IJMS, Vol. 21, Pages 4684: A Census and Categorization Method of Epitranscriptomic Marks International Journal of Molecular Sciences doi: 10.3390/ijms21134684 Authors: Julia Mathlin Loredana Le Le Pera Teresa Colombo In the past few years, thorough investigation of chemical modifications operated in the cells on ribonucleic acid (RNA) molecules is gaining momentum. This new field of research has been dubbed “epitranscriptomics”, in analogy to best-known epigenomics,...
Tue Jun 30, 2020 03:00
IJMS, Vol. 21, Pages 4681: Emerging Strategies Targeting Catabolic Muscle Stress Relief International Journal of Molecular Sciences doi: 10.3390/ijms21134681 Authors: Scalabrin Adams Labeit Bowen Skeletal muscle wasting represents a common trait in many conditions, including aging, cancer, heart failure, immobilization, and critical illness. Loss of muscle mass leads to impaired functional mobility and severely impedes the quality of life. At present, exercise training remains...
Tue Jun 30, 2020 03:00
IJMS, Vol. 21, Pages 4682: Wnt/β-Catenin Signaling in Oral Carcinogenesis International Journal of Molecular Sciences doi: 10.3390/ijms21134682 Authors: Reyes Flores Betancur Peña-Oyarzún Torres Oral carcinogenesis is a complex and multifactorial process that involves cumulative genetic and molecular alterations, leading to uncontrolled cell proliferation, impaired DNA repair and defective cell death. At the early stages, the onset of potentially malignant lesions in...
Tue Jun 30, 2020 03:00
IJMS, Vol. 21, Pages 4680: Sleep Duration, Lipid Profile and Insulin Resistance: Potential Role of Lipoprotein(a) International Journal of Molecular Sciences doi: 10.3390/ijms21134680 Authors: Korostovtseva Alieva Rotar Bochkarev Boyarinova Sviryaev Konradi Shlyakhto Lipoprotein (a) (Lp(a)) is considered a genetic factor for cardiovascular disease playing an important role in atherogenesis and thrombosis, but the evidence about its association with sleep...
Tue Jun 30, 2020 03:00
IJMS, Vol. 21, Pages 4678: Deciphering the Binding of Salicylic Acid to Arabidopsis thaliana Chloroplastic GAPDH-A1 International Journal of Molecular Sciences doi: 10.3390/ijms21134678 Authors: Pokotylo Hellal Bouceba Hernandez-Martinez Kravets Leitao Espinasse Kleiner Ruelland Salicylic acid (SA) has an essential role in the responses of plants to pathogens. SA initiates defence signalling via binding to proteins. NPR1 is a transcriptional co-activator...
Tue Jun 30, 2020 03:00
IJMS, Vol. 21, Pages 4679: Aldosterone Induces DNA Damage and Activation of Nrf2 Mainly in Tubuli of Mouse Kidneys International Journal of Molecular Sciences doi: 10.3390/ijms21134679 Authors: Balhorn Hartmann Schupp Hypertensive patients have an increased risk of developing chronic kidney disease (CKD). Many of these patients have increased levels of the blood pressure regulating mineralocorticoid aldosterone. As a protection against aldosterone-induced damage, kidney cells...
Tue Jun 30, 2020 03:00
IJMS, Vol. 21, Pages 4676: Remodeling Matrix Synthesis in a Rat Model of Aortocaval Fistula and the Cyclic Stretch: Impaction in Pulmonary Arterial Hypertension-Congenital Heart Disease International Journal of Molecular Sciences doi: 10.3390/ijms21134676 Authors: Chang Huang Chen Lai Pulmonary arterial hypertension-congenital heart disease (PAH-CHD) is characterized by systemic to pulmonary arterial shunts and sensitively responds to volume overload and stretch of the vascular...
Tue Jun 30, 2020 03:00
IJMS, Vol. 21, Pages 4675: Vimentin as a Multifaceted Player and Potential Therapeutic Target in Viral Infections International Journal of Molecular Sciences doi: 10.3390/ijms21134675 Authors: Ramos Stamatakis Oeste Pérez-Sala Vimentin is an intermediate filament protein that plays key roles in integration of cytoskeletal functions, and therefore in basic cellular processes such as cell division and migration. Consequently, vimentin has complex implications in pathophysiology....
