Of the six or more different species of early humans, all belonging to the genus Homo, only we Homo sapiens have managed to survive. Now, a study combining climate modeling and the fossil record in search of clues to what led to all those earlier extinctions suggests that climate change -- the inability to adapt to either warming or cooling temperatures -- likely played a major role in sealing their fate.
Thu Oct 15, 2020 18:17
Abstract Objective To study the associations of objectively measured physical activity (PA) and sedentary time (ST) with the combined outcome of incident stroke, myocardial infarction (MI) or all-cause mortality in older adults. Methods N = 3343 men and women aged 70 who participated in a health survey between 2012 and 2017 were included. Actigraph...
Thu Oct 15, 2020 03:00
Thu Oct 15, 2020 03:00
Abstract Iron deficiency (ID) is a prevailing nutritional concern amongst the athletic population due to the increased iron demands of this group. Athletes’ ability to replenish taxed iron stores is challenging due to the low bioavailability of dietary sources, and the interaction between exercise and hepcidin, the primary iron-regulatory hormone. To date, copious research has explored the link between exercise and iron regulation, with a more recent focus on optimising iron treatment...
Thu Oct 15, 2020 03:00
Radiation-induced angiosarcoma (RIAS) after breast-conserving surgery is quite rare. Risk factors for RIAS have yet to be identified, due largely to the very low incidence of this disease. The etiologic mechanisms of RIAS are not understood, although some reports suggest that genome instability may contribute to RIAS development. An 81-year-old Japanese woman presented to our hospital after developing multiple dark purple nodules on her left breast. She had undergone breast-conserving surgery for...
Thu Oct 15, 2020 18:48
There is a growing body of literature outlining the association between certain hematological malignancies, such as chronic myelomonocytic leukemia (CMML), and systemic autoimmune diseases. Diagnosis and management can be difficult, particularly when autoimmune phenomena overlap with features of the underlying illness. This is especially the case in patients who develop immune-mediated cytopenias in the context of underlying bone marrow disease. CMML associated with immune thrombocytopenia and hemolytic...
Thu Oct 15, 2020 18:41
Real-time quantitative PCR (RT-qPCR) is the gold standard to quantify the BCR-ABL1 transcript for molecular response monitoring in chronic myeloid leukemia (CML) patients, and it plays a pivotal role in clinical decision-making process, even if it presents technical limits. Increasing data suggest that digital PCR (dPCR) is more accurate and reliable than RT-qPCR in CML minimal residual disease monitoring and in patients’ selection for treatment discontinuation. But what about the identification...
Thu Oct 15, 2020 18:28
Leptomeningeal carcinomatosis accounts for only 4% of cases of multiple cranial neuropathies. Here, we report the case of a patient who presented with multiple synchronous cranial neuropathies. After treatment for neuroborreliosis and broad infectious workup, endobronchial ultrasound-guided mediastinal lymph node biopsy confirmed a diagnosis of metastatic BRAF-mutated lung adenocarcinoma with leptomeningeal involvement. To our knowledge, this is the first reported case of metastatic BRAF-driven lung...
Thu Oct 15, 2020 18:26
Abstract Polydactyly is a limb malformation and can occur as nonsyndromic polydactyly, syndromic polydactyly, or along with other limb defects. A few genes have been identified that cause various forms of syndromic and nonsyndromic polydactyly, of which GLI3 has been extensively explored. In the present study, GLI3 gene was screened by direct resequencing in 15 polydactyly cases with or without other anomalies. GLI3 screening revealed two novel pathogenic variants, NM_000168.6:c.3414delC [p.(H1138Qfs*68)]...
Thu Oct 15, 2020 21:37
Abstract Congenital glycosylation disorders (CDG) are inherited metabolic diseases due to defective glycoprotein and glycolipid glycan assembly and attachment. MOGS‐CDG is a rare disorder with seven patients from five families reported worldwide. We report on a 19‐year‐old girl with MOGS‐CDG. At birth she presented facial dysmorphism, marked hypotonia, and drug‐resistant tonic seizures. In the following months, her motility was strongly limited by dystonia, with forced posture of the head and of...
Thu Oct 15, 2020 21:37
Abstract Rosai‐Dorfman Disease (RDD), or sinus histiocytosis with massive lymphadenopathy, is a rare entity characterized by proliferating S100‐positive histiocytes. It is most commonly found in lymph nodes with extranodal involvement usually occurring in the head and neck. Pancreatic involvement is extremely rare. The pathology department archives were searched for fine needle aspirations and pancreatic resections showing evidence of RDD. Clinicopathologic features, cytologic smears, cell blocks,...
Thu Oct 15, 2020 19:36
Abstract Risk assessment is critical to determine the timing of elective surgeries and preserve valuable resources in time of pandemic. This study was undertaken to better understand the potential value of molecular testing to risk‐stratify thyroid nodules with malignant cytology (Bethesda VI). Systematic review of the literature contributed 21 studies representing 2036 preoperative specimens. The BRAF p.V600E substitution was detected in 46% to 90% of cases with a pooled positivity rate of 70%...
Wed Oct 14, 2020 19:11
The aim of this study was to assess the protective effect of experimental solutions containing chitosan at different viscosities with or without fluoride (TiF4/NaF) on dentin loss in vitro. Bovine dentin samples (n = 15) were prepared and allocated to one of the following treatments: (i) 0.5% chitosan (500 mPas); (ii) 0.5% chitosan (2,000 mPas); (iii) 0.042% NaF and 0.049% TiF4; (iv) as (iii) with addition of 0.5% chitosan (500 mPas); (v) as (iii) with addition of 0.5% chitosan (2,000 mPas); (vi)...
Thu Oct 15, 2020 14:24
Higher yttria content enhances the translucency and appearance of dental zirconia materials. Alterations in material composition also affect mechanical properties. The aim of this study was to compare the fracture load after artificial short‐term aging of monolithic, full‐contour zirconia crowns with different amounts of yttria‐stabilization. Sixty crowns (thirty super high translucent crowns (5Y‐Z) and thirty high translucent crowns (3Y‐Z)) were produced to fit a model of a premolar with a shallow...
Thu Oct 15, 2020 11:23
AbstractIn recent years, alloplastic temporomandibular joint (TMJ) replacement has become a permissible procedure for the reconstruction of severely destroyed TMJs. The use of computer-aided design/computer-aided manufacturing (CAD/CAM) has extended the range of applications to complex anatomical situations. The aim of the treatment is to improve the usually restricted mouth opening and thus oral hygiene and nutrition, which leads to a regular improvement in the general quality of life. The following...
Thu Oct 15, 2020 03:00
AbstractShiitake mushroom is a common ingredient in East Asian cuisines. Food processing/preparation can cause the mushroom to be soft and slimy, leading to accidental swallowing. Due to its high insoluble fibre content, it remains the same size and shape in the intestinal tract. We present two cases of small bowel obstruction caused by shiitake mushroom requiring surgical intervention. Preoperative imaging showed dilated small bowel with a suspicious mass in the ileum. However, the exact cause was...
Wed Oct 14, 2020 03:00
Abstract Graduate medical education (GME) training commonly requires residents and fellows to engage in night float shift work. This review aims to assess the effectiveness of interventions for trainees when preparing for, completing, and recovering from working night float shifts. We reviewed all available studies published prior to September 2019 using PubMed, Scopus, CINAHL, the Cochrane library, PsycINFO, and Google Scholar databases. We included all original, primary research articles assessing...
Thu Oct 15, 2020 15:23
New Findings What is the central question of this study? How does resistance exercise affect peripheral haemodynamics in the active and inactive limb? What is the main finding and its importance? Preliminary data indicate that resistance exercise increases flow and shear rate in the active limb transiently. The same exercise has minimal, short‐lasting influence on peripheral haemodynamics in the inactive limb, but further research is required to elaborate on resistance‐exercise...
Thu Oct 15, 2020 11:13
New Findings The aim of the present study was to assess the effects of sleep restriction on self report and autonomic responses to neutral and sad film clips. Ratings of sadness and heart rate deceleration were greater while watching the sad clip, with no effect of sleep restriction; whereas heart rate variability and skin conductance were impacted by sleep restriction and to a lesser extent by film clips. Results suggest that autonomic function was adaptively altered by sleep restriction, so as...
Wed Oct 14, 2020 16:17
New Findings What is the central question of this study? What mechanisms account for the hypotension observed during chronic elevations in circulating 5‐hydroxytryptamine in rats? What is the main finding and its importance? Chronic 5‐hydroxytryptamine induced hypotension requires continued activation of the 5‐HT7 receptor subtype but does not require NO, an outcome that resolves previous conflicting results. Therapeutic interruption of the hypotensive actions of 5‐HT under pathophysiological...
Wed Oct 14, 2020 16:17
British Journal of Cancer, Published online: 15 October 2020; doi:10.1038/s41416-020-01115-wCorrection: Eribulin rapidly inhibits TGF-β-induced Snail expression and can induce Slug expression in a Smad4-dependent manner
Thu Oct 15, 2020 03:00
Publication date: Available online 14 October 2020Source: Practical Radiation OncologyAuthor(s): Soumyajit Roy, Scott Grimes, Scott C. Morgan, Daniel E. Spratt, Libni Eapen, Robert M. Mac Rae, Julia Malone, Julia Craig, Shawn Malone
Thu Oct 15, 2020 19:50
Publication date: Available online 14 October 2020Source: Practical Radiation OncologyAuthor(s): Annemrie Shepherd, Michelle Iocolano, Jonathan Leeman, Brandon S. Imber, Aaron T. Wild, Michael Offin, Jamie E. Chaft, James Huang, Andreas Rimner, Abraham J. Wu, Daphna Y. Gelblum, Narek Shaverdian, Charles B. Simone, Daniel R. Gomez, Ellen D. Yorke, Andrew Jackson
Thu Oct 15, 2020 19:50
Publication date: Available online 14 October 2020Source: Practical Radiation OncologyAuthor(s): Kei Ito, Yujiro Nakajima, Tsuyoshi Onoe, Hiroaki Ogawa, Hideyuki Harada, Makoto Saito, Katsuyuki Karasawa
Thu Oct 15, 2020 19:50
ObjectiveTo explore the level and influencing factors of frontline nurses’ post-traumatic growth (PTG) during COVID-19 epidemic.MethodsA cross-sectional survey was conducted in February 2020 in three hospitals in China. The Post-traumatic Growth Inventory (PTGI) was used to investigate the PTG of frontline nurses. Data on related factors, including demographic characteristics and subjective variables, were collected. The Event-Related Rumination Inventory was used to assess rumination. Pearson’s...
Thu Oct 15, 2020 19:00
Abstract Purpose Time-of-flight (TOF)-MR angiography (MRA) is an important imaging sequence for the surveillance and analysis of cerebral arteriovenous shunt (AVS), including arteriovenous malformation (AVM) and arteriovenous fistula (AVF). However, this technique has the disadvantage of a relatively long scan time. The aim of this study was to compare diagnostic accuracy between compressed sensing (CS)-TOF and conventional parallel...
Thu Oct 15, 2020 03:00
The continuing spread of SARS-CoV-2 remains a Public Health Emergency of International Concern. What physicians need to know about transmission, diagnosis, and treatment of Covid-19 is the subject of ongoing updates from infectious disease experts at the Journal. In this audio interview conducted…
Thu Oct 15, 2020 03:00
Presentation of Case. Dr. Kevin L. Ard: A 63-year-old man was evaluated at this hospital in the spring because of fever, confusion, headache, garbled speech, fatigue, vision changes, lymphocytic pleocytosis, and an elevated protein level in the cerebrospinal fluid (CSF). Approximately 5 years…
Thu Oct 15, 2020 03:00
The large majority of patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have mild or no symptoms, whereas a small proportion of patients have respiratory compromise, acute respiratory distress syndrome, and multiorgan failure (which is often fatal). The…
Thu Oct 15, 2020 03:00
Publication date: November 2020Source: Journal of Phonetics, Volume 83Author(s): Andreas Weise, Vered Silber-Varod, Anat Lerner, Julia Hirschberg, Rivka Levitan
Thu Oct 15, 2020 19:20
Abstract Objectives Given that 30‐50% of children with trisomy 21 have persistent obstructive sleep apnea (OSA) after adenotonsillectomy, we evaluated whether demographic, clinical and polysomnographic factors predicted persistent OSA and OSA severity after adenotonsillectomy. Design Retrospective study. Setting Secondary care hospital. Participants Retrospective review of 32 children with the diagnosis of trisomy 21 and OSA by polysomnography who underwent adenotonsillectomy,...
Thu Oct 15, 2020 15:00
This quality improvement study examines which techniques used in mastoidectomy can serve as indicators of surgeon level and whether these determinations of technique can be made based solely on the movement of the drill head or suction.
Thu Oct 01, 2020 03:00
This case report describes a transgender man in his 20s who presented with 9 months of right-sided rhinorrhea and spontaneous drainage of clear, salty nasal discharge consistent with idiopathic intracranial hypertension.
Thu Oct 01, 2020 03:00
The timely article by Mallen et al in this issue of JAMA Otolaryngology–Head & Neck Surgery is a practical application of telehealth to improve access to otolaryngology care. The goal of the study was to assess the reliability of telehealth in the diagnosis and triage of patients with suspected peritonsillar abscess (PTA). The authors tested the accuracy of PTA diagnosis by providing off-site otolaryngologists with a primary symptom and an oropharyngeal examination obtained using smartphone video...
Thu Oct 01, 2020 03:00
This Viewpoint examines the timing of performing tracheostomies, which are aerosol-generating procedures that may cause increased risk of COVID-19 transmission to health care workers.
Thu Oct 01, 2020 03:00
This essay describes the author’s experience of having COVID-19.
Thu Oct 01, 2020 03:00
This essay highlights the lessons to be learned from the COVID-19 pandemic on the importance of recognizing communication difficulties among those with hearing impairment.
Thu Oct 01, 2020 03:00
This case report describes a young girl who presented with a history of chronic, unilateral middle ear effusion that was treated with a pressure equalization tube.
Thu Oct 01, 2020 03:00
This secondary analysis compares the use of objective physiological measures with subjective caregiver symptom reports to identify the association between sleep disruption with or without intermittent hypoxemia and behavior in children who underwent surgical treatment for obstructive sleep apnea.
Thu Oct 01, 2020 03:00
This cadaver study examines the prevalence of severe acute respiratory syndrome coronavirus 2 colonization of the middle ear and mastoid in a sample of 3 patients.
Thu Oct 01, 2020 03:00
In Reply We thank Cazzador et al for their appreciation of the Viewpoint “Surgical Considerations for Tracheostomy During the COVID-19 Pandemic: Lessons Learned From the Severe Acute Respiratory Syndrome Outbreak.” Since the publication, several other groups have also developed guidelines for tracheostomy in the context of coronavirus disease 2019 (COVID-19), with similar goals of minimizing perioperative aerosolization risks.
Thu Oct 01, 2020 03:00
In Reply In his Letter to the Editor written in response to my article on over-the-counter (OTC) sinonasal medications, Weinberger succinctly addresses the problem of self-directed symptom relief by asking, what is a sinonasal medication? Consciously or unconsciously, the answer to this question drives countless individuals to local pharmacies in a quest for relief of what are perceived as sinus problems. Whether one actually has sinusitis, allergic rhinitis, or another upper respiratory infection...
Thu Oct 01, 2020 03:00
This case report describes a man in his 20s who presented with a 4-week history of progressive swelling of the midline forehead, recurrent headache, and sinus pain, and was subsequently diagnosed with Langerhans cell histiocytosis.
Thu Oct 01, 2020 03:00
In Reply We thank de Ru and Bayoumy for their comments regarding our article. We agree that a large proportion of patients with Bell palsy who have mild paralysis recover spontaneously, and that the combination of steroid and antiviral agents is more effective than steroids alone, particularly in patients with severe Bell palsy. Therefore, we appreciate the intention of de Ru and Bayoumy in their response to our article, as they have studied the outcomes of patients with Bell palsy treated with different...
Thu Oct 01, 2020 03:00
To the Editor Tay et al should be complimented on their Viewpoint “Surgical Considerations for Tracheostomy During the COVID-19 Pandemic: Lessons Learned From the Severe Acute Respiratory Syndrome Outbreak” highlighting preoperative and perioperative recommendations for tracheostomy during the coronavirus disease 2019 (COVID-19) pandemic. The authors searched the literature for tracheostomies performed during the previous outbreak of severe acute respiratory syndrome (SARS), finding 3 case series...
Thu Oct 01, 2020 03:00
A 73-year-old woman with chronic cervical neck pain presents with complaints of globus sensation, dysphagia, and localized throat swelling. She has a 1.5-cm cystlike mass on her left lateral pharyngeal wall. What is your diagnosis?
