“Effects of Single-dose Preoperative Pregabalin on Postoperative Pain and Opioid Consumption in Cleft Orthognathic Surgery”:
Background:
Several studies have illustrated the efficacy of pregabalin in decreasing postoperative opioid use in adults undergoing orthognathic surgery. We aimed to study the effects of a single dose of preoperative pregabalin on total opioid consumption after orthognathic surgery in individuals with cleft lip and palate.
Methods:
This is a retrospective cohort study of consecutive patients who underwent Le Fort I midface advancement between June 2012 and July 2019. All patients had a diagnosis of cleft lip and palate. The treatment group received a 1-time preoperative dose of pregabalin; the control group did not. Total morphine milligram equivalent (MME) consumption was calculated by adding intraoperative and postoperative opioid use during admission.
Results:
Twenty-three patients were included in this study; 12 patients received pregabalin. The pregabalin group had significantly lower total opioid consumption (total MME 70.95 MME; interquartile range [IQR]: 24.65–150.17) compared to the control group (138.00 MME; IQR: 105.00–232.48) (MU = 31.00, P = 0.031). The difference in mean pain scores in the treatment group (3.21 ± 2.03) and the control group (3.71 ± 2.95) was not statistically significant (P = 0.651, 95% confidence interval −1.75 to 2.75).
Conclusions:
A 1-time preoperative dose of pregabalin before orthognathic surgery in patients with cleft lip and palate reduced total opioid consumption during admission without increasing patient pain. A single preemptive dose of pregabalin should be considered an effective adjunct to pain management protocols in patients undergoing orthognathic surgery.
Address correspondence and reprint requests to Kamlesh B. Patel, MD, MSc, Washington University in St. Louis Plastic and Reconstructive Surgery 660 South Euclid Avenue, Campus Box 8238 St. Louis, MO 63110; E-mail: kamlesh.patel@wustl.edu
Received 16 July, 2020
Accepted 26 August, 2020
The authors report no conflicts of interest.
Financial Disclosure Statement: KBP is a consultant for Stryker CMF. The other authors have no financial interests in any of the products, devices, or drugs mentioned in this manuscript.
Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (www.jcraniofacialsurgery.com).
© 2020 by Mutaz B. Habal, MD.
Medicine RSS-Feeds by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com
Πληροφορίες
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Αρχειοθήκη ιστολογίου
-
►
2023
(366)
- ► Φεβρουαρίου (184)
- ► Ιανουαρίου (182)
-
►
2022
(2814)
- ► Δεκεμβρίου (182)
- ► Σεπτεμβρίου (213)
- ► Φεβρουαρίου (264)
- ► Ιανουαρίου (262)
-
►
2021
(3815)
- ► Δεκεμβρίου (229)
- ► Σεπτεμβρίου (276)
- ► Φεβρουαρίου (64)
-
▼
2020
(5754)
- ► Δεκεμβρίου (401)
-
▼
Σεπτεμβρίου
(365)
-
▼
Σεπ 24
(89)
- Spiritual peace and life meaning
- Video cognitive‐behavioral therapy for insomnia in...
- assessing focal renal lesions in pediatric patient...
- behavioural sex differences
- Fine needle aspiration cytology of cervical lymph ...
- Ameloblastoma diagnosis by fine‐needle aspiration ...
- Complications of Fluoroscopically Guided Cervical ...
- Low-Dose Naltrexone for Chronic Pain
- staging for head and neck cutaneous squamous cell ...
- Endoscopic transoral approach for resection of ret...
- Determining the number and distribution of intrapa...
- Transbronchial Needle Aspiration Cytology and Puru...
- Giant sublingual hamartoma with medial cleft tongue
- Inflammatory cytokine expression in the skin of pa...
- The real cause of right lower abdominal pain: an a...
- The regulatory role of exosomes in leukemia and th...
- Predictive value of cardiopulmonary fitness parame...
- Identification of differentially expressed genes b...
- Risk factors for surgical site infection after maj...
- Evaluation of stability of deep venous thrombosis ...
- Seasonal variation in notified tuberculosis cases
- Association between fish intake and glioma risk......
- Medical Oncology
- Extracranial Meningioma in the Scalp with Concurre...
- Multiple endo bronchial lipoma
- Human Papillomaviruses and Skin Cancer.
- Recurrent cisplatin-induced bradycardia.
- Management of recurrent and metastatic oral cavity...
- Neck management in patients with olfactory neurobl...
- Seeding of a Tumor in the Gastric Wall after Endos...
- An Endotracheal Plasmablastic Lymphoma.
- Oral melanomas in HIV-positive patients
- Nivolumab in patients with rare head and neck carc...
- Rare Cancers
- The potential contribution of trace amines (TA) to...
- SAGE Publications Ltd: Journal of International Me...
- European Journal of Nuclear Medicine and Molecular...
- Suppression of myocardial glucose metabolism in FD...
- 68 Ga-PSMA Cerenkov luminescence imaging in primar...
- The image quality, lesion detectability, and acqui...
- Imaging CXCR4 expression in patients with suspecte...
- Prolyl and lysyl hydroxylases in collagen synthesis
- New Ponto Care™ App for Bone-Anchored Hearing Devi...
- B3 lesion ....Vacuum‐assisted excisional biopsy ma...
- Pleural and pericardiac effusion could have radioi...
- 18F-FBPA PET in Sarcoidosis: Comparison to Inflamm...
- Malignant Peripheral Nerve Sheath Tumor Arising Fr...
- Castleman Disease
- Iatrogenic Lung Microembolism Resulted in Extraoss...
- Extrapulmonary Tuberculosis Mimicking Malignant Tumor
- Masticator Muscles After Cocaine Use
- Periappendicular Abscess
- Incidental Detection of Pancreatic Arteriovenous M...
- Necrobiotic Xanthogranuloma
- Pembrolizumab-Induced Thyroiditis and Colitis
- Left Ventricular Infected Thrombus Detected by 18F...
- Postablative 131I SPECT/CT Is Much More Sensitive ...
- Dynamic Whole-Body 18F-FDG PET for Minimizing Pati...
- Primary Inferior Vena Cava Leiomyosarcoma With Hep...
- Traditional Versus Virtual Surgery Planning of the...
- Comprehensive Treatment and Vascular Architecture ...
- Treatment of Osteomyelitic Bone following Cranial ...
- Syndrome of the Trephined Related to Inflation of ...
- Digital Analysis of Cranial Sutures CT Data
- Onlay Hydroxyapatite Cement for Secondary Craniopl...
- Smile Reanimation Surgery in Patients With Facial ...
- Spring-Assisted Surgery for Treatment of Sagittal ...
- Variations in Postoperative Management of Pediatri...
- Polyotia: the Confusing Auricular Malformation
- Spontaneous Bone Flap Resorption Following Craniop...
- Evaluation of Velopharyngeal Closure Ratio (VCR) b...
- Biomechanical Evaluation of Implant Osseointegrati...
- Treatment of Chronic Frontal Sinusitis and Frontal...
- Secondary Coronal Synostosis After Early Surgery f...
- Pediatric Mandibular Central Giant Cell Granuloma:...
- Management of Diplopia Following Orbital Fracture ...
- “Effects of Single-dose Preoperative Pregabalin on...
- A New Solution for Routine Endoscopic Aerosol-Gene...
- Endoscopic Repair of Nasal Septal Perforations Wit...
- The Immunological Properties of Isolated Lymphoid ...
- Lower-Dose Zinc for Childhood Diarrhea
- Granulomatous Amebic Encephalitis
- TMPRSS2, a SARS-CoV-2 internalization protease is ...
- Human papillomavirus oropharynx carcinoma: Aggress...
- Postoperative radiotherapy is associated with impr...
- International Journal of Molecular Sciences
- International Journal of Environmental Research ...
- Antibiotics
- Medicine by Alexandros G. Sfakianakis
-
▼
Σεπ 24
(89)
- ► Φεβρουαρίου (754)
- ► Ιανουαρίου (894)
-
►
2019
(146)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου