IJMS, Vol. 21, Pages 7642: Antineoplastic Activity of Chrysin against Human Hepatocellular Carcinoma: New Insight on GPC3/SULF2 Axis and lncRNA-AF085935 Expression International Journal of Molecular Sciences doi: 10.3390/ijms21207642 Authors: Iman O. Sherif Laila A. Al-Mutabagani Dina Sabry Nehal M. Elsherbiny The natural flavonoid chrysin possesses antiproliferative activity against various types of cancers, including hepatocellular carcinoma (HCC), which is a common malignancy....
IJMS, Vol. 21, Pages 7641: PGRMC1 Inhibits Progesterone-Evoked Proliferation and Ca2+ Entry Via STIM2 in MDA-MB-231 Cells International Journal of Molecular Sciences doi: 10.3390/ijms21207641 Authors: Carlos Cantonero Ginés M. Salido Juan A. Rosado Pedro C. Redondo Progesterone receptor membrane component 1 (PGRMC1) has been shown to regulate some cancer hallmarks. Progesterone (P4) evokes intracellular calcium (Ca2+) changes in the triple-negative breast cancer cell lines (MDA-MB-231,...
IJMS, Vol. 21, Pages 7644: Uncharacterized RNAs in Plasma of Alzheimer’s Patients are Associated with Cognitive Impairment and Show a Potential Diagnostic Power International Journal of Molecular Sciences doi: 10.3390/ijms21207644 Authors: Cristina Barbagallo Maria Teresa Di Martino Margherita Grasso Maria Grazia Salluzzo Francesca Scionti Filomena Irene Ilaria Cosentino Giuseppe Caruso Davide Barbagallo Cinzia Di Di Pietro Raffaele Ferri Filippo Caraci Michele...
IJMS, Vol. 21, Pages 7632: Downhill, Ultrafast and Fast Folding Proteins Revised International Journal of Molecular Sciences doi: 10.3390/ijms21207632 Authors: Mateusz Banach Katarzyna Stapor Leszek Konieczny Piotr Fabian Irena Roterman Research on the protein folding problem differentiates the protein folding process with respect to the duration of this process. The current structure encoded in sequence dogma seems to be clearly justified, especially in the case of proteins...
IJMS, Vol. 21, Pages 7639: Synthetic Biology on Acetogenic Bacteria for Highly Efficient Conversion of C1 Gases to Biochemicals International Journal of Molecular Sciences doi: 10.3390/ijms21207639 Authors: Sangrak Jin Jiyun Bae Yoseb Song Nicole Pearcy Jongoh Shin Seulgi Kang Nigel P. Minton Philippe Soucaille Byung-Kwan Cho Synthesis gas, which is mainly produced from fossil fuels or biomass gasification, consists of C1 gases such as carbon monoxide, carbon...
IJMS, Vol. 21, Pages 7640: Impact of A Cargo-Less Liposomal Formulation on Dietary Obesity-Related Metabolic Disorders in Mice International Journal of Molecular Sciences doi: 10.3390/ijms21207640 Authors: Varsha Komalla Behjat Sheikholeslami Gerard Li Bishwajit Bokshi Yik Lung Chan Alison Ung Brian Gregory Oliver Hui Chen Mehra Haghi Current therapeutic options for obesity often require pharmacological intervention with dietary restrictions. Obesity is associated...
IJMS, Vol. 21, Pages 7638: Receptor-Like Protein Kinases Function Upstream of MAPKs in Regulating Plant Development International Journal of Molecular Sciences doi: 10.3390/ijms21207638 Authors: Zhe Wang Xiaoping Gou Mitogen-activated protein kinases (MAPKs) are a group of protein kinase broadly involved in various signal pathways in eukaryotes. In plants, MAPK cascades regulate growth, development, stress responses and immunity by perceiving signals from the upstream regulators and...
IJMS, Vol. 21, Pages 7637: Phosphoproteomics Meets Chemical Genetics: Approaches for Global Mapping and Deciphering the Phosphoproteome International Journal of Molecular Sciences doi: 10.3390/ijms21207637 Authors: Jan Jurcik Barbara Sivakova Ingrid Cipakova Tomas Selicky Erika Stupenova Matus Jurcik Michaela Osadska Peter Barath Lubos Cipak Protein kinases are important enzymes involved in the regulation of various cellular processes. To function properly, each...
IJMS, Vol. 21, Pages 7635: Dissecting Total Plasma and Protein-Specific Glycosylation Profiles in Congenital Disorders of Glycosylation International Journal of Molecular Sciences doi: 10.3390/ijms21207635 Authors: Agnes L. Hipgrave Ederveen Noortje de Haan Melissa Baerenfaenger Dirk J. Lefeber Manfred Wuhrer Protein N-glycosylation is a multifactorial process involved in many biological processes. A broad range of congenital disorders of glycosylation (CDGs) have been described...
IJMS, Vol. 21, Pages 7633: The Non-Coding RNA GAS5 and Its Role in Tumor Therapy-Induced Resistance International Journal of Molecular Sciences doi: 10.3390/ijms21207633 Authors: George I. Lambrou Kyriaki Hatziagapiou Apostolos Zaravinos The growth arrest-specific transcript 5 (GAS5) is a >200-nt lncRNA molecule that regulates several cellular functions, including proliferation, apoptosis, invasion and metastasis, across different types of human cancers. Here, we reviewed...
IJMS, Vol. 21, Pages 7636: Extracellular Nucleotides Regulate Arterial Calcification by Activating Both Independent and Dependent Purinergic Receptor Signaling Pathways International Journal of Molecular Sciences doi: 10.3390/ijms21207636 Authors: Britt Opdebeeck Isabel R. Orriss Ellen Neven Patrick C. D’Haese Anja Verhulst Arterial calcification, the deposition of calcium-phosphate crystals in the extracellular matrix, resembles physiological bone mineralization. It is well-known...
IJMS, Vol. 21, Pages 7631: A Novel CCT5 Missense Variant Associated with Early Onset Motor Neuropathy International Journal of Molecular Sciences doi: 10.3390/ijms21207631 Authors: Vincenzo Antona Federica Scalia Elisa Giorgio Francesca C. Radio Alfredo Brusco Massimiliano Oliveri Giovanni Corsello Fabrizio Lo Celso Maria Vadalà Everly Conway de Macario Alberto J. L. Macario Francesco Cappello Mario Giuffrè Diseases associated with acquired or genetic...
