Journal of International Medical Research, Volume 48, Issue 9, September 2020. Primary thyroid hemangioma is an extremely rare clinical disease. Only 31 cases have been reported to date according to a PubMed search, and most were postoperatively diagnosed by pathologic examination. Ultrasonography is the first-line imaging modality for thyroid disease screening. However, preoperative ultrasonic diagnosis of thyroid hemangioma has been rarely reported. We herein describe a 24-year-old woman with a...
08:23
Journal of International Medical Research, Volume 48, Issue 9, September 2020. Spinal angiolipomas (SALs) are extremely rare benign tumors composed of both mature fatty tissue and anomalous vascular channels. We present two cases of SALs and review the clinical presentation, radiological appearance, pathological aspects, and treatment of this distinct clinicopathological mass. The patients’ neurologic symptoms improved postoperatively and follow-up revealed no signs of tumor recurrence or neurological...
08:06
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectivesThis study aimed to assess computed tomographic (CT) features of the normal pancreatic uncinate process (UP) and to classify UP types on the basis of morphological characteristics.MethodsFrom November 2017 to December 2018, consecutive Han Chinese adults were enrolled in this retrospective study. Morphometric evaluation of the UP was performed using CT imaging, including assessment of the maximal transverse diameter...
08:01
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveAlthough N6-methyladenosine (m6A) RNA methylation is the most common mRNA modification process, few studies have examined the role of m6A in stomach adenocarcinomas (STADs).MethodsIn this retrospective study, we analyzed 293 STAD samples from The Cancer Genome Atlas with complete clinicopathological feature profiles. The m6A methylation risk signature was derived from LASSO–Cox regression analyses with 15 m6A...
07:58
Journal of International Medical Research, Volume 48, Issue 9, September 2020. Retrocaval ureter is a rare disease associated with abnormal embryonic development. Here, we describe a patient who exhibited retrocaval ureter complicated by renal and ureteral calculi, which were treated by percutaneous nephrolithotomy combined with retroperitoneal laparoscopy. A 64-year-old man was admitted to our hospital because of intermittent back pain that had been present for more than 10 years. During hospitalization,...
07:56
Journal of International Medical Research, Volume 48, Issue 9, September 2020. At the end of 2019, novel coronavirus (COVID-19) infection was detected in Wuhan City, Hubei Province, China. The COVID-19 infection characteristics include a long incubation period, strong infectivity, and high fatality rate, and it negatively affects human health and social development. COVID-19 has become a common problem in the global medical and health system. It is essentially an acute self-limiting disease. Patients...
07:52
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveTo assess changes in plasma exosome levels and protein content in mice after long-term exercise.MethodsWe subjected 9-month-old adult C57BL/6J mice to daily treadmill running exercise for 4 weeks prior to the isolation of blood-derived exosomes. Exosomal proteins were identified using mass spectrometry.ResultsExtracellular bodies were successfully isolated from mouse blood. Protein levels were altered in blood-derived...
07:49
Journal of International Medical Research, Volume 48, Issue 9, September 2020. Congenital pseudarthrosis of the tibia (CPT) is a rare congenital malformation. It is characterized by a tibial anterior bowing deformity or specific types of non-union, which typically result from abnormal development of the tibia, leading to the formation of local pseudarthrosis. The treatment of CPT is very challenging. The advent of 3D printing and computer-assisted techniques in recent years has provided a new ancillary...
07:45
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveDexmedetomidine has a good sedative effect and does not affect the judgment of the patient's consciousness level. However, its effectiveness for sedation and cerebral protection after craniotomy in hypertensive intracerebral hemorrhage (HICH) patients is unknown.MethodsA retrospective study of 164 postoperative HICH patients who underwent sedation with dexmedetomidine or midazolam was conducted. The Ramsay sedation...
Thu Sep 24, 2020 10:48
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveTo determine the effect of personalized psychological interventions on the recovery of patients with sudden deafness.MethodsParticipants were 438 patients with sudden deafness who were randomly allocated to observation and control groups. Patients in the control group received routine nursing care and drug treatment. Patients in the observation group received personalized psychological interventions, routine nursing...
Thu Sep 24, 2020 10:46
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveThe index of maximal systolic acceleration ([AImax]: maximal systolic acceleration of the Doppler waveform divided by peak systolic velocity) shows diagnostic accuracy in screening of renal artery stenosis. This study aimed to determine whether an upstream factor of resistance, such as aortic valve stenosis (AVS), can affect Doppler parameters detected in the peripheral arteries.MethodsIn this prospective study,...
Thu Sep 24, 2020 10:44
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveTo investigate the changes in the diversity and dynamics of intestinal microflora in patients with neonatal necrotizing enterocolitis (NEC) in a single center in China.MethodsIn this prospective study conducted between 2016 and 2019, feces were collected from 28 neonates with NEC and 30 control neonates to analyze the species richness and Shannon’s diversity index of the bands, which were also sequenced via PCR-denaturing...
Thu Sep 24, 2020 10:43
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveThe aim of this prospective randomized controlled clinical trial was to explore the relationship between GPX3 methylation and Pai-Neng-Da (PND) in the treatment of patients with low-risk myelodysplastic syndrome (MDS).MethodsThere were 82 low-risk MDS patients who were randomly divided into the following two groups: androl, thalidomide, and PND capsule (ATP group, n = 41); or androl and thalidomide (AT group,...
Thu Sep 24, 2020 10:41
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveThe aims of this study were to investigate the prevalence of sports injuries in school physical education (PE) and leisure-time sports among 1011 15- to 16-year-old adolescents in relation to physical activity, and to examine goal orientation.MethodsA survey was used with additional narrative descriptions.ResultsThere was a higher prevalence of injuries in leisure time (645/993 = 65%) than in PE (519/998 = 52%)....
Thu Sep 24, 2020 10:37
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveThis study was performed to explore the effects of ligation of the intersphincteric fistula tract (LIFT) on pain scores and serum levels of vascular endothelial growth factor (VEGF) and interleukin (IL)-2 in patients with simple anal fistulas.MethodsNinety patients with simple anal fistulas were evenly randomized into a study group (treated with LIFT) and a control group (treated with traditional anal fistulectomy)...
Thu Sep 24, 2020 10:35
Journal of International Medical Research, Volume 48, Issue 9, September 2020. Primary multiple obturator nerve schwannomas originate from Schwann cells and are extremely rare. Patients with schwannomas are asymptomatic and a retroperitoneal schwannoma is often misdiagnosed as an adnexal mass. In the present study, we describe a 58-year-old woman in whom a right adnexal mass accompanied by endometrial polyp was found incidentally through transvaginal ultrasound. The mass was diagnosed as multiple...
Thu Sep 24, 2020 10:30
Journal of International Medical Research, Volume 48, Issue 9, September 2020. Most intraocular metastases are detected in the choroid, iris, ciliary body, or retina. Conversely, tumors rarely metastasize to the optic disc, and they even less frequently present as the initial sign of cancer. In this study, we presented the case of a patient who first visited the ophthalmology department because of gradual visual impairment without any systemic symptoms, and she was ultimately diagnosed with non-small-cell...
Thu Sep 24, 2020 10:28
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveLiraglutide (Lir) protects cardiomyocytes against high glucose-induced myocardial damage. This study investigated whether Notch signaling participated in the antiapoptotic effects of Lir on rat H9c2 cardiomyocytes subjected to hypoxia followed by reoxygenation (H/R).MethodsWe used H9c2 rat cardiomyocytes as a model of H/R and measured viability, apoptosis, and expression of the apoptotic genes Bax and Bcl-2 and...
Thu Sep 24, 2020 10:23
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveTo assess physical performance (PP) and physical activity (PA) among older adults visiting primary healthcare centres (PHCCs) in Riyadh.MethodsIn this cross-sectional study, men and women (n = 74) aged ≥60 years were recruited from five PHCCs across Riyadh, Saudi Arabia, between 19 February and 6 August 2017. The Timed Up & Go test was used to assess PP. Self-reported PA was assessed using the Physical Activity...
Thu Sep 24, 2020 10:22
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveThe aim of this study was to predict disease-free (DFS) and overall (OS) survival of cancer patients through expression of CUE domain containing 2 (CUEDC2) protein.MethodsIn this retrospective study, we investigated CUEDC2 expression in 75 serous ovarian cancer tissues and 34 tubal fimbria tissues by immunohistochemistry. Chemoresistance was analyzed using clinical follow-up data.ResultsCUEDC2 expression scores...
Thu Sep 24, 2020 10:19
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveCardiac diseases lead to heart failure (HF), but the progression can take several years. Using blood samples to monitor changes in the heart before clinical symptoms begin may help to improve patient management.MethodsMicroarray data GSE42955 and GSE9128 were used as study datasets and GSE16499, GSE57338, and GSE59867 were used as validation groups. The “limma” package from R Language was used to identify differentially...
Thu Sep 24, 2020 10:17
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveTo investigate whether the Notch–Hif-1α signaling pathway is involved in liver regeneration.MethodsRats were divided into two groups and treated with daily intraperitoneal injections of saline (control) or the gamma-secretase inhibitor, Fli-06, for 2 days. Two-thirds of the rat livers were resected and rats were later euthanized at specific time points post-resection to analyze the remnant livers. Each group's...
Thu Sep 24, 2020 10:15
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveThis study aimed to examine the association between slow-wave sleep ([SWS] N3 stage) and the risk of hypertension in patients with obstructive sleep apnea (OSA) or primary snorers.MethodsA retrospective cross-sectional study of 1145 participants who were evaluated for suspected OSA at our Sleep Medical Center were included. Among these participants, 1022 had OSA and 123 were primary snorers. Logistic regression...
Thu Sep 24, 2020 08:37
Journal of International Medical Research, Volume 48, Issue 9, September 2020. Pelvic congestion syndrome (PCS) typically causes chronic non-cyclical abdominal pain with a considerable negative effect on the quality of life of women. However, pediatric cases with PCS are limited and non-invasive therapy for adolescent patients has not been reported. We report here a 13-year-old girl who presented with intermittent abdominal pain since the age of 2 years and her symptoms further deteriorated after...
Thu Sep 24, 2020 08:29
Journal of International Medical Research, Volume 48, Issue 9, September 2020. PurposeTo investigate associations between the clinical characteristics and incubation periods of patients infected with coronavirus disease 2019 (COVID-19) in Wuhan, China.MethodsComplete clinical and epidemiological data from 149 patients with COVID-19 at a hospital in Hunan Province, China, were collected and retrospectively analyzed.ResultsAnalysis of the distribution and receiver operator characteristic curve of incubation...
Thu Sep 24, 2020 07:57
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveTo evaluate the clinical efficacy of an allogeneic bone cage (Biocage; Beijing Datsing Bio-Tech Co., Ltd., Beijing, China) for treatment of single-segment lumbar degenerative disease in patients with a high risk of non-fusion.MethodsFrom January 2013 to December 2016, 67 patients who underwent lumbar fusion were divided into the Biocage group (n = 33) and polyether ether ketone (PEEK) group (n = 34). The patients...
Wed Sep 23, 2020 08:51
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveTo identify serum protein markers in midtrimester that predict preterm delivery.MethodsA retrospective case–control study randomly selected patients that experienced spontaneous preterm birth and healthy control patients that experienced a normal delivery at term. A proteomic analysis was undertaken using the data-independent acquisition method.ResultsA total of 30 singleton pregnant women were randomly selected...
Wed Sep 23, 2020 08:49
Journal of International Medical Research, Volume 48, Issue 9, September 2020. Double-chambered left ventricle (DCLV) is a rare congenital cardiac abnormality. We retrospectively analyzed the diagnosis and treatment of a patient with DCLV who was admitted to Jiading Central Hospital of Shanghai Medical College in August 2019. The initial symptom of the 55-year-old male patient was stroke. He was preliminarily diagnosed with DCLV by echocardiography and this diagnosis was confirmed by contrast-enhanced...
Wed Sep 23, 2020 08:47
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveAbdominal examination findings in pediatric acute appendicitis (AA) significantly vary by age. Therefore, grading systems have been developed for diagnosing pediatric appendicitis, and laboratory and radiological findings have an important role in this diagnosis. However, there is a need to develop new parameters for diagnosing AA. This study aimed to investigate the diagnostic value of platelet indices in AA.MethodsThis...
Wed Sep 23, 2020 08:44
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectivesNormokalemic periodic paralysis (NormoKPP) of skeletal muscle is an autosomal dominant disorder caused by mutations in the gene encoding voltage-gated sodium channel protein type 4 subunit alpha (SCN4A), which leads to ion channel dysfunction. Little is known about the relationship between genotype and the clinical symptoms of NormoKPP. The present study aimed to evaluate the genetic variation in a large Chinese...
