine combined with surgical treatment is effective in relieving upper airway obstruction.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

neonate; prognosis; upper airway obstruction
PMID: 31914263 DOI: 10.13201/j.issn.1001-1781.2019.12.009



Conflict of interest statement


Publication type


Select item 3191426248.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Dec;33(12):1148-1153. doi: 10.13201/j.issn.1001-1781.2019.12.008.
[Using of ¹⁸F-FDG to evaluate the effect of traumatic olfactory nerve injury on drug delivery through the nasal-brain pathway: a PET-MRI pilot study].
[Article in Chinese; Abstract available in Chinese from the publisher]
Su BH1, Sun ZF1, Chen ZW2, Zhu ZW3, Gao X1, Zhang XL3, Wei YX1.

Author information
1Department of Otolaryngology Head and Neck Surgery，Capital Medical University Affiliated Anzhen Hospital，Beijing，100029，China.2GE Healthcare of Beijing.3Department of Nuclear Medicine，Capital Medical University Affiliated Anzhen Hospital.

Abstract


Objective:This study evaluated the effect of traumatic olfactory nerve injury on drug delivery through the nasal-brain pathway via the instillation of ¹⁸F-FDG at the olfactory cleft. Method:Seven healthy volunteers and 5 patients with traumatic dysosmia were enrolled in the study. Subjects were all instilled with ¹⁸F-FDG on each side of the olfactory cleft under endoscopy. After 12 hours, a PET/MR scan was performed to track the metabolism pathway of ¹⁸F-FDG. Then, we compared the diameter of the olfactory bulb and the olfactory bulb intake between normal volunteers and patients with traumatic olfactory disorders. Result:In healthy volunteers, there was a significant difference in ¹⁸F-FDG uptake between the regions of interest in which ¹⁸F-FDG was or was not in contact with the cribriform plate（P=0.012 7）; this difference also existed in patients with traumatic olfactory disorders（P=0.038 1）. Patients with traumatic olfactory disorders did not exhibit significant differences in ¹⁸F-FDG uptake in the region of interest compared with healthy volunteers（P=0.937 2）. Conclusion:The olfactory bulb is obviously atrophied in patients with traumatic olfactory dysfunction, and the uptake of ¹⁸F-FDG in the olfactory bulb region of interest is also reduced. The administration of ¹⁸F-FDG via olfactory fissure area can enter olfactory bulb and parafrontal tissues through the nasal brain pathway,¹⁸F-FDG can enter the central nervous system through the nasal-brain pathway, which is not affected by olfactory nerve transection injury.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

PET/MR; nasal-brain pathway; olfaction disorders; olfactory nerve; ¹⁸F-FDG
PMID: 31914262 DOI: 10.13201/j.issn.1001-1781.2019.12.008



Conflict of interest statement


Publication type


Select item 3191426149.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Dec;33(12):1142-1147. doi: 10.13201/j.issn.1001-1781.2019.12.007.
[Correlation of tissue eosinophil count and modified CT olfactory cleft score and olfactory function in patients with nasal polyps].
[Article in Chinese; Abstract available in Chinese from the publisher]
Zhang LC1, Hu CH1, Han XY1, Sun ZF1, Wu DW1, Yu W2, Yao LY1, Sun JW3, Wei YX1.

Author information
1Department of Otolaryngology Head and Neck Surgery，Beijing An Zhen Hospital，Capital Medical University，Beijing，100029，China.2Department of Pathology，Beijing An Zhen Hospital，Capital Medical University.3Department of Otolaryngology Head and Neck Surgery，the First Affiliated Hospital of USTC，An Hui Provincial Hospital.