IJMS, Vol. 21, Pages 7634: Percolation Conduction of Carbon Nanocomposites International Journal of Molecular Sciences doi: 10.3390/ijms21207634 Authors: Grigorii S. Bocharov Alexander V. Eletskii Carbon nanocomposites present a new class of nanomaterials in which conducting carbon nanoparticles are a small additive to a non-conducting matrix. A typical example of such composites is a polymer matrix doped with carbon nanotubes (CNT). Due to a high aspect ratio of CNTs, inserting rather...
IJMS, Vol. 21, Pages 7629: Relative Centrifugal Force (RCF; G-Force) Affects the Distribution of TGF-β in PRF Membranes Produced Using Horizontal Centrifugation International Journal of Molecular Sciences doi: 10.3390/ijms21207629 Authors: Kargarpour Nasirzade Panahipour Miron Gruber Solid platelet-rich fibrin (PRF) is produced with centrifugation tubes designed to accelerate clotting. Thus, activated platelets may accumulate within the fibrin-rich extracellular matrix...
IJMS, Vol. 21, Pages 7630: Meiotic Nuclear Architecture in Distinct Mole Vole Hybrids with Robertsonian Translocations: Chromosome Chains, Stretched Centromeres, and Distorted Recombination International Journal of Molecular Sciences doi: 10.3390/ijms21207630 Authors: Sergey Matveevsky Artemii Tretiakov Anna Kashintsova Irina Bakloushinskaya Oxana Kolomiets Genome functioning in hybrids faces inconsistency. This mismatch is manifested clearly in meiosis during chromosome...
IJMS, Vol. 21, Pages 7626: Comparison of Methods for Bulk Automated Simulation of Glycosidic Bond Conformations International Journal of Molecular Sciences doi: 10.3390/ijms21207626 Authors: Victor Stroylov Maria Panova Philip Toukach Six empirical force fields were tested for applicability to calculations for automated carbohydrate database filling. They were probed on eleven disaccharide molecules containing representative structural features from widespread classes of carbohydrates....
IJMS, Vol. 21, Pages 7628: The Role of Resolvins: EPA and DHA Derivatives Can Be Useful in the Prevention and Treatment of Ischemic Stroke International Journal of Molecular Sciences doi: 10.3390/ijms21207628 Authors: Nikola Tułowiecka Dariusz Kotlęga Piotr Prowans Małgorzata Szczuko Introduction: Most ischemic strokes develop as a result of atherosclerosis, in which inflammation plays a key role. The synthesis cascade of proinflammatory mediators participates in the process...
IJMS, Vol. 21, Pages 7627: SOX9 Knockout Induces Polyploidy and Changes Sensitivity to Tumor Treatment Strategies in a Chondrosarcoma Cell Line International Journal of Molecular Sciences doi: 10.3390/ijms21207627 Authors: Sabine Stöckl Georg Lindner Shushan Li Philipp Schuster Sebastian Haferkamp Ferdinand Wagner Peter M. Prodinger Gabriele Multhoff Melanie Boxberg Axel Hillmann Richard J. Bauer Susanne Grässel As most chemotherapeutic drugs are ineffective...
IJMS, Vol. 21, Pages 7625: Development of Conformational Antibodies to Detect Bcl-xL’s Amyloid Aggregates in Metal-Induced Apoptotic Neuroblastoma Cells International Journal of Molecular Sciences doi: 10.3390/ijms21207625 Authors: Alexis Gonneaud Fatima-Zohra Fakhir Emeline Landas Enora Le Tallec Elisabeth Chartier-Garcia Christine Almunia Alexandre Chenal Vincent Forge Christel Marquette Bcl-xL, a member of the Bcl-2 family, is a pro-survival protein involved...
IJMS, Vol. 21, Pages 7623: Molecular Mechanisms and Emerging Therapeutics for Osteoporosis International Journal of Molecular Sciences doi: 10.3390/ijms21207623 Authors: Ji-Yoon Noh Young Yang Haiyoung Jung Osteoporosis is the most common chronic metabolic bone disease. It has been estimated that more than 10 million people in the United States and 200 million men and women worldwide have osteoporosis. Given that the aging population is rapidly increasing in many countries, osteoporosis...
IJMS, Vol. 21, Pages 7622: IRF-1 Inhibits Angiogenic Activity of HPV16 E6 Oncoprotein in Cervical Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21207622 Authors: Seung Bae Rho Seung-Hoon Lee Hyun-Jung Byun Boh-Ram Kim Chang Hoon Lee HPV16 E6 oncoprotein is a member of the human papillomavirus (HPV) family that contributes to enhanced cellular proliferation and risk of cervical cancer progression via viral infection. In this study, interferon regulatory...
IJMS, Vol. 21, Pages 7624: Role of Cadherins in Cancer—A Review International Journal of Molecular Sciences doi: 10.3390/ijms21207624 Authors: Ilona Kaszak Olga Witkowska-Piłaszewicz Zuzanna Niewiadomska Bożena Dworecka-Kaszak Felix Ngosa Toka Piotr Jurka Cadherins play an important role in tissue homeostasis, as they are responsible for cell-cell adhesion during embryogenesis, tissue morphogenesis, differentiation and carcinogenesis. Cadherins are inseparably connected...
IJMS, Vol. 21, Pages 7620: Deferred Administration of Afobazole Induces Sigma1R-Dependent Restoration of Striatal Dopamine Content in a Mouse Model of Parkinson’s Disease International Journal of Molecular Sciences doi: 10.3390/ijms21207620 Authors: Ilya A. Kadnikov Ekaterina R. Verbovaya Dmitry N. Voronkov Mikhail V. Voronin Sergei B. Seredenin Previously, we demonstrated that the immediate administration of multitarget anxiolytic afobazole slows down the progression of...
IJMS, Vol. 21, Pages 7621: Exploration of Feasible Immune Biomarkers for Immune Checkpoint Inhibitors in Head and Neck Squamous Cell Carcinoma Treatment in Real World Clinical Practice International Journal of Molecular Sciences doi: 10.3390/ijms21207621 Authors: Hui-Ching Wang Tsung-Jang Yeh Leong-Perng Chan Chin-Mu Hsu Shih-Feng Cho Recurrent locally advanced or metastatic head and neck squamous cell carcinoma (HNSCC) is associated with dismal prognosis because of its highly...
