Short-term outcomes after a neonatal arterial ischemic stroke

Short-term outcomes after a neonatal arterial ischemic stroke:

Abstract

Purpose

The purpose of this study is to determine the frequency and radiological predictors of recurrent acute symptomatic seizures (RASS) and motor impairment at discharge after a neonatal arterial ischemic stroke (NAIS).

Methods

In a nonconcurrent cohort study, 33 full-term newborns with NAIS confirmed by MRI are admitted into our hospital between January 2003 and December 2012. Stroke size, calculated as stroke volume divided by whole brain volume (WBV), was categorized as > or < 3.3% of WBV. A univariate analysis of categorical variables was performed using Fisher’s exact test. A multivariate analysis was performed using logistic regression models including all variables with a p value < 0.1 in the univariate analysis.

Results

The median age at NAIS was 2 days (IQR, 1–5.6), 36.4% were girls. The stroke size was > 3.3 of WBV in 48.5% of the cases, and 54.5% showed multifocal lesions. Involvement of the cerebral cortex (54.5%), thalamus (48.5%), posterior limb of the internal capsule (36.4%), basal ganglia (36.4%), and brainstem (28.2%) were found. At discharge, 45.5% of newborns had a motor deficit, and 27.3% had at least two seizures. Multivariate analyses revealed that stroke size > 3.3% of WBV (OR: 8.1, CI: 1.2–53.9) and basal ganglia involvement (OR: 12.8, CI: 1.7–95.4) predicted motor impairment at discharge. Cortical involvement of temporal and frontal lobes (OR: 14, CI: 2.2–88.1; and OR: 9.1, CI: 1.2–72.6) were predictive of RASS.

Conclusion

Stroke size and location are independent risk factors for adverse short-term neurological outcomes in full-term newborns following a NAIS.