Abstract Background Patient frailty among patients with non‐valvular atrial fibrillation (NVAF) is associated with adverse health outcomes and increased risk of mortality. Additional evidence is needed to evaluate effective and safe NVAF treatment in this patient population. Objectives This subgroup analysis of the ARISTOPHANES study compared the risk of stroke/systemic embolism (S/SE) and major bleeding (MB) among frail NVAF patients prescribed non‐vitamin K antagonist oral...
Tue Jun 30, 2020 11:25
Mon Jun 29, 2020 22:56
Background Endoscopic ultrasound–guided fine needle aspiration (EUS‐FNA) is a sensitive and specific tool in the risk stratification of pancreatic lesions, including cysts. The sensitivity and specificity of EUS‐FNA has been shown to improve when cytology is combined with next‐generation sequencing (NGS). Ideally, fresh cyst fluid is used for NGS. In this pilot study, we explore the possibility of sequencing DNA derived from residual alcohol‐fixed pancreatic aspirates. Methods Residual cytologic...
Mon Jun 29, 2020 17:31
Background Variability in preanalytical and analytical steps for immunocytochemistry (ICC) on cytology samples is poorly defined. The objective of this study was to evaluate current practices for ICC on cytology samples in European laboratories. Methods A link to an online survey with 19 questions about ICC practices was distributed to cytology laboratories through national representatives in the European Federation of Cytology Societies. Results In total, 245 laboratories responded...
Mon Jun 29, 2020 17:29
Background In the United States, the rate of cervical cancer is disproportionally higher in Hispanic and black women compared with white women. In the current study, the authors compared human papillomavirus (HPV) testing and cytology results among black and white women over a 24‐month period. They then assessed the rates in young women in 2011 compared with 2017 according to race. Methods The authors searched the gynecologic cytology case files for black and white women treated at Johns Hopkins...
Mon Jun 29, 2020 17:25
Journal of Cutaneous Medicine and Surgery, Ahead of Print.
Mon Jun 29, 2020 10:04
Journal of Cutaneous Medicine and Surgery, Ahead of Print. BackgroundIn Québec, targeted biologic therapies for moderate to severe plaque psoriasis are restricted to patients who have not responded to phototherapy or conventional systemic treatment, primarily due to high drug costs. Apremilast, an oral treatment for plaque psoriasis, was added to the Québec provincial health insurance plan (Régie de l’assurance maladie du Québec; RAMQ) formulary in 2015, making this the only province in Canada with...
Mon Jun 29, 2020 06:38
Abstract Lack of dopamine (DA) in the striatum and the consequential dysregulation of thalamo‐cortical circuits are major causes of motor impairments in Parkinson’s disease. The striatum receives multiple cortical and subcortical afferents. Its role in movement control and motor skills learning is regulated by DA from the nigro‐striatal pathway. In Parkinson’s disease, DA loss affects striatal network activity and induces a functional imbalance of its output pathways, impairing thalamo‐cortical...
Mon Jun 29, 2020 12:16
Abstract Background The oral health of pre-schoolers is garnering international as a crisis as good oral health is a key precursor to positive health outcomes. Internationally, and within Aotearoa/New Zealand, responses been restricted to those based in a medical model and the commercialisation of oral health. Absent from existing commentary are the lived realities of parents/caregivers beliefs, attitudes and responsiveness, or...
Tue Jun 30, 2020 03:00
Mon Jun 29, 2020 12:13
Abstract Pancreatic ductal adenocarcinoma (PDAC) is resistant to virtually all chemo‐ and targeted therapeutic approaches. Epigenetic regulators represent a novel class of drug targets. Among them, BET and HDAC proteins are central regulators of chromatin structure and transcription, and preclinical evidence suggests effectiveness of combined BET and HDAC inhibition in PDAC. Here, we describe that TW9, a newly generated adduct of the BET inhibitor (+)‐JQ1 and class I HDAC inhibitor CI994, is a potent...
Mon Jun 29, 2020 12:12
Abstract Overall survival rates for patients with advanced osteosarcoma have remained static for over three decades. An in vitro analysis of osteosarcoma cell lines for sensitivity to an array of approved cancer therapies revealed that panobinostat, a broad spectrum histone deacetalyase (HDAC) inhibitor, is highly effective at triggering osteosarcoma cell death. Using in vivo models of orthotopic and metastatic osteosarcoma, here we report that panobinostat impairs the growth of primary osteosarcoma...
