JCDD, Vol. 7, Pages 4: The Prognostic Importance of TAPSE in Early and in Stable Cardiovascular Diseases Journal of Cardiovascular Development and Disease doi: 10.3390/jcdd7010004 Authors: Paolo Giovanardi Enrico Tincani Marco Maioli Stefano Tondi The identification of predictors of major cardiovascular events (MACES) represents a big challenge, especially in early and stable cardiovascular diseases. This prospective study comparatively evaluated the prognostic importance of...
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JCM, Vol. 9, Pages 233: The Association between Dietary Intake, Asthma, and PCOS in Women from the Australian Longitudinal Study on Women’s Health Journal of Clinical Medicine doi: 10.3390/jcm9010233 Authors: Grieger Hodge Mishra Joham Moran Dietary intake potentially modifies the prevalence or severity of asthma. The prevalence of asthma is higher in women with polycystic ovary syndrome (PCOS); it is not known if diet confounds or modifies the association between asthma...
JCM, Vol. 9, Pages 232: Complete Revascularization of Multivessel Coronary Artery Disease Does Not Improve Clinical Outcome in ST-Segment Elevation Myocardial Infarction Patients with Reduced Left Ventricular Ejection Fraction Journal of Clinical Medicine doi: 10.3390/jcm9010232 Authors: Kang Zheng Park Park Rhee Lee Han Yang Kang Koo Kim The benefit of complete revascularization (CR) in ST-segment elevation myocardial infarction (STEMI) patients...
JCM, Vol. 9, Pages 231: The Efficacy of Therapeutic Respiratory Muscle Training Interventions in People with Bronchiectasis: A Systematic Review and Meta-Analysis. Journal of Clinical Medicine doi: 10.3390/jcm9010231 Authors: Martín-Valero Jimenez-Cebrian Moral-Munoz de-la-Casa-Almeida Rodriguez-Huguet Casuso-Holgado Background: Respiratory muscle dysfunction is an important health problem with high morbidity and mortality and associated costs in patients with bronchiectasis...
JCM, Vol. 9, Pages 234: Intact Stimulus–Response Conflict Processing in ADHD—Multilevel Evidence and Theoretical Implications Journal of Clinical Medicine doi: 10.3390/jcm9010234 Authors: Bluschke Mückschel Roessner Beste Attention-deficit-hyperactivity disorder (ADHD) is closely associated with deficits in cognitive control. It seems, however, that the degree of deficits strongly depends on the examined subprocess, with the resolution of stimulus–stimulus conflicts...
JCM, Vol. 9, Pages 228: Cochlear Implantation Outcome in Children with DFNB1 locus Pathogenic Variants Journal of Clinical Medicine doi: 10.3390/jcm9010228 Authors: Oziębło Obrycka Lorens Skarżyński Ołdak Almost 60% of children with profound prelingual hearing loss (HL) have a genetic determinant of deafness, most frequently two DFNB1 locus (GJB2/GJB6 genes) recessive pathogenic variants. Only few studies combine HL etiology with cochlear implantation (CI) outcome. Patients...
JCM, Vol. 9, Pages 227: Creatinine to Body Weight Ratio Is Associated with Incident Diabetes: Population-Based Cohort Study Journal of Clinical Medicine doi: 10.3390/jcm9010227 Authors: Hashimoto Okamura Hamaguchi Obora Kojima Fukui We investigated the association between creatinine to body weight (Cre/BW) ratio and incident diabetes. In this cohort study, 9659 men and 7417 women were follow up mean (SD) 5.6 (3.5) years and 5.4 (3.4) years, respectively. For men,...
JCM, Vol. 9, Pages 229: Morpho-Functional Evaluation of Full-Thickness Macular Holes by the Integration of Optical Coherence Tomography Angiography and Microperimetry Journal of Clinical Medicine doi: 10.3390/jcm9010229 Authors: Bacherini Savastano Dragotto Finocchio Lenzetti Bitossi Tartaro Giansanti Barca Savastano Caporossi Vannozzi Sodi Luca Faraldi Virgili Rizzo (1) Objective: To use optical coherence tomography angiography...
JCM, Vol. 9, Pages 230: Influence of Pneumonia on the Survival of Patients with COPD Journal of Clinical Medicine doi: 10.3390/jcm9010230 Authors: Ji Vázquez Cano González Moreno Lajas Maestu Díez Background: Pneumonia is a frequent infection. Chronic obstructive pulmonary disease (COPD) can present with comorbidities, including pneumonia. It is known that COPD worsens the evolution of pneumonia, but few studies describe the impact of pneumonia on COPD evolution....
JCM, Vol. 9, Pages 226: Induction of HO-1 by Mevastatin Mediated via a Nox/ROS-Dependent c-Src/PDGFRα/PI3K/Akt/Nrf2/ARE Cascade Suppresses TNF-α-Induced Lung Inflammation Journal of Clinical Medicine doi: 10.3390/jcm9010226 Authors: Chih-Chung Lin Wei-Ning Lin Rou-Ling Cho Chien-Chung Yang Yi-Cheng Yeh Li-Der Hsiao Hui-Ching Tseng Chuen-Mao Yang Background: Mevastatin (MVS), a 3-hydroxy-3-methylglutaryl coenzyme, a reductase (HMG-CoA) inhibitor, has anti-inflammatory...
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JFB, Vol. 11, Pages 4: Fabrication of Polymeric Microparticles by Electrospray: The Impact of Experimental Parameters Journal of Functional Biomaterials doi: 10.3390/jfb11010004 Authors: Alan Í. S. Morais Ewerton G. Vieira Samson Afewerki Ricardo B. Sousa Luzia M. C. Honorio Anallyne N. C. O. Cambrussi Jailson A. Santos Roosevelt D. S. Bezerra Josy A. O. Furtini Edson C. Silva-Filho Thomas J. Webster Anderson O. Lobo Microparticles (MPs) with controlled...
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JoF, Vol. 6, Pages 14: Unraveling How Candida albicans Forms Sexual Biofilms Journal of Fungi doi: 10.3390/jof6010014 Authors: Perry Hernday Nobile Biofilms, structured and densely packed communities of microbial cells attached to surfaces, are considered to be the natural growth state for a vast majority of microorganisms. The ability to form biofilms is an important virulence factor for most pathogens, including the opportunistic human fungal pathogen Candida albicans. C....
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Medical Sciences, Vol. 8, Pages 3: Acknowledgement to Reviewers of Medical Sciences in 2019 Medical Sciences doi: 10.3390/medsci8010003 Authors: <i>Medical Sciences</i> Editorial Office
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Medicina, Vol. 56, Pages 33: Total Exenteration En Bloc with a Nephrectomy for Locally Advanced Cervical Cancer Invading a Pelvic Kidney—a Case Report and Literature Review Medicina doi: 10.3390/medicina56010033 Authors: Bacalbasa Balescu Vilcu Dima Diaconu Iliescu Filipescu Brezean Introduction: Extended pelvic resection might be the option of choice in patients presenting locally advanced cervical cancer. However, the possibility of a co-existence of an...
Medicina, Vol. 56, Pages 32: Evaluation of Maternal and Neonatal Outcomes of Assisted Reproduction Technology: A Retrospective Cohort Study Medicina doi: 10.3390/medicina56010032 Authors: Tanaka Tanaka Osato Kusaka Maegawa Taniguchi Ikeda Background: To evaluate maternal and neonatal outcomes of assisted reproductive technology (ART). Materials and Methods: Pregnant women registered from 2015 through 2017 (n = 6994) at five perinatal centers that managed high-risk...
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Metabolites, Vol. 10, Pages 37: Metabolomics in the Context of Plant Natural Products Research: From Sample Preparation to Metabolite Analysis Metabolites doi: 10.3390/metabo10010037 Authors: Salem Perez de Souza Serag Fernie Farag Ezzat Alseekh Plant-derived natural products have long been considered a valuable source of lead compounds for drug development. Natural extracts are usually composed of hundreds to thousands of metabolites, whereby the bioactivity...
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Microorganisms, Vol. 8, Pages 119: Modulation of Antibacterial, Antioxidant, and Anti-Inflammatory Properties by Drying of Prunus domestica L. Plum Juice Extracts Microorganisms doi: 10.3390/microorganisms8010119 Authors: Silvan Michalska-Ciechanowska Martinez-Rodriguez The consumption of plums in a fresh form is seasonal, therefore the transformation of plum juice extracts into powdered form is a good alternative for its longer availability throughout the year. The drying process...
Microorganisms, Vol. 8, Pages 118: Occupational Exposures to Organic Dust in Irish Bakeries and a Pizzeria Restaurant Microorganisms doi: 10.3390/microorganisms8010118 Authors: Viegas Fleming Kadir Almeida Caetano Quintal Gomes Twarużek Kosicki Viegas Coggins For decades, occupational exposure to flour dust has been linked to a range of respiratory diseases, including occupational asthma, thought to result from exposure to fungi present in the flour....
Microorganisms, Vol. 8, Pages 117: Subcellular Location of Piscirickettsia salmonis Heat Shock Protein 60 (Hsp60) Chaperone by Using Immunogold Labeling and Proteomic Analysis Microorganisms doi: 10.3390/microorganisms8010117 Authors: Oliver Sánchez Valenzuela Hernández Pontigo Rauch Garduño Avendaño-Herrera Yáñez Piscirickettsia salmonis is the causative bacterial agent of piscirickettsiosis, a systemic fish disease that significantly impacts the Chilean...
Microorganisms, Vol. 8, Pages 116: Industrial Validation of a Promising Functional Strain of Lactobacillus plantarum to Improve the Quality of Italian Sausages Microorganisms doi: 10.3390/microorganisms8010116 Authors: Daniela Campaniello Barbara Speranza Antonio Bevilacqua Clelia Altieri Maria Rosaria Corbo Milena Sinigaglia This paper proposes the industrial validation of a functional strain of Lactobacillus plantarum (strain 178). First, acidification in a meat model...
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Molecules, Vol. 25, Pages 363: α- and β-Substituted Metal-Free Phthalocyanines: Synthesis, Photophysical and Electrochemical Properties Molecules doi: 10.3390/molecules25020363 Authors: Hande Pekbelgin Karaoğlu Ayfer Kalkan Burat Two novel phthalonitrile derivatives, bearing two hexyloxy groups and a benzodioxin (or a naphthodioxin) annulated ring, along with their corresponding metal-free phthalocyanines (H2Pc) were prepared. FT-IR, mass, electronic absorption, 1H NMR, and 13C NMR...
Molecules, Vol. 25, Pages 362: New Zampanolide Mimics: Design, Synthesis, and Antiproliferative Evaluation Molecules doi: 10.3390/molecules25020362 Authors: Guanglin Chen Ziran Jiang Qiang Zhang Guangdi Wang Qiao-Hong Chen Zampanolide is a promising microtubule-stabilizing agent (MSA) with a unique chemical structure. It is superior to the current clinically used MSAs due to the covalent nature of its binding to β-tubulin and high cytotoxic potency toward multidrug-resistant...
Molecules, Vol. 25, Pages 360: Design of Disruptors of the Hsp90–Cdc37 Interface Molecules doi: 10.3390/molecules25020360 Authors: Ilda D’Annessa Naama Hurwitz Valentina Pirota Giovanni Luca Beretta Stella Tinelli Mark Woodford Mauro Freccero Mehdi Mollapour Nadia Zaffaroni Haim Wolfson Giorgio Colombo The molecular chaperone Hsp90 is a ubiquitous ATPase-directed protein responsible for the activation and structural stabilization of a large clientele of...
Molecules, Vol. 25, Pages 361: Synthesis of Elaborate Benzofuran-2-carboxamide Derivatives through a Combination of 8-Aminoquinoline Directed C–H Arylation and Transamidation Chemistry Molecules doi: 10.3390/molecules25020361 Authors: Oschmann Johansson Holm Pourghasemi-Lati Verho Herein, we present a short and highly modular synthetic route that involves 8-aminoquinoline directed C–H arylation and transamidation chemistry, and which enables access to a wide range...
Molecules, Vol. 25, Pages 358: Androgen Receptor in Breast Cancer—Clinical and Preclinical Research Insights Molecules doi: 10.3390/molecules25020358 Authors: Anestis Zoi Papavassiliou Karamouzis The Androgen Receptor (AR) is emerging as an important factor in the pathogenesis of breast cancer (BC), which is the most common malignancy among females worldwide. The concordance of more than 70% of AR expression in primary and metastatic breast tumors implies that AR may be...
