Πέμπτη 24 Σεπτεμβρίου 2020

European Journal of Nuclear Medicine and Molecular Imaging

 

Response to the letter to the editor: Lassen et al. 3D PET/CT 82 Rb PET myocardial blood flow quantification: comparison of half-dose and full-dose protocols
European Journal of Nuclear Medicine and Molecular Imaging
Tue Sep 01, 2020 03:00
Classification of negative and positive 18 F-florbetapir brain PET studies in subjective cognitive decline patients using a convolutional neural network
Abstract Purpose Visual reading of 18F-florbetapir positron emission tomography (PET) scans is used in the diagnostic process of patients with cognitive disorders for assessment of amyloid-ß (Aß) depositions. However, this can be time-consuming, and difficult in case of borderline amyloid pathology. Computer-aided pattern recognition can be helpful in this process but needs to be validated. The aim of this work was to develop, train,...
European Journal of Nuclear Medicine and Molecular Imaging
Wed Sep 02, 2020 03:00
18F-FDG simultaneous PET/MR monitoring treatment response of a Turcot syndrome case
European Journal of Nuclear Medicine and Molecular Imaging
Wed Sep 02, 2020 03:00
Long-term outcome of “Sandwich” chemo-PRRT: a novel treatment strategy for metastatic neuroendocrine tumors with both FDG- and SSTR-avid aggressive disease
Abstract Objective The primary aims of this study were to evaluate the long-term outcome of a “sandwich chemo-PRRT (SCPRRT)” regimen with regard to therapeutic response rate, progression-free survival (PFS), and overall survival (OS) rates in metastatic neuroendocrine tumors (NETs) with both somatostatin receptor (SSTR)– and fluorodeoxyglucose (FDG)-avid aggressive disease. Additionally, health-related quality of life (HRQoL) scales,...
European Journal of Nuclear Medicine and Molecular Imaging
Wed Sep 02, 2020 03:00
[ 68 Ga]Ga-Prostate-Specific Membrane Antigen PET/CT: a novel method for imaging patients with hepatocellular carcinoma
Abstract Purpose Prostate-specific membrane antigen (PSMA) is not only highly expressed on the surface prostate cancer cells but is also elevated during angiogenesis in other cancer cell types, including hepatocellular carcinoma (HCC). This study aimed to evaluate the feasibility of using PET/CT imaging with [68Ga]Ga-PSMA-11 in HCC and its impact on patient management. ...
European Journal of Nuclear Medicine and Molecular Imaging
Thu Sep 03, 2020 03:00
Grey zone amyloid burden affects memory function: the SCIENCe project
Abstract Purpose To determine thresholds for amyloid beta pathology and evaluate associations with longitudinal memory performance with the aim to identify a grey zone of early amyloid beta accumulation and investigate its clinical relevance. Methods We included 162 cognitively normal participants with subjective cognitive decline from the SCIENCe...
European Journal of Nuclear Medicine and Molecular Imaging
Fri Sep 04, 2020 03:00
Head-to-head comparison of DFO* and DFO chelators: selection of the best candidate for clinical 89 Zr-immuno-PET
Abstract Purpose Almost all radiolabellings of antibodies with 89Zr currently employ the hexadentate chelator desferrioxamine (DFO). However, DFO can lead to unwanted uptake of 89Zr in bones due to instability of the resulting metal complex. DFO*-NCS and the squaramide ester of DFO, DFOSq, are novel analogues that gave more stable 89Zr complexes than DFO in pilot experiments. Here, we directly compare these linker-chelator systems to...
European Journal of Nuclear Medicine and Molecular Imaging
Sat Sep 05, 2020 03:00
Clinical feasibility and impact of fully automated multiparametric PET imaging using direct Patlak reconstruction: evaluation of 103 dynamic whole-body 18 F-FDG PET/CT scans
Abstract Purpose Functional imaging by standard whole-body (WB) 18F-flurodeoxyglucose (FDG) positron emission tomography (PET) is an integrated part of disease diagnostics. Recently, a clinical dynamic whole-body (D-WB) FDG PET/CT scanning protocols has been developed allowing for quantitative imaging of tissue metabolic rate of FDG (MRFDG). It was the purpose of this retrospective study to evaluate whether MRFDG imaging is feasible...
