AbstractExposure to body odors (chemosignals) collected under different emotional states (i.e., emotional chemosignals) can modulate our visual system, biasing visual perception. Recent research has suggested that exposure to fear body odors, results in a generalized faster access to visual awareness of different emotional facial expressions (i.e., fear, happy, and neutral). In the present study, we aimed at replicating and extending these findings by exploring if these effects are limited to fear...
Tue Jun 30, 2020 03:00
We read with great interest the paper by Kirsch et al. entitled “Lack of supporting data make the risks of a clinical trial of radiation therapy as a treatment for COVID-19 pneumonia unacceptable”. The authors make valid points that merit serious consideration, but in the setting of an ongoing pandemic without effective therapies, the recommendation against carefully designed clinical trials is understandable but not the only valid point of view.
Tue Jun 30, 2020 03:00
Recently, Radiotherapy and Oncology published an article entitled “Workflow and Protection Procedures During the Coronavirus Disease 2019 (COVID-19) Outbreak: Experience of the Hubei Cancer Hospital in Wuhan, China.” describing multiple measures for patient and staff COVID-19 protection and prevention at the Hubei Cancer Hospital” [1].
Tue Jun 30, 2020 03:00
The Covid-19 pandemic imposes reflections on the priorities of oncological treatments, and particularly on the balance between benefits by receiving RT and the increased infective risk. A shared perspective is discriminating (by prioritization) the treatments not to be delayed or omitted from the ones suitable for such an option [1,2]. van deHaar et al. provided a priority list for RT and addressed the issue of available resources to deliver RT in each Center along different phases of the infective...
Tue Jun 30, 2020 03:00
The addition of androgen deprivation therapy (ADT) to radiotherapy (RT) is the standard of care for prostate cancer patients with unfavourable intermediate risk (UIR) and high-risk disease. In this population, ADT has been shown to improve oncological outcomes by increasing RT local effect [1–3] and likely by reducing the micrometastatic burden. Although the role of ADT in high-risk prostate cancer patients is firmly established, the benefit associated with this therapy in UIR patients treated with...
Tue Jun 30, 2020 03:00
Bacterial infections are responsible for a large number of deaths every year worldwide. On average, 80% of the African population cannot afford conventional drugs. Moreover, many synthetic antibiotics are associated with side effects and progressive increase in antimicrobial resistance. Currently, there is growing interest in discovering new antibacterial agents from ethnomedicinal plants. About 60% of the population living in developing countries depends on herbal drugs for healthcare needs. This...
04:05
Gastric diseases are increasing with the infection of Campylobacter jejuni. Late stages of infection lead to peptic ulcer and gastric carcinoma. C. jejuni infects people within different stages of their life, especially childhood, causing severe diarrhea; it infects around two-thirds of the world population. Due to bacterial resistance against standard antibiotic, a new strategy is needed to impede Campylobacter infections. Plants provide highly varied structures with antimicrobial use which are...
04:05
Odor-baited devices are increasingly needed to compliment long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) for control of residual malaria transmission. However, the odor-baited devices developed so far are bulky, dependent on the source of electricity and carbon dioxide (CO2), and they are logistically unsuitable for scaling up in surveillance and control of malaria vectors. We designed a passive and portable outdoor host seeking device (POHD) and preliminarily evaluated...
03:50
Idiopathic nonhistaminergic acquired angioedema (InH-AAE) is a rare disease characterized by submucosal swelling without concomitant urticaria and poor response to antihistamines and corticosteroids.1 Compared with other forms of hereditary and acquired angioedema, InH-AAE seems to have a predilection for facial and tongue swelling, and is often difficult to diagnose as patients have normal laboratory values and no family history.1 To our knowledge, there have been no publications to date describing...
Tue Jun 30, 2020 03:00
Adrenergic urticaria (AU) is a rare and infrequently reported disease that presents with intermittent outbreaks of stress-induced diffuse pruritic urticarial papules. First described in 19851, there has been growing literature further elucidating the mechanism of the disease as well as novel therapeutic options. A frequently occurring challenge in the diagnosis of AU is differentiating it from the more common cholinergic urticaria (CU). While in AU the papules are surrounded by halos of hypopigmented...
Tue Jun 30, 2020 03:00
Fraction exhaled nitric oxide (FeNO) is a non-invasive biomarker of type-2 asthma that can predict response to inhaled corticosteroid(ICS) therapy. Little is known regarding the magnitude of FeNO reduction following an oral corticosteroid(OCS) course and less is known whether there are differential responses based on race in children with mild-to-moderate asthma.
Tue Jun 30, 2020 03:00
A 27-year-old woman having angioedema attacks without concomitant urticaria since she was seven was diagnosed as hereditary angioedema (HAE) Type II in our clinic in 2014. She did not have any siblings. Her mother was also diagnosed as Type II HAE in our clinic. On admission, she was complaining of frequent recurrent angioedema of her extremities and lips and episodic abdominal pain with nausea and vomiting which was occasionally concomitant.
Tue Jun 30, 2020 03:00
Food allergy (FA) is a chronic condition of emerging global concern. Surveys have been conducted in numerous countries to assess physician knowledge, attitude, and practices (KAP) pertaining to FA and anaphylaxis and substantial deficits in their KAP were identified.
Tue Jun 30, 2020 03:00
Abstract Purpose Although stereotactic radiosurgery (SRS) has been proven to be effective and safe for treating intracranial meningiomas, concerns have been raised about the use of SRS for large-sized tumors involving the skull base that frequently encroach onto adjacent critical neural structures. The purpose of this study was to investigate the role of hypofractionated SRS as a therapeutic option for large-sized skull base meningiomas....
03:00
Abstract Animal traditions are increasingly threatened by human impact on natural habitats, posing a challenge to conservation policies. In northeastern Brazil, bearded capuchins (Sapajus libidinosus) inhabiting the Cerrado–Caatinga biome of Fazenda Boa Vista use stone hammers and anvils to crack open palm nuts and other encased foods. The same species inhabiting the mangroves of Morro do Boi ambush crabs and process them using wooden hammers and anvils. These traditions are gradually...
03:00
Abstract Objectives This study investigated benefits of routine panendoscopy in staging of oral squamous cell cancer patients. Materials and methods From 2013 to 2017, 194 oral squamous cell cancer patients were staged. Reports of routine flexible panendoscopy including oropharyngolaryngoscopy, bronchoscopy, and esophagogastroduodenoscopy were retrospectively...
03:00
Abstract Objectives The corona disease (COVID-19) is developing into one of the greatest challenges for healthcare professionals around the world. In this article, we report the detailed actions taken in the Department of Conservative Dentistry and Periodontology, University Hospital, Ludwig-Maximilians-University (LMU), Munich, Germany, during the early phase of the COVID-19 pandemic. ...
03:00
The recognition and description of new diseases often resemble the parable of the blind men and the elephant, with each declaring that the part of the beast they have touched fully defines it. As the coronavirus disease 2019 (Covid-19) pandemic has evolved, case reports have appeared describing…
Mon Jun 29, 2020 03:00
Purpose: Chemerin (RARRES2) is an endogenous leukocyte chemoattractant that recruits innate immune cells through its receptor, CMKLR1. RARRES2 is widely expressed in non-hematopoietic tissues and often downregulated across multiple tumor types compared to normal tissue. Recent studies show that augmenting chemerin in the tumor microenvironment significantly suppresses tumor growth, in part by recruiting immune effector cells. However, as tumor cells express functional chemokine/chemoattractant receptors...
Tue Jun 30, 2020 16:15
BACKGROUND: Patients with central nervous system (CNS) tumors are typically treated with radiation therapy, but this is not curative and results in the upregulation of phosphorylated signal transducer and activator of transcription 3 (p-STAT3), which drives invasion, angiogenesis, and immune suppression. Therefore, we investigated the combined effect of an inhibitor of STAT3 and whole-brain radiation therapy (WBRT) in a murine model of glioma. METHODS: C57BL/6 mice underwent intracerebral implantation...
Tue Jun 30, 2020 16:15
Addition of anti-estrogen treatment in patients with malignant PEComa progressing to mTOR inhibitors
Purpose. Perivascular epitheloid cell tumors (PEComas) are rare mesenchymal neoplasms. mTOR inhibitors are the most active agents in PEComa and in patients progressing to mTOR inhibitors other available therapies have limited benefit. Preclinical evidences showed a crosstalk between the mTOR pathway and estrogen receptor signalling. This provided a rationale for adding an anti-estrogen treatment in female patients becoming resistant to mTOR inhibitors. Methods. Since April 2018, female patients...
Tue Jun 30, 2020 16:15
Background: Eryaspase is composed of L-asparaginase encapsulated in erythrocytes and has demonstrated significant efficacy in a randomized phase 2 trial. We assessed the prognostic and predictive value of circulating tumor DNA (ctDNA) in patients plasma included in this trial. Patients and methods: Samples prospectively collected pre-treatment were centrally analyzed by next-generation sequencing. Prognostic values of baseline ctDNA and ctDNA early changes between day 0 and 28 were assessed...
Tue Jun 30, 2020 16:15
Purpose: Combination therapy with reduced-dose programmed death 1 inhibitor plus standard-dose cytotoxic T-lymphocyte-associated antigen 4 inhibitor demonstrated efficacy, but substantial toxicity, in melanoma. We present long-term results of part 1B of KEYNOTE-029, which assessed safety and efficacy of standard-dose pembrolizumab plus reduced-dose ipilimumab in advanced melanoma. Experimental Design:-Part 1B was an expansion cohort of the open-label, phase Ib portion of KEYNOTE-029. Eligible patients...
Tue Jun 30, 2020 16:15
Six months on from the start of the COVID-19 pandemic parts of the U.K. have this month begun to follow many of our mainland European neighbours in loosening lockdown restrictions. Progress is far behind that of our Antipodean cousins, where rapidly enforced rigid quarantine and public health measures have been so effective - New Zealanders will delight in having beaten Australia to cross the line first in the race to go 16 days without a new case. Schools are reopening, families and friends are...
03:00
in response to critical Personal Protective Equipment (PPE) shortages during the COVID-19 pandemic, MedsupplydriveUK was established by ENT trainee Ms. Jasmine Ho, and MedsupplydriveUK Scotland by two Plastic Surgery trainees (Ms. Gillian Higgins and Mrs. Eleanor Robertson). We applied the principles of creative problem solving and multidisciplinary collaboration instilled by our specialty. Since March 2020, we have recruited over 400 volunteers to mobilise over 200,000 pieces of high quality PPE...
03:00
MutantHuntWGS is a user-friendly pipeline for analyzing Saccharomyces cerevisiae whole-genome sequencing data. It uses available open-source programs to: (1) perform sequence alignments for paired and single-end reads, (2) call variants, and (3) predict variant effect and severity. MutantHuntWGS outputs a shortlist of variants while also enabling access to all intermediate files. To demonstrate its utility, we use MutantHuntWGS to assess multiple published datasets; in all cases, it detects the same...
01:01
The genome sequences of archeological Saccharomyces cerevisiae isolates can reveal insights about the history of human baking, brewing and winemaking activities. A yeast strain called Jean-Talon was recently isolated from the vaults of the Intendant's Palace of Nouvelle France on a historical site in Québec City. This site was occupied by breweries from the end of the 17th century until the middle of the 20th century when poisoning caused by cobalt added to the beer led to a shutdown of brewing activities....
01:01
Tyrosine kinase inhibitors have revolutionized the world of cancer treatment in recent years, profoundly improving survival of patients with chronic myeloid leukemia (CML) and beyond. However, off-target toxicities of these inhibitors are well-described, and resistance has become a paramount concern. Novel allosteric inhibitors of the Abelson (ABL) family of tyrosine kinases, including GNF-2, GNF-5, and ABL-001, are equipped to overcome these issues. Several contemporary studies have demonstrated...
Tue Jun 30, 2020 16:56
Maximal safe resection of malignant tissue is associated with improved progression-free survival and better response to radiation and chemotherapy for glioblastoma (GBM) patients. 5-aminolevulinic acid (5-ALA) is the current FDA-approved standard for intraoperative brain tumor visualization. Unfortunately, autofluorescence in diffuse areas and high fluorescence in dense tissues significantly limit discrimination at tumor margins. The present study is the first to compare 5-ALA to an investigational...
Tue Jun 30, 2020 16:56
Nasopharyngeal carcinoma (NPC) is a squamous cell carcinoma with a proclivity for systemic dissemination, leading many patients to present with advanced-stage disease and fail available treatments. There is a notable lack of targeted therapies for NPC, despite working knowledge of multiple proteins with integral roles in NPC cancer biology. These proteins include EZH2, Snail, eIF4E, and IMPDH, which are all overexpressed in NPC and correlated with poor prognosis. These proteins are known to be modulated...
Tue Jun 30, 2020 16:56
In this report, we describe the development and testing of a new coated plate which improves the sensitivity and accuracy in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-ToF-MS). The coated plate was covered with a thin layer of hydrophobic silicon dioxide, which enabled sample enrichment due to the water repellent nature of the silicon dioxide surface. Sensitivity and required laser strengths were tested using peptide standards, with the results that these...
Tue Jun 30, 2020 18:20
Circular RNAs (circRNAs), as a recently established group of endogenous noncoding RNAs, have been involved in the occurrence and development of different malignancies. Gastric cancer (GC) remains a globally significant contributor to death in cancer patients due to insufficient early diagnosis, limited treatment measures, and poor prognosis. An increasing number of studies have found that many circRNAs are dysregulated in GC and are closely associated with its tumorigenesis and metastasis. Thus,...
Tue Jun 30, 2020 18:05
Purpose. We assessed the clinical outcomes and toxicities following hypofractionation with helical tomographic intensity-modulated radiotherapy technology (tomotherapy) in patients with stage III non-small cell lung cancer (NSCLC) who were not candidates for surgery or concurrent chemoradiation. Methods. Forty-three patients with stage III NSCLC who were treated between 2011 and 2017 were enrolled. The prescription doses for gross target volume and clinical target volume were 70 Gy and 60 Gy (respectively)...
Tue Jun 30, 2020 17:50
This study aimed to investigate whether chronic unpredictable mild stress (CUMS) affects follicular development in ovaries through the nerve growth factor (NGF)/high affinity nerve growth factor receptor, the Tropomyosin-related kinase A (TrkA) receptor, mediated signaling pathway and to reveal the relationship between chronic stress and premature ovarian insufficiency (POI) development. In this experiment, a CUMS rat model was constructed. It was found that serum estradiol (E2), anti-Mullerian hormone...
Tue Jun 30, 2020 12:50
Background. With the development of three-dimensional printing (3DP) technology, the patient-specific instrumentation (PSI) has been widely applied in total knee arthroplasty (TKA). The purpose of this study was to compare the gait parameters of patients with 3DP personalized guide-assisted and standard TKA. Methods. Retrospective analysis of the advanced knee OA cases in our hospital between June 2017 and June 2018 was conducted. 30 cases received 3DP personalized guide-assisted TKA (group A), and...
Tue Jun 30, 2020 12:50
Armadillo gene subfamily members (ARMCX1-6) are well-known to regulate protein-protein interaction involved in nuclear transport, cellular connection, and transcription activation. Moreover, ARMCX signals on cell pathways also implicated in carcinogenesis and tumor progression. However, little is known about the associations of the ARMCX subfamily members with gastric carcinoma. This study investigated the prognostic value of ARMCX subfamily mRNA expression levels with the prognosis of gastric carcinoma...
Tue Jun 30, 2020 12:35
Objective. Lupus nephritis (LN) is a major and severe complication of systemic lupus erythematosus (SLE). Neutrophil gelatinase-associated lipocalin (NGAL), as a promising next-generation biomarker in clinical nephrology, has received extensive attention. However, its diagnostic performance in LN has high variability. Therefore, we performed an updated meta-analysis to further evaluate the diagnostic accuracy of urinary NGAL (uNGAL). Materials and Methods. PubMed, Embase, and Cochrane Library were...
Tue Jun 30, 2020 11:35
Tue Jun 30, 2020 10:20
British Journal of Cancer, Published online: 01 July 2020; doi:10.1038/s41416-020-0963-yCDK5RAP3 as tumour suppressor negatively regulates self-renewal and invasion and is regulated by ERK1/2 signalling in human gastric cancer
03:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου