The relationship between the levels of interleukin-17 and 25-hydroxyvitamin D in vitiligo outcome

The relationship between the levels of interleukin-17 and 25-hydroxyvitamin D in vitiligo outcome: Mohamed I Metwalli, Fathia M Khattab, Manal M El Amin, Menna Allah H Abdel Aziz



Egyptian Journal of Dermatology and Venerology 2020 40(1):1-8



Background The active form of vitamin D (1,25 hydroxyvitamin D) mediates the interaction between vitamin D and immune diseases including vitiligo, which was found to be associated with lower 25(OH)D levels.

Objective To evaluate the role of vitamin D and interleukin (IL)-17 in vitiligo and its relationship with autoimmune diseases and to assess the therapeutic effect of vitamin D in patients with vitiligo.

Patients and methods A total of 44 patients with vitiligo were measured for vitamin D and IL-17. Those with a low level of vitamin D took vitamin D droplet for 3 months and were then re-evaluated with Vitiligo European Task Force score before and after treatment.

Results A significant negative correlation was found between vitamin D and IL-17 levels. A statistically significant increase in vitamin D level and decrease in IL-17 level was seen after treatment when compared with before treatment, accompanied by improvement of Vitiligo European Task Force scoring values after treatment.

Conclusion The use of systemic vitamin D as a treatment modality for vitiligo can achieve reasonable improvement comparable to traditional modalities.