Cancers, Vol. 12, Pages 1186: Malignant Pleural Mesothelioma: Genetic and Microenviromental Heterogeneity as an Unexpected Reading Frame and Therapeutic Challenge Cancers doi: 10.3390/cancers12051186 Authors: Abbott Bortolotto Benvenuti Lancia Filippi Stella Mesothelioma is a malignancy of serosal membranes including the peritoneum, pleura, pericardium and the tunica vaginalis of the testes. Malignant mesothelioma (MM) is a rare disease with a global incidence...
Thu May 07, 2020 03:00
Cancers, Vol. 12, Pages 1185: Therapeutic Targeting of Autophagy for Renal Cell Carcinoma Therapy Cancers doi: 10.3390/cancers12051185 Authors: Trace M. Jones Jennifer S. Carew Steffan T. Nawrocki Kidney cancer is the 7th most prevalent form of cancer in the United States with the vast majority of cases being classified as renal cell carcinoma (RCC). Multiple targeted therapies have been developed to treat RCC, but efficacy and resistance remain a challenge. In recent years,...
Thu May 07, 2020 03:00
Cancers, Vol. 12, Pages 1184: The Association between Selective Serotonin Reuptake Inhibitors (SSRIs) Use and the Risk of Bladder Cancer: A Nationwide Population-Based Cohort Study Cancers doi: 10.3390/cancers12051184 Authors: Yi-Chun Liu Vincent Chin-Hung Chen Mong-Liang Lu Min-Jing Lee Roger S. McIntyre Amna Majeed Yena Lee Yi-Lung Chen Background: Past studies suggest mixed associations between selective serotonin reuptake inhibitor (SSRI) prescription...
Thu May 07, 2020 03:00
Cancers, Vol. 12, Pages 1182: Prediction of High-Grade Clear Cell Renal Cell Carcinoma Based on Plasma mRNA Profiles in Patients with Localized Pathologic T1N0M0 Stage Disease Cancers doi: 10.3390/cancers12051182 Authors: Jee Soo Park Hyo Jung Lee Ahmad Almujalhem Hatem Hamed Althubiany Alqahatani Ali A Won Sik Jang Jongchan Kim Seung Hwan Lee Koon Ho Rha Won Sik Ham A high nuclear grade is crucial to predicting tumor recurrence and metastasis...
Thu May 07, 2020 03:00
Cancers, Vol. 12, Pages 1181: Immunotherapy in Bladder Cancer: Current Methods and Future Perspectives Cancers doi: 10.3390/cancers12051181 Authors: Mikołaj Wołącewicz Rafał Hrynkiewicz Ewelina Grywalska Tomasz Suchojad Tomasz Leksowski Jacek Roliński Paulina Niedźwiedzka-Rystwej Bladder cancer is one of the most significant genitourinary cancer, causing high morbidity and mortality in a great number of patients. Over the years, various treatment methods...
Thu May 07, 2020 03:00
Cancers, Vol. 12, Pages 1183: Long-Term Follow-Up Outcomes after Percutaneous US/CT-Guided Radiofrequency Ablation for cT1a-b Renal Masses: Experience from Single High-Volume Referral Center Cancers doi: 10.3390/cancers12051183 Authors: Giovanni Mauri Francesco Alessandro Mistretta Guido Bonomo Nicola Camisassi Andrea Conti Paolo Della Vigna Matteo Ferro Stefano Luzzago Daniele Maiettini Gennaro Musi Nicolò Piacentini Gianluca Maria Varano Ottavio...
Thu May 07, 2020 03:00
Cancers, Vol. 12, Pages 1177: On-Treatment Changes in FIB-4 and 1-Year FIB-4 Values Help Identify Patients with Chronic Hepatitis B Receiving Entecavir Therapy Who Have the Lowest Risk of Hepatocellular Carcinoma Cancers doi: 10.3390/cancers12051177 Authors: Hung-Wei Wang Hsueh-Chou Lai Tsung-Hui Hu Wen-Pang Su Sheng-Nan Lu Chia-Hsin Lin Chao-Hung Hung Po-Heng Chuang Jing-Houng Wang Mei-Hsuan Lee Chien-Hung Chen Cheng-Yuan Peng Noninvasive...
Thu May 07, 2020 03:00
Cancers, Vol. 12, Pages 1180: Targeting Nuclear NAD+ Synthesis Inhibits DNA Repair, Impairs Metabolic Adaptation and Increases Chemosensitivity of U-2OS Osteosarcoma Cells Cancers doi: 10.3390/cancers12051180 Authors: Alexandra Kiss Arnold Péter Ráduly Zsolt Regdon Zsuzsanna Polgár Szabolcs Tarapcsák Isotta Sturniolo Tarek El‐Hamoly László Virág Csaba Hegedűs Osteosarcoma (OS) is the most common bone tumor in children and adolescents. Modern OS treatment,...
Thu May 07, 2020 03:00
Cancers, Vol. 12, Pages 1178: The Impact of Whole Genome Data on Therapeutic Decision-Making in Metastatic Prostate Cancer: A Retrospective Analysis Cancers doi: 10.3390/cancers12051178 Authors: Megan Crumbaker Eva K.F. Chan Tingting Gong Niall Corcoran Weerachai Jaratlerdsiri Ruth J. Lyons Anne-Maree Haynes Anna A. Kulidjian Anton M.F. Kalsbeek Desiree C. Petersen Phillip D. Stricker Christina A.M. Jamieson Peter I. Croucher Christopher...
Thu May 07, 2020 03:00
Cancers, Vol. 12, Pages 1179: Dysregulation of Rho GTPases in Human Cancers Cancers doi: 10.3390/cancers12051179 Authors: Haiyoung Jung Suk Ran Yoon Jeewon Lim Hee Jun Cho Hee Gu Lee Rho GTPases play central roles in numerous cellular processes, including cell motility, cell polarity, and cell cycle progression, by regulating actin cytoskeletal dynamics and cell adhesion. Dysregulation of Rho GTPase signaling is observed in a broad range of human cancers, and is...
Thu May 07, 2020 03:00
Cancers, Vol. 12, Pages 1176: Surgery for Unresectable Stage IIIC and IV Melanoma in the Era of New Systemic Therapy Cancers doi: 10.3390/cancers12051176 Authors: Stephanie A. Blankenstein Maureen J. B. Aarts Franchette W. P. J. van den Berkmortel Marye J. Boers-Sonderen Alfons J. M. van den Eertwegh Margreet G. Franken Jan Willem B. de Groot John B. A. G. Haanen Geke A. P. Hospers Ellen Kapiteijn Djura Piersma Rozemarijn S. van Rijn Karijn...
Thu May 07, 2020 03:00
Cancers, Vol. 12, Pages 1175: The Extracellular Matrix Influences Ovarian Carcinoma Cells’ Sensitivity to Cisplatinum: A First Step towards Personalized Medicine Cancers doi: 10.3390/cancers12051175 Authors: Andrea Balduit Chiara Agostinis Alessandro Mangogna Veronica Maggi Gabriella Zito Federico Romano Andrea Romano Rita Ceccherini Gabriele Grassi Serena Bonin Deborah Bonazza Fabrizio Zanconati Giuseppe Ricci Roberta Bulla The...
Thu May 07, 2020 03:00
Cancers, Vol. 12, Pages 1172: Inducing Angiogenesis, a Key Step in Cancer Vascularization, and Treatment Approaches Cancers doi: 10.3390/cancers12051172 Authors: Harman Saman Syed Shadab Raza Shahab Uddin Kakil Rasul Angiogenesis is a term that describes the formation of new blood and lymphatic vessels from a pre-existing vasculature. This allows tumour cells to acquire sustenance in the form of nutrients and oxygen and the ability to evacuate metabolic waste. As one...
Wed May 06, 2020 03:00
Cancers, Vol. 12, Pages 1174: CD34+CD38-CD123+ Leukemic Stem Cell Frequency Predicts Outcome in Older Acute Myeloid Leukemia Patients Treated by Intensive Chemotherapy but Not Hypomethylating Agents Cancers doi: 10.3390/cancers12051174 Authors: François Vergez Marie-Laure Nicolau-Travers Sarah Bertoli Jean-Baptiste Rieu Suzanne Tavitian Pierre Bories Isabelle Luquet Véronique De Mas Laetitia Largeaud Audrey Sarry Françoise Huguet Eric Delabesse...
