The Immunological Properties of Isolated Lymphoid Follicles

Uncovering the Immunological Properties of Isolated Lymphoid Follicles:

Abstract

The intestine is the largest organ of the body and exhibits the greatest amount and diversity of immune cells. Intestinal homeostasis is tightly controlled by the gut mucosal immune network, which involves gut‐associated lymphoid tissues (GALT), secretory IgA (sIgA), mucosal immune cells (i.e. T helper (Th), T follicular (Tfh) and T regulatory (Treg) cells), cytokines, chemokines and commensal bacteria, among others. Unsurprisingly, crosstalk between these cells and their local environment is crucial for the maturation and function of the immune system, and the disruption of this communication often leads to the development of immune disorders.