IJMS, Vol. 21, Pages 7619: CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of Receptors CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 Ligands International Journal of Molecular Sciences doi: 10.3390/ijms21207619 Authors: Jan Korbecki Szymon Grochans Izabela Gutowska Katarzyna Barczak Irena Baranowska-Bosiacka CC chemokines (or β-chemokines) are 28 chemotactic cytokines with an N-terminal CC domain that play an important role in immune system...
IJMS, Vol. 21, Pages 7618: Assessing and Overcoming Resistance Phenomena against a Genetically Modified Vaccinia Virus in Selected Cancer Cell Lines International Journal of Molecular Sciences doi: 10.3390/ijms21207618 Authors: Susanne Berchtold Julia Beil Christian Raff Irina Smirnow Martina Schell Janina D’Alvise Silvia Gross Ulrich M. Lauer Genetically modified vaccinia viruses (VACVs) have been shown to possess profound oncolytic capabilities. However, tumor...
IJMS, Vol. 21, Pages 7614: Post-Transcriptional Expression Control in Platelet Biogenesis and Function International Journal of Molecular Sciences doi: 10.3390/ijms21207614 Authors: Carolin T. Neu Tony Gutschner Monika Haemmerle Platelets are highly abundant cell fragments of the peripheral blood that originate from megakaryocytes. Beside their well-known role in wound healing and hemostasis, they are emerging mediators of the immune response and implicated in a variety of pathophysiological...
IJMS, Vol. 21, Pages 7616: Varying Atmospheric CO2 Mediates the Cold-Induced CBF-Dependent Signaling Pathway and Freezing Tolerance in Arabidopsis International Journal of Molecular Sciences doi: 10.3390/ijms21207616 Authors: Jinyoung Y. Barnaby Joonyup Kim Mura Jyostna Devi David H. Fleisher Mark L. Tucker Vangimalla R. Reddy Richard C. Sicher Changes in the stomatal aperture in response to CO2 levels allow plants to manage water usage, optimize CO2 uptake and adjust...
IJMS, Vol. 21, Pages 7617: Calcium-Sensing Receptor in Adipose Tissue: Possible Association with Obesity-Related Elevated Autophagy International Journal of Molecular Sciences doi: 10.3390/ijms21207617 Authors: Pamela Mattar Sofía Sanhueza Gabriela Yuri Lautaro Briones Claudio Perez-Leighton Assaf Rudich Sergio Lavandero Mariana Cifuentes Autophagy is upregulated in adipose tissue (AT) from people with obesity. We showed that activation of the calcium-sensing receptor...
IJMS, Vol. 21, Pages 7615: Circulating MiRNA-195-5p and -451a in Diabetic Patients with Transient and Acute Ischemic Stroke in the Emergency Department International Journal of Molecular Sciences doi: 10.3390/ijms21207615 Authors: Mauro Giordano Maria Consiglia Trotta Tiziana Ciarambino Michele D’Amico Marilena Galdiero Federico Schettini Diego Paternosto Marta Salzillo Roberto Alfano Vincenzo Andreone Lorenzo Salvatore Malatino Gianni Biolo Giuseppe Paolisso...
IJMS, Vol. 21, Pages 7613: Establishment of Acquired Cisplatin Resistance in Ovarian Cancer Cell Lines Characterized by Enriched Metastatic Properties with Increased Twist Expression International Journal of Molecular Sciences doi: 10.3390/ijms21207613 Authors: Entaz Bahar Ji-Ye Kim Hyun-Soo Kim Hyonok Yoon Ovarian cancer (OC) is the most lethal of the gynecologic cancers, and platinum-based treatment is a part of the standard first-line chemotherapy regimen. However,...
IJMS, Vol. 21, Pages 7612: Light Energy Dose and Photosensitizer Concentration Are Determinants of Effective Photo-Killing against Caries-Related Biofilms International Journal of Molecular Sciences doi: 10.3390/ijms21207612 Authors: Abdulrahman A. Balhaddad Mohammed S. AlQranei Maria S. Ibrahim Michael D. Weir Frederico C. Martinho Hockin H. K. Xu Mary Anne S. Melo Caries-related biofilms and associated complications are significant threats in dentistry, especially...
IJMS, Vol. 21, Pages 7611: Alanine Scanning Mutagenesis of the DRYxxI Motif and Intracellular Loop 2 of Human Melanocortin-4 Receptor International Journal of Molecular Sciences doi: 10.3390/ijms21207611 Authors: Li-Kun Yang Ya-Xiong Tao The melanocortin-4 receptor (MC4R) is a member of the G-protein-coupled receptor (GPCR) superfamily, which has been extensively studied in obesity pathogenesis due to its critical role in regulating energy homeostasis. Both the Gs-cAMP and ERK1/2...
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IJNS, Vol. 6, Pages 80: Translating Molecular Technologies into Routine Newborn Screening Practice International Journal of Neonatal Screening doi: 10.3390/ijns6040080 Authors: Sarah M. Furnier Maureen S. Durkin Mei W. Baker As biotechnologies advance and better treatment regimens emerge, there is a trend toward applying more advanced technologies and adding more conditions to the newborn screening (NBS) panel. In the current Recommended Uniform Screening Panel (RUSP), all conditions...
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JCDD, Vol. 7, Pages 45: Effect of Evolocumab on Lipoprotein(a) and PCSK9 in Healthy Individuals with Elevated Lipoprotein(a) Level Journal of Cardiovascular Development and Disease doi: 10.3390/jcdd7040045 Authors: Afanasieva Ezhov Klesareva Razova Chubykina Egiazaryan Sherstyuk Afanasieva Utkina Pokrovsky Background and aims: The aim of this study was to investigate the influence of a single injection of Evolocumab on the dynamics of Lp(a), fractions...
JCDD, Vol. 7, Pages 44: An Appreciation of Anatomy in the Molecular World Journal of Cardiovascular Development and Disease doi: 10.3390/jcdd7040044 Authors: Bjarke Jensen Vincent M. Christoffels Antoon F. M. Moorman Robert H. Anderson is one of the most important and accomplished cardiac anatomists of the last decades, having made major contributions to our understanding of the anatomy of normal hearts and the pathologies of acquired and congenital heart diseases. While cardiac...
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JCM, Vol. 9, Pages 3316: Changes in Gene Expression Associated with Collagen Regeneration and Remodeling of Extracellular Matrix after Percutaneous Electrolysis on Collagenase-Induced Achilles Tendinopathy in an Experimental Animal Model: A Pilot Study Journal of Clinical Medicine doi: 10.3390/jcm9103316 Authors: Sánchez-Sánchez Calderón-Díez Herrero-Turrión Méndez-Sánchez Arias-Buría Fernández-de-las-Peñas Percutaneous electrolysis is an emerging intervention proposed...
JCM, Vol. 9, Pages 3317: Normative Database for All Retinal Layer Thicknesses Using SD-OCT Posterior Pole Algorithm and the Effects of Age, Gender and Axial Lenght Journal of Clinical Medicine doi: 10.3390/jcm9103317 Authors: Palazon-Cabanes Palazon-Cabanes Rubio-Velazquez Lopez-Bernal Garcia-Medina Villegas-Perez Our aim was to provide, for the first time, reference thickness values for the SD-OCT posterior pole algorithm (PPA) available for Spectralis OCT device...
JCM, Vol. 9, Pages 3313: Scope of Artificial Intelligence in Screening and Diagnosis of Colorectal Cancer Journal of Clinical Medicine doi: 10.3390/jcm9103313 Authors: Hemant Goyal Rupinder Mann Zainab Gandhi Abhilash Perisetti Aman Ali Khizar Aman Ali Neil Sharma Shreyas Saligram Benjamin Tharian Sumant Inamdar Globally, colorectal cancer is the third most diagnosed malignancy. It causes significant mortality and morbidity, which can be reduced by early diagnosis...
JCM, Vol. 9, Pages 3315: SARS-CoV-2 Viral Load, IFNλ Polymorphisms and the Course of COVID-19: An Observational Study Journal of Clinical Medicine doi: 10.3390/jcm9103315 Authors: Emanuele Amodio Rosaria Maria Pipitone Stefania Grimaudo Palmira Immordino Carmelo Massimo Maida Tullio Prestileo Vincenzo Restivo Fabio Tramuto Francesco Vitale Antonio Craxì Alessandra Casuccio The course of SARS-CoV-2 infection ranges from asymptomatic to a multiorgan disease....
JCM, Vol. 9, Pages 3312: Diagnostic Power of Galectin-3 in Rheumatic Diseases Journal of Clinical Medicine doi: 10.3390/jcm9103312 Authors: Ewa Gruszewska Bogdan Cylwik Ewa Gińdzieńska-Sieśkiewicz Otylia Kowal-Bielecka Barbara Mroczko Lech Chrostek Background: The purpose of our study was to assess the diagnostic power of galectin-3 and compare its between rheumatic diseases and with routinely used tests such as CRP and ESR. Methods: Eighty-two patients with rheumatoid...
JCM, Vol. 9, Pages 3310: Effects on Health-Related Quality of Life of Biofeedback Physiotherapy of the Pelvic Floor as an Adjunctive Treatment Following Surgical Repair of Cystocele Journal of Clinical Medicine doi: 10.3390/jcm9103310 Authors: Pedro-Santiago Borrego-Jimenez Bárbara-Yolanda Padilla-Fernandez Sebastián Valverde-Martinez Maria-Helena Garcia-Sanchez Maria-de-la-O Rodriguez-Martin Maria-Pilar Sanchez-Conde Maria-Carmen Flores-Fraile Magaly Marquez-Sanchez Javier...
JCM, Vol. 9, Pages 3311: Winter Exercise and Speleotherapy for Allergy and Asthma: A Randomized Controlled Clinical Trial Journal of Clinical Medicine doi: 10.3390/jcm9103311 Authors: Freidl Huber Braunschmid Romodow Pichler Weisböck-Erdheim Mayr Hartl (1) Background: The prevalence of allergic respiratory diseases is still rising and efforts towards holistic treatments should be made. Although speleotherapy is widely applied in Europe to treat chronic airway...
JCM, Vol. 9, Pages 3314: Association between Obstructive Sleep Apnea and SYNTAX Score Journal of Clinical Medicine doi: 10.3390/jcm9103314 Authors: Sayaki Ishiwata Yasuhiro Tomita Sugao Ishiwata Koji Narui Hiroyuki Daida Takatoshi Kasai Obstructive sleep apnea (OSA) is related to an increased risk of cardiovascular diseases, including coronary artery disease (CAD). We investigated the association between OSA and the severity of CAD by assessing coronary angiography findings....
JCM, Vol. 9, Pages 3309: Pancreatitis Associated with Viral Hepatitis: Systematic Review Journal of Clinical Medicine doi: 10.3390/jcm9103309 Authors: Nikola Panic Sladjana Mihajlovic Miroslav Vujasinovic Milutin Bulajic Johannes-Matthias Löhr Background: We conducted a systematic review in order to summarize the available data on pancreatitis associated with viral hepatitis. Methods: A comprehensive literature search of Medline, Scopus and ISI Web of Science databases was...
JCM, Vol. 9, Pages 3308: Targeting Endothelial Cell Metabolism by Inhibition of Pyruvate Dehydrogenase Kinase and Glutaminase-1 Journal of Clinical Medicine doi: 10.3390/jcm9103308 Authors: Céline A. Schoonjans Barbara Mathieu Nicolas Joudiou Luca X. Zampieri Davide Brusa Pierre Sonveaux Olivier Feron Bernard Gallez Targeting endothelial cell (EC) metabolism should impair angiogenesis, regardless of how many angiogenic signals are present. The dependency of proliferating...
JCM, Vol. 9, Pages 3307: Stem Cells Regenerating the Craniofacial Skeleton: Current State-Of-The-Art and Future Directions Journal of Clinical Medicine doi: 10.3390/jcm9103307 Authors: Jeremie D. Oliver Wasila Madhoun Emily M. Graham Russell Hendrycks Maranda Renouard Michael S. Hu The craniofacial region comprises the most complex and intricate anatomical structures in the human body. As a result of developmental defects, traumatic injury, or neoplastic tissue formation,...
JCM, Vol. 9, Pages 3306: Restaging Transurethral Resection of Bladder Tumours after BCG Immunotherapy Induction in Patients with T1 Non-Muscle-Invasive Bladder Cancer Might not Be Associated with Oncologic Benefit Journal of Clinical Medicine doi: 10.3390/jcm9103306 Authors: Wojciech Krajewski Marco Moschini Łukasz Nowak Sławomir Poletajew Andrzej Tukiendorf Luca Afferi Jeremy Teoh Tim Muilwijk Steven Joniau Alessandro Tafuri Alessandro Antonelli Alessandra...
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JoF, Vol. 6, Pages 224: Candida auris Direct Detection from Surveillance Swabs, Blood, and Urine Using a Laboratory-Developed PCR Method Journal of Fungi doi: 10.3390/jof6040224 Authors: Robert C. Walchak Seanne P. Buckwalter Nicole M. Zinsmaster Katrina M. Henn Katelyn M. Johnson Jolene M. Koelsch Senait A. Herring Lory K. Steinmetz Katelyn A. Reed Jean E. Barth Jenna M. Rasmusson Jill L. Fischer Paula Snippes Vagnone Priya Sampathkumar Nancy L. Wengenack...
JoF, Vol. 6, Pages 223: Use of the Versatility of Fungal Metabolism to Meet Modern Demands for Healthy Aging, Functional Foods, and Sustainability Journal of Fungi doi: 10.3390/jof6040223 Authors: Jacqueline A. Takahashi Bianca V. R. Barbosa Bruna de A. Martins Christiano P. Guirlanda Marília A. F. Moura Aging-associated, non-transmissible chronic diseases (NTCD) such as cancer, dyslipidemia, and neurodegenerative disorders have been challenged through several strategies...
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JPM, Vol. 10, Pages 172: Subclinical Cognitive and Neuropsychiatric Correlates and Hippocampal Volume Features of Brain White Matter Hyperintensity in Healthy People Journal of Personalized Medicine doi: 10.3390/jpm10040172 Authors: Gianfranco Spalletta Mariangela Iorio Daniela Vecchio Federica Piras Valentina Ciullo Nerisa Banaj Stefano L. Sensi Walter Gianni Francesca Assogna Carlo Caltagirone Fabrizio Piras White matter hyperintensities (WMH) are associated...
JPM, Vol. 10, Pages 171: Comparison of Clonogenic Survival Data Obtained by Pre- and Post-Irradiation Methods Journal of Personalized Medicine doi: 10.3390/jpm10040171 Authors: Takahiro Oike Yuka Hirota Narisa Dewi Maulany Darwis Atsushi Shibata Tatsuya Ohno Clonogenic assays are the gold standard to measure in vitro radiosensitivity, which use two cell plating methods, before or after irradiation (IR). However, the effect of the plating method on the experimental outcome...
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Life, Vol. 10, Pages 243: Quercitrin Ameliorates Hyperlipidemia and Hepatic Steatosis in Ovariectomized Mice Life doi: 10.3390/life10100243 Authors: Haeng Jeon Hur Yeon-Hui Jeong Sang Hee Lee Mi Jeong Sung Nonalcoholic fatty liver disease (NAFLD) is associated with progressive metabolic diseases. Estrogen deficiency increases the NAFLD risk among postmenopausal women. Thus, effective agents to prevent and treat NAFLD in postmenopausal women are required. Quercitrin (Quer) is...
Life, Vol. 10, Pages 242: Clinical Evaluation of a Custom Gene Panel as a Tool for Precision Male Infertility Diagnosis by Next-Generation Sequencing Life doi: 10.3390/life10100242 Authors: Rossella Cannarella Vincenza Precone Giulia Guerri Gian Maria Busetto Gian Carlo Di Renzo Sandro Gerli Elena Manara Astrit Dautaj Matteo Bertelli Aldo Eugenio Calogero Background: Up to 15% of couples are infertile and male factor infertility accounts for approximately 50%...
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Medicina, Vol. 56, Pages 542: Predictive Value of HPV, p53, and p16 in the Post-Treatment Evolution of Malignant Tumors of the Oropharynx and Retromolar Trigone–Oropharynx Junction Medicina doi: 10.3390/medicina56100542 Authors: Bogdan Mihail Cobzeanu Mihail Dan Cobzeanu Mihaela Moscalu Octavian Dragos Palade Luminița Rădulescu Dragoș Negru Liliana Gheorghe Moisii Luiza Maria Cobzeanu Loredana Beatrice Ungureanu Patricia Vonica Daniela Viorelia Matei Daniela...
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Medicines, Vol. 7, Pages 66: Pomegranate Juice Extract Decreases Cisplatin Toxicity on Peripheral Blood Mononuclear Cells Medicines doi: 10.3390/medicines7100066 Authors: Mohamad Nasser Ziad Damaj Akram Hijazi Othmane Merah Batoul Al-Khatib Nadine Hijazi Christine Trabolsi Ragida Damaj Mouhamad Nasser Background: Lung cancer is one of the most prevalent cancers worldwide. Chemotherapy regimens, targeted against lung cancer, are considered an effective treatment;...
Medicines, Vol. 7, Pages 65: Effects of Diaphragmatic Breathing on Health: A Narrative Review Medicines doi: 10.3390/medicines7100065 Authors: Hidetaka Hamasaki Background: Breathing is an essential part of life. Diaphragmatic breathing (DB) is slow and deep breathing that affects the brain and the cardiovascular, respiratory, and gastrointestinal systems through the modulation of autonomic nervous functions. However, the effects of DB on human health need to be further investigated....
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Membranes, Vol. 10, Pages 289: Enhancing the Antibacterial Properties of PVDF Membrane by Hydrophilic Surface Modification Using Titanium Dioxide and Silver Nanoparticles Membranes doi: 10.3390/membranes10100289 Authors: Kajeephan Samree Pen-umpai Srithai Panaya Kotchaplai Pumis Thuptimdang Pisut Painmanakul Mali Hunsom Sermpong Sairiam This work investigates polyvinylidene fluoride (PVDF) membrane modification to enhance its hydrophilicity and antibacterial properties....
Membranes, Vol. 10, Pages 287: Integrating Pressure-Driven Membrane Separation Processes to Improve Eco-Efficiency in Cheese Manufacture: A Preliminary Case Study Membranes doi: 10.3390/membranes10100287 Authors: Scott Benoit Julien Chamberland Alain Doyen Manuele Margni Christian Bouchard Yves Pouliot Pressure-driven membrane separation processes are commonly used in cheese milk standardization. Using ultrafiltration (UF) or microfiltration (MF), membrane separation processes...
Membranes, Vol. 10, Pages 286: Enhanced Selective Hydrogen Permeation through Graphdiyne Membrane: A Theoretical Study Membranes doi: 10.3390/membranes10100286 Authors: Quan Liu Long Cheng Gongping Liu Graphdiyne (GDY), with uniform pores and atomic thickness, is attracting widespread attention for application in H2 separation in recent years. However, the challenge lies in the rational design of GDYs for fast and selective H2 permeation. By MD and DFT calculations, several flexible...
Membranes, Vol. 10, Pages 288: Scaling Risk Assessment in Nanofiltration of Mine Waters Membranes doi: 10.3390/membranes10100288 Authors: Krzysztof Mitko Ewa Laskowska Marian Turek Piotr Dydo Krzysztof Piotrowski Nanofiltration can be applied for the treatment of mine waters. One of the main problems is the risk of crystallization of sparingly soluble salts on the membrane surface (scaling). In this work, a series of batch-mode nanofiltration experiments of the mine waters...
Membranes, Vol. 10, Pages 285: A Review of CFD Modelling and Performance Metrics for Osmotic Membrane Processes Membranes doi: 10.3390/membranes10100285 Authors: Kang Yang Toh Yong Yeow Liang Woei Jye Lau Gustavo A. Fimbres Weihs Simulation via Computational Fluid Dynamics (CFD) offers a convenient way for visualising hydrodynamics and mass transport in spacer-filled membrane channels, facilitating further developments in spiral wound membrane (SWM) modules for desalination...
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Microorganisms, Vol. 8, Pages 1592: Gut Microbiome in Children from Indigenous and Urban Communities in México: Different Subsistence Models, Different Microbiomes Microorganisms doi: 10.3390/microorganisms8101592 Authors: Andrés Sánchez-Quinto Daniel Cerqueda-García Luisa I. Falcón Osiris Gaona Santiago Martínez-Correa Javier Nieto Isaac González-Santoyo The human gut microbiome is an important component that defines host health. Childhood is a particularly important...
Microorganisms, Vol. 8, Pages 1590: Microbiota of the Therapeutic Euganean Thermal Muds with a Focus on the Main Cyanobacteria Species Microorganisms doi: 10.3390/microorganisms8101590 Authors: Barbara Gris Laura Treu Raffaella Margherita Zampieri Fabrizio Caldara Chiara Romualdi Stefano Campanaro Nicoletta La Rocca The Euganean Thermal District has been known since Roman times for the therapeutic properties of peloids, obtained from natural clays that have undergone...
Microorganisms, Vol. 8, Pages 1591: Pet-Human Gut Microbiome Host Classifier Using Data from Different Studies Microorganisms doi: 10.3390/microorganisms8101591 Authors: Nadia Bykova Nikita Litovka Anna Popenko Sergey Musienko (1) Background: microbiome host classification can be used to identify sources of contamination in environmental data. However, there is no ready-to-use host classifier. Here, we aimed to build a model that would be able to discriminate between pet and...
Microorganisms, Vol. 8, Pages 1589: Baltic Group Tick-Borne Encephalitis Virus Phylogeography: Systemic Inconsistency Pattern between Genetic and Geographic Distances Microorganisms doi: 10.3390/microorganisms8101589 Authors: Andrei A. Deviatkin Ivan S. Kholodilov Oxana A. Belova Sergey V. Bugmyrin Lubov A. Bespyatova Anna Y. Ivannikova Yulia A. Vakulenko Alexander N. Lukashev Galina G. Karganova Tick-Borne Encephalitis Virus (TBEV) is a dangerous arbovirus widely...
Microorganisms, Vol. 8, Pages 1587: Gut Microbiota and Immune System Interactions Microorganisms doi: 10.3390/microorganisms8101587 Authors: Ji Youn Yoo Maureen Groer Samia Valeria Ozorio Dutra Anujit Sarkar Daniel Ian McSkimming Dynamic interactions between gut microbiota and a host’s innate and adaptive immune systems play key roles in maintaining intestinal homeostasis and inhibiting inflammation. The gut microbiota metabolizes proteins and complex carbohydrates,...
Microorganisms, Vol. 8, Pages 1588: Evaluation of Filamentous Fungi and Yeasts for the Biodegradation of Sugarcane Distillery Wastewater Microorganisms doi: 10.3390/microorganisms8101588 Authors: Graziella Chuppa-Tostain Melissa Tan Laetitia Adelard Alain Shum-Cheong-Sing Jean-Marie François Yanis Caro Thomas Petit Sugarcane Distillery Spent Wash (DSW) is among the most pollutant industrial effluents, generally characterized by high Chemical Oxygen Demand (COD), high...
Microorganisms, Vol. 8, Pages 1586: Yogurt Produced by Novel Natural Starter Cultures Improves Gut Epithelial Barrier In Vitro Microorganisms doi: 10.3390/microorganisms8101586 Authors: Nikola Popović Emilija Brdarić Jelena Đokić Miroslav Dinić Katarina Veljović Nataša Golić Amarela Terzić-Vidojević Yogurt is a traditional fermented dairy product, prepared with starter cultures containing Streptococcus thermophilus and Lactobacillus bulgaricus that has gained widespread...
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Molecules, Vol. 25, Pages 4743: A Rose Extract Protects the Skin against Stress Mediators: A Potential Role of Olfactory Receptors Molecules doi: 10.3390/molecules25204743 Authors: Romain Duroux Anne Mandeau Gaelle Guiraudie-Capraz Yannick Quesnel Estelle Loing Olfactory receptors (ORs) are expressed and active in various human tissues, including the skin. Although the sense of smell plays an important physiological role in the regulation of mood and stress, a link between...