Tue Jun 30, 2020 03:00
IJMS, Vol. 21, Pages 4673: Human Serum Albumin in the Presence of AGuIX Nanoagents: Structure Stabilisation without Direct Interaction International Journal of Molecular Sciences doi: 10.3390/ijms21134673 Authors: Xiaomin Yang Marta Bolsa-Ferruz Laurent Marichal Erika Porcel Daniela Salado-Leza François Lux Olivier Tillement Jean-Philippe Renault Serge Pin Frank Wien Sandrine Lacombe The gadolinium-based nanoagent named AGuIX® is a unique radiosensitizer...
Tue Jun 30, 2020 03:00
IJMS, Vol. 21, Pages 4674: The Inflammasome Adaptor Protein ASC in Mild Cognitive Impairment and Alzheimer’s Disease International Journal of Molecular Sciences doi: 10.3390/ijms21134674 Authors: Scott Stephens Desir Dietrich Keane de Rivero Vaccari Mild cognitive impairment (MCI) is characterized by memory loss in the absence of dementia and is considered the translational stage between normal aging and early Alzheimer’s disease (AD). Patients with MCI...
Tue Jun 30, 2020 03:00
IJMS, Vol. 21, Pages 4677: Photosensitive Supramolecular Micelle-Mediated Cellular Uptake of Anticancer Drugs Enhances the Efficiency of Chemotherapy International Journal of Molecular Sciences doi: 10.3390/ijms21134677 Authors: Alemayehu Fan Ilhami Chiu Lee Cheng The development of stimuli-responsive supramolecular micelles with high drug-loading contents that specifically induce significant levels of apoptosis in cancer cells remains challenging. Herein, we report...
Tue Jun 30, 2020 03:00
IJMS, Vol. 21, Pages 4671: LC–ESI–FT–MSn Metabolite Profiling of Symphytum officinale L. Roots Leads to Isolation of Comfreyn A, an Unusual Arylnaphthalene Lignan International Journal of Molecular Sciences doi: 10.3390/ijms21134671 Authors: Gilda D’Urso Milena Masullo Jacqueline Seigner Yvonne M. Holper-Schichl Rainer de Martin Alberto Plaza Sonia Piacente Preparations of comfrey (Symphytum officinale L.) roots are used topically to reduce inflammation. Comfrey anti-inflammatory...
Tue Jun 30, 2020 03:00
IJMS, Vol. 21, Pages 4672: Nonsense Suppression Therapy: New Hypothesis for the Treatment of Inherited Bone Marrow Failure Syndromes International Journal of Molecular Sciences doi: 10.3390/ijms21134672 Authors: Bezzerri Api Allegri Fabrizzi Corey Cipolli Inherited bone marrow failure syndromes (IBMFS) are a group of cancer-prone genetic diseases characterized by hypocellular bone marrow with impairment in one or more hematopoietic lineages. The pathogenesis of IBMFS...
Tue Jun 30, 2020 03:00
IJMS, Vol. 21, Pages 4663: Combination of HIV-1 and Diabetes Enhances Blood Brain Barrier Injury via Effects on Brain Endothelium and Pericytes International Journal of Molecular Sciences doi: 10.3390/ijms21134663 Authors: Slava Rom Sachin Gajghate Malika Winfield Nancy L. Reichenbach Yuri Persidsky Despite combined antiretroviral therapy (ART) achieving efficient HIV replication control, HIV-associated neurocognitive disorders (HAND) continue to be highly prevalent in HIV-infected...
Tue Jun 30, 2020 03:00
IJMS, Vol. 21, Pages 4669: Phytoene synthase 1 (Psy-1) and lipoxygenase 1 (Lpx-1) Genes Influence on Semolina Yellowness in Wheat Mediterranean Germplasm International Journal of Molecular Sciences doi: 10.3390/ijms21134669 Authors: Roberto Parada Conxita Royo Agata Gadaleta Pasqualina Colasuonno Ilaria Marcotuli Iván Matus Dalma Castillo Adriano Costa de Camargo Jorge Araya-Flores Dolors Villegas Andrés R. Schwember Phytoene synthase 1 (Psy1) and lipoxygenase...
Tue Jun 30, 2020 03:00
IJMS, Vol. 21, Pages 4668: Protein Kinase CK2 Controls CaV2.1-Dependent Calcium Currents and Insulin Release in Pancreatic β-Cells International Journal of Molecular Sciences doi: 10.3390/ijms21134668 Authors: Scheuer Philipp Becker Nalbach Ampofo Montenarh Götz The regulation of insulin biosynthesis and secretion in pancreatic β-cells is essential for glucose homeostasis in humans. Previous findings point to the highly conserved, ubiquitously expressed...
