With regard to the letter written by Kirkby C, investigating a hypothetical benefit of the whole lung low dose radiotherapy (LDRT) to treat COVID-19 pneumonia, several considerations should be examined in light of the recent advances in the pathophysiology of COVID-19 pneumonia provided by autopsies.
Thu May 07, 2020 03:00
In the contest of COVID-19 rapid spread in Italy, the Italian Government in March 2020 released an official recommendation statement indicating .1
Thu May 07, 2020 03:00
The COVID-19 pandemic is a devastating catastrophe to the whole world, China is the first country seriously affected. This review shows that it is possible to stop wide-spread infection in the country and to provide good quality oncology services even during this challenging period, through concerted efforts with well-organized actions at all levels (National/Municipal, Hospital and Department). The key strategies leading to successful impacts are summarized for sharing. In addition to making practice...
Thu May 07, 2020 03:00
COVID-19 has emerged as a major global health threat since December, 2019. By April 1st, 2020, there were more than 800,000 patients with confirmed COVID-19 infection worldwide.Radiotherapy is continuous in treatment schedule. Interruption of the treatment or delay of the treatment may jeopardise therapeutic efficacy.Liang et al.[1]demonstrated that due to receipt of immunotherapy, cancer patients are at higher risk to be infected with COVID-19. Recently, Xie[2] et al. revealed cancer patients older...
Thu May 07, 2020 03:00
We would like to thank Troost et al. [1] and Magrini et al. [2] for their feedback and for opening a broader discussion about radiotherapy treatment of COVID-19 positive lung cancer patients during the time of the pandemic [3]. We propose differentiating two separate aspects and risk categories which need to be considered in this situation.
Thu May 07, 2020 03:00
What is our threshold? Departmental planning for radiation oncology’s future in the time of COVID-19
The outbreak of novel coronavirus disease 2019 (COVID-2019) is of significant concern. As of this writing, the slope of the upward portion of the logarithmic curve of cases and deaths in the US is unclear and much is unknown about the virology and epidemiology of the disease. Furthermore, the short- and long-term impact of this pandemic on the medical community and society, at-large, is yet to be understood. Nevertheless, it is becoming clearer, however, that we are settling into a new and dynamic...
Thu May 07, 2020 03:00
Accurate image guidance is essential to minimise setup errors and facilitate reduced margins in prostate radiotherapy. This is especially the case for ultrahypofractionation which may become standard within a few years. However, streamlined workflows are required to reduce interobserver variability in matching and to improve departmental efficiency.Fig 1.
Wed May 06, 2020 03:00
We thank the author for this letter and welcome the critical discussion on the potential of LDRT as a treatment for COVID-19 pneumonia. While indeed models for RILI may provide useful insight into COVID-19 disease progression, and successful treatments for radiation-induced lung injury may also be applicable to COVID-19-induced lung injury, this does not invalidate the hypothesis that low doses (< 100 cGy) of ionizing radiation may provide a beneficial anti-inflammatory effect in the treatment...
Wed May 06, 2020 03:00
We thank the authors for their response and welcome critical discussion on the potential of LDRT as a treatment for COVID-19 pneumonia. Kefayat and Ghahremani raise several valid points in their letter. Certainly further study on the matter is warranted. Based on historical evidence in the literature and the current pandemic status, the radiation therapy community would be justified in designing both pre-clinical and clinical trials to modern standards to investigate the effectiveness of LDRT against...
Wed May 06, 2020 03:00
Following the announcement of the COVID-19 pandemic by the World Health Organization in March 2020, the outbreak of new coronavirus in Iran and most of the world has posed severe challenges in the treatment of cancer patients. This group of patients is more prone to this new virus due to immune-compromised status following active treatment and frequent visits to hospitals [1].
Wed May 06, 2020 03:00
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