We aimed to assess the kinetics of the release of proinflammatory cytokines and to clarify clinical usefulness as an indicator of the disease activity in human parechovirus type 3 virus (HPeV3)-induced sepsis-like syndrome. We measured serum levels of neopterin, interleukin (IL)-6 and the soluble forms of tumor necrosis factor (TNF) receptor types I (sTNF-RI) and II (sTNF-RII). Serum samples were obtained from 12 patients with HPeV3-induced sepsis-like syndrome and 28 healthy children. Disease course...
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We present a case of herpes zoster ophthalmicus in an otherwise healthy 14-month-old male associated with vaccine-strain varicella-zoster virus 11 weeks after monovalent varicella vaccine administration. Herpes zoster ophthalmicus, especially in the setting of familial immunoglobulin A deficiency, prompted further immunologic workup. A high index of suspicion is necessary for timely diagnosis and treatment of vaccine-strain herpes zoster. (Source: The Pediatric Infectious Disease Journal)
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Conclusion. The bismuth quadruple regimen using minocycline/amoxicillin showed a better eradication effect with fewer side effects in patients with untreated H. pylori infections. The bismuth quadruple regimen with minocycline/metronidazole had a good eradication effect with more obvious side effects and might be recommended to patients with penicillin allergy. PMID: 31933634 [PubMed] (Source: Gastroenterology Research and Practice)
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ConclusionThe revision surgery rate for CRSwNP was 24.9% among those with at least 6 months of follow ‐up. Risk factors for higher revision rates included younger age, previous surgery, longer follow‐up, and surgery at the MUSC prior to 2009. As we enter an era of personalized medicine, it is important to consider patient‐ and surgeon‐specific factors, which impact revision surgery rates. (Source: International Forum of Allergy and Rhinology)
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(Source: Journal of Inflammation Research)
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Publication date: March 2020Source: Molecular Immunology, Volume 119Author(s): Zhao-Xing Zang, Cheng Dan, Li Zhou, Qi-Ya Zhang, Jian-Fang Gui, Yi-Bing ZhangAbstractFish interferon (IFN)-mediated antiviral innate immunity is the first line of defense against virus invasion. In the present study, we identify two fish IFN genes (here tentatively named IFNa and IFNc) with different-sized 3′ UTRs from clone F strain of gibel carp Carassius auratus gibelio. Carp IFNa has a relatively short 3′UTR without...
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(Source: Journal of Asthma and Allergy)
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CRISPR-Cas9 engineered CYBBko THP-1 cell lines display an inflammatory profile with increased IL-1 β, IL-6 and TNF-α secretion as consequence of NADPH-induced ROS deficiency. This phenotype is reminiscent of the one observed in phagocytes from CGD patients. (Source: Journal of Allergy and Clinical Immunology)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Publication date: Available online 15 January 2020Source: Bioactive Carbohydrates and Dietary FibreAuthor(s): Xin Qi, Richard F. TesterAbstractCarbohydrates play a number of roles in the gut - although their presence and activity reach beyond the gut to other parts of the body. The carbohydrate family are not simply sources of energy and/or dietary fibre but at least some act on the gut associated lymphoid tissue both directly and indirectly (via microorganisms themselves and via products of microbiological...
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Publication date: Available online 15 January 2020Source: Fish & Shellfish ImmunologyAuthor(s): Lang Lang, Minnan Bao, Weixin Jing, Wei Chen, Lan WangAbstractToll is essential in innate immune system which is important for defense against bacterial, fungal and viral infections in invertebrates. Our previous study showed that cadmium (Cd) could change the expression pattern of ShToll3 in the epithelium (gills and midgut from the freshwater crab Sinopotamon henanense) infected by Aeromonas hydrophila....
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Publication date: Available online 15 January 2020Source: Fish & Shellfish ImmunologyAuthor(s): Jing Wang, Wenjing Hong, Fei ZhuAbstractAstakine is a crucial factor in the proliferation and differentiation of hematopoietic stem cells and is directly involved in hematopoiesis in crustaceans. To assess the role of Astakine in the innate immune system of Scylla paramamosain, the immune responses in healthy and Astakine-inhibited S. paramamosain were investigated in the present study. The RNA transcripts...
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Authors: Alejandro Martínez-Rodríguez Daniela Alejandra Loaiza-Martínez Javier Sánchez-Sánchez Pablo J. Marcos-Pardo Soledad Prats Fernando Alacid Jacobo A. Rubio-Arias Celiac disease (CD) is an immunological disorder that mainly affects the small intestine, generating an inflammatory process in response to the presence of gluten (a protein). Autoimmune diseases are part of a group of diseases that are difficult to diagnose without a specific protocol or consensus to detect...
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Pediatric allergic diseases are a major public health concern, and previous studies have suggested that exposure to traffic-related air pollution (TRAP) exposure is a risk factor. These studies have typically ass... (Source: Environmental Health)
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CONCLUSION: In conclusion, chitinases can be used as potential biomarkers in prognosis and diagnosis of several inflammatory diseases and allergies and the design of novel chitinase inhibitors may act as key and rational scaffolds in designing of some novel therapeutic agents in the treatment of variety of inflammatory diseases. PMID: 31934842 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
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Authors: Rodrigues MA, Torres T PMID: 31933476 [PubMed - in process] (Source: European Annals of Allergy and Clinical Immunology)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Publication date: Available online 14 January 2020Source: The Lancet HIVAuthor(s): Oliver Ratmann, Joseph Kagaayi, Matthew Hall, Tanya Golubchick, Godfrey Kigozi, Xiaoyue Xi, Chris Wymant, Gertrude Nakigozi, Lucie Abeler-Dörner, David Bonsall, Astrid Gall, Anne Hoppe, Paul Kellam, Jeremiah Bazaale, Sarah Kalibbala, Oliver Laeyendecker, Justin Lessler, Fred Nalugoda, Larry W Chang, Tulio de OliveiraSummaryBackgroundInternational and global organisations advocate targeting interventions to areas of...
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Authors: Barrios Y, Franco A, Alonso-Larruga A, Sánchez-Machín I, Poza-Guedes P, Gonzalez R, Matheu V PMID: 31932269 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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CONCLUSIONS: The HAE-AS is a short, valid, reliable and psychometrically sound measure of disease activity for C1-INH-HAE, which may be useful for research studies. PMID: 31932270 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)
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Authors: Touati N, Chiriac AM, Bourrain JL, Demoly P PMID: 31932271 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)
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Authors: Sánchez-Guerrero IM, Nieto A, Meseguer J, Navarro M, López Sáez MP, Magdalena MK, Sánchez Pérez N, Pineda F, López Sánchez JD PMID: 31932272 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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Authors: Nettis E, Bonzano L, Patella V, Detoraki C, Trerotoli P, Lombardo C, Italian DADReL study group PMID: 31932274 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)
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Authors: Cabañas R, Ramírez E, Sendagorta E, Alamar R, Barranco R, Blanca-López N, Doña I, Fernández J, Garcia-Nunez I, García-Samaniego J, Lopez-Rico R, Marín-Serrano E, Mérida C, Moya C, Ortega-Rodríguez NR, Rivas Becerra B, Rojas-Perez-Ezquerra P, Sánchez-González MJ, Vega-Cabrera C, Vila-Albelda C, Bellón T Abstract BACKGROUND AND OBJECTIVE: The DRESS syndrome (Drug Reaction with Eosinophilia and Systemic Symptoms) is a complex multisystemic severe drug hypersensitivity reaction whose...
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Authors: Tomás-Pérez M, Iglesias-Souto FJ, Bartolome B PMID: 31932273 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)
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CONCLUSION: Brazilian adult patients with severe atopic dermatitis need treatments to efficiently control the disease and improve quality of life. PMID: 31932275 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)
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ConclusionDeficient apoptosis and autophagy through MAPK/JNK and PI3K/mTOR pathways may have a role in the pathogenesis of nasal polyposis.ResumoIntroduçãoA polipose nasal é uma doença inflamatória progressiva que reduz a qualidade de vida dos pacientes. Os efeitos das vias apoptóticas e autofágicas na patogênese da polipose nasal ainda não são claramente conhecidos.ObjetivoNeste estudo, objetivamos investigar as vias apoptóticas MAPK/JNK, antiapoptóticas PI3K/mTOR e autofágicas LC3 as quais se encontram...
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Publication date: Available online 15 January 2020Source: Actas Dermo-Sifiliográficas (English Edition)Author(s): F.J. Miquel Miquel (Source: Actas Dermo-Sifiliograficas)
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Authors: Rudd BD Abstract Neonatal CD4+ and CD8+ T cells have historically been characterized as immature or defective. However, recent studies prompt a reinterpretation of the functions of neonatal T cells. Rather than a population of cells always falling short of expectations set by their adult counterparts, neonatal T cells are gaining recognition as a distinct population of lymphocytes well suited for the rapidly changing environment in early life. In this review, I will highlight new...
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AbstractPurpose of ReviewThis review provides an update on the immunopathogenesis of tuberculous pericarditis (TBP), investigations to confirm tuberculous etiology, the limitations of anti-tuberculous therapy (ATT), and recent efficacy trials.Recent FindingsA profibrotic immune response characterizes TBP, with low levels of AcSDKP, high levels of γ-interferon and IL-10 in the pericardium, and high levels of TGF-β and IL-10 in the blood. These findings may have implications for future therapeutic...
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CONCLUSIONS: Our explorative study identified new tumor tissue-based molecular characteristics associated with response to anti-PD-1/PD-L1 therapy in MCC. These observations warrant further investigations in larger patient cohorts to confirm their potential value as predictive markers. PMID: 31932494 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
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. (Source: Human Vaccines and Immunotherapeutics)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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ConclusionsChildren monosensitized to Can f 5 show different reactions to male and female dog extract provocation using both skin prick test and conjunctival allergen provocation test, suggesting tolerance to female dogs. (Source: The Journal of Allergy and Clinical Immunology: In Practice)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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Publication date: Available online 14 January 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Thanh-Thao (Adriana) Le, Jie Shen Fok, Sherin Vareeckal Joseph, Preethi Eldi, Timothy Chataway, William Smith, Pravin Hissaria (Source: The Journal of Allergy and Clinical Immunology: In Practice)
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ConclusionsThis study suggests that ICS treatment can decrease the risk of exacerbation in patients with ACO, and that a blood eosinophil count of ≥300 cells/μL can predict the response to ICS treatment. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
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AbstractThe presence of naturally occurring cytokine-specific autoantibodies (c-aAb) in humans is well established, as well as associations to selected pathologies. However, the overall influence of c-aAb on immunocompetence remains largely unknown. In this paper, we performed a large-scale investigation of c-aAb association with infection risk. A cohort of healthy Danish blood donors was screened for c-aAb against IL-1 α, IL-6, IL-10, IFNα, and GM-CSF using a Luminex-based multiplex assay, and results...
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ConclusionsPresent results provide new evidence of the significant relation between workplace exposure to mold odor and adult-onset ACOS. (Source: Clinical and Translational Allergy)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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The immune system plays a fundamental role at mucosal barriers in maintaining tissue homeostasis. This is particularly true for the gut where cells are flooded with microbial-derived signals and antigens, which constantly challenge the integrity of the intestinal barrier. Multiple immune cell populations equipped with both pro- and anti-inflammatory functions reside in the gut tissue and these cells tightly regulate intestinal health and functions. Dysregulation of this finely tuned system can progressively...
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In this study, we examined transcriptomic changes triggered by MSU in neutrophils and their impact on the corresponding proteins, as well as the role of various signaling pathways in prominent functional responses. We report for the first time that neutrophils can secrete the monocyte chemoattractant, CCL4, in response to MSU. Accordingly, we found that transcription factors NF-κB, CREB, and C/EBP are belatedly activated by MSU crystals, and at least the former is involved in chemokine generation....
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In gray matter pathology of multiple sclerosis, neurodegeneration associates with a high degree of meningeal inflammatory activity. Importantly, ectopic lymphoid follicles (eLFs) were identified at the inflamed meninges of patients with progressive multiple sclerosis. Besides T lymphocytes, they comprise B cells and might elicit germinal center (GC)-like reactions. GC reactions are controlled by FOXP3+ T-follicular regulatory cells (TFR), but it is unknown if they participate in autoantibody production...
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We report that pregnancy-induced involution is not caused by loss of TECs since their number does not change during or after pregnancy. However, during pregnancy, we observed a significant depletion of all thymocyte subsets downstream of the double-negative 1 (DN1) differentiation stage. Variations in thymocyte numbers correlated with conspicuous changes in the transcriptome of cortical TECs (cTECs). The transcriptomic changes affected predominantly cTEC expression of Foxn1, its targets and several...
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