IJMS, Vol. 21, Pages 3484: Understanding the Binding Induced Folding of Intrinsically Disordered Proteins by Protein Engineering: Caveats and Pitfalls International Journal of Molecular Sciences doi: 10.3390/ijms21103484 Authors: Francesca Malagrinò Lorenzo Visconti Livia Pagano Angelo Toto Francesca Troilo Stefano Gianni Many proteins lack a well-defined three-dimensional structure in isolation. These proteins, typically denoted as intrinsically disordered proteins (IDPs),...
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IJMS, Vol. 21, Pages 3483: Overview of Dual-Acting Drug Methotrexate in Different Neurological Diseases, Autoimmune Pathologies and Cancers International Journal of Molecular Sciences doi: 10.3390/ijms21103483 Authors: Przemysław Koźmiński Paweł Krzysztof Halik Raphael Chesori Ewa Gniazdowska Methotrexate, a structural analogue of folic acid, is one of the most effective and extensively used drugs for treating many kinds of cancer or severe and resistant forms of autoimmune...
Thu May 14, 2020 03:00
IJMS, Vol. 21, Pages 3481: Tunneling Nanotubes-Mediated Protection of Mesenchymal Stem Cells: An Update from Preclinical Studies International Journal of Molecular Sciences doi: 10.3390/ijms21103481 Authors: Thangavelu Soundara Rajan Agnese Gugliandolo Placido Bramanti Emanuela Mazzon Tunneling nanotubes (TNTs) are thin membrane elongations among the cells that mediate the trafficking of subcellular organelles, biomolecules, and cues. Mesenchymal stem cells (MSCs) receive substantial...
Thu May 14, 2020 03:00
IJMS, Vol. 21, Pages 3482: A Novel 3D Bioprinter Using Direct-Volumetric Drop-On-Demand Technology for Fabricating Micro-Tissues and Drug-Delivery International Journal of Molecular Sciences doi: 10.3390/ijms21103482 Authors: Brian E. Grottkau Zhixin Hui Yonggang Pang Drop-on-demand (DOD) 3D bioprinting technologies currently hold the greatest promise for generating functional tissues for clinical use and for drug development. However, existing DOD 3D bioprinting technologies have...
Thu May 14, 2020 03:00
IJMS, Vol. 21, Pages 3478: Seminal Plasma, Sperm Concentration, and Sperm-PMN Interaction in the Donkey: An In Vitro Model to Study Endometrial Inflammation at Post-Insemination International Journal of Molecular Sciences doi: 10.3390/ijms21103478 Authors: Jordi Miró Henar Marín Jaime Catalán Marion Papas Sabrina Gacem Marc Yeste In the donkey, artificial insemination (AI) with frozen-thawed semen is associated with low fertility rates, which could be partially augmented...
Thu May 14, 2020 03:00
IJMS, Vol. 21, Pages 3480: The GOLIATH Project: Towards an Internationally Harmonised Approach for Testing Metabolism Disrupting Compounds International Journal of Molecular Sciences doi: 10.3390/ijms21103480 Authors: Juliette Legler Daniel Zalko Fabien Jourdan Miriam Jacobs Bernard Fromenty Patrick Balaguer William Bourguet Vesna Munic Kos Angel Nadal Claire Beausoleil Susana Cristobal Sylvie Remy Sibylle Ermler Luigi Margiotta-Casaluci Julian L....
Thu May 14, 2020 03:00
IJMS, Vol. 21, Pages 3477: microRNAs as promising biomarkers of platelet activity in antiplatelet therapy monitoring International Journal of Molecular Sciences doi: 10.3390/ijms21103477 Authors: Krammer Mayr Hackl Given the high morbidity and mortality of cardiovascular diseases (CVDs), novel biomarkers for platelet reactivity are urgently needed. Ischemic events in CVDs are causally linked to platelets, small anucleate cells important for hemostasis. The major side-effect...
Thu May 14, 2020 03:00
IJMS, Vol. 21, Pages 3479: Novel Medicinal Mushroom Blend as a Promising Supplement in Integrative Oncology: A Multi-Tiered Study using 4T1 Triple-Negative Mouse Breast Cancer Model International Journal of Molecular Sciences doi: 10.3390/ijms21103479 Authors: Roda Luca Iorio Ratto Siciliani Ferrari Cobelli Borsci Priori Chinosi Ronchi Franco Di Francia Berretta Locatelli Gregori Savino Bottone Rossi Although medicinal...
Thu May 14, 2020 03:00
IJMS, Vol. 21, Pages 3462: Nutrients and Porphyria: An Intriguing Crosstalk International Journal of Molecular Sciences doi: 10.3390/ijms21103462 Authors: Elena Di Pierro Francesca Granata Porphyria refers to a group of fascinating diseases from a metabolic and nutritional standpoint as it provides an example of how metabolic manipulation can be used for therapeutic purposes. It is characterized by defects in heme synthesis, particularly in the erythrocytes and liver. Specific enzymes...
Thu May 14, 2020 03:00
IJMS, Vol. 21, Pages 3476: Improving the Size Homogeneity of Multicore Superparamagnetic Iron Oxide Nanoparticles International Journal of Molecular Sciences doi: 10.3390/ijms21103476 Authors: Barry J. Yeh Tareq Anani Allan E. David Superparamagnetic iron oxide nanoparticles (SPIONs) have been widely explored for use in many biomedical applications. Methods for synthesis of magnetic nanoparticle (MNP), however, typically yield multicore structures with broad size distribution,...
Thu May 14, 2020 03:00
IJMS, Vol. 21, Pages 3469: CX3CR1-Targeted PLGA Nanoparticles Reduce Microglia Activation and Pain Behavior in Rats with Spinal Nerve Ligation International Journal of Molecular Sciences doi: 10.3390/ijms21103469 Authors: Chan Noh Hyo Jung Shin Seounghun Lee Song I Kim Yoon-Hee Kim Won Hyung Lee Dong Woon Kim Sun Yeul Lee Young Kwon Ko Activation of CX3CR1 in microglia plays an important role in the development of neuropathic pain. Here, we investigated whether...
Thu May 14, 2020 03:00
IJMS, Vol. 21, Pages 3474: COVID-19 and Individual Genetic Susceptibility/Receptivity: Role of ACE1/ACE2 Genes, Immunity, Inflammation and Coagulation. Might the Double X-chromosome in Females Be Protective against SARS-CoV-2 Compared to the Single X-Chromosome in Males? International Journal of Molecular Sciences doi: 10.3390/ijms21103474 Authors: Gemmati Bramanti Serino Secchiero Zauli Tisato In December 2019, a novel severe acute respiratory syndrome (SARS) from...
Thu May 14, 2020 03:00
IJMS, Vol. 21, Pages 3475: A Novel Protocol for Detection of Senescence and Calcification Markers by Fluorescence Microscopy International Journal of Molecular Sciences doi: 10.3390/ijms21103475 Authors: Herrmann Babic Tölle Eckardt van der Giet Schuchardt Vascular calcification and stiffening of the arterial wall is a systemic phenomenon that is associated with aging and it can be increased by several risk factors. The underlying mechanisms, especially the pathways...
Thu May 14, 2020 03:00
IJMS, Vol. 21, Pages 3473: Increased Level of Vascular Endothelial Growth Factors by 4-hexylresorcinol is Mediated by Transforming Growth Factor-β1 and Accelerates Capillary Regeneration in the Burns in Diabetic Animals International Journal of Molecular Sciences doi: 10.3390/ijms21103473 Authors: Dae-Won Kim You-Young Jo Umberto Garagiola Je-Yong Choi Yei-Jin Kang Ji-Hyeon Oh Seong-Gon Kim 4-Hexyl resorcinol (4HR) is an organic compound and has been used in skin care...
Thu May 14, 2020 03:00
IJMS, Vol. 21, Pages 3465: Galactofuranose-Related Enzymes: Challenges and Hopes International Journal of Molecular Sciences doi: 10.3390/ijms21103465 Authors: Mateja Seničar Pierre Lafite Svetlana V. Eliseeva Stéphane Petoud Ludovic Landemarre Richard Daniellou Galactofuranose is a rare form of the well-known galactose sugar, and its occurrence in numerous pathogenic micro-organisms makes the enzymes responsible for its biosynthesis interesting targets. Herein, we review...
Thu May 14, 2020 03:00
IJMS, Vol. 21, Pages 3467: Dynamic Changes of Heart Failure Biomarkers in Response to Parabolic Flight International Journal of Molecular Sciences doi: 10.3390/ijms21103467 Authors: Peter Jirak Bernhard Wernly Michael Lichtenauer Vera Paar Marcus Franz Thorben Knost Thaer Abusamrah Malte Kelm Johanna M. Muessig Nana-Yaw Bimpong-Buta Christian Jung Background: we aimed at investigating the influence of weightlessness and hypergravity by means of parabolic...
Thu May 14, 2020 03:00
IJMS, Vol. 21, Pages 3472: Identification of Upstream Transcriptional Regulators of Ischemic Cardiomyopathy Using Cardiac RNA-Seq Meta-Analysis International Journal of Molecular Sciences doi: 10.3390/ijms21103472 Authors: Alimadadi Aryal Manandhar Joe Cheng Ischemic cardiomyopathy (ICM), characterized by pre-existing myocardial infarction or severe coronary artery disease, is the major cause of heart failure (HF). Identification of novel transcriptional regulators in...
Thu May 14, 2020 03:00
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