Age- and movement-related modulation of cortical oscillations in a mouse model of presbycusis

Age- and movement-related modulation of cortical oscillations in a mouse model of presbycusis:



Publication date: Available online 15 October 2020

Source: Hearing Research

Author(s): J.A. Rumschlag, J.W. Lovelace, K.A. Razak




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Hearing Research
Available online 15 October 2020, 108095
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Age- and movement-related modulation of cortical oscillations in a mouse model of presbycusis
Author links open overlay panelJ.A.RumschlagaJ.W.LovelacebK.A.RazakabShow more
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Highlights


•

Gamma oscillations and entrainment decrease with age in C57bl/6 mice•

Movement increases EEG gamma power in all age groups of mice•

Deficits in temporal processing in aged mice is seen even when responses are robust•

These data provide novel markers of presbycusis-related auditory processing deficits



Abstract


Brain oscillations are associated with specific cognitive and sensory processes. How age-related hearing loss (presbycusis) alters cortical oscillations is unclear. Altered inhibitory neurotransmission and temporal processing deficits contribute to speech recognition impairments in presbycusis. Specifically, age-related reduction in parvalbumin positive interneurons and perineuronal nets in the auditory cortex predicts a reduction in gamma oscillations that may lead to a decline in temporal precision and attention. To test the hypothesis that resting and evoked gamma oscillations decline with presbycusis, EEGs were recorded from the auditory and frontal cortex of awake, freely moving C57BL/6J mice at three ages (3, 14 and 24 months). Resting EEG data were analyzed according to movement state (move versus still). Evoked responses were recorded following presentation of noise bursts or amplitude modulated noise with time varying modulation frequencies. We report an age-related decrease in resting gamma power, a decline in gamma-range synchrony to time varying stimuli, and an increase in noise evoked and induced gamma power. A decline in temporal processing is seen in aged mice that exhibit robust auditory-evoked potentials, dissociating hearing loss from temporal processing deficits. We also report an increase in gamma power when mice moved compared to the still state. However, the movement-related modulation of gamma oscillations did not change with age. Together, these data identify a number of novel markers of presbycusis-related changes in auditory and frontal cortex. Because EEGs are commonly recorded in humans, the mouse data may serve as translation relevant preclinical biomarkers to facilitate the development of therapeutics to delay or reverse central auditory processing deficits in presbycusis.

Keywords
auditory cortex
aging
presbycusis
temporal processing
gamma oscillations
EEG
parvalbumin
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