Wed May 06, 2020 03:00
Cancers, Vol. 12, Pages 1173: Breast Fibroblasts and ECM Components Modulate Breast Cancer Cell Migration Through the Secretion of MMPs in a 3D Microfluidic Co-Culture Model Cancers doi: 10.3390/cancers12051173 Authors: Karina M. Lugo-Cintrón Max M. Gong José M. Ayuso Lucas Tomko David J. Beebe María Virumbrales-Muñoz Suzanne M. Ponik The extracellular matrix (ECM) composition greatly influences cancer progression, leading to differential invasion, migration,...
Wed May 06, 2020 03:00
Cancers, Vol. 12, Pages 1171: APC Mutation Marks an Aggressive Subtype of BRAF Mutant Colorectal Cancers Cancers doi: 10.3390/cancers12051171 Authors: Lochlan J. Fennell Alexandra Kane Cheng Liu Diane McKeone Winnie Fernando Chang Su Catherine Bond Saara Jamieson Troy Dumenil Ann-Marie Patch Stephen H. Kazakoff John V. Pearson Nicola Waddell Barbara Leggett Vicki L. J Whitehall Background: WNT activation is a hallmark of colorectal...
Wed May 06, 2020 03:00
Cancers, Vol. 12, Pages 1170: Adhesion and Migration Response to Radiation Therapy of Mammary Epithelial and Adenocarcinoma Cells Interacting with Different Stiffness Substrates Cancers doi: 10.3390/cancers12051170 Authors: Valeria Panzetta Giuseppe La Verde Mariagabriella Pugliese Valeria Artiola Cecilia Arrichiello Paolo Muto Marco La Commara Paolo A. Netti Sabato Fusco The structural and mechanical properties of the microenvironmental context have...
Wed May 06, 2020 03:00
Cancers, Vol. 12, Pages 1167: Venous Thromboembolism in Cancer Patients on Simultaneous and Palliative Care Cancers doi: 10.3390/cancers12051167 Authors: Silvia Riondino Patrizia Ferroni Girolamo Del Monte Vincenzo Formica Fiorella Guadagni Mario Roselli Simultaneous care represents the ideal integration between early supportive and palliative care in cancer patients under active antineoplastic treatment. Cancer patients require a composite clinical, social and...
Wed May 06, 2020 03:00
Cancers, Vol. 12, Pages 1168: Recent Advances in Targeted Therapies for Advanced Gastrointestinal Malignancies Cancers doi: 10.3390/cancers12051168 Authors: Jasmine C. Huynh Erin Schwab Jingran Ji Edward Kim Anjali Joseph Andrew Hendifar May Cho Jun Gong The treatment of advanced gastrointestinal (GI) cancers has become increasingly molecularly driven. Molecular profiling for HER2 and PD-L1 status is standard for metastatic gastroesophageal (GEJ) cancers...
Wed May 06, 2020 03:00
Cancers, Vol. 12, Pages 1169: All-Trans Retinoic Acid Stimulates Viral Mimicry, Interferon Responses and Antigen Presentation in Breast-Cancer Cells Cancers doi: 10.3390/cancers12051169 Authors: Marco Bolis Gabriela Paroni Maddalena Fratelli Arianna Vallerga Luca Guarrera Adriana Zanetti Mami Kurosaki Silvio Ken Garattini Maurizio Gianni’ Monica Lupi Linda Pattini Maria Monica Barzago Mineko Terao Enrico Garattini All-trans retinoic...
Wed May 06, 2020 03:00
Cancers, Vol. 12, Pages 1166: Multicenter Evaluation of Independent High-Throughput and RT-qPCR Technologies for the Development of Analytical Workflows for Circulating miRNA Analysis Cancers doi: 10.3390/cancers12051166 Authors: Anna Babayan Martin H. D. Neumann Andrei Herdean Jonathan M. Shaffer Melanie Janning Franca Kobus Sonja Loges Francesca Di Pasquale Mikael Kubista Martin Schlumpberger Rita Lampignano Thomas Krahn Thomas Schlange...
Tue May 05, 2020 03:00
Cancers, Vol. 12, Pages 1163: 18F-FDG Pet Parameters and Radiomics Features Analysis in Advanced Nsclc Treated with Immunotherapy as Predictors of Therapy Response and Survival Cancers doi: 10.3390/cancers12051163 Authors: Giulia Polverari Francesco Ceci Valentina Bertaglia Maria Lucia Reale Osvaldo Rampado Elena Gallio Roberto Passera Virginia Liberini Paola Scapoli Vincenzo Arena Manuela Racca Andrea Veltri Silvia Novello Désirée Deandreis...
