EMT signaling: potential contribution of CRISPR/Cas gene editing.

EMT signaling: potential contribution of CRISPR/Cas gene editing.:

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EMT signaling: potential contribution of CRISPR/Cas gene editing.

Cell Mol Life Sci. 2020 Feb 01;:

Authors: Mohammadinejad R, Biagioni A, Arunkumar G, Shapiro R, Chang KC, Sedeeq M, Taiyab A, Hashemabadi M, Pardakhty A, Mandegary A, Thiery JP, Aref AR, Azimi I

Abstract

Epithelial to mesenchymal transition (EMT) is a complex plastic and reversible cellular process that has critical roles in diverse physiological and pathological phenomena. EMT is involved in embryonic development, organogenesis and tissue repair, as well as in fibrosis, cancer metastasis and drug resistance. In recent years, the ability to edit the genome using the clustered regularly interspaced palindromic repeats (CRISPR) and associated protein (Cas) system has greatly contributed to identify or validate critical genes in pathway signaling. This review delineates the complex EMT networks and discusses recent studies that have used CRISPR/Cas technology to further advance our understanding of the EMT process.

PMID: 32008085 [PubMed - as supplied by publisher]