To study the complex functionality of groups of cells, and to one day build replacement tissues, researchers have been trying to find a way to generate artificial vascular networks capable of supplying oxygen and nutrients to thousands of cells. Extrusion 3D printing, in which a liquefied material is layered down and allowed to harden, has proven to be insufficient to produce fine structures with complex morphologies. Rice University scientists, with the help of others, have now developed...
Tue Jun 30, 2020 19:47
Philips won FDA approval for its HeartStart FR3 and HeartStart FRx automated external defibrillators (AEDs). The HeartStart FR3 is an advanced device intended for use by medical professionals, including paramedics, and features such capabilities as “quick shock” to minimize hands-off time, and military-level ruggedness, ECG monitoring for non-cardiac arrest victims, and a battery that can deliver up to 300 shocks from a single charge. The HeartStart FRx, on the other hand,...
Tue Jun 30, 2020 19:40
ObjectivesWe investigated the association between low-dose external occupational radiation exposure and circulatory disease morbidity among diagnostic medical radiation workers.MethodsA cohort of 11 500 diagnostic medical radiation workers was linked with the National Dosimetry Registry data and the National Health Insurance Service data. Relative risks (RRs) were calculated to explore the association between occupational factors and circulatory disease morbidity, and excess relative risks per 100...
Tue Jun 30, 2020 19:00
Sir,On the 6th of April, the WHO provided guidance about personal protective equipment (PPE) for healthcare workers (HCWs) in healthcare settings areas that have reported cases of COVID-19, stating that HCWs working in settings where aerosol-generating procedures were performed should wear a particulate respirator (N95 or FFP2), whereas in their previous recommendations, such masks were restricted to those who actually performed such procedures. This a step forward, although insufficient, towards...
Tue Jun 30, 2020 19:00
Calcific uremic arteriolopathy is a rare condition affecting chronic kidney disease (CKD) patients on long-term dialysis. The clinical manifestations include subcutaneous skin necrosis and ulcers secondary to calcification of the subcutaneous blood vessels. The necrotic tissue often becomes a nidus of infection. The prognosis is often poor. We present a case of a renal allograft recipient who developed a subcutaneous necrotic lesion which was subsequently infected by Rhizopus spp. The patient underwent...
Tue Jun 30, 2020 09:50
Nature Communications, Published online: 30 June 2020; doi:10.1038/s41467-020-16834-0The United Kingdom has experienced a strong heat wave in 2019 that set a new temperature record for the country of 38.7 °C. In this study the authors show that under climate change, local temperatures are increasingly likely to exceed 35 °C and 40 °C in the next decades and, hence, summers like the one of 2019 become more frequent.
Tue Jun 30, 2020 03:00
Tue Jun 30, 2020 03:00
Nature Communications, Published online: 30 June 2020; doi:10.1038/s41467-020-17047-1Adeno-associated viruses (AAVs) are vehicles for gene therapy in humans, but currently only a limited amount of AAV serotypes is available. Here, the authors identify a novel AAV, AAVv66, and demonstrate enhanced production yields, virion stability, and CNS transduction compared to the clinically approved serotype AAV2.
Tue Jun 30, 2020 03:00
Nature Communications, Published online: 30 June 2020; doi:10.1038/s41467-020-17273-7Author Correction: Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension
Tue Jun 30, 2020 03:00
Nature Communications, Published online: 30 June 2020; doi:10.1038/s41467-020-17031-9On-implant spike sorting methods utilize static waveform features for the classification. Here, the authors propose a framework based on dynamic selection of features that is more accurate and requires less memory.
Tue Jun 30, 2020 03:00
Tue Jun 30, 2020 03:00
Tue Jun 30, 2020 03:00
Publication date: Available online 30 June 2020Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Ahmad Safadi, Shlomi Kleinman, Dana Gigi, Anat Wengier, Itay Oz, Abraham Abergel, Ilan Koren, Omer J. Ungar
Tue Jun 30, 2020 19:38
Publication date: Available online 29 June 2020Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): K. Dowgierd, D. Larysz, P. Szymor, M. Kozakiewicz
Tue Jun 30, 2020 19:38
Publication date: Available online 30 June 2020Source: Magnetic Resonance ImagingAuthor(s): Hojin Ha, Kyung Jin Park, Petter Dyverfeldt, Tino Ebbers, Dong Hyun Yang
Tue Jun 30, 2020 19:37
Automated measurement of fat infiltration in the hip abductors from Dixon magnetic resonance imaging
Publication date: Available online 29 June 2020Source: Magnetic Resonance ImagingAuthor(s): Martin A. Belzunce, Johann Henckel, Anastasia Fotiadou, Anna Di Laura, Alister Hart
Tue Jun 30, 2020 19:37
Publication date: Available online 29 June 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Sunil Mutalik, Aditya Tadinada, Marco R. Molina, Andrés Sinisterra, Alan Lurie
Tue Jun 30, 2020 19:36
BACKGROUND:Secondary traumatic stress (STS) may occur in the caretakers of individuals who have experienced traumatic events or are suffering and, when severe, may be associated with posttraumatic stress disorder (PTSD) at a diagnostic level due to STS. For respiratory therapists (RTs), the incidence of STS and PTSD at a diagnostic level due to STS has not been examined. We assessed the prevalence of self-reported STS and PTSD at a diagnostic level due to STS in licensed RTs.METHODS:Licensed RTs...
Tue Jun 30, 2020 18:46
Tue Jun 30, 2020 18:46
BACKGROUND:Switching patients affected by early severe ARDS and undergoing extracorporeal membrane oxygenation (ECMO) from controlled ventilation to spontaneous breathing can be either beneficial or harmful, depending on how effectively the breathing pattern is controlled with ECMO. Identifying the factors associated with ineffective control of spontaneous breathing with ECMO may advance our pathophysiologic understanding of this syndrome.METHODS:We conducted a prospective study in subjects with...
Tue Jun 30, 2020 18:46
Redirection of our clinical attention from the pressures and volumes of the individual cycle to the broader and more inclusive considerations of energy load and power has untapped potential to reduce iatrogenic risk from ventilation (ie, ventilator-induced lung injury). Power is the product of breathing frequency and inflation energy per breath. Yet, while feasible to calculate at the bedside, measuring total power may not prove to be precise enough for accurate prediction of ventilator-induced lung...
Tue Jun 30, 2020 18:46
BACKGROUND:The overwhelming demand for mechanical ventilators due to COVID-19 has stimulated interest in using one ventilator for multiple patients (ie, multiplex ventilation). Despite a plethora of information on the internet, there is little supporting evidence and no human studies. The risk of multiplex ventilation is that ventilation and PEEP effects are largely uncontrollable and depend on the difference between patients’ resistance and compliance. It is not clear whether volume control ventilation...
Tue Jun 30, 2020 18:46
BACKGROUND:Soft mist inhalers (SMIs) generate aerosols with a smaller particle size than pressurized metered-dose inhalers (pMDIs). However, the whole-span particle size distribution (PSD) of SMIs and the optimal delivery method of SMIs during mechanical ventilation have not been fully investigated. This study aimed to measure the PSD of the SMI alone and the SMI coupled to an inhalation aid (eg, a spacer, a valved holding chamber), as well as the delivery efficiency of SMI in different actuation...
Tue Jun 30, 2020 18:46
BACKGROUND:The use of shared ventilation, or the simultaneous support of multiple patients connected in parallel to a single mechanical ventilator, is receiving considerable interest for addressing the severe shortage of mechanical ventilators available during the novel coronavirus pandemic (COVID-19). In this paper we highlight the potentially disastrous consequences of naïve shared ventilation, in which patients are simply connected in parallel to a ventilator without any regard to their individual...
Tue Jun 30, 2020 18:46
Predicted values for pulmonary function tests differ significantly from the reference values used for many other diagnostic tests. Historically, simple equations using age, height, and sex were used to “predict” normal lung function. However, these multiple factors interact in complex ways to determine what the expected lung function values are in healthy subjects. Healthy individuals exhibit a wide range of variability for most pulmonary function variables, and this variability is not consistent...
Tue Jun 30, 2020 18:46
BACKGROUND:We tested whether work of breathing in premature newborns estimated by phase angle (θ) by using respiratory inductance plethysmography is decreased during neurally-adjusted ventilatory assist (NAVA) noninvasive ventilation (NIV) versus NIV alone.METHODS:NAVA NIV and NIV were applied in random order while using respiratory inductance plethysmography to measure the phase angle.RESULTS:Patient-ventilator asynchrony was decreased during NAVA NIV; however, the phase angle was not different...
