Correlation between squamous cell carcinoma antigen 1 and 2 levels and disease severity and clinical type of atopic dermatitis

Correlation between squamous cell carcinoma antigen 1 and 2 levels and disease severity and clinical type of atopic dermatitis: Mohamed H Khatter, Fathia M Khattab, Amal A Zidan, Mai M Al-Hakim



Egyptian Journal of Dermatology and Venerology 2020 40(1):9-14



Background Serum levels of squamous cell carcinoma antigen (SCCA) 1 and 2 induced by type 2 cytokines such as interleukin 4 and interleukin 13 are increased in patients with atopic dermatitis (AD).

Objective This study aimed to assess and correlate the severity and clinical types of AD by serum level of SCC antigen 1 and SCC antigen 2 in AD patients.

Patients and methods Twenty-four AD patients (12 adults and 12 children) and 24 healthy controls were included in this study to assess the SCORAD score and to measure SCCA1 and SCCA2.

Results There was a statistically significant difference between the children and adult groups in SCCA1 and SCCA2 with higher levels in adults than children maybe due to the long duration of disease, chronicity, and severity of disease and there was a positive correlation between SCCA1 and SCCA2, and severity of disease.

Conclusion Serum levels of SCCA1 and SCCA2 correlate with severity of disease and clinical types and provide its role in the pathogenesis of Atopic Dermatitis. Further studies may evaluate the therapeutic effect of their blockage in the improvement of Atopic Dermatitis.