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Acta Trop. 2020 Jan 30;:105380
Authors: Qian MB, Jiang ZH, Ge T, Wang X, Zhou CH, Zhu HH, Zhou XN
Abstract
Clonorchis sinensis infection is caused by ingestion of raw freshwater fish containing the infective larvae of Clonorchis sinensis. It is highly endemic in East Asia, especially in China. Selective chemotherapy of people who report habitual eating of raw freshwater fish is a control measure. As the performance of this screening technique has not yet been fully evaluated in China, a cross-sectional study was conducted, covering 16 counties in four major clonorchiasis-endemic provinces. About 1 000 participants were enrolled from each county. In total, 16 230 participants were enrolled from 16 counties. Faecal samples were collected and examined for helminth eggs and each person enrolled was asked about their practice with respect to eating raw freshwater fish. The overall prevalence of C. sinensis infection was 10.8% among 16 230 participants, ranging from 0 to 53.7% in the 16 counties, while the percentage of inhabitants commonly eating raw freshwater fish was 26.5%, ranging from 0 to 79.1%. The overall sensitivity and specificity of screening for C. sinensis infection in this way was 82.3% and 80.3%, respectively, yielding a Youden's index of 0.6. The overall positive and negative likelihood ratios were 4.2 and 0.2, respectively, while the overall positive and negative predictive values were 33.5% and 97.4%, respectively. Furthermore, the sensitivity was higher with regard to high-intensity infections compared to light infections.
PMID: 32007446 [PubMed - as supplied by publisher]
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