Molecules, Vol. 25, Pages 4744: Determination of Volatile Organic Compounds and Antibacterial Activity of the Amazonian Cyanobacterium Synechococcus sp. Strain GFB01 Molecules doi: 10.3390/molecules25204744 Authors: Samuel Cavalcante do Amaral Agenor Valadares Santos Maria Paula da Cruz Schneider Joyce Kelly Rosário da Silva Luciana Pereira Xavier Cyanobacteria exhibit great biotechnological potential due to their capacity to produce compounds with various applicability....
Molecules, Vol. 25, Pages 4742: Synthesis and Characterization of Ion Pairs between Alkaline Metal Ions and Anionic Anti-Aromatic and Aromatic Hydrocarbons with π-Conjugated Central Seven- and Eight-Membered Rings Molecules doi: 10.3390/molecules25204742 Authors: Jan Bloch Stefan Kradolfer Thomas L. Gianetti Detlev Ostendorf Subal Dey Victor Mougel Hansjörg Grützmacher The synthesis, isolation and full characterization of ion pairs between alkaline metal ions (Li+,...
Molecules, Vol. 25, Pages 4741: Enhanced Fire Safety of Rigid Polyurethane Foam via Synergistic Effect of Phosphorus/Nitrogen Compounds and Expandable Graphite Molecules doi: 10.3390/molecules25204741 Authors: Chuan Liu Ping Zhang Yongqian Shi Xiaohui Rao Suncheng Cai Libi Fu Yuezhan Feng Liancong Wang Xueqin Zheng Wei Yang In order to explore highly efficient flame-retardant rigid polyurethane foam (RPUF), phosphorus/nitrogen compounds and expandable graphite...
Molecules, Vol. 25, Pages 4740: Molecularly Imprinted Polymer Micro- and Nano-Particles. A review Molecules doi: 10.3390/molecules25204740 Authors: Beatriz Fresco-Cala Alex Batista Soledad Cárdenas In recent years, molecularly imprinted polymers (MIPs) have become an excellent solution to the selective and sensitive determination of target molecules in complex matrices where other similar and relative structural compounds could coexist. Although MIPs show the inherent properties...
Molecules, Vol. 25, Pages 4739: Chemical Composition, Nutritional Value, and Biological Evaluation of Tunisian Okra Pods (Abelmoschus esculentus L. Moench) Molecules doi: 10.3390/molecules25204739 Authors: Mariem Haj Romdhane Hassiba Chahdoura Lillian Barros Maria Inês Dias Rúbia Carvalho Gomes Corrêa Patricia Morales Maria Ciudad-Mulero Guido Flamini Hatem Majdoub Isabel C.F.R. Ferreira The aim of this work was to perform an unprecedented in-depth study...
Molecules, Vol. 25, Pages 4738: Application of Antimicrobial Polymers in the Development of Dental Resin Composite Molecules doi: 10.3390/molecules25204738 Authors: Jing Xue Jing Wang Daoshuo Feng Haofei Huang Ming Wang Dental resin composites have been widely used in a variety of direct and indirect dental restorations due to their aesthetic properties compared to amalgams and similar metals. Despite the fact that dental resin composites can contribute similar mechanical...
Molecules, Vol. 25, Pages 4737: Unravelling the Biological Activities of the Byttneria pilosa Leaves Using Experimental and Computational Approaches Molecules doi: 10.3390/molecules25204737 Authors: Mifta Ahmed Jyoti Niloy Barua Mohammad Shafaet Hossain Muminul Hoque Tahmina Akter Bristy Shabnur Mahmud Kamruzzaman Kamruzzaman Md. Adnan Md. Nazim Uddin Chy Arkajyoti Paul Mir Ezharul Hossain Talha Bin Emran Jesus Simal-Gandara Byttneria pilosa is locally...
Molecules, Vol. 25, Pages 4736: Highly Efficient Extraction Procedures Based on Natural Deep Eutectic Solvents or Ionic Liquids for Determination of 20-Hydroxyecdysone in Spinach Molecules doi: 10.3390/molecules25204736 Authors: Sylwia Bajkacz Kornelia Rusin Anna Wolny Jakub Adamek Karol Erfurt Anna Chrobok A novel, efficient extraction procedure based on natural deep eutectic solvents (NADES) and ionic liquids (ILs) for determination of 20-hydroxyecdysone (20-E) in spinach...
Molecules, Vol. 25, Pages 4734: Evaluation of Structurally Different Ionic Liquid-Based Surfactants in a Green Microwave-Assisted Extraction for the Flavonoids Profile Determination of Mangifera sp. and Passiflora sp. Leaves from Canary Islands Molecules doi: 10.3390/molecules25204734 Authors: Kristýna Moučková Idaira Pacheco-Fernández Juan H. Ayala Petra Bajerová Verónica Pino Aqueous solutions of ionic liquids (ILs) with surface active properties were used as extraction...
Molecules, Vol. 25, Pages 4733: Modeling of Chemoperfusion vs. Intravenous Administration of Cisplatin in Wistar Rats: Adsorption and Tissue Distribution Molecules doi: 10.3390/molecules25204733 Authors: Galina Kireeva Stepan Kruglov Mikhail Maydin Ekaterina Gubareva Elena Fedoros Ekaterina Zubakina Natalya Ivanenko Marina Bezruchko Nikolay Solovyev Hyperthermic intraperitoneal chemoperfusion (HIPEC) is an established form of locoregional chemotherapy of peritoneum...
Molecules, Vol. 25, Pages 4735: Extraction Techniques and Analytical Methods for Characterization of Active Compounds in Origanum Species Molecules doi: 10.3390/molecules25204735 Authors: Maša Knez Knez Hrnčič Darija Cör Jana Simonovska Željko Knez Zoran Kavrakovski Vesna Rafajlovska Phytochemical research based on ethnopharmacology is gaining interest in industries such as functional food, nutraceuticals, cosmetics and pharmaceutical industries. Plants and plant extracts...
Molecules, Vol. 25, Pages 4731: Flame Retardancy and Thermal Behavior of an Unsaturated Polyester Modified with Kaolinite–Urea Intercalation Complexes Molecules doi: 10.3390/molecules25204731 Authors: Lina Yue Junfei Li Xuan Zhou Yingjuan Sun Ming Gao Taohua Zhu Xiaoqian Zhang Teng Feng Zhanhong Shi Yongchun Liu Organic modified kaolinite-urea intercalation complex (KUIC) was prepared using dimethyl sulfoxide (DMSO) as the precursor of kaolinite intercalation....
