Antibiotics, Vol. 9, Pages 21: Host-Directed Therapy as a Novel Treatment Strategy to Overcome Tuberculosis: Targeting Immune Modulation Antibiotics doi: 10.3390/antibiotics9010021 Authors: Ahmed Raqib Guðmundsson Bergman Agerberth Rekha Tuberculosis (TB) is one of the leading causes of mortality and morbidity, particularly in developing countries, presenting a major threat to the public health. The currently recommended long term treatment regimen with multiple...
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Antioxidants, Vol. 9, Pages 53: Perinatal Exposure to Tartrazine Triggers Oxidative Stress and Neurobehavioral Alterations in Mice Offspring Antioxidants doi: 10.3390/antiox9010053 Authors: Gadah Albasher Najla Maashi Saleh Alfarraj Rafa Almeer Tarfa Albrahim Fatimah Alotibi May Bin-Jumah Ayman M. Mahmoud The use of synthetic azo dyes as coloring agents in food products has dramatically increased. This study evaluated the effect of perinatal exposure to tartrazine...
Antioxidants, Vol. 9, Pages 51: Gamma Tocopherol Reduced Chemotherapeutic-Induced ROS in an Ovarian Granulosa Cell Line, But Not in Breast Cancer Cell Lines In Vitro Antioxidants doi: 10.3390/antiox9010051 Authors: Daniela Figueroa Gonzalez Fiona Young Doxorubicin and cyclophosphamide are used to treat breast cancer, but they also cause infertility through off-target cytotoxicity towards proliferating granulosa cells that surround eggs. Each chemotherapeutic generates reactive oxygen...
Antioxidants, Vol. 9, Pages 52: Antioxidant Therapy in Parkinson’s Disease: Insights from Drosophila melanogaster Antioxidants doi: 10.3390/antiox9010052 Authors: De Lazzari Sandrelli Whitworth Bisaglia Reactive oxygen species (ROS) play an important role as endogenous mediators in several cellular signalling pathways. However, at high concentrations they can also exert deleterious effects by reacting with many macromolecules including DNA, proteins and lipids. The precise...
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Biology, Vol. 9, Pages 14: Optimizing the Design of Diatom Biosilica-Targeted Fusion Proteins in Biosensor Construction for Bacillus anthracis Detection Biology doi: 10.3390/biology9010014 Authors: Ford Xiong Hecht Squier Rorrer Roesijadi In vivo functionalization of diatom biosilica frustules by genetic manipulation requires careful consideration of the overall structure and function of complex fusion proteins. Although we previously had transformed Thalassiosira...
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Biomedicines, Vol. 8, Pages 8: The Gut Microbiome and Type 2 Diabetes Mellitus: Discussing a Complex Relationship Biomedicines doi: 10.3390/biomedicines8010008 Authors: Sikalidis Maykish Type 2 diabetes mellitus (T2DM) is a disease that affects over 9% of the United States population and is closely linked to obesity. While obesity was once thought to stem from a sedentary lifestyle and diets high in fat, recent evidence supports the idea that there is more complexity pertinent to...
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Biomolecules, Vol. 10, Pages 104: IL10 rs1800872 Is Associated with Non-Steroidal Anti-Inflammatory Drugs Exacerbated Respiratory Disease in Mexican-Mestizo Patients Biomolecules doi: 10.3390/biom10010104 Authors: Gandhi Fernando Pavón-Romero Gloria Pérez-Rubio Fernando Ramírez-Jiménez Enrique Ambrocio-Ortiz Cristian Rubén Merino-Camacho Ramcés Falfán-Valencia Luis M. Teran Non-steroidal anti-inflammatory drugs (NSAID) exacerbated respiratory disease (N-ERD) is a disease...
Biomolecules, Vol. 10, Pages 102: Structure Modeling of the Norepinephrine Transporter Biomolecules doi: 10.3390/biom10010102 Authors: Góral Łątka Bajda The norepinephrine transporter (NET) is one of the monoamine transporters. Its X-ray crystal structure has not been obtained yet. Inhibitors of human NET (hNET) play a major role in the treatment of many central and peripheral nervous system diseases. In this study, we focused on the spatial structure of a NET constructed by...
Biomolecules, Vol. 10, Pages 103: Essential Oils of Lamiaceae Family Plants as Antifungals Biomolecules doi: 10.3390/biom10010103 Authors: Karpiński The incidence of fungal infections has been steadily increasing in recent years. Systemic mycoses are characterized by the highest mortality. At the same time, the frequency of infections caused by drug-resistant strains and new pathogens e.g., Candida auris increases. An alternative to medicines may be essential oils, which can have a...
Biomolecules, Vol. 10, Pages 98: Seed Priming with Jasmonic Acid Counteracts Root Knot Nematode Infection in Tomato by Modulating the Activity and Expression of Antioxidative Enzymes Biomolecules doi: 10.3390/biom10010098 Authors: Shagun Bali Parminder Kaur Vijay Lakshmi Jamwal Sumit G. Gandhi Anket Sharma Puja Ohri Renu Bhardwaj Mohammad Ajmal Ali Parvaiz Ahmad The environmental stress, biotic as well as abiotic, is the main cause of decreased growth and crop...
Biomolecules, Vol. 10, Pages 100: Autophagy Function and Regulation in Kidney Disease Biomolecules doi: 10.3390/biom10010100 Authors: Gur P. Kaushal Kiran Chandrashekar Luis A. Juncos Sudhir V. Shah Autophagy is a dynamic process by which intracellular damaged macromolecules and organelles are degraded and recycled for the synthesis of new cellular components. Basal autophagy in the kidney acts as a quality control system and is vital for cellular metabolic and organelle homeostasis....
Biomolecules, Vol. 10, Pages 101: Cell Penetrating Peptide as a High Safety Anti-Inflammation Ingredient for Cosmetic Applications Biomolecules doi: 10.3390/biom10010101 Authors: Fu Kuo Lu Lin Wang Kao Lai Chang Cosmeceutical peptides have become an important topic in recent decades in both academic and industrial fields. Many natural or synthetic peptides with different biological functions including anti-ageing, anti-oxidation, anti-infection and anti-pigmentation...
Biomolecules, Vol. 10, Pages 99: Combining Physiological and Metabolomic Analysis to Unravel the Regulations of Coronatine Alleviating Water Stress in Tobacco (Nicotiana tabacum L.) Biomolecules doi: 10.3390/biom10010099 Authors: Jiayang Xu Yuyi Zhou Zicheng Xu Zheng Chen Liusheng Duan Drought is a major abiotic stress that restricts plants growth, development, and yield. Coronatine (COR), a mimic of JA-Ile, functions in plant tolerance to multiple stresses. In our study,...
Biomolecules, Vol. 10, Pages 97: Cotranslational Folding of Proteins on the Ribosome Biomolecules doi: 10.3390/biom10010097 Authors: Marija Liutkute Ekaterina Samatova Marina V. Rodnina Many proteins in the cell fold cotranslationally within the restricted space of the polypeptide exit tunnel or at the surface of the ribosome. A growing body of evidence suggests that the ribosome can alter the folding trajectory in many different ways. In this review, we summarize the recent examples...
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Brain Sciences, Vol. 10, Pages 33: Neuromuscular Mechanisms Underlying Changes in Force Production during an Attentional Focus Task Brain Sciences doi: 10.3390/brainsci10010033 Authors: Wiseman Alizadeh Halperin Lahouti Snow Power Button We examined the effects of attentional focus cues on maximal voluntary force output of the elbow flexors and the underlying physiological mechanisms. Eleven males participated in two randomized experimental sessions. In each...
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Cancers, Vol. 12, Pages 145: The Aryl Hydrocarbon Receptor Is Expressed in Thyroid Carcinoma and Appears to Mediate Epithelial-Mesenchymal-Transition Cancers doi: 10.3390/cancers12010145 Authors: Sonia Moretti Nicole Nucci Elisa Menicali Silvia Morelli Vittorio Bini Renato Colella Martina Mandarano Angelo Sidoni Efisio Puxeddu Aryl hydrocarbon receptor (AhR) is expected to promote initiation, progression and invasion of cancer cells regulating proliferation, differentiation,...
Cancers, Vol. 12, Pages 144: Targeted Nano-Drug Delivery of Colchicine against Colon Cancer Cells by Means of Mesoporous Silica Nanoparticles Cancers doi: 10.3390/cancers12010144 Authors: AbouAitah Hassan Swiderska-Sroda Gohar Shaker Wojnarowicz Opalinska Smalc-Koziorowska Gierlotka Lojkowski Antimitotics are important anticancer agents and include the natural alkaloid prodrug colchicine (COL). However, a major challenge of using COL as an anticancer...
Cancers, Vol. 12, Pages 143: The Future of Immunotherapy-Based Combination Therapy in Metastatic Renal Cell Carcinoma Cancers doi: 10.3390/cancers12010143 Authors: Garje An Greco Vaddepally Zakharia In the past two decades, there has been a significant improvement in the understanding of the molecular pathogenesis of Renal Cell Carcinoma (RCC). These insights in the biological pathways have resulted in the development of multiple agents targeting vascular endothelial...
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Cells, Vol. 9, Pages 138: Mmi1, the Yeast Ortholog of Mammalian Translationally Controlled Tumor Protein (TCTP), Negatively Affects Rapamycin-Induced Autophagy in Post-Diauxic Growth Phase Cells doi: 10.3390/cells9010138 Authors: Vojtova Hasek Translationally controlled tumor protein (TCTP) is a multifunctional and highly conserved protein from yeast to humans. Recently, its role in non-selective autophagy has been reported with controversial results in mammalian and human cells....
Cells, Vol. 9, Pages 143: Weighted Correlation Network Analysis Reveals CDK2 as a Regulator of a Ubiquitous Environmental Toxin-Induced Cell-Cycle Arrest Cells doi: 10.3390/cells9010143 Authors: Dubourg Nolze Kopf Gekle Schwerdt Environmental food contaminants constitute a threat to human health. For instance, the globally spread mycotoxin Ochratoxin A (OTA) contributes to chronic kidney damage by affecting proximal tubule cells via unknown mechanisms. We applied a top-down...
Cells, Vol. 9, Pages 139: Hypoxic Adaptation of Mitochondrial Metabolism in Rat Cerebellum Decreases in Pregnancy Cells doi: 10.3390/cells9010139 Authors: Graf Trofimova Ksenofontov Baratova Bunik Function of brain amino acids as neurotransmitters or their precursors implies changes in the amino acid levels and/or metabolism in response to physiological and environmental challenges. Modelling such challenges by pregnancy and/or hypoxia, we characterize the amino acid...
Cells, Vol. 9, Pages 142: Dissecting Mechanisms of Melanoma Resistance to BRAF and MEK Inhibitors Revealed Genetic and Non-Genetic Patient- and Drug-Specific Alterations and Remarkable Phenotypic Plasticity Cells doi: 10.3390/cells9010142 Authors: Hartman Sztiller-Sikorska Gajos-Michniewicz Czyz The clinical benefit of MAPK pathway inhibition in BRAF-mutant melanoma patients is limited by the development of acquired resistance. Using drug-naïve cell lines derived...
Cells, Vol. 9, Pages 140: Sterculic Acid: The Mechanisms of Action beyond Stearoyl-CoA Desaturase Inhibition and Therapeutic Opportunities in Human Diseases Cells doi: 10.3390/cells9010140 Authors: Peláez Pariente Pérez-Sala Larráyoz In many tissues, stearoyl-CoA desaturase 1 (SCD1) catalyzes the biosynthesis of monounsaturated fatty acids (MUFAS),(i.e., palmitoleate and oleate) from their saturated fatty acid (SFA) precursors (i.e., palmitate and stearate), influencing...
Cells, Vol. 9, Pages 141: Investigating the Potential and Pitfalls of EV-Encapsulated MicroRNAs as Circulating Biomarkers of Breast Cancer Cells doi: 10.3390/cells9010141 Authors: Moloney Gilligan Joyce O’Neill O’Brien Khan Glynn Waldron Maguire Holian Naughton Elhadi Grealish Malone McDermott Dockery Ritter Prina-Mello Kerin Dwyer Extracellular vesicles (EVs) shuttle microRNA (miRNA) throughout the circulation...
Cells, Vol. 9, Pages 136: Delineating the Molecular Basis of the Calmodulin‒bMunc13-2 Interaction by Cross-Linking/Mass Spectrometry—Evidence for a Novel CaM Binding Motif in bMunc13-2 Cells doi: 10.3390/cells9010136 Authors: Piotrowski Moretti Ihling Haedicke Liepold Lipstein Meiler Jahn Sinz Exploring the interactions between the Ca2+ binding protein calmodulin (CaM) and its target proteins remains a challenging task. Members of the Munc13 protein family...
Cells, Vol. 9, Pages 137: RNA-Based Therapeutics: From Antisense Oligonucleotides to miRNAs Cells doi: 10.3390/cells9010137 Authors: Bajan Hutvagner The first therapeutic nucleic acid, a DNA oligonucleotide, was approved for clinical use in 1998. Twenty years later, in 2018, the first therapeutic RNA-based oligonucleotide was United States Food and Drug Administration (FDA) approved. This promises to be a rapidly expanding market, as many emerging biopharmaceutical companies are...
Cells, Vol. 9, Pages 144: Metformin Inhibits Tumor Metastasis through Suppressing Hsp90α Secretion in an AMPKα1-PKCγ Dependent Manner Cells doi: 10.3390/cells9010144 Authors: Gong Wang Jiang Zhang Feng Fu Luo Metformin has been documented in epidemiological studies to mitigate tumor progression. Previous reports show that metformin inhibits tumor migration in several cell lines, such as MCF-7 and H1299, but the mechanisms whereby metformin exerts its inhibitory...
Cells, Vol. 9, Pages 135: Post-Translational Modification and Natural Mutation of TRPC Channels Cells doi: 10.3390/cells9010135 Authors: Liu Yao Tsang : Transient Receptor Potential Canonical (TRPC) channels are homologues of Drosophila TRP channel first cloned in mammalian cells. TRPC family consists of seven members which are nonselective cation channels with a high Ca2+ permeability and are activated by a wide spectrum of stimuli. These channels are ubiquitously expressed...
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Climate, Vol. 8, Pages 8: Thermal Mitigation of the Indoor and Outdoor Climate by Green Curtains in Japanese Condominiums Climate doi: 10.3390/cli8010008 Authors: Abe Rijal Hiroki Iijima Ohta In recent years, “green curtains” have become one of the most prevalent thermal mitigation methods in Japan. They can be considered as green infrastructure for achieving thermal comfort and reducing energy use. To examine the thermal mitigation effect of the...
Climate, Vol. 8, Pages 7: Climate Change Adaptation Options for Coastal Communities and Local Governments Climate doi: 10.3390/cli8010007 Authors: Laura Sinay R. W. (Bill) Carter Extreme weather events and failure to adapt to the likely impacts of climate change are two of the most significant threats to humanity. Therefore, many local communities are preparing adaptation plans. Even so, much of what was done has not been published in the peer-reviewed literature. This means that...
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Dentistry Journal, Vol. 8, Pages 5: Promoting Inclusion Oral Health: Social Interventions to Reduce Oral Health Inequities Dentistry Journal doi: 10.3390/dj8010005 Authors: Ruth Freeman To advance our understanding of inclusion oral health and to address the impact of social exclusion upon oral health, this group of papers sets out to provide an argument for the need for social and community-based interventions, theoretically underpinned by pluralistic definitions of evidence-based practice...
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Diagnostics, Vol. 10, Pages 28: Enhanced Colorimetric Signal for Accurate Signal Detection in Paper-Based Biosensors Diagnostics doi: 10.3390/diagnostics10010028 Authors: Harpaz Eltzov Ng Marks Tok Abstract: Paper-based colorimetric biosensors combine the use of paper with colorimetric signal detection. However, they usually demonstrate lower sensitivities because a signal amplification procedure has not been used. Stopping the reaction of colorimetric signal generation...
Diagnostics, Vol. 10, Pages 27: Deep Learning Techniques for Automatic Detection of Embryonic Neurodevelopmental Disorders Diagnostics doi: 10.3390/diagnostics10010027 Authors: Attallah Sharkas Gadelkarim The increasing rates of neurodevelopmental disorders (NDs) are threatening pregnant women, parents, and clinicians caring for healthy infants and children. NDs can initially start through embryonic development due to several reasons. Up to three in 1000 pregnant women have...