Tue Jun 30, 2020 03:00
IJMS, Vol. 21, Pages 4670: Body Composition Findings by Computed Tomography in SARS-CoV-2 Patients: Increased Risk of Muscle Wasting in Obesity International Journal of Molecular Sciences doi: 10.3390/ijms21134670 Authors: Gualtieri Falcone Romano Macheda Correale Arciello Polimeni Lorenzo Obesity is a characteristic of COVID-19 patients and the risk of malnutrition can be underestimated due to excess of fat: a paradoxical danger. Long ICU hospitalization...
Tue Jun 30, 2020 03:00
IJMS, Vol. 21, Pages 4666: Go with the Flow—Trophoblasts in Flow Culture International Journal of Molecular Sciences doi: 10.3390/ijms21134666 Authors: Beatrice A. Brugger Jacqueline Guettler Martin Gauster With establishment of uteroplacental blood flow, the perfused fetal chorionic tissue has to deal with fluid shear stress that is produced by hemodynamic forces across different trophoblast subtypes. Amongst many other cell types, trophoblasts are able to sense fluid shear stress...
Tue Jun 30, 2020 03:00
IJMS, Vol. 21, Pages 4665: Natural Medicines and Their Underlying Mechanisms of Prevention and Recovery from Amyloid Β-Induced Axonal Degeneration in Alzheimer’s Disease International Journal of Molecular Sciences doi: 10.3390/ijms21134665 Authors: Tomoharu Kuboyama Ximeng Yang Chihiro Tohda In Alzheimer’s disease (AD), amyloid β (Aβ) induces axonal degeneration, neuronal network disruption, and memory impairment. Although many candidate drugs to reduce...
Tue Jun 30, 2020 03:00
IJMS, Vol. 21, Pages 4664: The Mitochondrial Genome Assembly of Fennel (Foeniculum vulgare) Reveals Two Different atp6 Gene Sequences in Cytoplasmic Male Sterile Accessions International Journal of Molecular Sciences doi: 10.3390/ijms21134664 Authors: Palumbo Vitulo Vannozzi Magon Barcaccia Cytoplasmic male sterility (CMS) has always aroused interest among researchers and breeders, being a valuable resource widely exploited not only to breed F1 hybrid varieties but also...
Tue Jun 30, 2020 03:00
IJMS, Vol. 21, Pages 4662: Putative Roles for Peptidylarginine Deiminases in COVID-19 International Journal of Molecular Sciences doi: 10.3390/ijms21134662 Authors: Elif Damla Arisan Pinar Uysal-Onganer Sigrun Lange Peptidylarginine deiminases (PADs) are a family of calcium-regulated enzymes that are phylogenetically conserved and cause post-translational deimination/citrullination, contributing to protein moonlighting in health and disease. PADs are implicated in a range of inflammatory...
Tue Jun 30, 2020 03:00
IJMS, Vol. 21, Pages 4667: Chronic Sildenafil Treatment Improves Vasomotor Function in a Mouse Model of Accelerated Aging International Journal of Molecular Sciences doi: 10.3390/ijms21134667 Authors: Golshiri Ataei Ataabadi Brandt van der Pluijm de Vries Danser Roks Aging leads to a loss of vasomotor control. Both vasodilation and vasoconstriction are affected. Decreased nitric oxide–cGMP-mediated relaxation is a hallmark of aging. It contributes to...
Tue Jun 30, 2020 03:00
IJMS, Vol. 21, Pages 4659: Pharmacogenomics and Pharmacogenetics in Osteosarcoma: Translational Studies and Clinical Impact International Journal of Molecular Sciences doi: 10.3390/ijms21134659 Authors: Hattinger Patrizio Luppi Serra High-grade osteosarcoma (HGOS) is a very aggressive bone tumor which primarily affects adolescents and young adults. Although not advanced as is the case for other cancers, pharmacogenetic and pharmacogenomic studies applied to HGOS have been...
Tue Jun 30, 2020 03:00
IJMS, Vol. 21, Pages 4660: Investigation of Cytotoxic T Lymphocyte Function during Allorejection in the Anterior Chamber of the Eye International Journal of Molecular Sciences doi: 10.3390/ijms21134660 Authors: Chang Wirkner Krause Rettig Cytotoxic T lymphocytes (CTL) are an essential part of our immune system by killing infected and malignant cells. To fully understand this process, it is necessary to study CTL function in the physiological setting of a living organism...
Tue Jun 30, 2020 03:00
IJMS, Vol. 21, Pages 4661: Food for Bone: Evidence for a Role for Delta-Tocotrienol in the Physiological Control of Osteoblast Migration International Journal of Molecular Sciences doi: 10.3390/ijms21134661 Authors: Lavinia Casati Francesca Pagani Roberto Maggi Francesco Ferrucci Valeria Sibilia Bone remodeling and repair require osteogenic cells to reach the sites that need to be rebuilt, indicating that stimulation of osteoblast migration could be a promising osteoanabolic...
Tue Jun 30, 2020 03:00
IJMS, Vol. 21, Pages 4657: Ethylene Is Not Essential for R-Gene Mediated Resistance but Negatively Regulates Moderate Resistance to Some Aphids in Medicago truncatula International Journal of Molecular Sciences doi: 10.3390/ijms21134657 Authors: Zhang Kamphuis Guo Jacques Singh Gao Ethylene is important for plant responses to environmental factors. However, little is known about its role in aphid resistance. Several types of genetic resistance against multiple aphid...
Tue Jun 30, 2020 03:00
IJMS, Vol. 21, Pages 4656: Identification, Characterization, and Functional Analysis of Chitin Synthase Genes in Glyphodes pyloalis Walker (Lepidoptera: Pyralidae) International Journal of Molecular Sciences doi: 10.3390/ijms21134656 Authors: Zuo-Min Shao Yi-Jiangcheng Li Jian-Hao Ding Zhi-Xiang Liu Xiao-Rui Zhang Jun Wang Sheng Sheng Fu-An Wu Glyphodes pyloalis Walker (G. pyloalis) causes significant damage to mulberry every year, and we currently lack effective...
Tue Jun 30, 2020 03:00
IJMS, Vol. 21, Pages 4658: The Effect of Lycium barbarum Polysaccharides on Pyroptosis‐Associated Amyloid β1-40 Oligomers-Induced Adult Retinal Pigment Epithelium 19 Cell Damage International Journal of Molecular Sciences doi: 10.3390/ijms21134658 Authors: Yang So Lo Lam Age-related macular degeneration (AMD) is a sight-threatening disease with limited treatment options. We investigated whether amyloid β1-40 (Aβ1-40) could cause pyroptosis and evaluated...
Tue Jun 30, 2020 03:00
IJMS, Vol. 21, Pages 4654: Sugary Logistics Gone Wrong: Membrane Trafficking and Congenital Disorders of Glycosylation International Journal of Molecular Sciences doi: 10.3390/ijms21134654 Authors: Linders Peters ter Beest Lefeber van den Bogaart Glycosylation is an important post-translational modification for both intracellular and secreted proteins. For glycosylation to occur, cargo must be transported after synthesis through the different compartments of the Golgi...
Tue Jun 30, 2020 03:00
IJMS, Vol. 21, Pages 4655: Nicotinamide Phosphoribosyltransferase (Nampt)/Nicotinamide Adenine Dinucleotide (NAD) Axis Suppresses Atrial Fibrillation by Modulating the Calcium Handling Pathway International Journal of Molecular Sciences doi: 10.3390/ijms21134655 Authors: Duo Feng DongZhu Xu Nobuyuki Murakoshi Kazuko Tajiri Rujie Qin Saori Yonebayashi Yuta Okabe Siqi Li Zixun Yuan Kazutaka Aonuma Masaki Ieda Aging and obesity are the most prominent risk factors...
Tue Jun 30, 2020 03:00
IJMS, Vol. 21, Pages 4652: Aspirin Modifies Inflammatory Mediators and Metabolomic Profiles and Contributes to the Suppression of Obesity-Associated Breast Cancer Cell Growth International Journal of Molecular Sciences doi: 10.3390/ijms21134652 Authors: Hsieh Chiu Wang Kuo Breast cancer is the most common cancer among women. Adiposity generally accompanies immune cell infiltration and cytokine secretion, which is ideal for tumor development. Aspirin is a chemopreventive...
Tue Jun 30, 2020 03:00
IJMS, Vol. 21, Pages 4644: A Simple Method for the Production of Human Skin Equivalent in 3D, Multi-Cell Culture International Journal of Molecular Sciences doi: 10.3390/ijms21134644 Authors: Łukasz Szymański Krystyna Jęderka Aleksandra Cios Martyna Ciepelak Aneta Lewicka Wanda Stankiewicz Sławomir Lewicki An important problem for researchers working in the field of dermatology is the preparation of the human skin equivalent (HSE). Here, we describe a simple and reliable...
Tue Jun 30, 2020 03:00
IJMS, Vol. 21, Pages 4651: Small-Angle Scattering and Multifractal Analysis of DNA Sequences International Journal of Molecular Sciences doi: 10.3390/ijms21134651 Authors: lEugen Mircea Anitas The arrangement of A, C, G and T nucleotides in large DNA sequences of many prokaryotic and eukaryotic cells exhibit long-range correlations with fractal properties. Chaos game representation (CGR) of such DNA sequences, followed by a multifractal analysis, is a useful way to analyze the corresponding...
Tue Jun 30, 2020 03:00
IJMS, Vol. 21, Pages 4653: Metabolic Shift of an Isogenic Strain of Enterococcus faecalis 14, Deficient in Its Own Bacteriocin Synthesis, as Revealed by a Transcriptomic Analysis International Journal of Molecular Sciences doi: 10.3390/ijms21134653 Authors: Rabia Ladjouzi Anca Lucau-Danila Djamel Drider The production of antimicrobial molecules often involves complex biological pathways. This study aimed at understanding the metabolic and physiological networks of enterocin EntDD14-associated...
Tue Jun 30, 2020 03:00
IJMS, Vol. 21, Pages 4650: Complex Characterization of Germline Large Genomic Rearrangements of the BRCA1 and BRCA2 Genes in High-Risk Breast Cancer Patients—Novel Variants from a Large National Center International Journal of Molecular Sciences doi: 10.3390/ijms21134650 Authors: Bozsik Pócza Papp Vaszkó Butz Patócs Oláh Large genomic rearrangements (LGRs) affecting one or more exons of BRCA1 and BRCA2 constitute a significant part of the mutation spectrum of...
Tue Jun 30, 2020 03:00
IJMS, Vol. 21, Pages 4649: In Situ Detection of Endogenous HIV Activation by Dynamic Nuclear Polarization NMR and Flow Cytometry International Journal of Molecular Sciences doi: 10.3390/ijms21134649 Authors: Overall Price Albert Gao Alaniva Judge Sesti Wender Kyei Barnes We demonstrate for the first time in-cell dynamic nuclear polarization (DNP) in conjunction with flow cytometry sorting to address the cellular heterogeneity of in-cell samples. Utilizing...
Tue Jun 30, 2020 03:00
IJMS, Vol. 21, Pages 4648: Molecular Mapping of Hydrogen Sulfide Targets in Normal Human Keratinocytes International Journal of Molecular Sciences doi: 10.3390/ijms21134648 Authors: Gross-Amat Guillen Gimeno Salzet Lebonvallet Misery Auxenfans Nataf Although sulfur-rich thermal waters have ancestrally been used in the context of dermatological conditions, a global mapping of the molecular effects exerted by H2S on human keratinocytes is still lacking. To...
Tue Jun 30, 2020 03:00
IJMS, Vol. 21, Pages 4647: Silver Nanoparticles Surface-Modified with Carbosilane Dendrons as Carriers of Anticancer siRNA International Journal of Molecular Sciences doi: 10.3390/ijms21134647 Authors: Pędziwiatr-Werbicka Gorzkiewicz Horodecka Abashkin Klajnert-Maculewicz Peña-González Sánchez-Nieves Gómez de la Mata Bryszewska Gene therapy is a promising approach in cancer treatment; however, current methods have a number of limitations mainly due...
Tue Jun 30, 2020 03:00
IJMS, Vol. 21, Pages 4646: NRF2 Knockdown Resensitizes 5-Fluorouracil-Resistant Pancreatic Cancer Cells by Suppressing HO-1 and ABCG2 Expression International Journal of Molecular Sciences doi: 10.3390/ijms21134646 Authors: Eui Joo Kim Yoon Jae Kim Hye In Lee Seok-Hoo Jeong Hyo Jung Nam Jae Hee Cho Chemoresistance is a leading cause of morbidity and mortality in patients with pancreatic cancer and remains an obstacle to successful treatment. The antioxidant transcription...
Tue Jun 30, 2020 03:00
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