Thu Oct 01, 2020 03:00
In the Research Letter titled, “SARS-CoV-2 Virus Isolated From the Mastoid and Middle Ear: Implications for COVID-19 Precautions During Ear Surgery,” published on July 23, 2020, funding from the National Institutes of Health was omitted. The funding and role of the funder has been added.
Thu Oct 01, 2020 03:00
This cohort study examines the association of the lymph node ratio with overall survival in patients with papillary thyroid cancer.
Thu Oct 01, 2020 03:00
This Viewpoint encourages clinicians to listen to patient concerns regarding the varying treatment options available for single-sided deafness.
Thu Oct 01, 2020 03:00
Mission Statement: JAMA Otolaryngology–Head & Neck Surgery provides timely information for physicians and scientists concerned with diseases of the head and neck. Given the diversity of structure and function based in this anatomic region, JAMA Otolaryngology–Head & Neck Surgery publishes clinical, translational, and population health research from an array of disciplines. We place a high priority on strong study designs that accurately identify etiologies, evaluate diagnostic strategies,...
Thu Oct 01, 2020 03:00
This systematic review and consensus study uses a modified Delphi consensus process, informed by a systematic review of the literature and 30 international specialists, to develop 20 evidence-based consensus statements regarding the use of unilateral cochlear implants in adults with severe, profound, or moderate sloping to profound bilateral sensorineural hearing loss.
Thu Oct 01, 2020 03:00
This comparative effectiveness research study explores the potential of otolaryngology telemedical consultation in triaging and diagnosing patients with suspected peritonsillar abscess.
Thu Oct 01, 2020 03:00
This multicenter nonrandomized clinical trial examines the effectiveness of cochlear implants, as measured by improvement on the AzBio Sentence Test, for newly implanted Medicare beneficiaries who meet the expanded indications of an AzBio Sentence Test score of 41% to 60% in their best-aided condition.
Thu Oct 01, 2020 03:00
To the Editor In his Original Investigation, McCoul expresses concern regarding confusion caused by the panoply of over-the-counter (OTC) sinonasal medications. But a more relevant question might be, what is a sinonasal medication?
Thu Oct 01, 2020 03:00
This secondary analysis of a nonrandomized clinical trial explores the audiometric and holistic effects of cochlear implantation in a group of adults 65 years or older compared with an optimized bilateral hearing aid condition.
Thu Oct 01, 2020 03:00
A 62-year-old man presents with metastatic p16-positive squamous cell carcinoma and a primary cancer in the right tonsil. What is your diagnosis?
Thu Oct 01, 2020 03:00
This nonrandomized controlled trial investigates the safety and effectiveness of a single-ear cochlear implant in a group of optimized adult hearing aid users with and without mild cognitive impairment across a variety of outcome domains.
Thu Oct 01, 2020 03:00
This case report describes clinicopathologic and ultrastructural postmortem findings observed in the olfactory system of 2 patients with SARS-CoV-2.
Thu Oct 01, 2020 03:00
In Reply We thank Thong et al for their letter. We chose our method because it allows easy setup and takedown for continued microscope use after drilling is complete. We have taken to using the Sterile-Z Back Table Drape because it has a perforation down the middle to allow for easy break-away when it is no longer needed. As stated in our original Research Letter, we expect better modifications to come about, and otolaryngologists will always be a creative group.
Thu Oct 01, 2020 03:00
To the Editor We compliment Yoo et al on their impressive cohort study reviewing data on 1364 patients with Bell palsy. However, we need more data to be able to concur with some of their conclusions. Their discussion correctly expresses our view that combination therapy should be used, especially in cases of severe palsy. Unfortunately, the data are not presented in a way that differentiates the severity of the palsy. The most important concern regarding their study is whether the prescription of...
Thu Oct 01, 2020 03:00
This case report describes a woman in her 30s who presented with worsening left-sided facial weakness and was diagnosed with a perineurioma.
Thu Oct 01, 2020 03:00
This Patient Page describes the risks and benefits of immunotherapy for the treatment of common allergies.
Thu Oct 01, 2020 03:00
A Cost-effective Solution to Limit Aerosol Transmission of Infectious Agents During Mastoid Drilling
To the Editor We were interested by the recent article by Carron, et al “A Simple Technique for Droplet Control During Mastoid Surgery” because we have also been considering the challenges of performing mastoidectomy in the coronavirus disease 2019 era. Mastoidectomy is an aerosol-generating procedure (AGP) owing to the use of drills and presence of potentially virus-containing respiratory mucosa lining the mastoid air cells. The recommended personal protective equipment for AGPs is a FFP3 mask and...