Abstract


Objective:To investigate the effect of tissue eosinophil count on olfactory function in patients with chronic sinusitis with nasal polyps（CRSwNP）. Method:We prospectively selected 59 patients with CRSwNP. All the patients were not treated with oral or topical glucocorticoids for at least 1 month at the time of enrollment. All the nasal polyps were taken under local anesthesia in the outpatient department for eosinophil count and percentage calculation. The patients were divided into eosinophilic CRSwNP（ECRS group） and non-eosinophilic CRSwNP（non-ECRS group）. Baseline data was compared between the two groups. Spearman correlation analysis was performed on tissue eosinophil count and Lund-Mackay score, modified olfactory cleft scores, Sniffin' Sticks olfactory test, olfactory evoked potential peak latency and amplitude respectively. Result:Thirty-five of 59 patients with CRSwNP completed olfactory evoked potential test, from whom we collected stable waveforms. The ECRS group had a higher olfactory cleft area CT score, ethmoid sinus CT score and blood eosinophil count and percentage; there was a significant difference between the ECRS group and the non-ECRS group in single and bilateral odor test threshold（T value）（P=0.017）. There was no significant correlation between tissue eosinophil count and subjective olfactory VAS score（P>0.05）. Tissue eosinophil count was related to the bilateral T value in Sniffin' Sticks olfactory test（r=-0.322, P=0.013）, anterior and posterior olfactory cleft area scores（r=0.431 and 0.415, respectively, P=0.001） and olfactory evoked potential N1 latency（r=0.504, P=0.001） and P2 latency（r=0.374, P=0.020）, but not related to Lund-Mackay scores. In addition, there was a significant correlation between the unilateral T score in Sniffin' Sticks test and the unilateral olfactory evoked potential N1 latency（r=-0.505, P=0.002）. Conclusion:The increase of tissue eosinophilia was closely related to olfactory disfunctions in CRSwNP. It could be reflected by modified CT olfactory cleft score, Sniffin' Sticks olfactory test T value and oERP peak latency. In addition, T value was negatively consistent with latency of oERP N1 peak.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

eosinophils; nasal polyps; olfaction; olfactory event-related potential; sinus CT
PMID: 31914261 DOI: 10.13201/j.issn.1001-1781.2019.12.007



Conflict of interest statement


Publication type


Select item 3191426050.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Dec;33(12):1138-1141;1147. doi: 10.13201/j.issn.1001-1781.2019.12.006.
[Changes of serum E2 and Otolin-1 levels in postmenopausal women with BPPV].
[Article in Chinese; Abstract available in Chinese from the publisher]
Feng MY1, Zhuang JH1, Gu HH1, Tian Q1, Zhang ZH1.

Author information
1Department of Neurology，Shanghai Changzheng Hospital of Navy Medical University，Shanghai，200003，China.

Abstract


Objective:To investigate the changes of serum estradiol（E2） and otolith structural protein Otolin-1 levels in postmenopausal women with benign paroxysmal positional vertigo（BPPV）. Method:Forty postmenopausal women diagnosed as primary BPPV were selected as the experimental group. Meanwhile, 40 postmenopausal women without vertigo during the same time were selected as the control group. 4 ml of fasting peripheral venous blood was extracted in the morning, and E2 and Otolin-1 protein levels in serum of the two groups were detected by electrochemiluminescence（ECL） and ELISA, respectively. Result:①The serum level of E2 in the experimental group was（29.11±15.11） pg/ml, which was lower than that in the control group（37.18±12.24） pg/ml（P=0.010）. ②The serum level of Otolin-1 in the experimental group was（361.55±186.14） pg/ml, which was significantly higher than that in the control group（282.61±139.98） pg/ml（P=0.035）. ③Spearman correlation analysis was carried out on the serum levels of Otolin-1 and E2 in the experimental group and the control group, respectively, and no correlation was found between them（P=0.403 and 0.363, respectively）. ④In the control group, age was negatively correlated with serum E2 level（P=0.044, r=-0.320）, suggesting that age was only weakly correlated with E2 level. However, in the experimental group, there was no correlation between the two（P=0.148）. ⑤There was no correlation between age and serum Otolin-1 level in the two groups（P=0.705 and 0.076, respectively）. Conclusion:Compared with postmenopausal patients without vertigo, the level of E2 in postmenopausal BPPV patients decreased, but the level of Otolin-1 increased significantly. Therefore, the serum level of Otolin-1 may be used as a bio-marker to assist the diagnosis and efficacy evaluation of postmenopausal women with BPPV.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

Otolin-1; bio-marker; estradiol; postmenopausal women; vertigo
PMID: 31914260 DOI: 10.13201/j.issn.1001-1781.2019.12.006



Conflict of interest statement


Publication type


Select item 3191425951.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Dec;33(12):1134-1137. doi: 10.13201/j.issn.1001-1781.2019.12.005.
[A clinical analysis of 27 cases of simultaneous bilateral sudden sensorineural hearing loss].
[Article in Chinese; Abstract available in Chinese from the publisher]
Sun CL1, Guo DN1, Shen J1, Du XD1.

Author information
1Department of Otolaryngology Head and Neck Surgery，Affiliated Hospital of Jiangnan University，Wuxi，214062，China.

Abstract


Objective:To compare the clinical characteristics and therapeutic effects between simultaneous bilateral sudden sensorineural hearing loss（Si-BSSHL） and unilateral sudden sensorineural hearing loss（USSHL）. Method:The clinical data of 27 cases of Si-BSSHL were retrospectively analyzed, including the characteristics of the disease, clinical manifestations, audiological examination, hematological examination, and therapeutic effect, and compared with those of 139 cases of USSHL. Result:There was a statistically significant difference in the age（65.85±9.17 vs 56.95±13.18, P<0.01） and no significant difference in sex ratio（P>0.05） between the two groups. The proportion of Si-BSSHL patients with vertigo, ear fullness, hypertension, diabetes, coronary heart disease and stroke had no statistical difference compared with those of USSHL（P>0.05）, the proportion of patients with tinnitus in Si-BSSHL group was significantly lower than that in USSHL group（P<0.05）. The distribution of hearing loss degree and the type of audiometry in Si-BSSHL group were significantly different from those in USSHL group, PTA before treatment and the proportion of profound hearing loss in Si-BSSHL group was significantly lower than that in USSHL group（P<0.05）, descending audiometry type was more common in Si-BSSHL group compared to USSHL（P<0.01）. Fibrinogen in Si-BSSHL group was significantly higher than that in USSHL group（P<0.05）. No significant difference was found between the two groups with respect to mean platelet volume, blood lipid and folic acid（P>0.05）. The total treatment effective rate in Si-BSSHL group was 44.44%, while that in USSHL group was 41.73%, there was no significant difference between the two groups（P>0.05）. Conclusion:Si-BSSHL has a female preponderance and tends to occur in advanced age in our cohort. Compared to USSHL patients, Si-BSSHL patients have less profound hearing loss and more descending audiograms, and the proportion of patients with extremely severe deafness is relatively small. There is no significant difference in the therapeutic effect between the two groups.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

audiology; deafness, sudden; treatment effectiveness
PMID: 31914259 DOI: 10.13201/j.issn.1001-1781.2019.12.005



Conflict of interest statement


Publication type


Select item 3191425852.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Dec;33(12):1129-1133. doi: 10.13201/j.issn.1001-1781.2019.12.004.
[Clinical application of HRCT three-dimensional reconstruction in traumatic ossicular chain interruption].
[Article in Chinese; Abstract available in Chinese from the publisher]
Ke RD1, Tang AZ1, Tang XL1, Gong L1, Fang Q1, Tan SH1.

Author information
1Department of Otolaryngology Head and Neck Surgery，the First Affiliated Hospital of Guangxi Medical University，Nanning，530021，China.

Abstract


Objective:To investigate the clinical value of HRCT three-dimensional reconstruction technique in traumatic auditory chain traumatic fracture. Method:The clinical data of 14 patients with traumatic ear ossicular chain interruption were analyzed retrospectively. To evaluate the injury site and degree of the auditory chain before surgery, all the 14 patients underwent,HRCT scanning and three-dimensional reconstruction. The reconstructed auditory chain was observed from multiple angles and compared with the surgical exploration results under microscope. Result:The coincidence rate between ossicular chain injury observed by temporal bone HRCT scan before operation and ossicular chain injury observed during surgery was only 28.57%, the coincidence rate between ossicular chain injury observed during surgery and ossicular chain injury observed by three-dimensional reconstruction is 85.71%.Therefore, three-dimensional reconstruction imaging technique could give the doctor more clearly and stereoscopic images for the destruction of ossicular chain. Conclusion:Preoperative three-dimensional reconstruction can display and diagnosis of auditory ossicular chain destruction more clearly. It can be used to accurately evaluate auditory ossicular chain pathological changes, to develop individualized surgical plans and assess the risk of surgery.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

computed tomography; three-dimensional reconstruction; traumatic acoustic chain dislocation
PMID: 31914258 DOI: 10.13201/j.issn.1001-1781.2019.12.004



Conflict of interest statement


Publication type


Select item 3191425753.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Dec;33(12):1125-1129. doi: 10.13201/j.issn.1001-1781.2019.12.003.
[Room tilt illusion: a chief complaint need to be alert in otology clinic].
[Article in Chinese; Abstract available in Chinese from the publisher]
Wang N1, Zhang CM2, Gao W2, Chen GG2.

Author information
1Clinical Medical Teaching Simulation Hospital of Shanxi Medical University，Taiyuan，030001，China.2Department of Otolaryngology Head and Neck Surgery，the First Hospital，Shanxi Medical University，Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer，Key Institute and Laboratory of Otolaryngology Affiliated with Shanxi Province.

