Elevated omentin-1 levels, their clinicopathological features, and the risk of colorectal cancer.

The association between Chinese patients' elevated omentin-1 levels, their clinicopathological features, and the risk of colorectal cancer.:

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The association between Chinese patients' elevated omentin-1 levels, their clinicopathological features, and the risk of colorectal cancer.

Int J Clin Exp Pathol. 2019;12(6):2264-2274

Authors: Zhao X, Zhang Y, Deng L, Wang Y, Li Y, Chen M

Abstract

To investigate the association between plasma omentin-1 levels and the risk of colorectal cancer (CRC) and the pathological changes of CRC, a total of 358 colorectal adenocarcinoma patients were included in the experience group, and 286 people were included in the control group. Their levels of omentin-1, adiponectin, visfatin, leptin, and their anthropometric and metabolic parameters were determined, and we analyzed the tertile distributions in the control group, according to the different levels: low, medium, and high. The results showed that the omentin-1 levels in patients with CRC were higher than the levels in the controls [(67.28 ± 32.25) vs (33.16 ± 19.93) ng/mL, P = 0.005]. The patients with the highest concentration of omentin-1 presented significantly higher odds for CRC, adjusted for potential confounding factors for CRC (odds ratio: 5.76; 95% CI 1.81-8.95; P = 0.001). The plasma omentin-1 level in CRC yielded a receiver operating characteristic curve area of 88.4%. The optimal sensitivity and specificity were 81.2% and 69.8% in discriminating CRC from the normal control. A high omentin-1 level was significantly associated the increasing stage of colorectal adenocarcinomas and the depth of invasion (P = 0.005, 0.026, respectively). The present study suggests an increased level of omentin-1 not only was a strong risk factor for CRC but could also represent a potential biomarker for CRC stage progression and CRC diagnosis in Chinese patients.

PMID: 31934050 [PubMed]