Leptomeningeal metastasis from solid tumors.

Leptomeningeal metastasis from solid tumors.:

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Leptomeningeal metastasis from solid tumors.

J Neurol Sci. 2020 Jan 23;411:116706

Authors: Thakkar JP, Kumthekar P, Dixit KS, Stupp R, Lukas RV

Abstract

Central nervous system (CNS) metastasis from systemic cancers can involve the brain parenchyma, leptomeninges (pia, subarachnoid space and arachnoid mater), and dura. Leptomeningeal metastases (LM), also known by different terms including neoplastic meningitis and carcinomatous meningitis, occur in both solid tumors and hematologic malignancies. This review will focus exclusively on LM arising from solid tumors with a goal of providing the reader an understanding of the epidemiology, pathophysiology, clinical presentation, prognostication, current management and future directions.

PMID: 32007755 [PubMed - as supplied by publisher]