Mon Jun 29, 2020 12:11
Abstract Therapeutics targeting the phosphatidylinositol 3‐kinase/mammalian target of rapamycin (PI3K/mTOR) pathway initially produce potent antitumor effects, but resistance frequently occurs. Using a phosphoproteome analysis, we found that colorectal cancer (CRC) cells exhibit resistance against PI3K/mTOR inhibition through feedback activation of multiple receptor tyrosine kinases, and their downstream focal adhesion kinase, Src and extracellular signal‐regulated kinases signaling. Unexpectedly,...
Mon Jun 29, 2020 12:10
Abstract Objectives The present study tests the effectiveness of entheseal robusticity (ER) as a potential predictor of adult age‐at‐death by applying multiple regression models to a large contemporary identified skeletal sample. Materials and Methods ER was recorded for 23 bilateral postcranial entheses on 481 adult individuals (271 females and 210 males) from the Frassetto identified skeletal collection of Sassari (Italy), following the method of Mariotti et al. 2007. ER scores were used...
Mon Jun 29, 2020 21:03
The neural crest cells that form the extrinsic enteric nervous system migrate to the para‐ and then the pre‐aortic regions. Concomitantly, the thoracic (left) and lumbar (right) splanchnic nerves extend ventrally to the pre‐aortic plexuses. Pre‐aortic nerve fibres from the coeliac and inferior mesenteric plexus extend further ventrally to connect to the intrinsic nerve fibres inside the gut wall. The herniated portions of the midgut become innervated only after return into the abdominal cavity....
Mon Jun 29, 2020 22:43
Diffusion tensor imaging (DTI) allows for the accurate visualisation and measurement of important muscle architecture factors such as muscle fibre lengths in vivo, but the accuracy of these data derived from this method has not been tested in a functional context, such as in subject‐specific musculoskeletal models. This study aimed to test the relative accuracy of personalised muscle architecture data from DTI and MRI compared to more generic data at predicting muscle torques in subject‐specific...
Mon Jun 29, 2020 22:39
The pelvic nerve is a mixed sensory‐motor nerve and a potential target of neuromodulation for pelvic organ dysfunction. We have visualised neural components within its individual fascicles and identified segregation of sensory pathways innervating the lower bowel and urinary tracts. We have also defined new features of sensory connectivity in the pelvic ganglia. These anatomical data will facilitate the design of experimental bioengineering strategies to specifically modulate each axon class. ...
Mon Jun 29, 2020 21:08
Abstract Background Although many studies have been conducted on the relationship between masticatory performance and nutrient ingestion in the elderly, few large‐scale studies have been carried out using relatively young individuals. Objectives The objective of this study was to clarify the association between the masticatory performance evaluated by the gummy‐jelly test, not by visual examination, and nutrient ingestion state based on the brief self‐administered diet history questionnaire...
Mon Jun 29, 2020 11:16
Abstract The aim of this work was to determine reliable anatomical landmarks for locating and preserving the abducens nerves (6th cranial nerves) during trans-facial or trans-nasal endoscopic approaches of skull base tumors involving the clivus and the petrous apex. In order to describe this specific anatomy, we carefully dissected 10 cadaveric heads under optic magnification. Several measurements were taken between the two petro-sphénoidal foramina, from the bottom of the sella...
Tue Jun 30, 2020 03:00
Abstract In everyday life, we often use graphical interfaces where the visual space is mapped to the motor space with a visuomotor gain called the control display gain. One of the key objectives in the field of Human Computer Interaction is to design this control display gain so as to enhance users’ performance. Although the control display gain involved in operating systems has been found to improve users’ pointing performance, the reasons for this improvement have not yet been...
Tue Jun 30, 2020 03:00
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveThis study aimed to detect circulating microRNA (miR)-17 and miR-20a levels in patients with pulmonary arterial hypertension (PAH), and to investigate whether circulating miR-17 levels are associated with PAH.MethodsThirty-five PAH patients and 20 healthy controls were enrolled in the study. Circulating miR-17 and miR-20a levels were measured using real-time PCR analysis.ResultsmiR-17 levels were significantly increased...
Tue Jun 30, 2020 07:41
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Sat Jun 27, 2020 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Sat Jun 27, 2020 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Sat Jun 27, 2020 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Fri Jun 26, 2020 10:00
High Altitude Medicine &Biology, Ahead of Print.
Thu Jun 25, 2020 10:00
Share Tweet Share Whatsapp Email View/Download PDF Download ---Citations--- BibTeX RIS Featured Case Report 10 (2); 120-131 doi:10.25259/APOS_45_2020 Buy Reprints ...
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Share Tweet Share Whatsapp Email View/Download PDF Download ---Citations--- BibTeX RIS Review Article 10 (2); 78-88 doi:10.25259/APOS_84_2020 Buy Reprints ...
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