ABSTRACT There are no studies which directly compare efficacy in PASI response of secukinumab and ixekizumab. The main aim of this study was to compare the efficacy and safety of both drugs used to treat moderate‐to‐severe psoriasis patients over 52 weeks. Secondary objectives were to identify which factors related to prior biologic treatment influenced their efficacy, and analyze data obtained at 12 weeks. A retrospective observational study was carried out, in which a group of the first 59 patients...
Tue Mar 17, 2020 19:18
Tue Mar 17, 2020 19:18
Abstract Normal human cultured melanocytes were exposed to various glutathione concentrations (0.1, 0.5, 1.0, 5.0, and 10.0 mg/mL) for 72 h. At the end of the experiment, proliferation, viability, migration, and ultra‐structural changes were monitored. Glutathione at the doses of 0.5 to 10.0 mg/mL reduced the viability of melanocytes significantly as compared to the control (P < 0.05). Glutathione significantly reduced the proliferation of melanocytes at the doses of 0.5 to 10.0 mg/mL as compared...
Tue Mar 17, 2020 19:18
Abstract Pityriasis lichenoides (PL) is an uncommon cutaneous disorder. Oral erythromycin is proposed to be effective in treating the disease. Here we reported 16 pediatric patients with PL and systematically reviewed published literatures on erythromycin treatment response in pediatric PL patients, to observed the different treatment response to erythromycin in the PLC and the PLEVA groups. Sixteen patients, 8 with PLC and 8 with PLEVA, were treated with erythromycin. In the PLC group, 25% (n = 2)...
Tue Mar 17, 2020 19:18
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b12530
Tue Mar 17, 2020 06:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c00969
Tue Mar 17, 2020 06:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b12464
Tue Mar 17, 2020 06:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b11454
Tue Mar 17, 2020 06:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c01062
Tue Mar 17, 2020 06:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b13755
Tue Mar 17, 2020 06:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c00290
Tue Mar 17, 2020 06:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c00992
Tue Mar 17, 2020 06:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c01778
Tue Mar 17, 2020 06:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c01274
Tue Mar 17, 2020 06:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05665
Tue Mar 17, 2020 06:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00324
Tue Mar 17, 2020 06:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05849
Tue Mar 17, 2020 06:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05209
Tue Mar 17, 2020 06:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05725
Tue Mar 17, 2020 06:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00222
Tue Mar 17, 2020 06:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b04499
Tue Mar 17, 2020 06:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00017
Tue Mar 17, 2020 06:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00160
Tue Mar 17, 2020 06:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00368
Tue Mar 17, 2020 06:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00403
Tue Mar 17, 2020 06:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05473
Tue Mar 17, 2020 06:00
When fossils are sparse and the lineages studied are very divergent morphologically, analyses based exclusively on morphology may lead to conflicting and unexpected hypotheses. Through integration of data from conservative genes/gene regions the terminals including these data can anchor or constrain the search, thereby practically circumscribing the search space of the combined analyses. In this study, we revisit the phylogeny of a highly divergent group of mosses, class Polytrichopsida. We supplemented...
Tue Mar 17, 2020 02:00
Bats provide key ecosystem services such as crop pest regulation, pollination, seed dispersal, and soil fertilization. Bats are also major hosts for biological agents responsible for zoonoses, such as coronaviruses (CoVs). The islands of the Western Indian Ocean are identified as a major biodiversity hotspot, with more than 50 bat species. In this study, we tested 1,013 bats belonging to 36 species from Mozambique, Madagascar, Mauritius, Mayotte, Reunion Island and Seychelles, based on molecular...
Tue Mar 17, 2020 02:00
Environmental limits of animal life are invariably revised upwards when the animals themselves are investigated in their natural habitats. Here we report results of a scientific mountaineering expedition to survey the high-altitude rodent fauna of Volcan Llullaillaco in the Puna de Atacama of northern Chile, an effort motivated by video documentation of mice (genus Phyllotis) at a record altitude of 6205 m. Among numerous trapping records at altitudes >5000 m, we captured a specimen of the yellow-rumped...
Tue Mar 17, 2020 02:00
When someone's trying to explain to you how to buy software, but you already got it for free. (Christina @ wocintechchat.com/Unsplash/)We all love free stuff. I mean, have you seen the line at Ben & Jerry’s on Free Cone Day? You’d think they were giving away Ferraris.But sadly, not all things come at so low a price. There’s a lot of great free software out there, but some of the best tools cost money—whether it’s a $4 app like Dark Sky or a $120-per-year subscription like Photoshop. If you’re...
Tue Mar 17, 2020 23:48
Merrily we roll along. (Blake Meyer via Unsplash/)There are few kids’ toys as timeless and practical as a wagon. The experience of rumbling down the sidewalk inside a miniature truck bed adds adventure to every play date or picnic. Watch siblings test their strength and pull each other around, or turn kids into transport operators while the parents clean up the yard. Unlike other toys, wagons are a tool kids and adults will find handy long after they’ve been outgrown. Here are our favorites.Like...
Tue Mar 17, 2020 23:23
Calling the Shots (Morteza Sarmadi, Christina Ta, Robert Langer, Ana Jaklenec/Koch Institute at MIT/)Medical images are crucial to saving lives. Health care experts use X-rays, ultrasounds, and more to uncover secret maladies and confirm that organ systems are up to speed. But what if they need to go deeper, to the cellular level, to dig into a biological mystery? For those cases, scientists turn to microscopy to take sharp, detailed photographs through 10x or 100x lenses. Or they rig their own setups...
Tue Mar 17, 2020 23:17
The Xbox Series X won't have the same flat box shape as previous consoles. (Microsoft/)Microsoft started dropping hints about the next generation Xbox last year. This week, however, the company has released some hard specs and more information about how the Xbox Series X will actually work when it arrives for holiday 2020. The coronavirus outbreak canceled the E3 video game trade show, but that hasn’t stopped the company from outlining its upcoming hardware.The problem, though, is that console spec...
Tue Mar 17, 2020 21:58
See what you can sculpt. (Depositphotos /)You don’t need a ceramics wheel class to start creating with clay. Grab a set of air-dry or polymer clay and start sculpting little toys or jewelry in your living room. They’re easy to work with, highly malleable, and just requires air drying or a home oven to set. Use it to create tiny accessories or realistic sculptures—something both you and your kids can enjoy.A colorful starter pack with 24 colors and sculpting accessories. (Amazon/)This versatile clay...
Tue Mar 17, 2020 20:48
Choose the right one for you. (NeONBRAND via Unsplash/)Despite all you’ve heard about it, virtual reality is still very much in its infancy. No doubt we’ll get to the point where we’ll look at clunky, old-fashioned VR headsets the way kids now look at stand-up coin-op arcade games. But satiating your curiosity around VR isn’t always easy, with a lot of the gear seeming to be impenetrably complicated.But rest assured, no matter what level of tech savvy you are, there is a way in to VR. From simple...
Tue Mar 17, 2020 20:43
COVID-19 may be with us for some time, but we are far from powerless. (Pexels/)The number of new COVID-19 cases in the United States is accelerating, and the impact of the pandemic is "definitely going to get worse before it gets better," Anthony Fauci, the nation’s leading expert on infectious diseases, said on March 12. "We will have a lot more cases," Fauci, who directs the National Institute of Allergy and Infectious Diseases, told CNN.At this point you are probably wondering, am I going to have...
Tue Mar 17, 2020 19:30
Stay in. Read a book. ( Radu Marcusu via Unsplash/)As Peter Falk so eloquently said in The Princess Bride, “When I was your age, television was called books.” And it might be a good time to unplug and escape for a while, don’t you think? Since we can assume a certain amount of science and technology bias here, we’ve found some of the best new sci-fi novels from the last year or so that will satisfy your need to get lost in a new world (or worlds).From alien contact to planet-hopping adventure to...
Tue Mar 17, 2020 19:13
If this is the first time you've ever heard of basturma, boy, you are in for a treat. (Kat Craddock/)This story was originally featured on Saveur.Basturma is to Armenia what bresaola is to Italy and cecina is to Spain—a ruddy hunk of air-dried beef with more umami punch per mouthful than the fanciest dry-aged steak—except it’s far more exciting. Unlike its simply-salted European brethren, basturma is garlicky and piquant and spiced with industrial quantities of paprika and fenugreek. It’s the type...
Tue Mar 17, 2020 18:00
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