Tue Jun 30, 2020 18:46
Tue Jun 30, 2020 18:46
BACKGROUND:Endotracheal intubation is a common procedure performed by respiratory therapists (RTs). The purpose of this study was to describe current RT intubation practices in North Carolina through the use of a survey instrument.METHODS:A survey was developed by the authors using REDCap. The survey was sent via email to all licensed RTs in North Carolina. Information collected included respondent demographics, intubation practices (including training and skill maintenance), and attitudes about...
Tue Jun 30, 2020 18:46
BACKGROUND:The purpose of this study was to assess graduate and undergraduate international respiratory therapy students’ perceptions of the impact of their international educational experience on their life experience and development.METHODS:Data were collected through a validated descriptive survey. Four main dimensions of development were assessed: professional respiratory therapist (RT) role, global understanding, personal development, and intellectual development.RESULTS:The sample size was...
Tue Jun 30, 2020 18:46
BACKGROUND:Respiratory ICUs (RICUs) have recently been implemented in France to fill the gap between ICUs and respiratory wards for patients who will require prolonged mechanical ventilation (PMV). The aim of this study was to describe the outcomes of subjects with tracheostomy who were undergoing PMV before and after implementing a RICU in our hospital.METHODS:Two cohorts were studied and followed up for 1 year. Cohort 1 included 66 subjects from December 2010 to December 2012, before implementing...
Tue Jun 30, 2020 18:46
BACKGROUND:Asthma educators are essential for providing patients with the knowledge and skills needed to control asthma. The purpose of this descriptive, cross-sectional survey was to examine the differences in practice patterns between certified and noncertified asthma educators.METHODS:Subjects (N = 98) included certified asthma educators (n = 66) and noncertified asthma educators (n = 32) who provided asthma education directly to patients and their families. Subjects were asked to complete an...
Tue Jun 30, 2020 18:46
Asthma is an obstructive airway disease affecting children and adults throughout the world. It is a heterogeneous disease with a variety of causes and treatments. Research in the diagnosis, treatment, and management of asthma is ongoing, and there were > 8,000 publications on asthma in 2019. This paper reviews several research articles about asthma from 2019 that are most relevant for practicing respiratory therapists caring for patients with asthma.
Tue Jun 30, 2020 18:46
BACKGROUND:The Pennsylvania Respiratory Research Collaborative formed in January 2017 for the purpose of providing mentorship and opportunities to participate in statewide research, quality improvement, and evidence-based practice projects. The inaugural project was designed to investigate and describe the practice of respiratory therapy in Pennsylvania.METHODS:A survey related to the practice and business of in-patient respiratory therapy departments was developed and sent to managers/directors...
Tue Jun 30, 2020 18:46
BACKGROUND:Clinical observations on the potential of pre-hospital antiplatelet therapy in preventing ARDS have been inconsistent. To further the correlation between antiplatelet therapy and ARDS, we conducted a meta-analysis to evaluate the effects of pre-hospital antiplatelet therapy on subjects with ARDS.METHODS:A literature search in major data banks was performed. We included prospective and retrospective cohorts, case-control trials, and randomized controlled trials that compared the ARDS incidence...
Tue Jun 30, 2020 18:46
BACKGROUND:The BODE (body mass index, air-flow obstruction, dyspnea, exercise capacity) index is a composite prognostic marker that predicts mortality in COPD. It includes body mass index, air-flow obstruction, dyspnea score, and exercise capacity by using the 6-min walk distance. However, a 30-m-long corridor is necessary to perform the test and this limits its use in clinical practice. Step tests may elicit distinct physiologic responses compared with the 6-min walk test but are easy to perform...
Tue Jun 30, 2020 18:46
Tue Jun 30, 2020 18:46
BACKGROUND:There is limited evidence supporting an optimum method for removing mucus from the airways of hospitalized infants with bronchiolitis. This study was designed to evaluate short-term physiologic effects between nasal aspiration and nasopharyngeal suctioning in infants.METHODS:Sixteen infants requiring hospitalization for supportive management of bronchiolitis were instrumented with transcutaneously measured partial pressure of carbon dioxide (PtcCO2) and SpO2 monitoring. Electrical impedance...
Tue Jun 30, 2020 18:46
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