Castleman Disease

68Ga-DOTATATE and 18F-FDG in Castleman Disease:



A 35-year-old woman with rectal neuroendocrine tumor, Ki-67 proliferation index less than 2%, and a mediastinal mass on CT postoperatively was referred for restaging with PET/CT 68Ga-DOTATATE. The examination showed uptake on the pelvic lymph node and mediastinal mass. Because of differences in lesions’ SUVs and clinical presentation, the hypothesis of lymphoma for the mediastinal mass was raised, and 18F-FDG PET/CT was performed, which showed glycolytic hypermetabolism in the mediastinal mass and absence of hypermetabolism in pelvic lymph nodes. Transthoracic biopsy of the mass revealed atypical large-cell lymphoid proliferation, and immunohistochemistry study was compatible with Castleman disease.

Received for publication January 30, 2020; revision accepted July 28, 2020.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Maria Eduarda Duarte de Mello Flamini, MSc, Rua José Aderval Chaves, 230/2501, Boa Viagem, 51111-030 Recife, Brazil. E-mail: mariaemello@gmail.com.

Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.

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Castleman disease (CD) is a rare disease of lymph nodes and related tissues. It was first described by Dr. Benjamin Castleman in the 1950s. It is also known as Castleman's disease, giant lymph node hyperplasia, and angiofollicular lymph node hyperplasia (AFH).Feb 1, 2018

What Is Castleman Disease? - American Cancer Society