Molecules, Vol. 25, Pages 357: Systematic Detection and Identification of Bioactive Ingredients from Citrus aurantium L. var. amara Using HPLC-Q-TOF-MS Combined with a Screening Method Molecules doi: 10.3390/molecules25020357 Authors: Yu Chen Liu Huang He Qing Zeng Bitter orange, Citrus aurantium L. var. amara (CAVA), is an important crop and its flowers and fruits are widely used in China as a food spice, as well as in traditional Chinese medicine, due to its...
Molecules, Vol. 25, Pages 359: Correlations Between Trace Elements in Selected Locations of the Human Brain in Individuals with Alcohol Use Disorder Molecules doi: 10.3390/molecules25020359 Authors: Cezary Grochowski Magdalena Szukała Jakub Litak Agnieszka Budny Jędrzej Proch Dariusz Majerek Eliza Blicharska Przemysław Niedzielski Trace element distribution varies in different locations of the human brain. Several elements were found to cause various negative effects,...
Molecules, Vol. 25, Pages 355: Pesticide Residues and Health Risk Assessment in Tomatoes and Lettuces from Farms of Metropolitan Region Chile Molecules doi: 10.3390/molecules25020355 Authors: Elgueta Valenzuela Fuentes Meza Manzur Liu Zhao Correa Over the last years, the detection of pesticide residues in the official food surveillance programs of Chile has been increased, mainly in fresh vegetables such as tomatoes and lettuces. The Metropolitana Region...
Molecules, Vol. 25, Pages 354: The Effects of Ultraviolet A/B Treatments on Anthocyanin Accumulation and Gene Expression in Dark-Purple Tea Cultivar ‘Ziyan’ (Camellia sinensis) Molecules doi: 10.3390/molecules25020354 Authors: Li Tan Zou Tan Huang Chen Tang ‘Ziyan’ is a novel anthocyanin-rich tea cultivar with dark purple young shoots. However, how its anthocyanin accumulation is affected by environmental factors, such as ultraviolet (UV),...
Molecules, Vol. 25, Pages 353: High-Throughput Screening Identifies Two Novel Small Molecule Enhancers of Recombinant Protein Expression Molecules doi: 10.3390/molecules25020353 Authors: Jiasong Chang Xiaoxu Chen Ruolin Wang Run Shi Xiaogang Wang Wei Lu Sanyuan Ma Qingyou Xia As a primary strategy for production of biological drugs, recombinant proteins produced by transient transfection of mammalian cells are essential for both basic research and industrial production....
Molecules, Vol. 25, Pages 352: Tunable Aryl Imidazolium Recyclable Ionic Liquid with Dual Brønsted–Lewis Acid as Green Catalyst for Friedel–Crafts Acylation and Thioesterification Molecules doi: 10.3390/molecules25020352 Authors: Lin Wu Thul Hung Chou Chen Lin Lin Reddy Wu Ho Luo Unique tunable aryl imidazolium ionic liquids successfully catalyzed Friedel–Crafts acylation and thioesterification in sealed tubes. These reactions can...
Molecules, Vol. 25, Pages 356: Continuous Flow Photochemistry for the Preparation of Bioactive Molecules Molecules doi: 10.3390/molecules25020356 Authors: Mara Di Filippo Cormac Bracken Marcus Baumann The last decade has witnessed a remarkable development towards improved and new photochemical transformations in response to greener and more sustainable chemical synthesis needs. Additionally, the availability of modern continuous flow reactors has enabled widespread applications...
Molecules, Vol. 25, Pages 351: Effects of Orange Extracts on Longevity, Healthspan, and Stress Resistance in Caenorhabditis elegans Molecules doi: 10.3390/molecules25020351 Authors: Jing Wang Na Deng Hong Wang Tong Li Ling Chen Bisheng Zheng Rui Hai Liu Orange, with various bioactive phytochemicals, exerts various beneficial health effects, including anti-cancer, antioxidant, and anti-inflammatory properties. However, its anti-aging effects remain unclear. In this study,...
Molecules, Vol. 25, Pages 349: Methods of the Analysis of Oxylipins in Biological Samples Molecules doi: 10.3390/molecules25020349 Authors: Ivan Liakh Alicja Pakiet Tomasz Sledzinski Adriana Mika Oxylipins are derivatives of polyunsaturated fatty acids and due to their important and diverse functions in the body, they have become a popular subject of studies. The main challenge for researchers is their low stability and often very low concentration in samples. Therefore, in...
Molecules, Vol. 25, Pages 348: AT-MSCs Antifibrotic Activity is Improved by Eugenol through Modulation of TGF-β/Smad Signaling Pathway in Rats Molecules doi: 10.3390/molecules25020348 Authors: Moustafa Fathy Motonori Okabe Heba M. Saad Eldien Toshiko Yoshida For hepatic failure, stem cell transplantation has been chosen as an alternative therapy, especially for mesenchymal stem cells (MSCs). The aim of this study was to investigate the effect of eugenol (EUG) on the in vivo...
Molecules, Vol. 25, Pages 350: Efficient and Stable Magnetic Chitosan-Lipase B from Candida Antarctica Bioconjugates in the Enzymatic Kinetic Resolution of Racemic Heteroarylethanols Molecules doi: 10.3390/molecules25020350 Authors: Cristina Georgiana Spelmezan László Csaba Bencze Gabriel Katona Florin Dan Irimie Csaba Paizs Monica Ioana Toșa Lipase B from Candida antarctica immobilized by covalent binding on sebacoyl-activated chitosan-coated magnetic nanoparticles proved...
Molecules, Vol. 25, Pages 347: Selective Upregulation by Theanine of Slc38a1 Expression in Neural Stem Cell for Brain Wellness Molecules doi: 10.3390/molecules25020347 Authors: Yukio Yoneda Koichi Kawada Nobuyuki Kuramoto Theanine is an amino acid abundant in green tea with an amide moiety analogous to glutamine (GLN) rather than glutamic acid (Glu) and GABA, which are both well-known as amino acid neurotransmitters in the brain. Theanine has no polyphenol and flavonoid structures...
Molecules, Vol. 25, Pages 345: Antifungal Styryloquinolines as Candida albicans Efflux Pump Inhibitors: Styryloquinolines are ABC Transporter Inhibitors Molecules doi: 10.3390/molecules25020345 Authors: Wioleta Cieslik Joanna Szczepaniak Anna Krasowska Robert Musiol Styrylquinolines are heterocyclic compounds that are known for their antifungal and antimicrobial activity. Metal complexation through hydroxyl groups has been claimed to be a plausible mechanism of action for these...
Molecules, Vol. 25, Pages 344: Simultaneous Determination of Six Isoflavones from Puerariae Lobatae Radix by CPE-HPLC and Effect of Puerarin on Tyrosinase Activity Molecules doi: 10.3390/molecules25020344 Authors: Limin Qu Ke Song Qi Zhang Jie Guo Juan Huang Tyrosinase inhibitors with excellent inhibitory activities and lower side effects have promising applications in the fields of medicine, agriculture, food sciences and cosmetics. In this study, a method for simultaneous...
Molecules, Vol. 25, Pages 346: Synthesis of Oligonucleotides Containing 2′-N-alkylaminocarbonyl-2′-amino-LNA (2′-urea-LNA) Moieties Using Post-Synthetic Modification Strategy Molecules doi: 10.3390/molecules25020346 Authors: Shoko Yamashita Kodai Nishida Takashi Osawa Ayumi Nakanishi Yuta Ito Yoshiyuki Hari The post-synthetic modification of an oligonucleotide is a powerful strategy for the synthesis of various analogs of the oligonucleotide, aiming to achieve the desired...
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Nanomaterials, Vol. 10, Pages 152: Continuum Modelling for Interacting Coronene Molecules with a Carbon Nanotube Nanomaterials doi: 10.3390/nano10010152 Authors: Kyle Stevens Thien Tran-Duc Ngamta Thamwattana James M. Hill The production of single dimensional carbon structures has recently been made easier using carbon nanotubes. We consider here encapsulated coronene molecules, which are flat and circular-shaped polycyclic aromatic hydrocarbons, inside carbon nanotubes. Depending...
Nanomaterials, Vol. 10, Pages 150: Electrospun Functional Materials toward Food Packaging Applications: A Review Nanomaterials doi: 10.3390/nano10010150 Authors: Luying Zhao Gaigai Duan Guoying Zhang Haoqi Yang Shuijian He Shaohua Jiang Electrospinning is an effective and versatile method to prepare continuous polymer nanofibers and nonwovens that exhibit excellent properties such as high molecular orientation, high porosity and large specific surface area. Benefitting...
Nanomaterials, Vol. 10, Pages 151: Supported Gold Nanoparticles as Catalysts in Peroxidative and Aerobic Oxidation of 1-Phenylethanol under Mild Conditions Nanomaterials doi: 10.3390/nano10010151 Authors: Pakrieva Ribeiro Kolobova Martins Carabineiro German Pichugina Jiang Pombeiro Bogdanchikova Corberán Pestryakov The efficiency of Au/TiO2 based catalysts in 1-phenylethanol oxidation was investigated. The role of support modifiers (La2O3...
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Nutrients, Vol. 12, Pages 227: Dietary Patterns and Dietary Adaptations in Women with and without Gestational Diabetes: Evidence from the Growing Up in New Zealand Study Nutrients doi: 10.3390/nu12010227 Authors: Lawrence Wall Bloomfield Diet is a cornerstone of the management of gestational diabetes (GDM). We investigated differences in dietary patterns and dietary adaptations among pregnant women with and without GDM participating in the Growing Up in New Zealand study. Presence...
Nutrients, Vol. 12, Pages 226: Energy Expenditure and Changes in Body Composition during Submarine Deployment—An Observational Study “DasBoost 2-2017” Nutrients doi: 10.3390/nu12010226 Authors: Rietjens Most Joris Helmhout Plasqui The present study was designed to objectively assess the effects of 3-months submarine deployment on behavioural and metabolic determinants of metabolic health. In 13 healthy, non-obese volunteers, we using stable isotope dilution, and plasma...
Nutrients, Vol. 12, Pages 225: Lactobacillus reuteri DSM 17938 and Magnesium Oxide in Children with Functional Chronic Constipation: A Double-Blind and Randomized Clinical Trial Nutrients doi: 10.3390/nu12010225 Authors: Kubota Ito Tomimoto Kanazaki Tsukiyama Kubota Kuroki Fujita Vandenplas Objective: Chronic functional constipation is a frequent condition. The aim of the study was to evaluate the efficacy of the probiotic Lactobacillus (L.) reuteri DSM...
Nutrients, Vol. 12, Pages 220: Antidiabetic Effect of Casein Glycomacropeptide Hydrolysates on High-Fat Diet and STZ-Induced Diabetic Mice via Regulating Insulin Signaling in Skeletal Muscle and Modulating Gut Microbiota Nutrients doi: 10.3390/nu12010220 Authors: Yuan Zhan Chang Du Mao This study evaluated the effects and the underlying mechanisms of casein glycomacropeptide hydrolysate (GHP) on high-fat diet-fed and streptozotocin-induced type 2 diabetes (T2D) in C57BL/6J...
Nutrients, Vol. 12, Pages 221: The Effect of Timing of Exercise and Eating on Postprandial Response in Adults: A Systematic Review Nutrients doi: 10.3390/nu12010221 Authors: Aqeel Forster Richards Hennessy McGowan Bhadra Guo Gelfand Delp Eicher-Miller Type 2 diabetes is a major public health concern. Management of this condition has focused on behavior modification through diet and exercise interventions. A growing body of evidence has focused on...
Nutrients, Vol. 12, Pages 222: Effects of Synbiotic Supplement on Human Gut Microbiota, Body Composition and Weight Loss in Obesity Nutrients doi: 10.3390/nu12010222 Authors: Sergeev Aljutaily Walton Huarte Targeting gut microbiota with synbiotics (probiotic supplements containing prebiotic components) is emerging as a promising intervention in the comprehensive nutritional approach to reducing obesity. Weight loss resulting from low-carbohydrate high-protein diets can be...