Tue May 05, 2020 03:00
Cancers, Vol. 12, Pages 1165: Hormone Receptor-Status Prediction in Breast Cancer Using Gene Expression Profiles and Their Macroscopic Landscape Cancers doi: 10.3390/cancers12051165 Authors: Seokhyun Yoon Hye Sung Won Keunsoo Kang Kexin Qiu Woong June Park Yoon Ho Ko The cost of next-generation sequencing technologies is rapidly declining, making RNA-seq-based gene expression profiling (GEP) an affordable technique for predicting receptor expression status and...
Tue May 05, 2020 03:00
Cancers, Vol. 12, Pages 1158: Hereditary Breast and Ovarian Cancer in Families from Southern Italy (Sicily)—Prevalence and Geographic Distribution of Pathogenic Variants in BRCA1/2 Genes Cancers doi: 10.3390/cancers12051158 Authors: Lorena Incorvaia Daniele Fanale Giuseppe Badalamenti Marco Bono Valentina Calò Daniela Cancelliere Marta Castiglia Alessia Fiorino Alessia Pivetti Nadia Barraco Sofia Cutaia Antonio Russo Viviana Bazan Recent...
Tue May 05, 2020 03:00
Cancers, Vol. 12, Pages 1164: Alterations of HPV-Related Biomarkers after Prophylactic HPV Vaccination. A Prospective Pilot Observational Study in Greek Women Cancers doi: 10.3390/cancers12051164 Authors: George Valasoulis Abraham Pouliakis George Michail Christine Kottaridi Aris Spathis Maria Kyrgiou Evangelos Paraskevaidis Alexandros Daponte The objective of this study was to investigate the hypothesis that HPV vaccination administered in patients with...
Tue May 05, 2020 03:00
Cancers, Vol. 12, Pages 1160: Combination of Withaferin-A and CAPE Provides Superior Anticancer Potency: Bioinformatics and Experimental Evidence to Their Molecular Targets and Mechanism of Action Cancers doi: 10.3390/cancers12051160 Authors: Anissa Nofita Sari Priyanshu Bhargava Jaspreet Kaur Dhanjal Jayarani F. Putri Navaneethan Radhakrishnan Seyad Shefrin Yoshiyuki Ishida Keiji Terao Durai Sundar Sunil C. Kaul Renu Wadhwa We have earlier...
Tue May 05, 2020 03:00
Cancers, Vol. 12, Pages 1161: Acquired Resistance to Immune Checkpoint Blockade Therapies Cancers doi: 10.3390/cancers12051161 Authors: Xianda Zhao Dechen Wangmo Matthew Robertson Subbaya Subramanian Immune checkpoint blockade therapy (ICBT) has revolutionized the treatment and management of numerous cancers, yet a substantial proportion of patients who initially respond to ICBT subsequently develop resistance. Comprehensive genomic analysis of samples from recent clinical...
Tue May 05, 2020 03:00
Cancers, Vol. 12, Pages 1162: Colorectal Cancer and Probiotics: Are Bugs Really Drugs? Cancers doi: 10.3390/cancers12051162 Authors: Purushottam Lamichhane Morgan Maiolini Omar Alnafoosi Sedra Hussein Hasan Alnafoosi Stewart Umbela Tayanna Richardson Nevien Alla Narottam Lamichhane Bobban Subhadra Rahul R. Deshmukh Colorectal cancer (CRC) is one of the most common types of cancer worldwide. There are many factors that predispose a patient...
Tue May 05, 2020 03:00
Cancers, Vol. 12, Pages 1159: RNA Editing Alters miRNA Function in Chronic Lymphocytic Leukemia Cancers doi: 10.3390/cancers12051159 Authors: Franz J. Gassner Nadja Zaborsky Daniel Feldbacher Richard Greil Roland Geisberger Chronic lymphocytic leukemia (CLL) is a high incidence B cell leukemia with a highly variable clinical course, leading to survival times ranging from months to several decades. MicroRNAs (miRNAs) are small non-coding RNAs that regulate the expression...
Tue May 05, 2020 03:00
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