Tranexamic acid versus topical mesolightening mixture using the dermaroller in the treatment of melisma: Adel A.S. Aly, Rania E.A. AbdElMaksoud, Inas Ismail
Egyptian Journal of Dermatology and Venerology 2020 40(1):45-52
Background Use of localized microinjection of tranexamic acid (TA) has been studied for the treatment of melasma and was proved to be effective, but transdermal delivery of this agent has not been well studied. The use of Dermaroller may increase the effective delivery of active ingredients in topical mesolightening mixture and TA.
Aim The aim of this split-face study was to compare the safety and efficacy of transdermal delivery of TA versus topical mesolightening mixture using the Dermaroller in the treatment of melasma.
Patients and methods This split-face study was carried out on 15 patients having melasma. For each patient, the following was done after taking an informed consent: history taking, dermatological examination, Wood’s light examination, Melanin Area and Severity Index (MASI) score calculation, photography, physician’s global assessment by independent investigators, patient’s global evaluation, eight sessions of transdermal delivery of TA and topical mesolightening mixture, with a session every week (mixture of kojic acid 3%, TA 0.01%, azelaic acid 4% (19,20), L-ascorbic acid 1 g, and water for injection), and recording of the adverse effects every session. This was followed by 3 months of follow-up.
Results The initial (pre-4) reduction of MASI (after the first four sessions) on the left side (TA treated) was significantly higher than that on the right side. Similarly, the later (four to eight sessions) (upon comparing the second set with the first set of sessions) and overall reduction was higher on the left side compared with that on the right side; however, these differences were not statistically significant in terms of MASI.
Conclusion TA and topical mesolightening mixture are individually effective in the treatment of melasma. TA is superior to mesolightening, as well as cost-effective in the treatment of melasma.
Medicine RSS-Feeds by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com
Πληροφορίες
Τρίτη 7 Ιανουαρίου 2020
Tranexamic acid versus topical mesolightening mixture using the dermaroller in the treatment of melisma
Αναρτήθηκε από
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
στις
10:21 μ.μ.
Ετικέτες
00302841026182,
00306932607174,
alsfakia@gmail.com,
Anapafseos 5 Agios Nikolaos 72100 Crete Greece,
Medicine by Alexandros G. Sfakianakis,
Telephone consultation 11855 int 1193
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Αρχειοθήκη ιστολογίου
-
►
2023
(366)
- ► Φεβρουαρίου (184)
- ► Ιανουαρίου (182)
-
►
2022
(2814)
- ► Δεκεμβρίου (182)
- ► Σεπτεμβρίου (213)
- ► Φεβρουαρίου (264)
- ► Ιανουαρίου (262)
-
►
2021
(3815)
- ► Δεκεμβρίου (229)
- ► Σεπτεμβρίου (276)
- ► Φεβρουαρίου (64)
-
▼
2020
(5754)
- ► Δεκεμβρίου (401)
- ► Σεπτεμβρίου (365)
- ► Φεβρουαρίου (754)
-
▼
Ιανουαρίου
(894)
-
▼
Ιαν 07
(84)
- Medicine by Alexandros G. Sfakianakis,Anapafseos 5...
- Journals
- Journals
- Prognostic significance of lactate dehydrogenase i...
- A metanalysis on cabozantinib and bone metastases:...
- miR-7641 depletion suppresses proliferation of gas...
- Clinical efficacy of irinotecan plus raltitrexed c...
- A novel bis-aryl urea compound inhibits tumor prol...
- Combination treatment of bicalutamide and curcumin...
- Downregulation of lncRNA HOTTIP Suppresses the Pro...
- A pre-existing population of ZEB2 + quiescent cell...
- Efficacy of FGFR inhibitors and combination therap...
- 10D1F, an Anti-HER3 Antibody that Uniquely Blocks ...
- Regulatory T cell depletion alters the tumor micro...
- Characterization of Immune Dysfunction and Identif...
- Tumor Analyses Reveal Squamous Transformation and ...
- Racial Differences in the Association between Lumi...
- Multifactorial deep learning reveals pan-cancer ge...
- LncRNA MAGI2-AS3 Upregulates Cytokine Signaling 1 ...
- Phase I Study of Yttrium-90 Radiolabeled M5A Anti-...
- Risk factors and predictive model of diarrhoea amo...
- Microsurgical Management of Ventral Intradural-Ext...
- A multi-institutional analysis of factors influenc...
- Dissection of the vertebral artery fenestration li...
- Surgical Treatment of an Intracranial Anterior Eth...
- Transblepharo-preseptal modified orbitozygomatic a...
- Side-to-end hypoglossal-facial neurorrhaphy for tr...
- Topical antiseptics for chronic suppurative otitis...
- Molecular and clinical characterization of human a...
- Prevalence of NUT carcinoma in head and neck: Anal...
- The role of eosinophils in immunotherapy.
- Food allergy in adults in Europe: what can we lear...
- Association of SOX2, OCT4 and WNT5A Expression in ...
- The Rare Radiographic Sunburst Appearance of Odont...
- Subclinical nephrotoxicity in patients with beta-t...
- Amplitude Modulated Noise for Tinnitus Suppression...
- Noise-Induced Change of Cortical Temporal Processi...
- Clinical significance of chemokine receptor antago...
- Relationship between Movement Stereotype and Focus...
- Features of the Dynamics of the Human EEG Spectrum...
- Neurophysiological Features of Cognitive Activity ...
- Neuroglobin in Purkinje Neurons in the Rate Cerebe...
- Recurrent Necrotizing Soft Tissue Infections with ...
- YARS as an oncogenic protein that promotes gastric...
- In Search of the Long-Desired ‘Copernican Therapeu...
- GSE
- Psychometric Properties of the Spanish Version of ...
- Dravet syndrome: Treatment options and management ...
- SCN1A/NaV1.1 channelopathies: Mechanisms in expres...
- SCN2A channelopathies: Mechanisms and models
- Social Inequalities in Fertility in Women Residing...
- SCN1A‐related phenotypes: Epilepsy and beyond
- SCN8A encephalopathy: Mechanisms and models
- Dravet syndrome as part of the clinical and geneti...
- Dravet syndrome and other sodium channel‐related e...
- Phenotypic spectrum and genetics of SCN2A‐related ...
- Gerbode defect and left ventricular-aortic discont...
- Dravet syndrome: Early electroclinical findings an...
- Predicting the impact of sodium channel mutations ...
- Hyperlipidemia in patients newly treated with anti...
- Arnica montana and Bellis perennis for seroma redu...
- Determining the prevalence and severity of cancer ...
- Spatial patterns of tau deposition are associated ...
- Feasibility of ovine and porcine models for simula...
- Applying Machine Learning in Liver Disease & Trans...
- Liver‐on‐a‐Chip Models of Fatty Liver Disease
- Woolly hair: a rare disorder
- Evaluation of interleukin-18 and soluble interleuk...
- Idiopathic orbital inflammatory syndrome: a dermat...
- Relation between insulin resistance and severity o...
- Tranexamic acid versus topical mesolightening mixt...
- Mechanism of muscle–tendon–bone complex developmen...
- The relationship between the levels of interleukin...
- Efficacy of dermoscopy in the diagnosis of differe...
- Foreplay importance from the point of view of a sa...
- Correlation between squamous cell carcinoma antige...
- Treatment of a wide wound area with extensive necr...
- Skin disorders among elderly patients
- Functional Electrical Stimulation for Presbyphonia...
- Analysis of Abdominal Dermal‐Fat Grafting to Repai...
- Gingival recession behavior with immediate implant...
- Effect of proton pump inhibitors on high-dose meth...
- Archives of Mental Health
- Medicine by Alexandros G. Sfakianakis,Anapafseos 5...
-
▼
Ιαν 07
(84)
-
►
2019
(146)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου