Antioxidants, Vol. 9, Pages 60: ABTS On-Line Antioxidant, α-Amylase, α-Glucosidase, Pancreatic Lipase, Acetyl- and Butyrylcholinesterase Inhibition Activity of Chaenomeles Fruits Determined by Polyphenols and other Chemical Compounds Antioxidants doi: 10.3390/antiox9010060 Authors: Turkiewicz Wojdyło Tkacz Nowicka Golis Bąbelewski This study aimed to identify and quantify the chemical composition and polyphenolic profile of 19 cultivars of Chaenomeles ×...
Thu Jan 09, 2020 02:00
Antioxidants, Vol. 9, Pages 59: Extraction Optimization and Evaluation of the Antioxidant and α-Glucosidase Inhibitory Activity of Polysaccharides from Chrysanthemum morifolium cv. Hangju Antioxidants doi: 10.3390/antiox9010059 Authors: Xiaoyan Hou Xia Huang Jianlong Li Guangyang Jiang Guanghui Shen Shanshan Li Qingying Luo Hejun Wu Meiliang Li Xingyan Liu Anjun Chen Meng Ye Zhiqing Zhang In order to evaluate the antioxidant and α-glucosidase...
Thu Jan 09, 2020 02:00
Atmosphere, Vol. 11, Pages 81: IEQ Field Investigation in High-Performance, Urban Elementary Schools
Atmosphere, Vol. 11, Pages 81: IEQ Field Investigation in High-Performance, Urban Elementary Schools Atmosphere doi: 10.3390/atmos11010081 Authors: Oldham Kim School buildings are one of the most commonly occupied building types for children, second only to their homes. Indoor environmental quality (IEQ) is an ongoing issue in schools, especially in urban environments where students are exposed to higher levels of outdoor pollutants. To examine this issue, five elementary school...
Thu Jan 09, 2020 02:00
Atmosphere, Vol. 11, Pages 80: Scavenging of Sub-Micron to Micron-Sized Microbial Aerosols during Simulated Rainfall Atmosphere doi: 10.3390/atmos11010080 Authors: Moore Hanlon Powers Schmale Christner The processes removing aerosols from the atmosphere during rainfall are generically referred to as scavenging. Scavenging influences aerosol distributions in the atmosphere, with consequent effects on cloud properties, radiative forcing, and human health. In this study,...
Thu Jan 09, 2020 02:00
Atmosphere, Vol. 11, Pages 78: Internal Structure of Asian Dust Particles over the Western North Pacific: Analyses Using Focused Ion Beam and Transmission Electron Microscopy Atmosphere doi: 10.3390/atmos11010078 Authors: Sayako Ueda Yusuke Miki Hiroki Kato Kazuhiko Miura Hiroyasu Nakayama Hiroshi Furutani Mitsuo Uematsu Mineral dust aerosols, which comprise multiple mineral species, are transported far from their source desert areas to the open ocean. After an Asian...
Thu Jan 09, 2020 02:00
Atmosphere, Vol. 11, Pages 79: Characterization of Urban New Particle Formation in Amman—Jordan Atmosphere doi: 10.3390/atmos11010079 Authors: Hussein Atashi Sogacheva Hakala Dada Petäjä Kulmala We characterized new particle formation (NPF) events in the urban background of Amman during August 2016–July 2017. The monthly mean of submicron particle number concentration was 1.2 × 104–3.7 × 104 cm−3 (exhibited seasonal,...
Thu Jan 09, 2020 02:00
Atmosphere, Vol. 11, Pages 77: Southern Hemisphere Sensitivity to ENSO Patterns and Intensities: Impacts over Subtropical South America Atmosphere doi: 10.3390/atmos11010077 Authors: Verónica Martín-Gómez Marcelo Barreiro Elsa Mohino El Niño flavors influence Subtropical South American (SSA) rainfall through the generation of one or two quasi-stationary Rossby waves. However, it is not yet clear whether the induced wave trains depend on the El Niño pattern...