European Journal of Nuclear Medicine and Molecular Imaging
Mon Sep 07, 2020 03:00
PET/MRI in prostate cancer: a systematic review and meta-analysis
Abstract Aim In recent years, the clinical availability of scanners for integrated positron emission tomography (PET) and magnetic resonance imaging (MRI) has enabled the practical potential of multimodal, combined metabolic-receptor, anatomical, and functional imaging to be explored. The present systematic review and meta-analysis summarize the diagnostic information provided by PET/MRI in patients with prostate cancer (PCa). ...
European Journal of Nuclear Medicine and Molecular Imaging
Tue Sep 08, 2020 03:00
Image-guided in situ detection of bacterial biofilms in a human prosthetic knee infection model: a feasibility study for clinical diagnosis of prosthetic joint infections
Abstract Purpose Due to an increased human life expectancy, the need to replace arthritic or dysfunctional joints by prosthetics is higher than ever before. Prosthetic joints are unfortunately inherently susceptible to bacterial infection accompanied by biofilm formation. Accurate and rapid diagnosis is vital to increase therapeutic success. Yet, established diagnostic modalities cannot directly detect bacterial biofilms on prostheses....
European Journal of Nuclear Medicine and Molecular Imaging
Tue Sep 08, 2020 03:00
Assessment of extra-parenchymal lung involvement in asymptomatic cancer patients with COVID-19 pneumonia detected on 18 F-FDG PET-CT studies
Abstract Background Lung involvement in patients with coronavirus disease 2019 (COVID-19) undergoing PET-CT has been previously reported. However, FDG uptake outside lung parenchyma was poorly characterized in detail. We evaluated the extra-parenchymal lung involvement in asymptomatic cancer patients with COVID-19 pneumonia through 18F-FDG PET-CT. Methods ...
European Journal of Nuclear Medicine and Molecular Imaging
Tue Sep 08, 2020 03:00
[ 68 Ga]Ga-DOTA-FAPI-04 PET/CT imaging in a case of prostate cancer with shoulder arthritis
European Journal of Nuclear Medicine and Molecular Imaging
Tue Sep 08, 2020 03:00
Increased incidence of interstitial pneumonia detected on [ 18 F]-FDG-PET/CT in asymptomatic cancer patients during COVID-19 pandemic in Lombardy: a casualty or COVID-19 infection?
Abstract Purpose The study aimed to compare the incidence of interstitial pneumonia on [18F]-FDG PET/CT scans between two 6-month periods: (a) the COVID-19 pandemic peak and (b) control period. Secondly, we compared the incidence of interstitial pneumonia on [18F]-FDG PET/CT and epidemiological data from the regional registry of COVID-19 cases. Additionally, imaging findings and the intensity of [18F]-FDG PET/CT uptake in terms of maximum...
European Journal of Nuclear Medicine and Molecular Imaging
Wed Sep 09, 2020 03:00
Molecular detection of Gram-positive bacteria in the human lung through an optical fiber–based endoscope
Abstract Purpose The relentless rise in antimicrobial resistance is a major societal challenge and requires, as part of its solution, a better understanding of bacterial colonization and infection. To facilitate this, we developed a highly efficient no-wash red optical molecular imaging agent that enables the rapid, selective, and specific visualization of Gram-positive bacteria through a bespoke optical fiber–based delivery/imaging...
European Journal of Nuclear Medicine and Molecular Imaging
Fri Sep 11, 2020 03:00
Giorgio Treglia, Luca Giovanella (Eds): Evidence-Based Positron Emission Tomography: Summary of Recent Meta-Analyses on PET
European Journal of Nuclear Medicine and Molecular Imaging
Fri Sep 11, 2020 03:00
Egesta Lopci, Stefano Fanti (Eds.): Atlas of Response to Immunotherapy
European Journal of Nuclear Medicine and Molecular Imaging
Fri Sep 11, 2020 03:00
An unusual presentation of recurrent T cell lymphoma: angiocentric pattern of cutaneous uptake on [ 18 F]FDG PET/CT
European Journal of Nuclear Medicine and Molecular Imaging
Sat Sep 12, 2020 02:44
Non-oncological applications of RGD-based single-photon emission tomography and positron emission tomography agents
Abstract Introduction Non-invasive imaging techniques (especially single-photon emission tomography and positron emission tomography) apply several RGD-based imaging ligands developed during a vast number of preclinical and clinical investigations. The RGD (Arg-Gly-Asp) sequence is a binding moiety for a large selection of adhesive extracellular matrix and cell surface proteins. Since the first identification of this sequence as the shortest...
European Journal of Nuclear Medicine and Molecular Imaging
Sat Sep 12, 2020 03:00
Correction to: 68Ga-PSMA PET/CT tumour intensity pre-operatively predicts adverse pathological outcomes and progression-free survival in localised prostate cancer
Figure 2b is incorrect in the original paper.
European Journal of Nuclear Medicine and Molecular Imaging
Sat Sep 12, 2020 03:00
A malignant birthmark detected by 18 F-FDG PET/CT in a patient with esophageal cancer
European Journal of Nuclear Medicine and Molecular Imaging
Tue Sep 15, 2020 03:00
(+)-[ 18 F]Flubatine as a novel α4β2 nicotinic acetylcholine receptor PET ligand—results of the first-in-human brain imaging application in patients with β-amyloid PET-confirmed Alzheimer’s disease and healthy controls
Abstract Purposes We present the first in-human brain PET imaging data of the new α4β2 nicotinic acetylcholine receptor (nAChR)–targeting radioligand (+)-[18F]Flubatine. Aims were to develop a kinetic modeling-based approach to quantify (+)-[18F]Flubatine and compare the data of healthy controls (HCs) and patients with Alzheimer’s disease (AD); to investigate the partial volume effect (PVE) on regional (+)-[18F]Flubatine binding; and...
European Journal of Nuclear Medicine and Molecular Imaging
Wed Sep 16, 2020 03:00
18 F-FDG-PET/CT indication in patients affected by differentiated thyroid cancer with elevated serum thyroglobulin and negative whole-body scanning after therapy with 131 I
European Journal of Nuclear Medicine and Molecular Imaging
Wed Sep 16, 2020 03:00
[ 18 F]-FDG PET/CT in oncologic patients with unsuspected asymptomatic infection with SARS-CoV-2
Abstract Purpose Spain has been one of the most affected countries by the COVID-19 pandemic, being among the countries with worse numbers, including the death rate. However, most patients are asymptomatic, although they are very contagious. The objective of this study was to investigate the incidence in oncological patients infected with SARS-CoV-2 that are asymptomatic for COVID-19 and at home and that undergo PET/CT for oncologic...
European Journal of Nuclear Medicine and Molecular Imaging
Wed Sep 16, 2020 03:00
Higher thyroid hormone levels and cancer
Abstract Purpose This narrative review aims to summarize the relationship between hyperthyroidism, upper reference range thyroid hormone (TH) levels, and cancer, and to address the clinical management of hyperthyroidism in cancer patients. Methods A comprehensive search was performed by an independent reviewer through Google Scholar and PubMed Electronic...
European Journal of Nuclear Medicine and Molecular Imaging
Fri Sep 18, 2020 02:29
European Association of Nuclear Medicine October 22 – 30, 2020 Virtual
European Journal of Nuclear Medicine and Molecular Imaging
Fri Sep 18, 2020 03:00
Biodistribution and dosimetry of a single dose of albumin-binding ligand [ 177 Lu]Lu-PSMA-ALB-56 in patients with mCRPC
Abstract Introduction PSMA-targeted radionuclide therapy with lutetium-177 has emerged as an effective treatment option for metastatic, castration-resistant prostate cancer (mCRPC). Recently, the concept of modifying PSMA radioligands with an albumin-binding entity was demonstrated as a promising measure to increase the tumor uptake in preclinical experiments. The aim of this study was to translate the concept to a clinical setting...
European Journal of Nuclear Medicine and Molecular Imaging
Sat Sep 19, 2020 03:00
How to better stratify the risk of differentiated thyroid carcinomas: the key role of radioactive iodine therapy, age, and gender
Abstract Purpose The risk of relapse of differentiated thyroid carcinomas (DTC) and their indication for radioactive iodine therapy (RAI) are assessed according to ATA risk stratification system principally based on tumor-nodes-metastasis (TNM) staging. However, while establishing the indication for RAI may be a “dilemma,” performing it can improve the risk stratification. We aimed to evaluate whether (1) the stratification of risk...
European Journal of Nuclear Medicine and Molecular Imaging
Mon Sep 21, 2020 03:00
Image-based dosimetry for 225 Ac-PSMA-I&T therapy using quantitative SPECT
European Journal of Nuclear Medicine and Molecular Imaging
Mon Sep 21, 2020 03:00
Response to 225 Ac-PSMA-I&T after failure of long-term 177 Lu-PSMA RLT in mCRPC
European Journal of Nuclear Medicine and Molecular Imaging
Tue Sep 22, 2020 03:00
Clinical utility of perfusion (Q)-single-photon emission computed tomography (SPECT)/CT for diagnosing pulmonary embolus (PE) in COVID-19 patients with a moderate to high pre-test probability of PE
Abstract Purpose We reviewed the clinical utility of perfusion (Q)-single-photon emission computed tomography (SPECT)/CT for diagnosing pulmonary embolus (PE) in patients hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV2). Methods Following the World Health Organization’s declaration of a global pandemic, our department policy...
European Journal of Nuclear Medicine and Molecular Imaging
Tue Sep 22, 2020 03:00
Diffuse multiple organs uptake of 99m Tc-MDP on SPECT/CT
European Journal of Nuclear Medicine and Molecular Imaging
Wed Sep 23, 2020 03:00
Management of differentiated thyroid cancer through nuclear medicine facilities during Covid-19 emergency: the telemedicine challenge
Abstract Purpose To investigate whether a telemedicine service (TMS) carried out during the Covid-19 pandemic impacted on management of patients with differentiated thyroid cancer (DTC). Methods We retrospectively reviewed the number and the findings of outpatient visits in DTC subjects referred between March 11, 2020, and May 31, 2020, during the...
European Journal of Nuclear Medicine and Molecular Imaging
Wed Sep 23, 2020 03:00
Characterization of MK6240, a tau PET tracer, in autopsy brain tissue from Alzheimer’s disease cases
Abstract Purpose MK6240 is a second-generation tau PET tracer designed to detect the neurofibrillary tangles in the brains of patients with Alzheimer’s disease (AD). The aim of the study was to characterize 3H-MK6240 in AD and control brain tissue and to compare its binding properties with those of first-generation tau PET tracers. Methods Saturation...
European Journal of Nuclear Medicine and Molecular Imaging
Thu Sep 24, 2020 03:00
PSMA PET total tumor volume predicts outcome of patients with advanced prostate cancer receiving [ 177 Lu]Lu-PSMA-617 radioligand therapy in a bicentric analysis
Abstract Introduction [177Lu]Lu-PSMA-617 (Lu-PSMA) radioligand therapy is an emerging treatment option for patients with end-stage prostate cancer. However, response to Lu-PSMA therapy is only achieved in approximately half of patients. It is clinically important to identify patients at risk of poor outcome. Therefore, the aim of this study was to evaluate pretherapeutic PSMA PET derived total tumor volume and related metrics as prognosticators...
European Journal of Nuclear Medicine and Molecular Imaging
Thu Sep 24, 2020 03:00
Longitudinal mouse-PET imaging: a reliable method for estimating binding parameters without a reference region or blood sampling
Abstract Longitudinal mouse PET imaging is becoming increasingly popular due to the large number of transgenic and disease models available but faces challenges. These challenges are related to the small size of the mouse brain and the limited spatial resolution of microPET scanners, along with the small blood volume making arterial blood sampling challenging and impossible for longitudinal studies. The ability to extract an input function directly...
European Journal of Nuclear Medicine and Molecular Imaging
Thu Sep 24, 2020 12:39
18 F-Fluorocholine uptake matching CT lesions in the lungs of a patient clinically cured from COVID-19 syndrome
European Journal of Nuclear Medicine and Molecular Imaging
Thu Sep 24, 2020 12:39
Imaging CXCR4 expression in patients with suspected primary hyperaldosteronism
Abstract Purpose It is challenging to differentiate unilateral aldosterone-producing adenoma (APA) from bilateral idiopathic adrenal hyperplasia (IAH) and nonfunctional adrenal adenoma (NFA) in primary aldosteronism (PA). In a first primarily ex vivo study detection, CXC chemokine receptor type 4 (CXCR4) expression has been shown to be a valuable tool for the detection of APA. In this study, we aimed to clinically evaluate CXCR4...
European Journal of Nuclear Medicine and Molecular Imaging
Thu Sep 24, 2020 12:39
New! F-18-based PET/CT for sodium-iodine-symporter-targeted imaging!
European Journal of Nuclear Medicine and Molecular Imaging
Thu Sep 24, 2020 12:39
The image quality, lesion detectability, and acquisition time of 18 F-FDG total-body PET/CT in oncological patients
Abstract Purpose The purpose was to investigate the effects of short acquisition time on the image quality and the lesion detectability of oncological 18F-FDG total-body PET/CT. Methods Nineteen oncological patients (6/13 women/men, age 65.6 ± 9.4 years) underwent total-body PET/CT on uEXPLORER scanner using 3D list mode. The administration...
European Journal of Nuclear Medicine and Molecular Imaging
Thu Sep 24, 2020 12:39
Reply to comment by J.P. Suarez Fernandez on “Consensus document for the diagnosis of prosthetic joint infections: a joint paper by the EANM, EBJIS, and ESR (with ESCMID endorsement)”
European Journal of Nuclear Medicine and Molecular Imaging
Thu Sep 24, 2020 12:39
68 Ga-PSMA Cerenkov luminescence imaging in primary prostate cancer: first-in-man series
Abstract Purpose Currently, approximately 11–38% of prostate cancer (PCa) patients undergoing radical prostatectomy have a positive surgical margin (PSM) on histopathology. Cerenkov luminescence imaging (CLI) using 68Ga-prostate-specific membrane antigen (68Ga-PSMA) is a novel technique for intraoperative margin assessment. The aim of this first-in-man study was to investigate the feasibility of intraoperative 68Ga-PSMA CLI. In...
European Journal of Nuclear Medicine and Molecular Imaging
Thu Sep 24, 2020 12:39
Suppression of myocardial glucose metabolism in FDG PET/CT: impact of dose variation in heparin bolus pre-administration
Abstract Introduction Adequate suppression of physiologic myocardial glucose uptake is important to ensure the interpretability and diagnostic reliability of [18F]fluorodeoxyglucose (FDG) PET/CT studies performed in the context of cardiac inflammation and infection. This study describes our experience with 4 preparatory protocols used in our institution. Methods...
European Journal of Nuclear Medicine and Molecular Imaging
Thu Sep 24, 2020 12:39
Letter to the editor: Is it reasonable to prescribe RAI for all DTC patients with a primary tumor diameter exceeding 1 cm?
European Journal of Nuclear Medicine and Molecular Imaging
Thu Sep 24, 2020 12:39
Comments on “Consensus document for the diagnosis of prosthetic joint infections: a joint paper by the EANM, EBJIS, and ESR (with ESCMID endorsement)”
European Journal of Nuclear Medicine and Molecular Imaging
Thu Sep 24, 2020 12:39
Ionathon A. Nye (Editor). Radiologic Physics Taught Through Cases
European Journal of Nuclear Medicine and Molecular Imaging
Thu Sep 24, 2020 12:39
Lung scintigraphy for pulmonary embolism diagnosis during the COVID-19 pandemic: does the benefit-risk ratio really justify omitting the ventilation study?
European Journal of Nuclear Medicine and Molecular Imaging
Thu Sep 24, 2020 12:39
Tracheobronchitis signs observed on ventilation lung scintigraphy during the course of COVID-19 infection
European Journal of Nuclear Medicine and Molecular Imaging
Thu Sep 24, 2020 12:39
Automated detection and quantification of COVID-19 pneumonia: CT imaging analysis by a deep learning-based software
Abstract Background The novel coronavirus disease 2019 (COVID-19) is an emerging worldwide threat to public health. While chest computed tomography (CT) plays an indispensable role in its diagnosis, the quantification and localization of lesions cannot be accurately assessed manually. We employed deep learning-based software to aid in detection, localization and quantification of COVID-19 pneumonia. ...
European Journal of Nuclear Medicine and Molecular Imaging
Thu Sep 24, 2020 12:39
FDG PET/CT evaluation of a patient recovering from COVID-19
European Journal of Nuclear Medicine and Molecular Imaging
Thu Sep 24, 2020 12:39
Correction to: Brain PET amyloid and neurodegeneration biomarkers in the context of the 2018 NIA-AA research framework: an individual approach exploring clinical-biomarker mismatches and sociodemographic parameters
In the last paragraph of the subsession “Recruitment of the study population and clinical Evaluation” (Material and methods session).
European Journal of Nuclear Medicine and Molecular Imaging
Thu Sep 24, 2020 12:39
FDG-PET/CT imaging during the Covid-19 emergency: a southern Italian perspective
Abstract Purpose To assess the impact of the Covid-19 pandemic on FDG-PET/CT work volume and to evaluate the occurrence of abnormal imaging findings suspicious or potentially diagnostic for interstitial pneumonia by Covid-19 infection in south Italy. Methods We retrospectively reviewed the number and the findings of FDG-PET/CT studies...
European Journal of Nuclear Medicine and Molecular Imaging
Thu Sep 24, 2020 12:39

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