Molecules, Vol. 25, Pages 4729: Structure and Dynamics of GPCRs in Lipid Membranes: Physical Principles and Experimental Approaches Molecules doi: 10.3390/molecules25204729 Authors: Andrew J. Y. Jones Florian Gabriel Aditi Tandale Daniel Nietlispach Over the past decade, the vast amount of information generated through structural and biophysical studies of GPCRs has provided unprecedented mechanistic insight into the complex signalling behaviour of these receptors. With this...
Molecules, Vol. 25, Pages 4732: Effect of Strain, Wood Substrate and Cold Treatment on the Yield and β-glucan Content of Ganoderma lucidum Fruiting Bodies Molecules doi: 10.3390/molecules25204732 Authors: Marta Cortina-Escribano Juha-Matti Pihlava Jari Miina Pyry Veteli Riikka Linnakoski Henri Vanhanen Wood residues from forestry industries can be potential raw materials for specialty and edible mushroom production. The aim of this study was to evaluate the suitability...
Molecules, Vol. 25, Pages 4730: Diels-Alder Additions as Mechanistic Probes–Interception of Silyl-Isoindenes: Organometallic Derivatives of Polyphenylated Cycloheptatrienes and Related Seven-Membered Rings Molecules doi: 10.3390/molecules25204730 Authors: Michael J. McGlinchey The intermediacy of short-lived isoindenes, generated in the course of metallotropic or silatropic shifts over the indene skeleton, can be shown by Diels-Alder trapping with tetracyanoethylene, leading to the complete...
Molecules, Vol. 25, Pages 4724: Capturing Peptide–GPCR Interactions and Their Dynamics Molecules doi: 10.3390/molecules25204724 Authors: Anette Kaiser Irene Coin Many biological functions of peptides are mediated through G protein-coupled receptors (GPCRs). Upon ligand binding, GPCRs undergo conformational changes that facilitate the binding and activation of multiple effectors. GPCRs regulate nearly all physiological processes and are a favorite pharmacological target. In particular,...
Molecules, Vol. 25, Pages 4728: A Comparison of Solubility, Stability, and Bioavailability between Astilbin and Neoastilbin Isolated from Smilax glabra Rhizoma Molecules doi: 10.3390/molecules25204728 Authors: Dan Zheng Yi-Ting Ruan Zhong-Ping Yin Qing-Feng Zhang Astilbin and neoastilbin are two flavonoid stereoisomers. In the present study, their solubility, stability, and bioavailability were compared in a rat. The results revealed that the water solubility of astilbin and...
Molecules, Vol. 25, Pages 4725: Vibrational Spectroscopy for Identification of Metabolites in Biologic Samples Molecules doi: 10.3390/molecules25204725 Authors: Kevin V. Hackshaw Joseph S. Miller Didem P. Aykas Luis Rodriguez-Saona Vibrational spectroscopy (mid-infrared (IR) and Raman) and its fingerprinting capabilities offer rapid, high-throughput, and non-destructive analysis of a wide range of sample types producing a characteristic chemical “fingerprint”...
Molecules, Vol. 25, Pages 4726: Hydration/Dehydration Behavior of Hydroxyethyl Cellulose Ether in Aqueous Solution Molecules doi: 10.3390/molecules25204726 Authors: Kengo Arai Toshiyuki Shikata Hydroxyethyl cellulose (HeC) maintains high water solubility over a wide temperature range even in a high temperature region where other nonionic chemically modified cellulose ethers, such as methyl cellulose (MC) and hydroxypropylmethyl cellulose (HpMC), demonstrate cloud points. In order...
Molecules, Vol. 25, Pages 4727: Ethanol Extract of Campsis grandiflora Flower and Its Organic Acid Components Have Inhibitory Effects on Autoinducer Type 1 Quorum Sensing Molecules doi: 10.3390/molecules25204727 Authors: Juanmei Zhang Fenghua Xu Lingling Yao Leyu Wang Miao Wang Gang Wang Chinese herbs are a useful resource bank for natural drug development, and have attracted considerable attention to exploit quorum sensing inhibitors (QSIs). This study was designed to...
Molecules, Vol. 25, Pages 4722: Mesoporous Silica as a Drug Delivery System for Naproxen: Influence of Surface Functionalization Molecules doi: 10.3390/molecules25204722 Authors: Lukáš Žid Vladimír Zeleňák Miroslav Almáši Adriana Zeleňáková Jaroslava Szücsová Jozef Bednarčík Monika Šuleková Alexander Hudák Lucia Váhovská In this work we describe the relationship between surface modification of hexagonally ordered mesoporous silica SBA-15 and loading/release characteristics...
Molecules, Vol. 25, Pages 4723: Merging Ligand-Based and Structure-Based Methods in Drug Discovery: An Overview of Combined Virtual Screening Approaches Molecules doi: 10.3390/molecules25204723 Authors: Javier Vázquez Manel López Enric Gibert Enric Herrero F. Javier Luque Virtual screening (VS) is an outstanding cornerstone in the drug discovery pipeline. A variety of computational approaches, which are generally classified as ligand-based (LB) and structure-based (SB) techniques,...
Molecules, Vol. 25, Pages 4721: Investigation of Dextran-Coated Superparamagnetic Nanoparticles for Targeted Vinblastine Controlled Release, Delivery, Apoptosis Induction, and Gene Expression in Pancreatic Cancer Cells Molecules doi: 10.3390/molecules25204721 Authors: Salim Albukhaty Sharafaldin Al-Musawi Salih Abdul Mahdi Ghassan M. Sulaiman Mona S. Alwahibi Yaser Hassan Dewir Dina A. Soliman Humaira Rizwana In the current study, the surface of superparamagnetic...
Molecules, Vol. 25, Pages 4717: Application of Supercritical Solvent Impregnation for Production of Zeolite Modified Starch-Chitosan Polymers with Antibacterial Properties Molecules doi: 10.3390/molecules25204717 Authors: Jelena Pajnik Ivana Lukić Jelena Dikić Jelena Asanin Milan Gordic Dusan Misic Irena Zizović Malgorzata Korzeniowska In the present study, supercritical solvent impregnation (SSI) has been applied to incorporate thymol into bio-composite polymers...
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