Thu Jan 09, 2020 02:00
Behavioral Sciences, Vol. 10, Pages 30: Migration and Adaptation as Indicators of Social Mobility Migrants Behavioral Sciences doi: 10.3390/bs10010030 Authors: Svetlana Gurieva Kristi Kõiv Olga Tararukhina The economic and social changes in modern society have resulted in intensive and extensive migrant activity. The article contains a review of social, psychological, and gender aspects of migration from three countries of Central Asia (former Soviet republic)—Kyrgyzstan,...
Thu Jan 09, 2020 02:00
Biomedicines, Vol. 8, Pages 10: Meta-Analysis of Hypoxic Transcriptomes from Public Databases Biomedicines doi: 10.3390/biomedicines8010010 Authors: Bono Hirota Hypoxia is the insufficiency of oxygen in the cell, and hypoxia-inducible factors (HIFs) are central regulators of oxygen homeostasis. In order to obtain functional insights into the hypoxic response in a data-driven way, we attempted a meta-analysis of the RNA-seq data from the hypoxic transcriptomes archived in public...
Thu Jan 09, 2020 02:00
Biomedicines, Vol. 8, Pages 9: Emerging Concepts and Challenges in Rheumatoid Arthritis Gene Therapy
Biomedicines, Vol. 8, Pages 9: Emerging Concepts and Challenges in Rheumatoid Arthritis Gene Therapy Biomedicines doi: 10.3390/biomedicines8010009 Authors: Andrei A. Deviatkin Yulia A. Vakulenko Ludmila V. Akhmadishina Vadim V. Tarasov Marina I. Beloukhova Andrey A. Zamyatnin Jr. Alexander N. Lukashev Rheumatoid arthritis (RA) is a systemic inflammatory joint disease affecting about 1% of the population worldwide. Current treatment approaches do not ensure a cure for...
Thu Jan 09, 2020 02:00
Biomolecules, Vol. 10, Pages 117: Sorafenib Inhibits Ribonucleotide Reductase Regulatory Subunit M2 (RRM2) in Hepatocellular Carcinoma Cells Biomolecules doi: 10.3390/biom10010117 Authors: Yang Lin Liu The main curative treatments for hepatocellular carcinoma (HCC) are surgical resection and liver transplantation, which only benefits 15% to 25% of patients. In addition, HCC is highly refractory and resistant to cytotoxic chemotherapy. Although several multi-kinase inhibitors,...
Thu Jan 09, 2020 02:00
Biomolecules, Vol. 10, Pages 116: Galectin Domain Containing Protein from Haemonchus contortus Modulates the Immune Functions of Goat PBMCs and Regulates CD4+ T-Helper Cells In Vitro Biomolecules doi: 10.3390/biom10010116 Authors: Naqvi Memon Jamil Naqvi Aimulajiang Gadahi Xu Song Li Yan Galectins are glycan-binding proteins that are widely expressed and distributed in mammalian tissues as well as cells of innate and adaptive immune responses. CD4+...
Thu Jan 09, 2020 02:00
Biomolecules, Vol. 10, Pages 114: Transport of Ca2+ and Ca2+-Dependent Permeability Transition in the Liver and Heart Mitochondria of Rats with Different Tolerance to Acute Hypoxia Biomolecules doi: 10.3390/biom10010114 Authors: Konstantin N. Belosludtsev Mikhail V. Dubinin Eugeny Yu. Talanov Vlada S. Starinets Kirill S. Tenkov Nadezhda M. Zakharova Natalia V. Belosludtseva The work examines the kinetic parameters of Ca2+ uptake via the mitochondrial calcium uniporter...
Thu Jan 09, 2020 02:00
Biomolecules, Vol. 10, Pages 115: Physicochemical Characterization and Evaluation of Emulsions Containing Chemically Modified Fats and Different Hydrocolloids Biomolecules doi: 10.3390/biom10010115 Authors: Małgorzata Kowalska Magdalena Woźniak Anna Żbikowska Mariola Kozłowska The study aims to investigate the physicochemical properties and stability of the dispersion systems containing structured fats as a fatty base. In this work, calf tallow and pumpkin seed oil blends were...
Thu Jan 09, 2020 02:00
Brain Sciences, Vol. 10, Pages 40: The Effect of Aging on the ERP Correlates of Feedback Processing in the Probabilistic Selection Task Brain Sciences doi: 10.3390/brainsci10010040 Authors: West Huet Feedback processing contributes to efficient learning, decision making, and social interaction. Studies using event-related brain potentials (ERPs) reveal that feedback processing is associated with transient ERP components over the medial frontal and posterior regions of the scalp...
Thu Jan 09, 2020 02:00
Brain Sciences, Vol. 10, Pages 39: Infants Segment Words from Songs—An EEG Study Brain Sciences doi: 10.3390/brainsci10010039 Authors: Snijders Benders Fikkert Children’s songs are omnipresent and highly attractive stimuli in infants’ input. Previous work suggests that infants process linguistic–phonetic information from simplified sung melodies. The present study investigated whether infants learn words from ecologically valid children’s...
Thu Jan 09, 2020 02:00
Brain Sciences, Vol. 10, Pages 37: Cortical Resonance to Visible and Invisible Visual Rhythms Brain Sciences doi: 10.3390/brainsci10010037 Authors: Claudio de’Sperati Humans are rather poor in judging the right speed of video scenes. For example, a soccer match may be sped up so as to last only 80 min without observers noticing it. However, both adults and children seem to have a systematic, though often biased, notion of what should be the right speed of a given video scene. We therefore...
Thu Jan 09, 2020 02:00
Brain Sciences, Vol. 10, Pages 38: Early Attentional Modulation by Working Memory Training in Young Adult ADHD Patients during a Risky Decision-Making Task Brain Sciences doi: 10.3390/brainsci10010038 Authors: Manon E. Jaquerod Sarah K. Mesrobian Alessandro E. P. Villa Michel Bader Alessandra Lintas Background: Working memory (WM) deficits and impaired decision making are among the characteristic symptoms of patients affected by attention deficit/hyperactivity disorder (ADHD)....
Thu Jan 09, 2020 02:00
Cancers, Vol. 12, Pages 169: Differential Depletion of Bone Marrow Resident B-ALL after Systemic Administration of Endosomal TLR Agonists Cancers doi: 10.3390/cancers12010169 Authors: Sumin Jo Abbas Fotovati Jesus Duque-Afonso Michael L. Cleary Peter van den Elzen Alix E. Seif Gregor S.D. Reid Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy. While frontline chemotherapy regimens are generally very effective, the prognosis for patients whose...
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Cancers, Vol. 12, Pages 168: ESC, ALK, HOT and LOT: Three Letter Acronyms of Emerging Renal Entities Knocking on the Door of the WHO Classification Cancers doi: 10.3390/cancers12010168 Authors: Farshid Siadat Kiril Trpkov Kidney neoplasms are among the most heterogeneous and diverse tumors. Continuous advancement of this field is reflected in the emergence of new tumour entities and an increased recognition of the expanding morphologic, immunohistochemical, molecular, epidemiologic...
Thu Jan 09, 2020 02:00
Cancers, Vol. 12, Pages 166: The Crossroads of Precision Medicine and Therapeutic Decision-Making: Use of an Analytical Computational Platform to Predict Response to Cancer Treatments Cancers doi: 10.3390/cancers12010166 Authors: Boichard Richard Kurzrock Metastatic cancer is a medical challenge that has been historically resistant to treatments. One area of leverage in cancer care is the development of molecularly-driven combination therapies, offering the possibility to overcome...
Thu Jan 09, 2020 02:00
Cancers, Vol. 12, Pages 167: Divergent Effects of Daidzein and its Metabolites on Estrogen-Induced Survival of Breast Cancer Cells Cancers doi: 10.3390/cancers12010167 Authors: Montalesi Cipolletti Cracco Fiocchetti Marino Although soy consumption is associated with breast cancer prevention, the low bioavailability and the extensive metabolism of soy-active components limit their clinical application. Here, the impact of daidzein (D) and its metabolites on estrogen-dependent...
Thu Jan 09, 2020 02:00
Cancers, Vol. 12, Pages 165: Photochemical Internalization: Light Paves Way for New Cancer Chemotherapies and Vaccines Cancers doi: 10.3390/cancers12010165 Authors: Šošić Selbo Kotkowska Kündig Høgset Johansen Photochemical internalization (PCI) is a further development of photodynamic therapy (PDT). In this report, we describe PCI as a potential tool for cellular internalization of chemotherapeutic agents or antigens and systematically review the ongoing research....
Thu Jan 09, 2020 02:00
Cancers, Vol. 12, Pages 163: Clinical Limitations of Photon, Proton and Carbon Ion Therapy for Pancreatic Cancer Cancers doi: 10.3390/cancers12010163 Authors: Dell’Oro Short Wilson Bezak Introduction: Despite improvements in radiation therapy, chemotherapy and surgical procedures over the last 30 years, pancreatic cancer 5-year survival rate remains at 9%. Reduced stroma permeability and heterogeneous blood supply to the tumour prevent chemoradiation from making a meaningful...
Thu Jan 09, 2020 02:00
Cancers, Vol. 12, Pages 162: Improvement in the Anti-Tumor Efficacy of Doxorubicin Nanosponges in In Vitro and in Mice Bearing Breast Tumor Models Cancers doi: 10.3390/cancers12010162 Authors: Monica Argenziano Casimiro Luca Gigliotti Nausicaa Clemente Elena Boggio Benedetta Ferrara Francesco Trotta Stefania Pizzimenti Giuseppina Barrera Renzo Boldorini Federica Bessone Umberto Dianzani Roberta Cavalli Chiara Dianzani Doxorubicin (DOX) is an anthracycline...
Thu Jan 09, 2020 02:00
Cancers, Vol. 12, Pages 164: Ferroptosis in Cancer Cell Biology Cancers doi: 10.3390/cancers12010164 Authors: Christina M. Bebber Fabienne Müller Laura Prieto Clemente Josephine Weber Silvia von Karstedt A major hallmark of cancer is successful evasion of regulated forms of cell death. Ferroptosis is a recently discovered type of regulated necrosis which, unlike apoptosis or necroptosis, is independent of caspase activity and receptor-interacting protein 1 (RIPK1) kinase...
Thu Jan 09, 2020 02:00
Cancers, Vol. 12, Pages 161: Krebs Cycle Intermediate-Modified Carbonate Apatite Nanoparticles Drastically Reduce Mouse Tumor Burden and Toxicity by Restricting Broad Tissue Distribution of Anticancer Drugs Cancers doi: 10.3390/cancers12010161 Authors: Sultana Mehbuba Hossain Syafiq Asnawi Zainal Abidin Ezharul Hoque Chowdhury The morphology, size, and surface area of nanoparticles (NPs), with the existence of functional groups on their surface, contribute to the drug binding affinity,...
Thu Jan 09, 2020 02:00
Cancers, Vol. 12, Pages 158: Stage IV Gastric Cancer: The Surgical Perspective of the Italian Research Group on Gastric Cancer Cancers doi: 10.3390/cancers12010158 Authors: Silvia Ministrini Maria Bencivenga Leonardo Solaini Chiara Cipollari Silvia Sofia Elisabetta Marino Alessia d’Ignazio Beatrice Molteni Gianni Mura Daniele Marrelli Maurizio Degiuli Annibale Donini Franco Roviello Giovanni de Manzoni Paolo Morgagni Guido A. M. Tiberio Background/Aim:...