Abstract


Objective:This study aims to investigated the clinical significance of room tilt illusion（RTI） in screening for central vertigo in otology clinic. Method:A retrospective study of 8 RTI cases out of 656 patients with dizziness and/or vertigo. The characteristics of the symptoms, signs, physical examination, and other examinations of RTI patients were analyzed. Result:①Patients with RTI complaints accounted for 1.2% of all patients with dizziness and/or vertigo in the same period. Of all 8 patients, 2 were with acute vestibular syndrome, 5 were with episodic vestibular syndrome, and one had no dizziness and/or vertigo attack. ②Two was diagnosed with acute cerebellar infarction, and 3 was diagnosed with posterior circulation transient ischemic attacks, 2 were diagnosed with definite vestibular migraine, and one was unable to identify the cause. ③All 8 patients had a sensation of environment tilting, which was episodic（single or repeated）, transient（seconds to minutes）, in the coronal plane, and with tilt angle 30-180°. ④Seven patients had dizziness and/or vertigo for minutes to hours after a transient RTI, and one patient had no other symptoms after RTI. ⑤All patients had no decrease in vHIT gain, 6 patients had abnormal oculomotor function, and one patient had mild horizontal semicircular canal paresis. Conclusion:Patients with RTI complaints mainly had central dizziness and vertigo diseases, and once are found in otology clinic, should be alert to the possibility of suffering from central diseases.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

posterior circulation ischemic; room tilt illusion; vertigo
PMID: 31914257 DOI: 10.13201/j.issn.1001-1781.2019.12.003



Conflict of interest statement


Publication type


Select item 3191425654.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Dec;33(12):1121-1124. doi: 10.13201/j.issn.1001-1781.2019.12.002.
[Anatomy and function of the Eustachian tube influence the development of chronic suppurative otitis media].
[Article in Chinese; Abstract available in Chinese from the publisher]
Yang J1, Wang YQ1, Sun JQ1, Sun JW1.

Author information
1Department of Otolaryngology Head and Neck Surgery，the First Affiliated Hospital of USTC，Division of Life Sciences and Medicine，University of Science and Technology of China，Hefei，230001，China.

Abstract


Objective:To explore the influence of anatomy and function of the Eustachian tube（ET） on the development of chronic suppurative otitis media. Method:We retrospectively enrolled 92 cases（184 ears） of adult patients with chronic suppurative otitis media（CSOM）, in whom 118 CSOM ears, 25 atelectasis ears and 41 normal ears were included. All patients underwent endoscopy, tympanometry, pure tone average, temporal bone computerized tomography scans and ET function test. Patients with pars flaccida retraction, cholesteatoma, ET obstruction or maxillofacial deformity were excluded. The length, angle and function of ET were analyzed. Result:The ET angle was （23.1±2.4） ° in CSOM ears, was （22.9±2.9） ° in atelectasis ears and was （25.1±3.0） ° in normal ears. The ETs were more horizontal in ears with CSOM and atelectasis（P<0.01）. The ET length was （39.2±4.3） mm in CSOM ears, was （41.7±5.8） mm in atelectasis ears and was （43.0±5.9） mm in normal ears. The ETs in CSOM ears were shorter compared to the ETs normal ears（P<0.01）. No significant difference was detected between the length of ETs of atelectasis ears and normal ears（P>0.05）. The ET dysfunction rate was 62% in CSOM ears, was 68% in atelectasis ears, which were both significantly higher than the dysfunction rate in normal ears（22%）（P<0.05）. Conclusion:The anatomical and functional changes of ETs contribute to the development of CSOM. For patients with more horizontal and shorter ETs as well as ETs dysfunction, more progressive treatment should be considered.

Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

KEYWORDS:

Eustachian tube; atelectasis; otitis media
PMID: 31914256 DOI: 10.13201/j.issn.1001-1781.2019.12.002



Conflict of interest statement


Publication type


Select item 3191425555.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Dec;33(12):1117-1120. doi: 10.13201/j.issn.1001-1781.2019.12.001.
[The significance of the updates of inner ear malformations].
[Article in Chinese]
Yang J, Liang M.

KEYWORDS:

cochlear implantation; cochlear nerve; cochlear nerve canal; inner ear malformation; internal auditory meatus
PMID: 31914255 DOI: 10.13201/j.issn.1001-1781.2019.12.001



Conflict of interest statement