Nutrients, Vol. 12, Pages 223: Could Omega 3 Fatty Acids Preserve Muscle Health in Rheumatoid Arthritis? Nutrients doi: 10.3390/nu12010223 Authors: Lanchais Capel Tournadre Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by a high prevalence of death due to cardiometabolic diseases. As observed during the aging process, several comorbidities, such as cardiovascular disorders (CVD), insulin resistance, metabolic syndrome and sarcopenia, are frequently...
Nutrients, Vol. 12, Pages 224: Chemical Profile, Antioxidative, and Gut Microbiota Modulatory Properties of Ganpu Tea: A Derivative of Pu-erh Tea Nutrients doi: 10.3390/nu12010224 Authors: Zheng Zeng Chen Peng Su Ganpu tea is an emerging tea drink produced from Pu-erh tea and the pericarp of Citrus reticulate Chachi (GCP). Recently, it has been increasingly favored by consumers due to the potential health effects and special taste. However, information concerning its...
Nutrients, Vol. 12, Pages 219: Heat-Killed Bifidobacterium breve B-3 Enhances Muscle Functions: Possible Involvement of Increases in Muscle Mass and Mitochondrial Biogenesis Nutrients doi: 10.3390/nu12010219 Authors: Kazuya Toda Yuki Yamauchi Azusa Tanaka Tetsuya Kuhara Toshitaka Odamaki Shin Yoshimoto Jin-zhong Xiao A previous clinical study on pre-obesity subjects revealed that Bifidobacterium breve B-3 shows anti-obesity effects and possibly increases muscle mass....
Nutrients, Vol. 12, Pages 218: Orthorexic Tendency and Eating Disorders Symptoms in Polish Students: Examining Differences in Eating Behaviors Nutrients doi: 10.3390/nu12010218 Authors: Marta Plichta Marzena Jezewska-Zychowicz Orthorexia nervosa (ON) may precede, ensue, or coexist with eating disorders (ED) and also affect eating behaviors. The aim of this study was to explore the dietary patterns (DPs) and other eating habits of people showing ON tendency, ED symptoms, and both ON...
Nutrients, Vol. 12, Pages 217: Effects of Daily Low-Dose Date Consumption on Glycemic Control, Lipid Profile, and Quality of Life in Adults with Pre- and Type 2 Diabetes: A Randomized Controlled Trial Nutrients doi: 10.3390/nu12010217 Authors: Tariq A. Alalwan Simone Perna Qaher A. Mandeel Aalaa Abdulhadi Adel Salman Alsayyad Giuseppe D’Antona Massimo Negro Antonella Riva Giovanna Petrangolini Pietro Allegrini Mariangela Rondanelli Dates have a low glycemic...
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Particles, Vol. 3, Pages 23: Acknowledgement to Reviewers of Particles in 2019 Particles doi: 10.3390/particles3010003 Authors: Particles Editorial Office
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Pathogens, Vol. 9, Pages 62: Challenges and Opportunities towards the Development of Risk Assessment at the Consumer Phase in Developing Countries—The Case of Campylobacter Cross-Contamination during Handling of Raw Chicken in Two Middle Eastern Countries Pathogens doi: 10.3390/pathogens9010062 Authors: Ihab Habib Ali Harb Ingrid Hansson Ivar Vågsholm Walaa Osama Salma Adnan Mohamed Anwar Neveen Agamy Sofia Boqvist In many low- and middle-income countries, data...
Pathogens, Vol. 9, Pages 61: Acknowledgement to Reviewers of Pathogens in 2019 Pathogens doi: 10.3390/pathogens9010061 Authors: <i>Pathogens</i> Editorial Office
Pathogens, Vol. 9, Pages 59: Efficacy Evaluation of Two Commercial Vaccines Against a Recombinant PRRSV2 Strain ZJnb16-2 From Lineage 8 and 3 in China Pathogens doi: 10.3390/pathogens9010059 Authors: Guangwei Han Huiling Xu Yanli Wang Zehui Liu Fang He From 2010, novel recombinant lineage 3 of porcine reproductive and respiratory syndrome virus 2 (PRRSV2) has continuously emerged China, which has brought about clinical outbreaks of the disease. Previously, a PRRSV2 strain...
Pathogens, Vol. 9, Pages 60: Essential Gene Clusters Involved in Copper Tolerance Identified in Acinetobacter baumannii Clinical and Environmental Isolates Pathogens doi: 10.3390/pathogens9010060 Authors: Rapee Thummeepak Renuka Pooalai Christian Harrison Lucy Gannon Aunchalee Thanwisai Narisara Chantratita Andrew D. Millard Sutthirat Sitthisak Copper is widely used as antimicrobial in agriculture and medicine. Copper tolerance mechanisms of pathogenic bacteria have...
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Pharmaceutics, Vol. 12, Pages 68: Strategic Approaches for Colon Targeted Drug Delivery: An Overview of Recent Advancements Pharmaceutics doi: 10.3390/pharmaceutics12010068 Authors: Lee Bajracharya Min Han Park Han Colon targeted drug delivery systems have gained a great deal of attention as potential carriers for the local treatment of colonic diseases with reduced systemic side effects and also for the enhanced oral delivery of various therapeutics vulnerable to...
Pharmaceutics, Vol. 12, Pages 69: Effects of Focused-Ultrasound-and-Microbubble-Induced Blood-Brain Barrier Disruption on Drug Transport under Liposome-Mediated Delivery in Brain Tumour: A Pilot Numerical Simulation Study Pharmaceutics doi: 10.3390/pharmaceutics12010069 Authors: Zhan Focused ultrasound (FUS) coupled with microbubbles (MB) has been found to be a promising approach to disrupt the blood-brain barrier (BBB). However, how this disruption affects drug transport remains unclear....
Pharmaceutics, Vol. 12, Pages 66: Along the Process Chain to Probiotic Tablets: Evaluation of Mechanical Impacts on Microbial Viability Pharmaceutics doi: 10.3390/pharmaceutics12010066 Authors: Vorländer Kampen Finke Kwade Today, probiotics are predominantly used in liquid or semi-solid functionalized foods, showing a rapid loss of cell viability. Due to the increasing spread of antibiotic resistance, probiotics are promising in pharmaceutical development because of their...