Thu Jan 09, 2020 02:00
Cancers, Vol. 12, Pages 160: Circulating Tumor Cells as a Marker of Disseminated Disease in Patients with Newly Diagnosed High-Risk Prostate Cancer Cancers doi: 10.3390/cancers12010160 Authors: Wojciech A. Cieślikowski Joanna Budna-Tukan Monika Świerczewska Agnieszka Ida Michał Hrab Agnieszka Jankowiak Martine Mazel Michał Nowicki Piotr Milecki Klaus Pantel Catherine Alix-Panabières Maciej Zabel Andrzej Antczak The aim of this study was to investigate...
Thu Jan 09, 2020 02:00
Cells, Vol. 9, Pages 170: RK-33 Is a Broad-Spectrum Antiviral Agent That Targets DEAD-Box RNA Helicase DDX3X Cells doi: 10.3390/cells9010170 Authors: Yang Atkinson Audsley Heaton Jans Borg Viral disease is one of the greatest burdens for human health worldwide, with an urgent need for efficacious antiviral strategies. While antiviral drugs are available, in many cases, they are prone to the development of drug resistance. A way to overcome drug resistance associated...
Thu Jan 09, 2020 02:00
Cells, Vol. 9, Pages 171: Transcriptional Coactivator TAZ Negatively Regulates Tumor Suppressor p53 Activity and Cellular Senescence Cells doi: 10.3390/cells9010171 Authors: Miyajima Kawarada Inoue Suzuki Mitamura Morishita Ohoka Imamura Hayashi Transcriptional coactivator with a PDZ-binding motif (TAZ) is one of the mammalian orthologs of Drosophila Yorkie, a transcriptional coactivator of the Hippo pathway. TAZ has been suggested to function as a regulator...
Thu Jan 09, 2020 02:00
Cells, Vol. 9, Pages 169: Role of microRNAs as Clinical Cancer Biomarkers for Ovarian Cancer: A Short Overview Cells doi: 10.3390/cells9010169 Authors: Staicu Predescu Rusu Radu Cretoiu Suciu Crețoiu Voinea Ovarian cancer has the highest mortality rate among gynecological cancers. Early clinical signs are missing and there is an urgent need to establish early diagnosis biomarkers. MicroRNAs are promising biomarkers in this respect. In this paper, we review...
Thu Jan 09, 2020 02:00
Cells, Vol. 9, Pages 168: Disruption of Beta-Cell Mitochondrial Networks by the Orphan Nuclear Receptor Nor1/Nr4a3 Cells doi: 10.3390/cells9010168 Authors: Close Dadheech Lemieux Wang Buteau Nor1, the third member of the Nr4a subfamily of nuclear receptor, is garnering increased interest in view of its role in the regulation of glucose homeostasis. Our previous study highlighted a proapoptotic role of Nor1 in pancreatic beta cells and showed that Nor1 expression was...
Thu Jan 09, 2020 02:00
Cells, Vol. 9, Pages 167: Mechanisms of Resistance to Anti-Cd38 Daratumumab in Multiple Myeloma Cells doi: 10.3390/cells9010167 Authors: Ilaria Saltarella Vanessa Desantis Assunta Melaccio Antonio Giovanni Solimando Aurelia Lamanuzzi Roberto Ria Clelia Tiziana Storlazzi Maria Addolorata Mariggiò Angelo Vacca Maria Antonia Frassanito Daratumumab (Dara) is the first-in-class human-specific anti-CD38 mAb approved for the treatment of multiple myeloma (MM). Although...
Thu Jan 09, 2020 02:00
Cells, Vol. 9, Pages 165: In Silico Analysis of the Age-Dependent Evolution of the Transcriptome of Mouse Skin Stem Cells Cells doi: 10.3390/cells9010165 Authors: Lorenzo-Martín Bustelo The stem cells located in the hair follicle bulge area are critical for skin regeneration and repair. To date, little is known about the evolution of the transcriptome of these cells across time. Here, we have combined genome-wide expression analyses and a variety of in silico tools to determine...
Thu Jan 09, 2020 02:00
Cells, Vol. 9, Pages 164: VAPB ER-Aggregates, A Possible New Biomarker in ALS Pathology Cells doi: 10.3390/cells9010164 Authors: Maria Piera L Cadoni Maria Luigia Biggio Giannina Arru Giannina Secchi Nicola Orrù Maria Grazia Clemente GianPietro Sechi Alfred Yamoah Priyanka Tripathi Sandro Orrù Roberto Manetti Grazia Galleri A point mutation (P56S) in the gene-encoding vesicle-associated membrane-protein-associated protein B (VAPB) leads to an autosomal-dominant...
Thu Jan 09, 2020 02:00
Cells, Vol. 9, Pages 163: Adipose Stem Cell-Derived Extracellular Vesicles Induce Proliferation of Schwann Cells via Internalization Cells doi: 10.3390/cells9010163 Authors: Maximilian Haertinger Tamara Weiss Anda Mann Annette Tabi Victoria Brandel Christine Radtke Recent studies showed a beneficial effect of adipose stem cell-derived extracellular vesicles (ADSC-EVs) on sciatic nerve repair, presumably through Schwann cell (SC) modulation. However, it has not yet been...
Thu Jan 09, 2020 02:00
Cells, Vol. 9, Pages 166: Shockwaves Suppress Adipocyte Differentiation via Decrease in PPARγ Cells doi: 10.3390/cells9010166 Authors: Cho Kim Jeong Park Adipogenesis is a crucial cellular process that contributes to the expansion of adipose tissue in obesity. Shockwaves are mechanical stimuli that transmit signals to cause biological responses. The purpose of this study is to evaluate the effects of shockwaves on adipogenesis. We treated 3T3L-1 cells and human primary preadipocytes...
Thu Jan 09, 2020 02:00
Cells, Vol. 9, Pages 162: Translation Efficiency and Degradation of ER-Associated mRNAs Modulated by ER-Anchored poly(A)-Specific Ribonuclease (PARN) Cells doi: 10.3390/cells9010162 Authors: Tian-Li Duan Han Jiao Guang-Jun He Yong-Bin Yan Translation is spatiotemporally regulated and endoplasmic reticulum (ER)-associated mRNAs are generally in efficient translation. It is unclear whether the ER-associated mRNAs are deadenylated or degraded on the ER surface in situ or in the...
Thu Jan 09, 2020 02:00
Cells, Vol. 9, Pages 161: Pathogens MenTORing Macrophages and Dendritic Cells: Manipulation of mTOR and Cellular Metabolism to Promote Immune Escape Cells doi: 10.3390/cells9010161 Authors: Lonneke V. Nouwen Bart Everts Myeloid cells, including macrophages and dendritic cells, represent an important first line of defense against infections. Upon recognition of pathogens, these cells undergo a metabolic reprogramming that supports their activation and ability to respond to the invading...
Thu Jan 09, 2020 02:00
Cells, Vol. 9, Pages 160: STIM Protein-NMDA2 Receptor Interaction Decreases NMDA-Dependent Calcium Levels in Cortical Neurons Cells doi: 10.3390/cells9010160 Authors: Joanna Gruszczynska-Biegala Klaudia Strucinska Filip Maciag Lukasz Majewski Maria Sladowska Jacek Kuznicki Neuronal Store-Operated Ca2+ Entry (nSOCE) plays an essential role in refilling endoplasmic reticulum Ca2+ stores and is critical for Ca2+-dependent neuronal processes. SOCE sensors, STIM1 and STIM2,...
Thu Jan 09, 2020 02:00
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