Thu Oct 01, 2020 03:00
This case report describes a man in his 20s who presented with persistent, severe, right-sided, throbbing throat pain and dysphagia and was found to have bony mass in the parapharyngeal space following a tonsillectomy.
Thu Oct 01, 2020 03:00
A Cost-effective Solution to Limit Aerosol Transmission of Infectious Agents During Mastoid Drilling
To the Editor We read with interest the research letter published online on April 28, 2020, titled “A Simple Technique for Droplet Control During Mastoid Surgery.” Mastoid bone drilling is an aerosol-generating procedure with the potential to transmit infectious agents from the upper aerodigestive tract via the eustachian tube and middle ear. Although there are no coronavirus disease 2019–specific data, other studies have found common viruses in the middle ear and nasopharynx. To continue safely...
Thu Oct 01, 2020 03:00
A young woman presents with saddle nose deformity, an unremarkable medical history, and elevated complement C and total hemolytic complement levels. What is your diagnosis?
Thu Oct 01, 2020 03:00
Hearing loss is the most common sensory disorder in humans. According to recent estimates by the World Health Organization, disabling hearing loss (>40 dB in the better-hearing ear in adults and >30 dB in the better-hearing ear in children) affects 466 million people worldwide, including 34 million children, and is expected to double to 900 million people by 2050. Left untreated, hearing loss is associated with health issues, deterioration in quality of life, and financial costs; the latter...
Thu Oct 01, 2020 03:00
Otolaryngologists (especially otologists and/or neurotologists) around the globe have been waiting 6 months for this study. Given the anatomic connection from the nasopharynx, site of initial infection and virus isolation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to the tympanic cavity through the eustachian tube, could the virus responsible for the coronavirus disease 2019 (COVID-19) and the current global pandemic gain access to the middle ear space and mastoid cavity, and...
Thu Oct 01, 2020 03:00
Dexmedetomidine (DEX), an α2-adrenergic agonist, has been widely used for anesthesia, pain control, and intensive care unit sedation. Besides sleep-like sedation, DEX has many other beneficial effects, such as anti-inflammation, antioxidation, and anticell death. Subarachnoid hemorrhage (SAH), a severe and potentially fatal form of stroke, is a complex disease that is divided into 2 phases: early brain injury and delayed cerebral ischemia. In each phase, several pathologic changes are involved, including...
Tue Oct 13, 2020 03:00
Background: The electroencephalogram (EEG) may be useful for monitoring anesthetic depth and avoiding overdose. We aimed to characterize EEG-recorded brain oscillations during increasing depth of anesthesia in a real-life surgical scenario. We hypothesized that alpha power and coherency will diminish as propofol dose increases between loss of consciousness (LOC) and an EEG burst suppression (BS) pattern. Methods: This nonrandomized dose-response clinical trial with concurrent control...
Tue Oct 13, 2020 03:00
Emergency Airway Management During Awake Craniotomy: Comparison of 5 Techniques in a Cadaveric Model
Background: During awake craniotomy, securing the patient’s airway might be necessary electively or emergently. The objective of this study was to compare the feasibility of airway management using a laryngeal mask airway (LMA) and 4 alternative airway management techniques in an awake craniotomy simulation. Methods: After completing a questionnaire, 9 anesthesia providers attempted airway management in a cadaver positioned to simulate awake craniotomy conditions. Following the simulation,...
Tue Oct 13, 2020 03:00
Publication date: Available online 15 October 2020Source: The Journal of Prosthetic DentistryAuthor(s): Menon Prasad Rajagopal, Pradeep Samuel, Subin Eranhikkal, Rahul Nageshraj
Thu Oct 15, 2020 19:01
Publication date: Available online 15 October 2020Source: The Journal of Prosthetic DentistryAuthor(s): Daniel Costa Ferreira de Almeida, Monica Diuana Calasans-Maia, Diego Zimmermann, Vittorio Moraschini
Thu Oct 15, 2020 19:01
Publication date: Available online 14 October 2020Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Alexei Gonzalez-Estrada, Ismael Carrillo-Martin, J. Ross Renew, Matthew A. Rank, Ronna L. Campbell, Gerald W. Volcheck
Thu Oct 15, 2020 18:47
Abstract BackgroundMicrosurgery is generally performed in narrow spaces with limited movement. Endoscopes that allow for angle changes have been developed using elastic materials, but they require a large bending space. We propose a new endoscope with a small sweep volume for angle changes.MethodsWe fabricated a prototype with a thumb‐operated joystick. The image sensor is attached to the tooltip. The image signal is input to a motor control board which computes inverse kinematics and transforms...
Wed Oct 14, 2020 22:29
Obesity is associated with life-threatening diseases and premature death and reduces life expectancy by 5 to 20 years. Bariatric surgery leads to durable weight loss and reduces the risk of cardiovascular disease, type 2 diabetes, and cancer. In 2007, we reported that bariatric surgery reduced…
Thu Oct 15, 2020 03:00
Abstract Background While anti‐TNF therapies are effective against psoriasis, 30‐50% of patients do not show an adequate response to these drugs. Different candidate‐gene pharmacogenetics studies have identified single nucleotide polymorphisms that may predict anti‐TNF drugs response in psoriasis. Nevertheless, only one paper has undertaken a pharmacogenomic approach failing to find significant biomarkers of biological drug response along the whole genome. Furthermore, most of the pharmacogenetic...
Thu Oct 15, 2020 17:30
Abstract The 14 authors of the first review article on hidradenitis suppurativa (HS) pathogenesis published 2008 in EXPERIMENTAL DERMATOLOGY cumulating from the 1st International Hidradenitis Suppurativa Research Symposium held March 30–April 2, 2006 in Dessau, Germany with 33 participants were prophetic when they wrote “Hopefully, this heralds a welcome new tradition: to get to the molecular heart of HS pathogenesis, which can only be achieved by a renaissance of solid basic HS research, as the...
Wed Oct 14, 2020 14:59
Abstract Drug resistance represents an obstacle in colorectal cancer treatment because of its association with poor prognoses. rBC2LCN is a lectin isolated from Burkholderia that binds cell surface glycans that have fucose moieties. Since fucosylation is often enhanced in many types of cancers, this lectin could be an efficient drug carrier if colorectal cancer cells specifically present such glycans. Therefore, we examined the therapeutic efficacy and toxicity of lectin drug conjugate therapy in...
Thu Oct 15, 2020 15:13
Abstract Peritoneal dissemination and malignant ascites in pancreatic ductal adenocarcinoma (PDAC) patients represent a major clinical issue. Lysophosphatidic acid (LPA) is a lipid mediator that modulates various cancer progression. Based on the increasing evidence showing that LPA is abundant in malignant ascites, we focused on Autotaxin (ATX), which is a secreted enzyme that is important for the production of LPA. This study aimed to elucidate the importance of the ATX‐LPA axis in malignant ascites...
Wed Oct 14, 2020 19:39
Abstract Glioblastoma (GBM) recurrence is attributed to the presence of therapy‐resistant glioblastoma stem cells (GSCs). Steroid receptor coactivator‐1 (SRC‐1) acts as an oncogenic regulator in many human tumors. The relationship between SRC‐1 and GBM has not yet been studied. Herein, we would like to investigate the role of SRC‐1 in GBM. In this study, we demonstrated that SRC‐1 expression is positively correlated with grades of glioma and inversely correlated with glioma patient’s prognosis....
Wed Oct 14, 2020 17:29
Abstract Purpose The purpose of this retrospective, cross‐sectional study is to evaluate if there is a difference in number of visits (including fabrication and post‐operative) and remake rate when comparing conventionally fabricated and digitally fabricated complete dentures by dental students in a pre‐doctoral student dental clinic. Materials and Methods This two‐year retrospective cross‐sectional study consisted of a chart review for patients receiving maxillary and/or mandibular complete...
Thu Oct 15, 2020 14:19
Obesity is associated with life-threatening diseases and premature death and reduces life expectancy by 5 to 20 years. Bariatric surgery leads to durable weight loss and reduces the risk of cardiovascular disease, type 2 diabetes, and cancer. In 2007, we reported that bariatric surgery reduced…
Thu Oct 15, 2020 03:00
Publication date: Available online 15 October 2020Source: Annals of Anatomy - Anatomischer AnzeigerAuthor(s): Nicol Zielinska, R. Shane Tubbs, Michal Podgórski, Piotr Karauda, Michal Polguj, Lukasz Olewnik
Thu Oct 15, 2020 18:20
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Vasculitis is an inflammatory process involving blood vessels of various sizes, including the small vessels in the kidneys to the large vessels, such as the aorta. This inflammatory condition is usually autoimmune in nature and is associated with involvement of many locations, such as the sinuses, lungs, kidneys, and even the heart. Specifically, eosinophilic granulomatosis with polyangiitis (EGPA)...
Thu Oct 15, 2020 14:50
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Severe acute respiratory syndrome coronavirus-2 infection (SARS-CoV-2), commonly known as COVID-19 (coronavirus disease-2019), began in the Wuhan District of Hubei Province, China. It is regarded as one of the worst pandemics, which has consumed both human lives and the world economy. COVID-19 infection mainly affects the lungs triggering severe hypoxemic respiratory failure, also providing a nidus...
Thu Oct 15, 2020 14:50
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Pancreatic pseudocyst is a common complication of pancreatitis. Pseudocysts may require decompression when they become painful, infected, or start compressing surrounding organs. Decompression is achieved by endoscopic cystogastrostomy. Recently, the use of lumen-apposing metal stent (LAMS) for cystogastrostomy has gained popularity due to ease of use and high technical success. LAMS has a wider lumen,...
Thu Oct 15, 2020 14:50
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. BackgroundToxoplasmosis gondii is ubiquitously present on earth and infection, including congenital infection, is common. Neurological, developmental, and ocular effects can be devastating in the congenital toxoplasmosis population. At present, there is no standard, nation-wide neonatal screening for this disease in the United States.Case PresentationA 17-month-old Caucasian female presented to our...
Thu Oct 15, 2020 14:50
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. A 74-year-old male with a recent bioprosthetic mitral valve placement presented with dyspnea, chills, and palpitations. Blood cultures on admission grew extended spectrum β-lactamase Escherichia coli. Transthoracic echocardiogram and transesophageal echocardiography were negative for valvular vegetations, but given the recent history of mitral valve replacement and difficulty visualizing valvular...
Wed Oct 14, 2020 15:54
Wed Oct 14, 2020 19:10
Abstract Background Although various factors were reported to be related to post‐herpetic neuralgia (PHN), studies based on adequate and comprehensive data were absent. Methods Data was extracted from cases of hospitalized patients with herpes zoster in dermatology department, Sichuan hospital of traditional Chinese medicine range from December, 2011 to February, 2018, and then cleaned to build prediction model with TREENET algorithms. Following evaluated the prediction model by ROC and...
Wed Oct 14, 2020 19:00
Publication date: January–February 2021Source: American Journal of Otolaryngology, Volume 42, Issue 1Author(s): Ravjit Singh, William Karantanis, Matthew Fadhil, Cassie Dow, Jordan Fuzi, Rachelle Robinson, Ian Jacobson
Thu Oct 15, 2020 18:06
Journal of International Medical Research, Volume 48, Issue 10, October 2020. We herein present a case involving a 23-year-old woman with gross hematuria. Cystoscopy revealed abnormal areas of the mucosa along the anterior and posterior bladder walls. These abnormalities were suspicious for neoplasia; however, a diagnosis was not established by subsequent biopsy. The patient underwent transurethral resection biopsy in which an isolated lesion along the anterior wall was completely resected and the...
Thu Oct 15, 2020 08:51
Journal of International Medical Research, Volume 48, Issue 10, October 2020. ObjectiveTo identify male infertility-related long non-coding (lnc)RNAs and an lncRNA-related competing endogenous (ce)RNA network.MethodsExpression data including 13 normospermic and eight teratozoospermic samples from postmortem donors were downloaded from the GEO database (GSE6872). The limma R package was used to discriminate dysregulated lncRNA and micro (m)RNA profiles. Gene ontology (GO) and Kyoto Encyclopedia of...
Thu Oct 15, 2020 08:44
Presentation of Case. Dr. Kevin L. Ard: A 63-year-old man was evaluated at this hospital in the spring because of fever, confusion, headache, garbled speech, fatigue, vision changes, lymphocytic pleocytosis, and an elevated protein level in the cerebrospinal fluid (CSF). Approximately 5 years…
Thu Oct 15, 2020 03:00
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