Abstract Rationale Synaptic neurotransmission with dopamine (DA), norepinephrine (NE), and serotonin (5-HT) is terminated primarily by reuptake into presynaptic terminals via the DA, NE, and 5-HT transporters (DAT/NET/SERT, respectively). Monoamine transporter inhibitors constitute one class of drugs used to treat both depression and pain, and therapeutic effects by these compounds often require repeated treatment for days or weeks. ...
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Abstract Rationale The beta-lactam antibiotic ceftriaxone reliably attenuates the reinstatement of cocaine seeking. While the restoration of nucleus accumbens core (NA core) GLT-1 expression is necessary for ceftriaxone to attenuate reinstatement, AAV-mediated GLT-1 overexpression is not sufficient to attenuate reinstatement and does not prevent glutamate efflux during reinstatement. ...
Thu May 07, 2020 03:00
Abstract Introduction We explore the transcription factors involved in the molecular mechanism of antipsychotic (AP)-induced acute extrapyramidalsymptoms (EPS) in order to identify new candidate genes for pharmacogenetic studies. Methods Protein-protein interaction (PPI) networks previously created from three pharmacogenomic models (in vitro, animal, and...
Thu May 07, 2020 03:00
Abstract Rationale Witnesses and victims typically provide the central leads in police investigations, yet statistics from past research indicates in many instances these individuals are intoxicated. Objectives To date, however, no research has looked at how best to interview such witnesses to maximise the amount of accurate information they recall. ...
Thu May 07, 2020 03:00
Abstract Rationale Prolinol aryl ethers and their rigidified analogues pyrrolidinyl benzodioxanes have a high affinity for mammalian α4β2 nicotinic acetylcholine receptors (nAChRs). Electrophysiological studies have shown that the former are full agonists and the latter partial agonists or antagonists of human α4β2 receptors, but their in vivo effects are unknown. Objectives...
Thu May 07, 2020 03:00
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