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EJIHPE, Vol. 10, Pages 358-374: Role of Family Motivation, Workplace Civility and Self-Efficacy in Developing Affective Commmitment and Organizational Citizenship Behavior European Journal of Investigation in Health, Psychology and Education doi: 10.3390/ejihpe10010027 Authors: Humaira Erum Ghulam Abid Francoise Contreras Talat Islam The mechanism connecting the antecedents to positive attitudes like affective commitment (AC) and positive behaviors like organizational citizenship...
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Fermentation, Vol. 6, Pages 6: Removal of Small-Molecular Byproducts from Crude Fructo-Oligosaccharide Preparations by Fermentation Using the Endospore-Forming Probiotic Bacillus coagulans Fermentation doi: 10.3390/fermentation6010006 Authors: Fan Burghardt Xiong Czermak Short-chain prebiotic fructo-oligosaccharides (FOS) produced by enzymatic conversion from sucrose often contains high concentration of monosaccharides as byproducts. In addition to conventional physical/chemical...
Fermentation, Vol. 6, Pages 5: Identification of Yeasts with Mass Spectrometry during Wine Production Fermentation doi: 10.3390/fermentation6010005 Authors: Kačániová Kunová Sabo Ivanišová Žiarovská Felsöciová Terentjeva The aim of the present study was to identify yeasts in grape, new wine “federweisser” and unfiltered wine samples. A total amount of 30 grapes, 30 new wine samples and 30 wine samples (15 white and 15 red) were collected from...
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Foods, Vol. 9, Pages 62: Alpha-Cyclodextrin Attenuates the Glycemic and Insulinemic Impact of White Bread in Healthy Male Volunteers Foods doi: 10.3390/foods9010062 Authors: Bär Diamantis Venetz The demonstration of a physiological benefit has recently become an indispensible element of the definition of dietary fibers. In the here-reported pilot study, the effect of alpha-cyclodextrin (alpha-CD) on the postprandial glycemic and insulinemic effect of starch was examined. Twelve...
Foods, Vol. 9, Pages 63: Consumers’ Perceptions and Sensory Properties of Beef Patty Analogues Foods doi: 10.3390/foods9010063 Authors: Taylor Ahmed Al-Juhaimi Bekhit The present study was carried out to gain consumer insights on the use of tempeh (a fermented soy bean product) to improve the healthiness of beef patties and to determine the acceptable level of tempeh (10%, 20%, or 30%) in the patty. The study consisted of conducting two focus groups (n = 15), a pilot sensory...
Foods, Vol. 9, Pages 59: The Bactericidal Effect of a Combination of Food-Grade Compounds and their Application as Alternative Antibacterial Agents for Food Contact Surfaces Foods doi: 10.3390/foods9010059 Authors: Kyung Min Park Sung-Geon Yoon Tae-Ho Choi Hyun Jung Kim Kee Jai Park Minseon Koo Chemical antibacterials are widely used to control microbial growth but have raised concerns about health risks. It is necessary to find alternative, non-toxic antibacterial agents...
Foods, Vol. 9, Pages 60: Integral Valorization of Pineapple (Ananas comosus L.) By-Products through a Green Chemistry Approach towards Added Value Ingredients Foods doi: 10.3390/foods9010060 Authors: Campos Ribeiro Teixeira Pastrana Pintado Industrial by-products are produced every day through fruit processing industries. Pineapple is not an exception; when processed, around 60% (w/w) of its weight are peels, stem, trimmings, and crown, the only used fruit part for human...
Foods, Vol. 9, Pages 61: Effect of Different Starches on the Rheological, Sensory and Storage Attributes of Non-fat Set Yogurt Foods doi: 10.3390/foods9010061 Authors: Saleh Mohamed Alamri Hussain Qasem Ibraheem This study was conducted to investigate the effect of various native starches on the rheological and textural properties of non-fat set yogurt. The yogurt samples were prepared while using five types of starches (potato, sweet potato, corn, chickpea, and...
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IJERPH, Vol. 17, Pages 398: Improving Knowledge That Alcohol Can Cause Cancer Is Associated with Consumer Support for Alcohol Policies: Findings from a Real-World Alcohol Labelling Study International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020398 Authors: Weerasinghe Schoueri-Mychasiw Vallance Stockwell Hammond McGavock Greenfield Paradis Hobin Knowledge that alcohol can cause cancer is low in Canada. Alcohol labels are...
IJERPH, Vol. 17, Pages 389: Rumination and Emotional Profile in Children with Specific Learning Disorders and Their Parents International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020389 Authors: Paola Bonifacci Valentina Tobia Vanessa Marra Lorenzo Desideri Roberto Baiocco Cristina Ottaviani Rumination, namely a cognitive process characterized by a repetitive thinking focused on negative feelings and thoughts, is a significant predictor...
IJERPH, Vol. 17, Pages 397: Does “Rural” Always Mean the Same? Macrosocial Determinants of Rural Populations’ Health in Poland International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020397 Authors: Ucieklak-Jeż Bem Rural areas, as well as urban ones, are not homogeneous in terms of social and economic conditions. Those surrounding large urban centers (suburban rural areas) act different roles than those located in remote areas. This study aims to...
IJERPH, Vol. 17, Pages 393: Evidence for Environmental Noise Effects on Health for the United Kingdom Policy Context: A Systematic Review of the Effects of Environmental Noise on Mental Health, Wellbeing, Quality of Life, Cancer, Dementia, Birth, Reproductive Outcomes, and Cognition International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020393 Authors: Clark Crumpler Notley This systematic review commissioned by the UK Department for the Environment,...
IJERPH, Vol. 17, Pages 388: Cross-Sectional Associations of Physical Fitness Performance Level and Sleep Duration among Older Adults: Results from the National Physical Fitness Survey in Taiwan International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020388 Authors: Lee Ho Yeh Hung Chang Liu Tseng Hsieh Research on relationships between physical fitness and sleep duration among older adults is scarce, especially in Taiwanese...
IJERPH, Vol. 17, Pages 396: Gender Informed or Gender Ignored? Opportunities for Gender Transformative Approaches in Brief Alcohol Interventions on College Campuses International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020396 Authors: Lindsay Wolfson Julie Stinson Nancy Poole Brief alcohol interventions are an effective strategy for reducing harmful and risky alcohol use and misuse. Many effective brief alcohol interventions include information...
IJERPH, Vol. 17, Pages 386: High Willingness to Participate in Partner Notification among Women Attending Reproductive Health and STI Clinics in Shenzhen, China: A Cross-Sectional Study International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020386 Authors: Weng Yu Hong Zhang Wen Wang Luo Ye Tang Wang Chen Cai Genital Chlamydia trachomatis (CT) is one of the most common sexually transmitted infections (STI) worldwide....
IJERPH, Vol. 17, Pages 395: A Random Parameters Ordered Probit Analysis of Injury Severity in Truck Involved Rear-End Collisions International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020395 Authors: Shao Ma Chen Song Pan You Social and economic burdens caused by truck-involved rear-end collisions are of great concern to public health and the environment. However, few efforts focused on identifying the difference of impacting factors...
IJERPH, Vol. 17, Pages 394: Can Exposure to Certain Urban Green Spaces Trigger Frontal Alpha Asymmetry in the Brain?—Preliminary Findings from a Passive Task EEG Study International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020394 Authors: Olszewska-Guizzo Sia Fogel Ho A growing body of evidence from observational and experimental studies shows the associations between exposure to urban green spaces (UGSs) and mental health outcomes. Little...
IJERPH, Vol. 17, Pages 387: Factors Associated with Alcohol-Related Injuries for Aboriginal and Non-Aboriginal Australians: An Observational Study International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020387 Authors: Snijder Calabria Dobbins Shakeshaft Alcohol use and related injuries are a leading risk factor for deaths and disabilities in Australia, particularly for Aboriginal and Torres Strait Islander people. An improved understanding...
IJERPH, Vol. 17, Pages 391: An Assessment of the Performance of the PLUS+ Tool in Supporting the Evaluation of Water Framework Directive Compliance in Scottish Standing Waters International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020391 Authors: Donnelly Helliwell May McCreadie Phosphorus is one of the main causes of waterbodies in Scotland being at less than good ecological status (GES) in terms of the water framework directive (WFD). In...
IJERPH, Vol. 17, Pages 390: Pathways to Increasing Adolescent Physical Activity and Wellbeing: A Mediation Analysis of Intervention Components Designed Using a Participatory Approach International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020390 Authors: Corder Werneck Jong Hoare Brown Foubister Wilkinson van Sluijs We assessed which intervention components were associated with change in moderate-to-vigorous physical activity...
