Congenital Glioblastoma Multiforme with Long-Term Childhood Survival: A Case Report and Systematic Review
Author links open overlay panelAdrian I.Espiritu12Bernadette B.Terencio34Roland Dominic G.Jamora15
1
Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines
2
Department of Clinical Epidemiology, College of Medicine, University of the Philippines Manila, Manila, Philippines
3
Department of Neurosciences, Section of Pediatric Neurology, Asian Brain Institute, Asian Hospital Medical Center, Muntinlupa, Philippines
4
Neuroscience Department, College of Medicine, San Beda University, Manila, Philippines
5
Institute for Neurosciences, St. Luke's Medical Center, Quezon City and Global City, Philippines
Received 17 March 2020, Accepted 29 March 2020, Available online 13 April 2020.
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Background
Congenital glioblastoma multiforme (cGBM) is an infrequent primary central nervous system tumor occurring within the first few months of life with a reported poor overall prognosis. Our objective was to describe our own clinical case of cGBM and review the literature of cGBM cases with prolonged survival.
Case Description
We report a case of cGBM with prolonged survival at 4 years. A systematic review was conducted on cases of cGBM with long-term childhood survival. We searched online databases until August 2019 for relevant articles. The patient underwent an emergency right hemicraniectomy with excision and biopsy of the right cerebral hemisphere mass and insertion of a ventriculoperitoneal shunt. At present, she is a 52-month-old child with good speech and minimal left hemiparesis and able to ambulate, with a Functional Independence Measure for Children score of 109. Out of 160 articles screened, there were 10 articles included. A total of 15 patients, including the present case, were analyzed qualitatively. The age at presentation ranged from 30 weeks' gestation to 35 days. Most patients underwent surgical excision (n = 13, 86.7%) and adjuvant chemotherapy (n = 10, 66.7%). The reported range of survival of these patients was from 27 to 110 months.
Conclusions
Limited evidence from 15 cases of cGBM suggests that surgical excision and/or chemotherapy may prolong the survival of patients. Therefore, these interventions may be offered and performed to patients with cGBM on a case-by-case basis. Larger clinical studies or registry-based information are necessary to substantiate the implications of our review.
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Key words
cGBMCongenital glioblastoma multiformeLong-term survivalSystematic review
Abbreviations and Acronyms
cGBMCongenital glioblastoma multiformeEGFREpidermal growth factor receptorPDGFRPlatelet-derived growth factor receptorpGBMPediatric glioblastoma multiforme
Conflict of interest statement: The authors declare that the article content was composed in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Adrian I. Espiritu and Bernadette B. Terencio are co–first authors.
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© 2020 Elsevier Inc. All rights reserved.
Author links open overlay panelAdrian I.Espiritu12Bernadette B.Terencio34Roland Dominic G.Jamora15
1
Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines
2
Department of Clinical Epidemiology, College of Medicine, University of the Philippines Manila, Manila, Philippines
3
Department of Neurosciences, Section of Pediatric Neurology, Asian Brain Institute, Asian Hospital Medical Center, Muntinlupa, Philippines
4
Neuroscience Department, College of Medicine, San Beda University, Manila, Philippines
5
Institute for Neurosciences, St. Luke's Medical Center, Quezon City and Global City, Philippines
Received 17 March 2020, Accepted 29 March 2020, Available online 13 April 2020.
crossmark-logo
Show less
https://doi.org/10.1016/j.wneu.2020.03.212Get rights and content
Background
Congenital glioblastoma multiforme (cGBM) is an infrequent primary central nervous system tumor occurring within the first few months of life with a reported poor overall prognosis. Our objective was to describe our own clinical case of cGBM and review the literature of cGBM cases with prolonged survival.
Case Description
We report a case of cGBM with prolonged survival at 4 years. A systematic review was conducted on cases of cGBM with long-term childhood survival. We searched online databases until August 2019 for relevant articles. The patient underwent an emergency right hemicraniectomy with excision and biopsy of the right cerebral hemisphere mass and insertion of a ventriculoperitoneal shunt. At present, she is a 52-month-old child with good speech and minimal left hemiparesis and able to ambulate, with a Functional Independence Measure for Children score of 109. Out of 160 articles screened, there were 10 articles included. A total of 15 patients, including the present case, were analyzed qualitatively. The age at presentation ranged from 30 weeks' gestation to 35 days. Most patients underwent surgical excision (n = 13, 86.7%) and adjuvant chemotherapy (n = 10, 66.7%). The reported range of survival of these patients was from 27 to 110 months.
Conclusions
Limited evidence from 15 cases of cGBM suggests that surgical excision and/or chemotherapy may prolong the survival of patients. Therefore, these interventions may be offered and performed to patients with cGBM on a case-by-case basis. Larger clinical studies or registry-based information are necessary to substantiate the implications of our review.
Previous article in issueNext article in issue
Key words
cGBMCongenital glioblastoma multiformeLong-term survivalSystematic review
Abbreviations and Acronyms
cGBMCongenital glioblastoma multiformeEGFREpidermal growth factor receptorPDGFRPlatelet-derived growth factor receptorpGBMPediatric glioblastoma multiforme
Conflict of interest statement: The authors declare that the article content was composed in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Adrian I. Espiritu and Bernadette B. Terencio are co–first authors.
View full text
© 2020 Elsevier Inc. All rights reserved.
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