Wed Sep 23, 2020 08:40
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveWe aimed to investigate risk factors related to remnant gallbladder (RGB) stones.MethodsThis retrospective study included 73 patients with RGB, in groups with and without RGB calculi. Univariate analyses were used to identify nine variables associated with RGB calculi: sex, age, body mass index (BMI), time to detection, surgical method, length of RGB, angle of RGB and common hepatic duct (CHD), choledocholithiasis,...
Wed Sep 23, 2020 08:32
Journal of International Medical Research, Volume 48, Issue 9, September 2020. BackgroundGastric schwannoma is a rarely seen gastric tumor accounting for only 0.2% of all gastric tumors. It is difficult to distinguish a gastric schwannoma from other gastric tumors preoperatively.Case presentation: A 30-year-old man with no significant medical history or physical examination findings presented with a 1-month history of right upper abdominal discomfort. The preoperative diagnosis was a gastrointestinal...
Wed Sep 23, 2020 08:27
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectivesEmpirical determination of phenylalanine (Phe) tolerance in patients with phenylketonuria (PKU) relies on frequent assessment of blood Phe concentrations in relation to Phe intake from detailed meal records. This study aimed to determine Phe tolerance in twin pregnancies.MethodsThe reviewed cases included three women with PKU who each had a singleton and twin pregnancy (i.e., they were pregnant twice). All patients...
Wed Sep 23, 2020 08:20
Journal of International Medical Research, Volume 48, Issue 9, September 2020. Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare autoinflammatory disorder without standardized therapy. Anti-tumor necrosis factor (TNF)-α agents, which have been widely used in recent treatment of SAPHO syndrome, may elicit severe paradoxical psoriasiform lesions. Therefore, physicians must reverse the paradoxical skin lesions in affected patients, while improving their clinical symptoms...
Wed Sep 23, 2020 08:16
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveTo investigate the association between the solute carrier family 6 member 4 (SLC6A4) gene L/S polymorphism and pulmonary arterial hypertension (PAH).MethodsThe relevant literature was retrieved from the PubMed® database and the data were extracted. STATA® version 12.0 software was used to calculate pooled odds ratios (ORs) and 95% confidence intervals (CI).ResultsEight case–control studies qualified for inclusion...
Wed Sep 23, 2020 08:15
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveThis study was performed to identify risk factors for anastomotic leakage (AL) and combine these factors to create a prediction model for the risk of AL after laparoscopic rectal cancer resection.MethodsThis retrospective study involved 185 patients with rectal cancer who underwent laparoscopic resection from March 2012 to February 2017. Five risk factors were analyzed by multivariate analysis. A prediction model...
Wed Sep 23, 2020 08:14
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveThe clinical efficacy of platelet-rich plasma (PRP) as adjuvant therapy in patients undergoing arthroscopic repair of meniscal injury remains controversial. This meta-analysis was performed to evaluate the clinical efficacy of PRP in the treatment of meniscal injury and provide evidence for the selection of clinical treatment options.MethodsA computer-based search of the PubMed, Embase, and Cochrane Library databases...
Wed Sep 23, 2020 08:12
Journal of International Medical Research, Volume 48, Issue 9, September 2020. Cases of extrahepatic bile duct carcinoma are mostly adenocarcinomas and extrahepatic bile duct squamous cell carcinomas are rare. We report here a case of choledochal squamous cell carcinoma in a young woman who underwent surgery and chemotherapy. The woman presented with abdominal discomfort. A physical examination showed tenderness in the upper abdomen. Laboratory tests showed elevated direct bilirubin, total bilirubin,...
Wed Sep 23, 2020 08:10
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveThis study aimed to examine the clinical value of a decrease in hemoglobin concentration (HC) after the onset of sepsis for predicting occurrence of necrotizing enterocolitis (NEC) in preterm infants with late-onset sepsis.MethodsWe performed a retrospective cohort study between January 2015 and January 2020. Premature neonates (gestational age <37 weeks) with late-onset sepsis (age >3 days) were enrolled....
Wed Sep 23, 2020 08:08
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