Pharmaceutics, Vol. 12, Pages 67: Predictive Model-Based Process Start-Up in Pharmaceutical Continuous Granulation and Drying Pharmaceutics doi: 10.3390/pharmaceutics12010067 Authors: Victoria Pauli Peter Kleinebudde Markus Krumme Continuous manufacturing (CM) is a promising strategy to achieve various benefits in the context of quality, flexibility, safety and cost in pharmaceutical production. One of the main technical challenges of CM is that the process needs to handle transient...
Pharmaceutics, Vol. 12, Pages 65: Antitumor Features of Vegetal Protein-Based Nanotherapeutics Pharmaceutics doi: 10.3390/pharmaceutics12010065 Authors: Silvia Voci Agnese Gagliardi Massimo Fresta Donato Cosco The introduction of nanotechnology into pharmaceutical application revolutionized the administration of antitumor drugs through the modulation of their accumulation in specific organs/body compartments, a decrease in their side-effects and their controlled release from...
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Pharmacy, Vol. 8, Pages 10: Pharmacists as a Source of Advice on Medication Use for Athletes Pharmacy doi: 10.3390/pharmacy8010010 Authors: Yee De Marco Salahudeen Peterson Thomas Naunton Kosari Background: The World Anti-Doping Agency (WADA) specifies substances that competitive sportspersons are not allowed to take. Some of these substances are contained in common medicines used in everyday medical practice and could be used by athletes by accident. Objectives:...
Pharmacy, Vol. 8, Pages 9: Prevalence and Perceived Effectiveness of Pharmaceutical Digital Marketing among Community Pharmacies in Saudi Arabia: A Cross-Sectional Questionnaire-Based Survey Pharmacy doi: 10.3390/pharmacy8010009 Authors: Said Bragazzi Pyatigorskaya This research analyzes the direct-to-consumer digital marketing technologies in terms of prevalence and effectiveness. A cross-sectional study design was carried out using the non-repeated random sampling technique....
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Plants, Vol. 9, Pages 112: Bioactivity of Common Pesticidal Plants on Fall Armyworm Larvae (Spodoptera frugiperda) Plants doi: 10.3390/plants9010112 Authors: Phambala Tembo Kasambala Kabambe Stevenson Belmain The fall armyworm (FAW), Spodoptera frugiperda (Lepidoptera: Noctuidae) is a recent invasive pest species that has successfully established across sub-Saharan Africa where it continues to disrupt agriculture, particularly smallholder cereal production. Management...
Plants, Vol. 9, Pages 111: Silicification of Root Tissues Plants doi: 10.3390/plants9010111 Authors: Lux Lukačová Vaculík Švubová Kohanová Soukup Martinka Bokor Silicon (Si) is not considered an essential element, however, its tissue concentration can exceed that of many essential elements in several evolutionary distant plant species. Roots take up Si using Si transporters and then translocate it to aboveground organs. In some plant species, root tissues...
Plants, Vol. 9, Pages 109: Potential of Grasses in Phytolith Production in Soils Contaminated with Cadmium Plants doi: 10.3390/plants9010109 Authors: Múcio Mágno de Melo Farnezi Enilson de Barros Silva Lauana Lopes dos Santos Alexandre Christofaro Silva Paulo Henrique Grazziotti Jeissica Taline Prochnow Israel Marinho Pereira Ivan da Costa Ilhéu Fontan Cadmium (Cd) is a very toxic heavy metal occurring in places with anthropogenic activities, making it one of the...
Plants, Vol. 9, Pages 108: Effect of Arbuscular Mycorrhizal Colonization on Cadmium-Mediated Oxidative Stress in Glycine max (L.) Merr. Plants doi: 10.3390/plants9010108 Authors: Molina Lugo Pérez Chaca Vargas-Gil Zirulnik Leporati Ferrol Azcón-Aguilar Cadmium is a heavy metal (HM) that inhibits plant growth and leads to death, causing great losses in yields, especially in Cd hyperaccumulator crops such as Glycine max (L.) Merr. (soybean), a worldwide economically...
Plants, Vol. 9, Pages 110: Interaction Effects of Nitrogen Source and Irrigation Regime on Tuber Quality, Yield, and Water Use Efficiency of Solanum tuberosum L. Plants doi: 10.3390/plants9010110 Authors: Mohamed A. M. Eid Ali A. Abdel-Salam Haythum M. Salem Samira E. Mahrous Mahmoud F. Seleiman Abdullah A. Alsadon Talaat H. I. Solieman Abdullah A. Ibrahim Two field experiments were conducted to investigate the effects of three drip irrigation regimes (G1: 120% crop...
Plants, Vol. 9, Pages 107: Toxic Effects of Single Antibiotics and Antibiotics in Combination on Germination and Growth of Sinapis alba L. Plants doi: 10.3390/plants9010107 Authors: Ulrike Timmerer Lennart Lehmann Ewald Schnug Elke Bloem Antibiotics enter agro-ecosystems via the application of farmyard manure, sewage sludge, animal by-products, or digestates. There are many open questions regarding the behavior of such compounds in the soil like their adsorption, degradation,...
Plants, Vol. 9, Pages 106: Evolution of Photorespiratory Glycolate Oxidase among Archaeplastida Plants doi: 10.3390/plants9010106 Authors: Ramona Kern Fabio Facchinelli Charles Delwiche Andreas P. M. Weber Hermann Bauwe Martin Hagemann Photorespiration has been shown to be essential for all oxygenic phototrophs in the present-day oxygen-containing atmosphere. The strong similarity of the photorespiratory cycle in cyanobacteria and plants led to the hypothesis that oxygenic...
Plants, Vol. 9, Pages 105: The Effect of Caffeine and Trifluralin on Chromosome Doubling in Wheat Anther Culture Plants doi: 10.3390/plants9010105 Authors: Sue Broughton Marieclaire Castello Li Liu Julie Killen Anna Hepworth Rebecca O’Leary Challenges for wheat doubled haploid (DH) production using anther culture include genotype variability in green plant regeneration and spontaneous chromosome doubling. The frequency of chromosome doubling in our program can vary from...
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Proteomes, Vol. 8, Pages 1: Special Issue “Top-down Proteomics: In Memory of Dr Alfred Yergey”. Alfred Linwood Yergey, III, 17 September 1941–27 May 2018 Proteomes doi: 10.3390/proteomes8010001 Authors: Jens R. Coorssen Matthew P. Padula Please see J [...]
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Religions, Vol. 11, Pages 44: Religion after the Royal Commission: Challenges to Religion–State Relations Religions doi: 10.3390/rel11010044 Authors: Kathleen McPhillips The findings and recommendations emanating from the Australian Royal Commission into Institutional Responses to Child Sexual Abuse (2012–2017) have advised religious organisations that they need to undertake significant changes to legal, governance and cultural/theological practices. The reason for urgency...
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Resources, Vol. 9, Pages 7: Social Sustainability Dilemma: Escape or Communicate? Managing Social Risks Upstream of the Bioenergy Supply Chain Resources doi: 10.3390/resources9010007 Authors: Elena Fedorova Kirsi Aaltonen Eva Pongrácz Supply chain risk management has been well researched over the years. However, management of social risks in bioenergy supply chains has been studied less in contemporary research. The ability of bioenergy companies to identify, properly address,...
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Risks, Vol. 8, Pages 6: Markov Chain Monte Carlo Methods for Estimating Systemic Risk Allocations Risks doi: 10.3390/risks8010006 Authors: Takaaki Koike Marius Hofert In this paper, we propose a novel framework for estimating systemic risk measures and risk allocations based on Markov Chain Monte Carlo (MCMC) methods. We consider a class of allocations whose jth component can be written as some risk measure of the jth conditional marginal loss distribution given the so-called crisis...
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Toxins, Vol. 12, Pages 50: Ciguatera Fish Poisoning: The Risk from an Aotearoa/New Zealand Perspective Toxins doi: 10.3390/toxins12010050 Authors: Rhodes Smith Murray Nishimura Finch Gambierdiscus and Fukuyoa species have been identified in Aotearoa/New Zealand’s coastal waters and G. polynesiensis, a known producer of ciguatoxins, has been isolated from Rangitāhua/Kermadec Islands (a New Zealand territory). The warming of the Tasman Sea and the waters around...
Toxins, Vol. 12, Pages 51: Dispersive Solid-Phase Extraction using Magnetic Carbon Nanotube Composite for the Determination of Emergent Mycotoxins in Urine Samples Toxins doi: 10.3390/toxins12010051 Authors: Arroyo-Manzanares Peñalver-Soler Campillo Viñas Dispersive magnetic solid-phase extraction (DMSPE) has received growing attention for sample treatment preconcentration prior to the separation of analytes due to its many advantages. In the present work, the potential...
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Viruses, Vol. 12, Pages 104: An RNA Thermometer Activity of the West Nile Virus Genomic 3′-Terminal Stem-Loop Element Modulates Viral Replication Efficiency during Host Switching Viruses doi: 10.3390/v12010104 Authors: Alexandra Meyer Marie Freier Tobias Schmidt Katja Rostowski Juliane Zwoch Hauke Lilie Sven-Erik Behrens Susann Friedrich The 3′-terminal stem-loop (3′SL) of the RNA genome of the flavivirus West Nile (WNV) harbors, in its stem,...
Viruses, Vol. 12, Pages 105: Reporter Assays for Ebola Virus Nucleoprotein Oligomerization, Virion-Like Particle Budding, and Minigenome Activity Reveal the Importance of Nucleoprotein Amino Acid Position 111 Viruses doi: 10.3390/v12010105 Authors: Lin Diehl Cai Finch Akusobi Kirchdoerfer Bollinger Schaffner Brown Saphire Andersen Kuhn Luban Sabeti For highly pathogenic viruses, reporter assays that can be rapidly performed are critically...
Viruses, Vol. 12, Pages 100: Development of a Multiplex RT-qPCR for the Detection of Different Clades of Avian Influenza in Poultry Viruses doi: 10.3390/v12010100 Authors: Tran Bac Le Hye Kwon Kim Woonsung Na Van Phan Le Min-Suk Song Daesub Song Dae Gwin Jeong Sun-Woo Yoon Since the initial detection of H5N1, a highly pathogenic avian influenza (HPAI) virus, in 1996 in China, numerous HPAI H5 lineages have been classified, and they continue to pose a threat to animal...
Viruses, Vol. 12, Pages 103: Real-Time Analysis of Individual Ebola Virus Glycoproteins Reveals Pre-Fusion, Entry-Relevant Conformational Dynamics Viruses doi: 10.3390/v12010103 Authors: Durham Howard Govindan Senjobe Fels Diehl Luban Chandran Munro The Ebola virus (EBOV) envelope glycoprotein (GP) mediates the fusion of the virion membrane with the membrane of susceptible target cells during infection. While proteolytic cleavage of GP by endosomal cathepsins...
Viruses, Vol. 12, Pages 101: Hepatitis C Virus Affects Tuberculosis-Specific T Cells in HIV-Negative Patients Viruses doi: 10.3390/v12010101 Authors: Mohamed Ahmed El-Mokhtar Sherein G. Elgendy Abeer Sharaf Eldin Elham Ahmed Hassan Ali Abdel Azeem Hasan Muhamad R. Abdel Hameed Douaa Sayed Eman H. Salama The occurrence of tuberculosis (TB) and hepatitis C virus (HCV) infections in the same patient presents a unique clinical challenge. The impact of HCV infection on...
Viruses, Vol. 12, Pages 102: Contribution of Dendritic Cells in Protective Immunity against Respiratory Syncytial Virus Infection Viruses doi: 10.3390/v12010102 Authors: Jung Kim Lee Respiratory syncytial virus (RSV) is a major cause of severe respiratory disease in infants and the elderly. The socioeconomic burden of RSV infection is substantial because it leads to serious respiratory problems, subsequent hospitalization, and mortality. Despite its clinical significance, a...
Viruses, Vol. 12, Pages 99: Detection and Molecular Characterization of Picobirnaviruses (PBVs) in the Mongoose: Identification of a Novel PBV Using an Alternative Genetic Code Viruses doi: 10.3390/v12010099 Authors: Alyssa Kleymann Anne A. M. J. Becker Yashpal S. Malik Nobumichi Kobayashi Souvik Ghosh We report high rates of detection (35.36%, 29/82) of genogroup-I (GI) picobirnaviruses (PBVs) in non-diarrheic fecal samples from the small Indian mongoose (Urva auropunctata)....
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Water, Vol. 12, Pages 247: Optimization and Analysis of Zeolite Augmented Electrocoagulation Process in the Reduction of High-Strength Ammonia in Saline Landfill Leachate Water doi: 10.3390/w12010247 Authors: Mohd Azhar Abd Hamid Hamidi Abdul Aziz Mohd Suffian Yusoff Sheikh Abdul Rezan This work examined the behavior of a novel zeolite augmented on the electrocoagulation process (ZAEP) using an aluminum electrode in the removal of high-strength concentration ammonia (3471 mg/L)...
Water, Vol. 12, Pages 248: Glacial Lake Outburst Flood (GLOF) Events and Water Response in A Patagonian Fjord Water doi: 10.3390/w12010248 Authors: Lauren Ross Iván Pérez-Santos Brigitte Parady Leonardo Castro Arnoldo Valle-Levinson Wolfgang Schneider As a result of climate change, the frequency of glacial lake outburst floods (GLOF) is increasing in Chilean Patagonia. Yet, the impacts of the flood events on the physics and biology of fjords is still unknown. Current velocities,...
Water, Vol. 12, Pages 244: Implementing the Water Framework Directive and Tackling Diffuse Pollution from Agriculture: Lessons from England and Scotland Water doi: 10.3390/w12010244 Authors: De Vito Fairbrother Russel Tackling diffuse pollution from agriculture is a key challenge for governments seeking to implement the European Union’s Water Framework Directive (WFD). In the research literature, how best to integrate and align effective measures for tackling diffuse...
Water, Vol. 12, Pages 245: Discharge Coefficients for Sluice Gates Set in Weirs at Different Upstream Wall Inclinations Water doi: 10.3390/w12010245 Authors: Lauria Calomino Alfonsi D’Ippolito Laboratory experiments and numerical simulations are performed to measure discharge coefficients in the case of a gate located on the upstream wall of a weir for flood storage. The effect of the gate slope and the side contraction have been taken into account. The study was first performed...
Water, Vol. 12, Pages 246: Assessing Anthropogenic Impacts on Chemical and Biochemical Oxygen Demand in Different Spatial Scales with Bayesian Networks Water doi: 10.3390/w12010246 Authors: Xu Jin Mo Tang Li In order to protect the water environment in seriously polluted basins, the impacts of anthropogenic activities (sewage outfalls and land use) on water quality should be assessed. The Bayesian network (BN) provides a convenient way to model these complex processes....
Water, Vol. 12, Pages 242: The Wall Stress of the Capsule Surface in the Straight Pipe Water doi: 10.3390/w12010242 Authors: Yang Ma Hydraulic capsule transportation is a new energy-saving transport mode. It is of great significance to the study of flow-field characteristics and pipeline-stress analysis. The purpose of this paper was to analyze the stress distribution on capsule surfaces when there is stationary in pipe flow. Results showed that the maximum shear stress on the capsule...
Water, Vol. 12, Pages 243: Quasi-Global Evaluation of IMERG and GSMaP Precipitation Products over Land Using Gauge Observations Water doi: 10.3390/w12010243 Authors: Wang Yong Understanding the error distribution of satellite precipitation products is conducive to obtaining accurate precipitation data, which is a very important input parameter in hydrological models and climate models. The error characteristics of Integrated Multi-satellite Retrievals for Global Precipitation Measurement...
Water, Vol. 12, Pages 239: A Comparative Study of Kernel Logistic Regression, Radial Basis Function Classifier, Multinomial Naïve Bayes, and Logistic Model Tree for Flash Flood Susceptibility Mapping Water doi: 10.3390/w12010239 Authors: Pham Phong Nguyen Qi Al-Ansari Amini Ho Tuyen Yen Ly Prakash Bui : Risk of flash floods is currently an important problem in many parts of Vietnam. In this study, we used four machine-learning methods, namely...
Water, Vol. 12, Pages 238: Efficient Double-Tee Junction Mixing Assessment by Machine Learning Water doi: 10.3390/w12010238 Authors: Luka Grbčić Lado Kranjčević Siniša Družeta Ivana Lučin A new approach in modeling of mixing phenomena in double-Tee pipe junctions based on machine learning is presented in this paper. Machine learning represents a paradigm shift that can be efficiently used to calculate needed mixing parameters. Usually, these parameters are obtained either by...
Water, Vol. 12, Pages 241: Experimental and Numerical Investigation of River Closure Project Water doi: 10.3390/w12010241 Authors: Lin Jin Ai Ding The success or failure of river closure is directly related to the construction period and project benefit. Therefore, it is very necessary to study the river closure by an appropriate method. In this paper, a 1D–2D coupled river closure model is established to optimize the closure flow rate, closure period, and layout...
Water, Vol. 12, Pages 240: A Simple Off-Grid Incubator for Microbiological Water Quality Analysis Water doi: 10.3390/w12010240 Authors: Carolina Bernardes Ricardo Bernardes Camille Zimmer Caetano C. Dorea There is a need for accessible and low-cost microbiological water quality testing in contexts where diarrheal illness is a major public health concern. In most cases, the quantification of Escherichia coli and other microbial indicators by conventional culture methods requires...
Water, Vol. 12, Pages 236: Magnetophoretic Harvesting of Nannochloropsis oculata Using Iron Oxide Immobilized Beads Water doi: 10.3390/w12010236 Authors: Feng-Jen Chu Terng-Jou Wan His Chen Chih-Hung Wu Po-Min Kao In this work, the harvesting of Nannochloropsis oculata microalgae through the use of nanosized Fe3O4 immobilized in polyvinyl alcohol (PVA)/sodium alginate (SA) as a flocculant (Fe3O4/PS) is investigated. Using the Fe3O4/PS immobilized beads could reduce the amount...
Water, Vol. 12, Pages 237: Lake Evolution, Hydrodynamic Outburst Flood Modeling and Sensitivity Analysis in the Central Himalaya: A Case Study Water doi: 10.3390/w12010237 Authors: Ashim Sattar Ajanta Goswami Anil. V. Kulkarni Adam Emmer Climate change has led to the formation of numerous high-altitude lakes of glacial origin in the Himalaya. Safed Lake is one of the largest glacial lakes, located at an elevation 4882 m a.s.l. in the state of Uttarakhand, central Himalaya, India....
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