IJERPH, Vol. 17, Pages 392: An Experimental Strategy for Capturing the Margins of Prepared Single Teeth with an Intraoral Scanner: A Prospective Clinical Study on 30 Patients International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020392 Authors: Francesco Guido Mangano Bidzina Margiani Ivan Solop Nadezhda Latuta Oleg Admakin Purpose: To present an experimental strategy for successfully capturing the margins of prepared single teeth with an...
IJERPH, Vol. 17, Pages 383: Exposure Models for REACH and Occupational Safety and Health Regulations
IJERPH, Vol. 17, Pages 383: Exposure Models for REACH and Occupational Safety and Health Regulations International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020383 Authors: John William Cherrie Wouter Fransman Gerardus Antonius Henrikus Heussen Dorothea Koppisch Keld Alstrup Jensen Model tools for estimating hazardous substance exposure are an accepted part of regulatory risk assessments in Europe, and models underpin control banding tools used...
IJERPH, Vol. 17, Pages 384: Determinants of Bone Health Status in a Multi-Ethnic Population in Klang Valley, Malaysia International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020384 Authors: Chin Yi Chan Shaanthana Subramaniam Norazlina Mohamed Soelaiman Ima-Nirwana Norliza Muhammad Ahmad Fairus Pei Yuen Ng Nor Aini Jamil Noorazah Abd Aziz Kok-Yong Chin Background and objectives: Studies on osteoporosis risk factors are limited...
IJERPH, Vol. 17, Pages 382: Fertility Deterioration in a Remediated Petroleum-Contaminated Soil International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020382 Authors: Verónica Isidra Domínguez-Rodríguez Randy H. Adams Mariloli Vargas-Almeida Joel Zavala-Cruz Enrique Romero-Frasca A soil that had been remediated by soil washing and chemical oxidation was evaluated, comparing it to an uncontaminated control soil ~30 m away. Profile descriptions...
IJERPH, Vol. 17, Pages 385: Combinations of Epidemiological and Experimental Studies in Air Pollution Research: A Narrative Review International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020385 Authors: Hannah Weisenberg Tianyu Zhao Joachim Heinrich Scientific literature is evolving to include more systematic reviews that encompass epidemiological and experimental papers so that the whole picture can be examined. The aim of this narrative review is...
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IJMS, Vol. 21, Pages 382: New Insights into the Biological and Pharmaceutical Properties of Royal Jelly International Journal of Molecular Sciences doi: 10.3390/ijms21020382 Authors: Saboor Ahmad Maria Graça Campos Filippo Fratini Solomon Zewdu Altaye Jianke Li Royal jelly (RJ) is a yellowish-white and acidic secretion of hypopharyngeal and mandibular glands of nurse bees used to feed young worker larvae during the first three days and the entire life of queen bees. RJ is...
IJMS, Vol. 21, Pages 383: Revisiting the Pharmacological Value of Glucagon: An Editorial for the Special Issue “The Biology and Pharmacology of Glucagon” International Journal of Molecular Sciences doi: 10.3390/ijms21020383 Authors: Timo D. Müller Kirk Habegger In 1921, a Canadian research team led by Frederick Banting and John Macleod succeeded in the isolation of insulin from pancreatic homogenate [...]
IJMS, Vol. 21, Pages 379: Recent Advances in Lipopolysaccharide Recognition Systems International Journal of Molecular Sciences doi: 10.3390/ijms21020379 Authors: Mazgaeen Gurung Lipopolysaccharide (LPS), commonly known as endotoxin, is ubiquitous and the most-studied pathogen-associated molecular pattern. A component of Gram-negative bacteria, extracellular LPS is sensed by our immune system via the toll-like receptor (TLR)-4. Given that TLR4 is membrane bound, it recognizes LPS...
IJMS, Vol. 21, Pages 380: TNF-Block Genotypes Influence Susceptibility to HIV-Associated Sensory Neuropathy in Indonesians and South Africans International Journal of Molecular Sciences doi: 10.3390/ijms21020380 Authors: Gaff Octaviana Pillay Mbenda Ariyanto Gan Cherry Kamerman Laws Price HIV-associated sensory neuropathy (HIV-SN) is a disabling complication of HIV disease and antiretroviral therapies (ART). Since stavudine was removed from recommended...
IJMS, Vol. 21, Pages 381: Preclinical Activity of Embryonic Annexin A2-Specific Chimeric Antigen Receptor T Cells Against Ovarian Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21020381 Authors: Leong Tan Cua Yong Chen Choo Chimeric antigen receptors (CARs) have found clinical success in B cell malignancies, but a dearth of potential targets limits their wider clinical application, especially in solid tumours. Here, we describe the development...
IJMS, Vol. 21, Pages 378: The Novel Synthetic Peptide AESIS-1 Exerts a Preventive Effect on Collagen-Induced Arthritis Mouse Model via STAT3 Suppression International Journal of Molecular Sciences doi: 10.3390/ijms21020378 Authors: Kim Jeon Song Kim Jung Kim Park Park Park Park Cho Rheumatoid arthritis (RA) is a chronic autoimmune disease that is associated with systemic inflammation and results in the destruction of joints and cartilage. The...
IJMS, Vol. 21, Pages 377: Correction: Abbasi, A. et al. Poly(2,6-dimethyl-1,4-phenylene oxide)-Based Hydroxide Exchange Separator Membranes for Zinc-Air Battery. Int. J. Mol. Sci. 2019, 20, 3678 International Journal of Molecular Sciences doi: 10.3390/ijms21020377 Authors: Abbasi Hosseini Somwangthanaroj Mohamad Kheawhom The authors would like to make the following corrections to their paper published in the International Journal of Molecular Science [...]
IJMS, Vol. 21, Pages 376: Na+-Coupled Nutrient Cotransport Induced Luminal Negative Potential and Claudin-15 Play an Important Role in Paracellular Na+ Recycling in Mouse Small Intestine International Journal of Molecular Sciences doi: 10.3390/ijms21020376 Authors: Nakayama Ishizuka Hempstock Ikari Hayashi Many nutrients are absorbed via Na+ cotransport systems, and therefore it is predicted that nutrient absorption mechanisms require a large amount of luminal Na+. It...
IJMS, Vol. 21, Pages 374: Effect of 15 BMI-Associated Polymorphisms, Reported for Europeans, across Ethnicities and Degrees of Amerindian Ancestry in Mexican Children International Journal of Molecular Sciences doi: 10.3390/ijms21020374 Authors: Paula Costa-Urrutia Carolina Abud Valentina Franco-Trecu Valentina Colistro Martha Eunice Rodríguez-Arellano Rafael Alvarez-Fariña Víctor Acuña Alonso Bernardo Bertoni Julio Granados In Mexico, the genetic mechanisms underlying...
IJMS, Vol. 21, Pages 373: Campylobacter concisus Impairs Sodium Absorption in Colonic Epithelium via ENaC Dysfunction and Claudin-8 Disruption International Journal of Molecular Sciences doi: 10.3390/ijms21020373 Authors: Praveen Kumar Nattramilarasu Roland Bücker Fábia Daniela Lobo de Sá Anja Fromm Oliver Nagel In-Fah Maria Lee Eduard Butkevych Soraya Mousavi Claudia Genger Sigri Kløve Markus M. Heimesaat Stefan Bereswill Michal R. Schweiger Hans Linde...
IJMS, Vol. 21, Pages 375: Structure and Stoichiometry of the Ton Molecular Motor International Journal of Molecular Sciences doi: 10.3390/ijms21020375 Authors: Celia Noinaj Buchanan The Ton complex is a molecular motor that uses the proton gradient at the inner membrane of Gram-negative bacteria to generate force and movement, which are transmitted to transporters at the outer membrane, allowing the entry of nutrients into the periplasmic space. Despite decades of investigation...
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JCM, Vol. 9, Pages 165: Rho Kinase Activity, Connexin 40, and Atrial Fibrillation: Mechanistic Insights from End-Stage Renal Disease on Dialysis Patients Journal of Clinical Medicine doi: 10.3390/jcm9010165 Authors: Calò Ravarotto Bertoldi Pagnin Rossi Rigato Davis Proietti Evidence on cellular/molecular mechanisms leading to atrial fibrillation (AF) are scanty. Increased expression of Rho kinase (ROCK) and myosin-phosphatase-target subunit-1 (MYPT-1), ROCK...
JCM, Vol. 9, Pages 164: Heart-Type Fatty Acid-Binding Protein (H-FABP) and its Role as a Biomarker in Heart Failure: What Do We Know So Far? Journal of Clinical Medicine doi: 10.3390/jcm9010164 Authors: Rezar Jirak Gschwandtner Derler Felder Haslinger Kopp Seelmaier Granitz Hoppe Lichtenauer Background: Heart failure (HF) remains one of the leading causes of death to date despite extensive research funding. Various studies are conducted every...
JCM, Vol. 9, Pages 166: Walking Speed: Japanese Data in Chronic Liver Diseases Journal of Clinical Medicine doi: 10.3390/jcm9010166 Authors: Nishikawa Enomoto Yoh Iwata Sakai Kishino Ikeda Takashima Aizawa Takata Hasegawa Ishii Yuri Nishimura Iijima Nishiguchi We aim to clarify the impact of walking speed (WS) and analyze factors linked to WS decline in patients with chronic liver diseases (CLDs, 165 males and 191 females,...
JCM, Vol. 9, Pages 160: Remote Ischemic Preconditioning Neither Improves Survival nor Reduces Myocardial or Kidney Injury in Patients Undergoing Transcatheter Aortic Valve Implantation (TAVI) Journal of Clinical Medicine doi: 10.3390/jcm9010160 Authors: Mandy Flechsig Tobias F. Ruf Willi Troeger Stephan Wiedemann Silvio Quick Karim Ibrahim Christian Pfluecke Akram Youssef Krunoslav M. Sveric Robert Winzer Frank R. Heinzel Axel Linke Ruth H. Strasser Kun...
JCM, Vol. 9, Pages 162: Nocturnal Hypoxemia Impacts Right Ventricle Diastolic Function in Obstructive Sleep Apnea: A Retrospective Observational Study Journal of Clinical Medicine doi: 10.3390/jcm9010162 Authors: Scotti Porta Olivares Comini Cinelli Scalvini Vitacca Obstructive sleep apnea (OSA), although a growing healthcare problem and documented risk factor for cardiovascular diseases, is still under-diagnosed in cardiac patients. To investigate the correlation...
JCM, Vol. 9, Pages 161: The Serum Cell-Free microRNA Expression Profile in MCTD, SLE, SSc, and RA Patients Journal of Clinical Medicine doi: 10.3390/jcm9010161 Authors: Stypinska Wajda Walczuk Olesinska Lewandowska Walczyk Paradowska-Gorycka Mixed connective tissue disease (MCTD) is a rare disorder characterized by symptoms that overlap two or more Autoimmune Connective Tissue Diseases (ACTDs). The aim of this study was to determine whether miRNAs participating...
JCM, Vol. 9, Pages 159: Prognostic Abilities of Serial Neuron-Specific Enolase and Lactate and their Combination in Cardiac Arrest Survivors During Targeted Temperature Management Journal of Clinical Medicine doi: 10.3390/jcm9010159 Authors: Ryoo Kim Sohn Ahn Seo Kim This study aimed to determine the prognostic ability of serial neuron-specific enolase (NSE) and lactate in cardiac arrest survivors treated with targeted temperature management (TTM) and to investigate...
JCM, Vol. 9, Pages 163: Associations between Daily Step Counts and Physical Fitness in Preschool Children Journal of Clinical Medicine doi: 10.3390/jcm9010163 Authors: Fang Zhang Zhou Li Lu Gao Quan Purpose: To investigate the relationships between daily step counts and physical fitness in preschool children. Methods: Preschoolers’ step counts were assessed by ActiGraph accelerometers consecutively for seven days. Physical fitness was assessed by a...
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Medicina, Vol. 56, Pages 21: Pain and Function in the Runner a Ten (din) uous Link Medicina doi: 10.3390/medicina56010021 Authors: Francis Thornley Jones Johnson A male runner (30 years old; 10-km time: 33 min, 46 sec) had been running with suspected insertional Achilles tendinopathy (AT) for ~2 years when the pain reached a threshold that prevented running. Diagnostic ultrasound (US), prior to a high-volume stripping injection, confirmed right-sided medial insertional AT....
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Membranes, Vol. 10, Pages 12: Monitoring the Interfacial Polymerization of Piperazine and Trimesoyl Chloride with Hydrophilic Interlayer or Macromolecular Additive by In Situ FT-IR Spectroscopy Membranes doi: 10.3390/membranes10010012 Authors: Yang The interfacial polymerization (IP) of piperazine (PIP) and trimesoyl chloride (TMC) has been extensively utilized to synthesize nanofiltration (NF) membranes. However, it is still a huge challenge to monitor the IP reaction, because of the...
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Metabolites, Vol. 10, Pages 27: Effects of Thymoquinone on Small-Molecule Metabolites in a Rat Model of Cerebral Ischemia Reperfusion Injury Assessed using MALDI-MSI Metabolites doi: 10.3390/metabo10010027 Authors: Tian Liu Fan Sun Huang Nie Zhao Pu Thymoquinone is one of the main components present in Nigella sativa seeds and is known to have various biological functions in inflammation, oxidative stress, tumors, aging, and in lowering blood glucose levels....
Metabolites, Vol. 10, Pages 26: Targeted Analysis of 46 Bile Acids to Study the Effect of Acetaminophen in Rat by LC-MS/MS Metabolites doi: 10.3390/metabo10010026 Authors: Vivaldy Prinville Leanne Ohlund Lekha Sleno Bile acids represent a large class of steroid acids synthesized in the liver and further metabolized by many bacterial and mammalian enzymes. Variations in bile acid levels can be used as a measure of liver function. There still exists, however, a need to study the...
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Microorganisms, Vol. 8, Pages 82: Evaluation and Predictive Modeling of Removal Condition for Bioadsorption of Indigo Blue Dye by Spirulina platensis Microorganisms doi: 10.3390/microorganisms8010082 Authors: Robledo-Padilla Aquines Silva-Núñez Alemán-Nava Castillo-Zacarías Ramirez-Mendoza Zavala-Yoe Iqbal Parra-Saldívar Among the different chemical and physical treatments used to remove the color of the textile effluents, bioremediation offers many benefits...
Microorganisms, Vol. 8, Pages 81: Transfigured Morphology and Ameliorated Production of Six Monascus Pigments by Acetate Species Supplementation in Monascus ruber M7 Microorganisms doi: 10.3390/microorganisms8010081 Authors: Virk Ramzan Virk Yuan Chen Monascus species have been used for the production of many industrially and medically important metabolites, most of which are polyketides produced by the action of polyketide synthases that use acetyl-CoA and malonyl-CoA...
Microorganisms, Vol. 8, Pages 83: Inoculation with Rhizophagus Irregularis Does Not Alter Arbuscular Mycorrhizal Fungal Community Structure within the Roots of Corn, Wheat, and Soybean Crops Microorganisms doi: 10.3390/microorganisms8010083 Authors: Renaut Daoud Masse Vialle Hijri Little is known about establishment success of the arbuscular mycorrhizal fungal (AMF) inocula and their effects on a soil-indigenous community of AMF. In this study, we assessed the effect...
Microorganisms, Vol. 8, Pages 80: Yeast Diversity Associated with the Phylloplane of Corn Plants Cultivated in Thailand Microorganisms doi: 10.3390/microorganisms8010080 Authors: Into Pontes Sampaio Limtong The ecology and diversity of phylloplane yeasts is less well understood in tropical regions than in temperate ones. Therefore, we investigated the yeast diversity associated with the phylloplane of corn, an economically important crop in Thailand, by a culture-dependent...
Microorganisms, Vol. 8, Pages 79: Evaluation of Immunomodulatory Activities of the Heat-Killed Probiotic Strain Lactobacillus casei IMAU60214 on Macrophages In Vitro Microorganisms doi: 10.3390/microorganisms8010079 Authors: Rocha-Ramírez Hernández-Ochoa Gómez-Manzo Marcial-Quino Cárdenas-Rodríguez Centeno-Leija García-Garibay Most Lactobacillus species have beneficial immunological (“immunoprobiotic”) effects in the host. However, it is unclear...
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Molbank, Vol. 2020, Article M1104: N′-Acetyl-3-methyl-1,6-diphenyl-1H-pyrazolo[3,4-b]pyridine-4-carbohydrazide Molbank doi: 10.3390/M1104 Authors: Soares Dias Synthesis of N′-acetyl-3-methyl-1,6-diphenyl-1H-pyrazolo[3,4-b]pyridine-4-carbohydrazide from the phenyl acetates of 3-acetyl-5-(3-methyl-1,6-diphenyl-1H-pyrazolo[3,4-b]pyridine-4-yl)-2,3-dihydro-1,3,4-oxadiazol-2-yl in alkaline medium and its characterization by spectroscopic methods.
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Molecules, Vol. 25, Pages 249: UV/Vis Light Induced Degradation of Oxytetracycline Hydrochloride Mediated byCo-TiO2 Nanoparticles Molecules doi: 10.3390/molecules25020249 Authors: Akel Boughaled Dillert El Azzouzi Bahnemann Pharmaceuticals, especially antibiotics, constitute an important group of aquatic contaminants given their environmental impact. Specifically, tetracycline antibiotics (TCs) are produced in great amounts for the treatment of bacterial infections in...
Molecules, Vol. 25, Pages 246: A New Look into the Mode of Action of Metal-Based Anticancer Drugs Molecules doi: 10.3390/molecules25020246 Authors: Marques Batista de Carvalho Mamede Dopplapudi Rudić Tyagi Garcia Sakai Batista de Carvalho The mode of action of Pt- and Pd-based anticancer agents (cisplatin and Pd2Spm) was studied by characterising their impact on DNA. Changes in conformation and mobility at the molecular level in hydrated DNA were analysed...
Molecules, Vol. 25, Pages 247: Caffeic Acid Attenuates Multi-Drug Resistance in Cancer Cells by Inhibiting Efflux Function of Human P-glycoprotein Molecules doi: 10.3390/molecules25020247 Authors: Teng Wang Liao Lan Hung : Multidrug resistance (MDR) is a complicated ever-changing problem in cancer treatment, and P-glycoprotein (P-gp), a drug efflux pump, is regarded as the major cause. In the way of developing P-gp inhibitors, natural products such as phenolic acids...
Molecules, Vol. 25, Pages 248: BC2L-C N-Terminal Lectin Domain Complexed with Histo Blood Group Oligosaccharides Provides New Structural Information Molecules doi: 10.3390/molecules25020248 Authors: Bermeo Bernardi Varrot Lectins mediate adhesion of pathogens to host tissues, filling in a key role in the first steps of infection. Belonging to the opportunistic pathogen Burkholderia cenocepacia, BC2L-C is a superlectin with dual carbohydrate specificity, believed to mediate cross-linking...
Molecules, Vol. 25, Pages 244: The Application of Reversible Intramolecular Sulfonamide Ligation to Modulate Reactivity in Organometallic Ruthenium(II) Diamine Complexes Molecules doi: 10.3390/molecules25020244 Authors: Samuel A. Kemp Timothy J. Prior Huguette Savoie Ross W. Boyle Benjamin S. Murray Metallation of biomacromolecular species forms the basis for the anticancer activity of many metallodrugs. A major limitation of these compounds is that their reactivity is indiscriminate...
Molecules, Vol. 25, Pages 243: Thermodynamic and Kinetic Study of Diels–Alder Reaction between Furfuryl Alcohol and N-Hydroxymaleimides—An Assessment for Materials Application Molecules doi: 10.3390/molecules25020243 Authors: Jamerson Carneiro de Oliveira Marie-Pierre Laborie Vincent Roucoules The study of Diels–Alder reactions in materials science is of increasing interest. The main reason for that is the potential thermoreversibility of the reaction. Aiming to predict...
Molecules, Vol. 25, Pages 245: Identification of Odor Active Compounds in Physalis peruviana L. Molecules doi: 10.3390/molecules25020245 Authors: Małgorzata A. Majcher Magdalena Scheibe Henryk H. Jeleń The volatiles of cape gooseberry fruit (Physalis peruviana L.) were isolated by solvent-assisted flavor evaporation (SAFE), odor active compounds identified by gas chromatography–olfactometry (GC-O) and gas chromatography–mass spectrometry (GC-MS). Quantitation...
Molecules, Vol. 25, Pages 241: Ag Nanoparticles Stabilized on Cyclodextrin Polymer Decorated with Multi-Nitrogen Atom Containing Polymer: An Efficient Catalyst for the Synthesis of Xanthenes Molecules doi: 10.3390/molecules25020241 Authors: Sadjadi Ghoreyshi Kahangi Dorraj Heravi In attempt to broaden the use of cyclodextrin polymer for catalytic purposes, a novel covalent hybrid system was prepared through growth of multi-nitrogen atom containing polymer (PMelamine) derived...
Molecules, Vol. 25, Pages 242: In Vitro Anthelmintic Activity of Saponins from Medicago spp. against Sheep Gastrointestinal Nematodes Molecules doi: 10.3390/molecules25020242 Authors: Maestrini Tava Mancini Tedesco Perrucci Gastrointestinal strongyle nematodes (GIS) are included among the most important parasites of small ruminants. The widespread drug resistance and drug residues in products of animal origin have increased the interest in the search for natural compounds...
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Nanomaterials, Vol. 10, Pages 115: An Emerging Visible-Light Organic–Inorganic Hybrid Perovskite for Photocatalytic Applications Nanomaterials doi: 10.3390/nano10010115 Authors: Bianca-Maria Bresolin Samia Ben Hammouda Mika Sillanpää The development of visible-light active photocatalysts is a current challenge especially energy and environmental-related fields. Herein, methylammonium lead iodide perovskite (MAIPb) was chosen as the novel semiconductor material for its ability of...
Nanomaterials, Vol. 10, Pages 114: Strong Biomimetic Immobilization of Pt-Particle Catalyst on ABS Substrate Using Polydopamine and Its Application for Contact-Lens Cleaning with H2O2 Nanomaterials doi: 10.3390/nano10010114 Authors: Ohkubo Aoki Kaibara Seino Mori Sasaki Endo Yamamura Polydopamine (PDA)—a known adhesive coating material—was used herein to strongly immobilize a Pt-particle catalyst on an acrylonitrile–butadiene–styrene...
Nanomaterials, Vol. 10, Pages 113: Effect of Graphene Oxide/Graphene Hybrid on Mechanical Properties of Cement Mortar and Mechanism Investigation Nanomaterials doi: 10.3390/nano10010113 Authors: Hongfang Sun Li Ling Zhili Ren Shazim Ali Memon Feng Xing This paper evaluated the effect of graphene oxide/graphene (GO/GR) hybrid on mechanical properties of cement mortar. The underlying mechanism was also investigated. In the GO/GR hybrid, GO was expected to act as a dispersant...
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Nutrients, Vol. 12, Pages 171: Sugar Reduction in Yogurt Products Sold in the UK between 2016 and 2019 Nutrients doi: 10.3390/nu12010171 Authors: J. Bernadette Moore Eiméar H. Sutton Neil Hancock The UK government has called for industry reformulation of foods that contribute most to sugar consumption in children’s diets, including yogurts. The aim of this work was to comprehensively survey yogurt products available in UK supermarkets in 2019 to determine whether sugar...
Nutrients, Vol. 12, Pages 168: Use of Mid-Upper Arm Circumference (MUAC) to Predict Malnutrition among Sri Lankan Schoolchildren Nutrients doi: 10.3390/nu12010168 Authors: Shinsugi Gunasekara Takimoto The double burden of malnutrition (under- and overnutrition) is a serious public health issue in childhood. The mid-upper arm circumference (MUAC) is a simple tool for screening nutritional status, but studies of the optimal cutoff to define malnutrition are limited. This study...
Nutrients, Vol. 12, Pages 170: Patterns of Weight Change One Year after Delivery Are Associated with Cardiometabolic Risk Factors at Six Years Postpartum in Mexican Women Nutrients doi: 10.3390/nu12010170 Authors: Soria-Contreras Trejo-Valdivia Cantoral Pizano-Zárate Baccarelli Just Colicino Deierlein Wright Oken Téllez-Rojo López-Ridaura Pregnancy is a contributor to the obesity epidemic in women, probably through postpartum weight retention...
Nutrients, Vol. 12, Pages 165: NCM 1921, a Mixture of Several Ingredients, Including Fatty Acids and Choline, Attenuates Atopic Dermatitis in 1-Chloro-2,4-Dinitrobenzene-Treated NC/Nga Mice Nutrients doi: 10.3390/nu12010165 Authors: Lee Yang Jo Shin Lee Park Kim Atopic dermatitis (AD) is a chronic inflammatory skin disease in humans. In this study, we evaluated the effects of a mixture (NCM 1921) of omega-3 butter, omega-3 beef tallow oil, omega-3 lard oil, caprylic...
Nutrients, Vol. 12, Pages 167: The Influence of Socioeconomic Status on Snacking and Weight among Adolescents: A Scoping Review Nutrients doi: 10.3390/nu12010167 Authors: Williamson Dilip Dillard Morgan-Daniel Lee Cardel Eating behaviors, including unhealthy snacking or excessive snacking leading to excess calorie consumption, may contribute to obesity among adolescents. Socioeconomic status (SES) also significantly influences eating behaviors, and low SES is associated...
Nutrients, Vol. 12, Pages 166: Discharging Women with Advanced Ovarian Cancer on Home Parenteral Nutrition: Making and Implementing the Decision Nutrients doi: 10.3390/nu12010166 Authors: Sowerbutts Lal Sremanakova Clamp Jayson Teubner Hardy Todd Raftery Sutton Burden Increasingly, patients with advanced ovarian cancer in bowel obstruction are receiving home parenteral nutrition (HPN). Little is known about making and implementing the decision....
Nutrients, Vol. 12, Pages 169: Impact of Nutrition on Pulmonary Arterial Hypertension Nutrients doi: 10.3390/nu12010169 Authors: Callejo Barberá Duarte Perez-Vizcaino Pulmonary arterial hypertension (PAH) is characterized by sustained vasoconstriction, vascular remodeling, inflammation, and in situ thrombosis. Although there have been important advances in the knowledge of the pathophysiology of PAH, it remains a debilitating, limiting, and rapidly progressive disease. Vitamin...
Nutrients, Vol. 12, Pages 163: All You Can Feed: Some Comments on Production of Mouse Diets Used in Biomedical Research with Special Emphasis on Non-Alcoholic Fatty Liver Disease Research Nutrients doi: 10.3390/nu12010163 Authors: Weiskirchen Weiper Tolba Weiskirchen The laboratory mouse is the most common used mammalian research model in biomedical research. Usually these animals are maintained in germ-free, gnotobiotic, or specific-pathogen-free facilities. In these facilities,...
Nutrients, Vol. 12, Pages 164: Herba Houttuyniae Extract Benefits Hyperlipidemic Mice via Activation of the AMPK/PGC-1α/Nrf2 Cascade Nutrients doi: 10.3390/nu12010164 Authors: Cao Lv Liu Fan Wang Feng Liu Zang Xing Liu Hyperlipidemia is associated with metabolic disorders, but the detailed mechanisms and related interventions remain largely unclear. As a functional food in Asian diets, Herba houttuyniae has been reported to have beneficial effects...
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Pharmaceuticals, Vol. 13, Pages 9: Mitogen-Activated Protein Kinase Inhibitors and T-Cell-Dependent Immunotherapy in Cancer Pharmaceuticals doi: 10.3390/ph13010009 Authors: Sandeep Kumar Daniel R. Principe Sunil Kumar Singh Navin Viswakarma Gautam Sondarva Basabi Rana Ajay Rana Mitogen-activated protein kinase (MAPK) signaling networks serve to regulate a wide range of physiologic and cancer-associated cell processes. For instance, a variety of oncogenic mutations often...
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Pharmaceutics, Vol. 12, Pages 51: Clay-Polymer Nanocomposites Prepared by Reactive Melt Extrusion for Sustained Drug Release Pharmaceutics doi: 10.3390/pharmaceutics12010051 Authors: Liu Lu Su Kun Zhang Abstract: Clay–polymer nanocomposites have exhibited a great potential as carriers for controlled release drug delivery. This study aims to prepare exfoliated montmorillonite–Eudragit RS nanocomposites using reactive melt extrusion and investigate...
Pharmaceutics, Vol. 12, Pages 48: In Vitro, Ex Vivo and In Vivo Evaluation of Microcontainers for Oral Delivery of Insulin Pharmaceutics doi: 10.3390/pharmaceutics12010048 Authors: Jørgensen Yu Venkatasubramanian Nielsen Nielsen Boisen Rades Müllertz Enhancing the oral bioavailability of peptides has received a lot of attention for decades but remains challenging, partly due to low intestinal membrane permeability. Combining a permeation enhancer (PE) with...
Pharmaceutics, Vol. 12, Pages 50: Metallic Nanoparticle-Based Optical Cell Chip for Nondestructive Monitoring of Intra/Extracellular Signals Pharmaceutics doi: 10.3390/pharmaceutics12010050 Authors: Lee Choi Cho Choi The biosensing platform is noteworthy for high sensitivity and precise detection of target analytes, which are related to the status of cells or specific diseases. The modification of the transducers with metallic nanoparticles (MNPs) has attracted attention...
Pharmaceutics, Vol. 12, Pages 49: Extended Intake of Mulberry Leaf Extract Delayed Metformin Elimination via Inhibiting the Organic Cation Transporter 2 Pharmaceutics doi: 10.3390/pharmaceutics12010049 Authors: Huh Na Bang Kim Kim Kim Kang Kim Baek Lee Cho Diabetes mellitus (DM) has become a major health problem in most countries of the world. DM causes many complications, including hyperglycemia, diabetic ketoacidosis, and death. In Asia, mulberry...
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Plants, Vol. 9, Pages 78: Roots and Leaf Extracts of Dipsacus fullonum L. and Their Biological Activities Plants doi: 10.3390/plants9010078 Authors: Jan Oszmiański Aneta Wojdyło Piotr Juszczyk Paulina Nowicka The aim of the study was to identify and evaluate the content of iridoids and phenolic compounds in the leaves and roots of Dipsacus fullonum L. They were identified and quantified by UPLC-PDA-MS/MS. Five iridoid compounds (loganic acid, loganin, sweroside, cantleyoside,...
Plants, Vol. 9, Pages 77: Studying the Influence of Apple Peel Polyphenol Extract Fortification on the Characteristics of Probiotic Yoghurt Plants doi: 10.3390/plants9010077 Authors: Ishtiaque Ahmad Anjum Khalique Muhammad Qamar Shahid Abdul Ahid Rashid Furukh Faiz Muhammad Asim Ikram Sheraz Ahmed Muhammad Imran Muhammad Asif Khan Muhammad Nadeem Muhammad Inam Afzal Muhammad Umer Kaleem Imdad Muhammad Shahbaz Bilal Rasool The aim of the current...
Plants, Vol. 9, Pages 76: Effects of Endophytic Bacillus Subtilis and Salicylic Acid on Postharvest Diseases (Phytophthora infestans, Fusarium oxysporum) Development in Stored Potato Tubers Plants doi: 10.3390/plants9010076 Authors: Oksana Lastochkina Andrey Baymiev Aysylu Shayahmetova Darya Garshina Igor Koryakov Irina Shpirnaya Liudmila Pusenkova Il’dar Mardanshin Cemal Kasnak Recep Palamutoglu Postharvest diseases of potato lead to significant food and economic...
Plants, Vol. 9, Pages 75: Potassium Application Improves Grain Yield and Alleviates Drought Susceptibility in Diverse Maize Hybrids Plants doi: 10.3390/plants9010075 Authors: Sami Ul-Allah Muhammad Ijaz Ahmad Nawaz Abdul Sattar Ahmed Sher Muhammad Naeem Umbreen Shahzad Umar Farooq Farukh Nawaz Khalid Mahmood Maize (Zea mays L.) is an important component of global food security but its production is threatened by abiotic stresses in climate change scenarios,...
Plants, Vol. 9, Pages 74: Symbionts as Filters of Plant Colonization of Islands: Tests of Expected Patterns and Environmental Consequences in the Galapagos Plants doi: 10.3390/plants9010074 Authors: Duchicela Bever Schultz The establishments of new organisms that arrive naturally or with anthropogenic assistance depend primarily on local conditions, including biotic interactions. We hypothesized that plants that rely on fungal symbionts are less likely to successfully colonize...
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Safety, Vol. 6, Pages 4: Retraction: Pavarin R.M. Alcohol Misuse Among Young Adults in Northern Italy. Safety 2019, 5, 31 Safety doi: 10.3390/safety6010004 Authors: Safety Editorial Office Safety Editorial Office Since publication, we have investigated more closely the ethical procedures associated with the title article [...]
Safety, Vol. 6, Pages 3: Analysis of Recommendations from Mining Incident Investigative Reports: A 50-Year Review Safety doi: 10.3390/safety6010003 Authors: Tetzlaff Eger Pegoraro Dorman Pakalnis A systematic analysis was conducted using ten occupational health and safety commissioned reports from Canada, New Zealand, United States, United Kingdom, and Australia spanning from 1967 to 2015. The objective was to identify commonalities and differences in the key recommendations...
Safety, Vol. 6, Pages 2: Quality Control of the Anchoring of Steel Bridge Barriers by Non-Destructive Testing Safety doi: 10.3390/safety6010002 Authors: Komárková Láník Ondřej Traffic barriers represent one of the basic road safety features. There are several types of traffic barriers based on the material from which they are made of and their location. Bridge structures are usually fitted with steel barriers. A steel barrier is, in fact, a relatively complex system linking...
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Sports, Vol. 8, Pages 5: Relative Age Effect of Sport Academy Adolescents, a Physiological Evaluation Sports doi: 10.3390/sports8010005 Authors: Ek Wollmer Karlsson Peterson Thorsson Olsson Malmborg Dencker The relationship between birth quarter distribution and physiological characteristics related to athletic skills, in adolescent sport academy students has not been fully investigated. In a cross-sectional study, we recruited 86 boys and 52 girls aged 12–14...
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Toxins, Vol. 12, Pages 39: Morphological and Molecular Identification of Microcystin-Producing Cyanobacteria in Nine Shallow Bulgarian Water Bodies Toxins doi: 10.3390/toxins12010039 Authors: Mariana Radkova Katerina Stefanova Blagoy Uzunov Georg Gärtner Maya Stoyneva-Gärtner The paper presents results from the first application of polyphasic approach in studies of field samples from Bulgaria. This approach, which combined the conventional light microscopy (LM) and molecular-genetic...
Toxins, Vol. 12, Pages 38: An Inducible Cre-lox System to Analyze the Role of LLO in Listeria monocytogenes Pathogenesis Toxins doi: 10.3390/toxins12010038 Authors: Nguyen Portnoy Listeriolysin O (LLO) is a pore-forming cytolysin that allows Listeria monocytogenes to escape from phagocytic vacuoles and enter the host cell cytosol. LLO is expressed continuously during infection, but it has been a challenge to evaluate the importance of LLO secreted in the host cell cytosol because...
Toxins, Vol. 12, Pages 37: Comprehensive Evaluation of the Efficiency of Yeast Cell Wall Extract to Adsorb Ochratoxin A and Mitigate Accumulation of the Toxin in Broiler Chickens Toxins doi: 10.3390/toxins12010037 Authors: Vartiainen Yiannikouris Apajalahti Moran Ochratoxin A (OTA) is a common mycotoxin contaminant in animal feed. When absorbed from the gastrointestinal tract, OTA has a propensity for pathological effects on animal health and deposition in animal tissues....
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Viruses, Vol. 12, Pages 72: Obstetric Ultrasonography to Detect Fetal Abnormalities in a Mouse Model for Zika Virus Infection Viruses doi: 10.3390/v12010072 Authors: Dominik Forster Jan Hendrik Schwarz Katrin Brosinski Ulrich Kalinke Gerd Sutter Asisa Volz In 2015 Zika virus (ZIKV) emerged for the first time in South America. The following ZIKV epidemic resulted in the appearance of a clinical phenotype with microcephaly and other severe malformations in newborns. So far,...
Viruses, Vol. 12, Pages 73: RNase L Is Involved in Liposaccharide-Induced Lung Inflammation Viruses doi: 10.3390/v12010073 Authors: Wei Chen Algehainy Zeng Liu Liu Liu Stacey Zhou RNase L mediates interferon (IFN) function during viral infection and cell proliferation. Furthermore, the role of RNase L in the regulation of gene expression, cell apoptosis, autophagy, and innate immunity has been well established in the last decade. Tissue distribution reveals...
Viruses, Vol. 12, Pages 74: Factors That Govern the Induction of Long-Lived Antibody Responses Viruses doi: 10.3390/v12010074 Authors: Chackerian Peabody The induction of long-lasting, high-titer antibody responses is critical to the efficacy of many vaccines. The ability to produce durable antibody responses is governed by the generation of the terminally differentiated antibody-secreting B cells known as long-lived plasma cells (LLPCs). Once induced, LLPCs likely persist for decades,...
Viruses, Vol. 12, Pages 71: Single-Cell Analysis Uncovers a Vast Diversity in Intracellular Viral Defective Interfering RNA Content Affecting the Large Cell-to-Cell Heterogeneity in Influenza A Virus Replication Viruses doi: 10.3390/v12010071 Authors: Kupke Ly Börno Ruff Timmermann Vingron Haas Reichl Virus replication displays a large cell-to-cell heterogeneity; yet, not all sources of this variability are known. Here, we study the effect of defective interfering...
Viruses, Vol. 12, Pages 70: Virus-Induced Flowering by Apple Latent Spherical Virus Vector: Effective Use to Accelerate Breeding of Grapevine Viruses doi: 10.3390/v12010070 Authors: Maeda Kikuchi Kasajima Li Yamagishi Yamashita Yoshikawa Apple latent spherical virus (ALSV) was successfully used in promoting flowering (virus-induced flowering, VIF) in apple and pear seedlings. In this paper, we report the use of ALSV vectors for VIF in seedlings and in vitro cultures...
Viruses, Vol. 12, Pages 69: Evaluation of the LIAISON XL Zika Capture IgM II for the Diagnosis of Zika Virus Infections Viruses doi: 10.3390/v12010069 Authors: Pérez-Olmeda Sánchez-Seco Vázquez Balfagón de la Fuente Murillo Minguito de Ory The aim of this study is to evaluate the performance characteristics of the LIAISON XL Zika Capture IgM II. For this purpose we tested 128 samples obtained from recent infections caused by the Zika (ZIKV; 74 samples),...
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Water, Vol. 12, Pages 172: Exploring Proper Spacing Threshold of Non-Submerged Spur Dikes with Ipsilateral Layout Water doi: 10.3390/w12010172 Authors: Gu Cao Gu Lu Concerning the clustering of spur dikes on river systems, the spacing thresholds of twin spur dikes are important parameters to influence the estimations on the impact scales of spur dike groups and the overall responses of river systems. In this study, both numerical investigations and experimental measurements...
Water, Vol. 12, Pages 173: Assessment of E. coli Attenuation during Infiltration of Treated Wastewater: A Pathway to Future Managed Aquifer Recharge Water doi: 10.3390/w12010173 Authors: Donn Reed Vanderzalm Page Treated wastewater (TWW) infiltration into non-potable aquifers has been used for decades in Western Australia for disposal and reuse. These wastewater treatment plants (WWTPs) are mostly pond systems, infiltrating secondary TWW with some activated sludge. There...
Water, Vol. 12, Pages 171: Numerical Investigation of Vortex Induced Vibration for Submerged Floating Tunnel under Different Reynolds Numbers Water doi: 10.3390/w12010171 Authors: Jin Liu Geng Jin Zhang Liu A 2D numerical model was established to investigate vortex induced vibration (VIV) for submerged floating tunnel (SFT) by solving incompressible viscous Reynolds average Navier-Stokes equations in the frame of Abitrary Lagrangian Eulerian (ALE). The numerical...
Water, Vol. 12, Pages 169: Research Trends in the Use of Remote Sensing for Inland Water Quality Science: Moving Towards Multidisciplinary Applications Water doi: 10.3390/w12010169 Authors: Simon N. Topp Tamlin M. Pavelsky Daniel Jensen Marc Simard Matthew R. V. Ross Remote sensing approaches to measuring inland water quality date back nearly 50 years to the beginning of the satellite era. Over this time span, hundreds of peer-reviewed publications have demonstrated promising...
Water, Vol. 12, Pages 170: Hazard Assessment Based on the Combination of DAN3D and Machine Learning Method for Planning Closed-Type Barriers against Debris-Flow Water doi: 10.3390/w12010170 Authors: Cheon Lee Lee If a slope located near a densely populated region is susceptible to debris-flow hazards, barriers are used as a mitigation method by placing them in flow channels; i.e., flowpaths. Selecting the location and the design of a barrier requires hazard assessment to determine...
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