Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Introduction:The purpose of this study is to evaluate the diagnostic value of macrophage migration inhibitory factor in patients with nasopharyngeal carcinoma.Materials and Methods:The expression levels of macrophage migration inhibitory factor in nasopharyngeal carcinoma cell lines, tumor tissues, and plasma were measured by real-time polymerase chain reaction, Western blotting, enzyme-linked immunosorbent assay,...
Wed Jun 24, 2020 13:29
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Objective:To explore the clinical efficacy of HiPorfin photodynamic therapy for advanced esophageal cancer and evaluate its impact on survival.Methods:Retrospective analysis of 32 patients with advanced obstructive esophageal cancer at our institution from September 2013 to December 2016. HiPorfin was infused as the photosensitizer at a dose of 5 mg/kg, and after 48 hours, 630-nm laser irradiation was subsequently...
Wed Jun 24, 2020 12:25
Presentation of Case. Dr. Denise De Las Nueces: A 66-year-old homeless man who had sought refuge at a local men’s congregate shelter for the past several years was evaluated for cough and rhinorrhea during the pandemic of coronavirus disease 2019 (Covid-19), the disease caused by severe acute…
Wed Jun 24, 2020 03:00
Future Oncology, Ahead of Print.
Wed Jun 24, 2020 13:53
Future Oncology, Ahead of Print.
Tue Jun 09, 2020 14:30
Stem Cells and Development, Ahead of Print.
Mon Jun 22, 2020 10:00
Abstract Objectives From 2016 to 2018 Florida documented 1471 cases of Zika virus, 299 of which were pregnant women (Florida Department of Health, https://www.floridahealth.gov/diseases-and-conditions/mosquito-bornediseases/surveillance.html, 2019a). Florida’s response required unprecedented rapid and continuous cross-sector communication, adaptation, and coordination. Zika tested public health systems in new ways, particularly for...
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Virtual care models are used to follow-up patients with cardiovascular implantable electronic devices (CIED), including pacemakers, implantable cardioverter defibrillators, and cardiac resynchronization therap...
Wed Jun 24, 2020 03:00
Hypertension is one of the public health challenges. Various risk factors are associated with hypertension, including social demographics, geographical location, health behaviours, and social stress. Intervent...
Wed Jun 24, 2020 03:00
This review will provide an overview of published data comparing transposition of the extensor indicis pollicis (EIP) tendon and palmaris longus (PL) tendon grafting in thumb extension reconstruction following...
Tue Jun 23, 2020 03:00
Soft Robotics, Ahead of Print.
Mon Jun 22, 2020 10:00
Abstract Computer-aided diagnosis (CAD) has revolutionized the field of medical diagnosis. They assist in improving the treatment potentials and intensify the survival frequency by early diagnosing the diseases in an efficient, timely, and cost-effective way. The automatic segmentation has led the radiologist to successfully segment the region of interest to improve the diagnosis of diseases from medical images which is not so efficiently possible by manual segmentation. The aim...
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Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Mon Jun 22, 2020 10:00
Rejuvenation Research, Ahead of Print.
Wed Jun 24, 2020 10:00
If I die tonightMarch onFor Ahmaud, for George, for BreonnaFor Freddie, for Botham, for Eric, for TrayvonFor TamirFor that young black girl, Dajerria, who was thrown to the groundKneeled on by a cop and arrested at that pool party in a bathing suit in TexasRemember that?March onFor my grandparents…
Wed Jun 24, 2020 03:00
The genus Monosporascus represents an enigmatic group of fungi important in agriculture and widely distributed in natural arid ecosystems. Of the nine described species, two (M. cannonballus and M. eutypoides) are important pathogens on the roots of members of Cucurbitaceae in agricultural settings. The remaining seven species are capable of colonizing roots from a diverse host range without causing obvious disease symptoms. Recent molecular and culture studies have shown that members of the genus...
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Genetic and epidemiological studies have found that variations in the amyloid precursor protein (APP) and the apoliopoprotein E (APOE) genes represent major modifiers of the progressive neurodegeneration in Alzheimer's disease (AD). An extra copy of or gain-of-function mutations in APP correlate with early onset AD. Compared to the other variants (APOE2 and APOE3), the 4 allele of APOE (APOE4) hastens and exacerbates early and late onset forms of AD. Convenient in vivo models to study how APP and...
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Exp Clin Endocrinol DiabetesDOI: 10.1055/a-1149-8989The diabetic foot syndrome (DFS) is the most important cause for non-traumatic major amputation in adult individuals and actually one of the most frightening events in diabetics’ life. Despite the often protracted treatment of infected DFS at the end patients are often confronted with amputation. We investigated 352 individuals with infected DFS in two age separated-groups....
Wed Jun 24, 2020 02:00
Jeffrey Nadel, William T CouldwellNeurology India 2020 68(7):101-105 Patients with pituitary masses who undergo transsphenoidal resection are at risk for a number of medical complications postoperatively. Among these are disturbances in fluid and sodium homeostasis, including diabetes insipidus (DI) and syndrome of inappropriate secretion of antidiuretic hormone (SIADH). It is believed that these pathologic states are a result of damage to the hypothalamic–pituitary axis from surgery, as are...
Wed Jun 24, 2020 00:00
Mario Giordano, Rudolf FahlbuschNeurology India 2020 68(7):2-6 The aim of the present paper is to provide essential knowledge of neuroendocrinology. This article is based on the daily experience and frequent confrontation with endocrinological problems interdisciplinary cooperation since the early time when determination of pituitary hormones became available.
Wed Jun 24, 2020 00:00
Ramesh S Doddamani, Manjari Tripathi, Raghu Samala, Mohit Agrawal, Bhargavi Ramanujam, Jitin Bajaj, Shabari Girishan, Madhavi Tripathi, CS Bal, Ajay Garg, P Sarat ChandraNeurology India 2020 68(7):146-153 Background: The management of hypothalamic hamartomas (HH) rests upon the type of presentation. These are rare congenital benign lesions presenting either with central precocious puberty (CPP), drug refractory epilepsy (DRE) or combination of both. We present here our experience in the management...
Wed Jun 24, 2020 00:00
Rima Sathyakumar, Geeta ChackoNeurology India 2020 68(7):7-12 The classification of tumors of the pituitary gland has seen several changes in recent years. The 4th edition of the World Health Organization Classification of Tumours of Endocrine Organs, published in 2017, saw the introduction of a classification based on cell lineage using immunohistochemistry for both pituitary specific hormones as well as pituitary specific transcription factors. The term “hormone-producing” was thus replaced...
Wed Jun 24, 2020 00:00
Ashraf Abdali, Ludmila Astaf`eva, Yuriy Trunin, Pavel Kalinin, Andrey Golanov, Badshahzar Abdali, Gennady Chmutin, Alexey Shkarubo, Bipin ChaurasiaNeurology India 2020 68(7):129-133 Cushing's disease is caused by a pituitary tumor causing increased production of adrenocorticotropic hormone, which leads to chronic hypersecretion of cortisol through adrenal cortices. Endoscopic trans-sphenoidal adenomectomy is the first choice of treatment with greatest efficiency for the treatment of the disease....
Wed Jun 24, 2020 00:00
Kunal Thakkar, Vijaya Sarathi, Nalini S ShahNeurology India 2020 68(7):13-19 Pituitary adenomas (PA) account for approximately 15% of all intracranial neoplasms. Pituitary adenomas can be of different subtypes based on the cell of origin or associated hormone hypersecretion (non-functioning pituitary adenoma, prolactinoma, somatotropinoma, corticotropinoma, thyrotropinoma, and gonadotropinoma). Functioning PAs are associated with relatively higher morbidity and mortality because of associated...
Wed Jun 24, 2020 00:00
Bhawani Shanker Sharma, Arvind Ranwa, Kanwaljeet GargNeurology India 2020 68(7):85-91 Endoscopic endonasal surgery for pituitary tumors can be performed safely with a good outcome. Complications are uncommon and relate most often to nearby structures at risk. The authors detail the nuances, tips and tricks useful in avoiding complications and their early detection and management.
Wed Jun 24, 2020 00:00
Jugal V Gada, Prudwiraj Sanamandra, Sagar A Barasara, Yash V Chauhan, Nikhil M BhagwatNeurology India 2020 68(7):20-27 Functioning pituitary tumors contribute to significant morbidity and mortality. Proper diagnostic approach and management is essential for optimal outcomes. Prolactinomas, the commonest of these, are the only tumors which can be managed medically. Acromegaly, apart from acral enlargement, can have multiple comorbidities like diabetes, hypertension, and obstructive sleep apnea....
Wed Jun 24, 2020 00:00
Tejpal Gupta, Abhishek ChatterjeeNeurology India 2020 68(7):113-122 Pituitary adenomas are benign tumors arising in the adenohypophysis and comprise 8%–20% of all reported primary brain tumors in the west. Transsphenoidal surgery with an aim to achieve complete tumor resection is the recommended first-line treatment for nonfunctioning as well as secretory pituitary adenoma. External beam radiation therapy (RT) has been demonstrated to be an effective treatment modality for pituitary adenoma,...
Wed Jun 24, 2020 00:00
Vaman Khadilkar, Madhura KarguppikarNeurology India 2020 68(7):28-32 CNS tumours and their treatment commonly lead to endocrinopathies in children. Advances in surgical techniques, chemotherapy and radiotherapy have improved the survival in children with CNS tumours however they have also added to the late effect burden. Since the pituitary and hypothalamus regulate many important bodily functions, loss in their function leads to major derangements in growth and hormonal milieu. This article...
Wed Jun 24, 2020 00:00
Manjul Tripathi, Rajesh Chhabra, Pinaki Dutta, Liza Das, Sandeep Mohindra, Satyvati Mohindra, Sonikpreet AulakhNeurology India 2020 68(7):137-140
Wed Jun 24, 2020 00:00
Chandrashekhar E Deopujari, Salman T ShaikhNeurology India 2020 68(7):33-38 Pituitary tumors may well be the most common brain tumors with a mean incidence of 16.7%. Even small tumors become symptomatic when they arise from functioning cells and produce devastating effects on the body. The nonfunctioning tumors may become quite large before producing symptoms due to raised intracranial pressure or mass effect on the surrounding structures, most commonly, the optic apparatus. Many of them remain...
Wed Jun 24, 2020 00:00
Manas K Panigrahi, Y B V K Chandrasekhar, Sudhindra VooturiNeurology India 2020 68(7):39-43 Prolactinomas are a complex neuroendocrine challenge for the neurosurgeon. Management of prolactinoma patients requires centres that include neuroendocrinologists, neurosurgeons, neuroradiologists. Although dopamine agonists are the current mainstay of management of prolactinomas, surgery was often preferred management option prior to 1980, before the advent of dopamine agonists. Importantly, all patients...
Wed Jun 24, 2020 00:00
Joao Paulo Almeida, Raha Tabasinejad, Aristotelis Kalyvas, Hirokazu Takami, Nilesh Mohan, Philip J O'Halloran, Miguel Marigil Sanchez, Carlos Velasquez, Gelareh Zadeh, Fred GentiliNeurology India 2020 68(7):92-100 Introduction: Endoscopic endonasal approach (EEA) has become the preferred surgical approach for resection of pituitary adenomas in most centers. This technique has a number of advantages such as improved visualization and maneuverability, when compared to microscopic transsphenoidal...
Wed Jun 24, 2020 00:00
Sauradeep Sarkar, Ari G ChackoNeurology India 2020 68(7):44-51 Growth hormone (GH) hypersecretion from a pituitary adenoma results in acromegaly, an endocrinological disorder with multiple systemic manifestations that presents several unique challenges in terms of perioperative management and long term outcomes. Current guidelines provide stringent criteria for determining biochemical remission, necessitating an aggressive approach to management. Despite the development of several non-surgical...
Wed Jun 24, 2020 00:00
Manish Baldia, Simon Rajaratnam, Vedantam RajshekharNeurology India 2020 68(7):106-112 Objective and Aims: To study hormonal axis (HA) dysfunction pre-operatively and at three months after surgery in patients with large (>3 cms) (Hardy's grade C) and giant (>4 cms) nonfunctioning pituitary adenomas (NFPA). Methods: One hundred thirty nine patients operated between 2006 and 2017, with 3 months post-operative hormonal evaluation, were included in this retrospective study. HA damage was...
Wed Jun 24, 2020 00:00
Sapna Nayak, Preeti Dabadghao, Priyadarshi Dixit, Vikas Dwivedi, Arun K Srivastava, Sanjay BehariNeurology India 2020 68(7):52-65 Cushing's disease is rare in the paediatric age group. The disease manifestations are similar to that seen in adults. Most of the management protocols have, therefore, been adopted from experience in adults and the therapeutic strategies employed in the latter group. Management of paediatric Cushing's disease poses significant challenges with regard to achieving an...
Wed Jun 24, 2020 00:00
Kanwaljeet Garg, Manmohan SinghNeurology India 2020 68(7):123-128 Pituitary adenomas are one of the common indications for gamma knife radiosurgery. Gamma knife enables one to deliver a very high radiation dose to the target in a single fraction. Due to steep radiation fall out of Gamma Knife, the adjacent visual apparatus gets minimal radiation. The aim of stereotactic radiosurgery for pituitary adenomas is to stop tumor growth, normalize hormonal hypersecretion, preserve pituitary function,...
Wed Jun 24, 2020 00:00
Atul Goel, Sukhdeep Jhawar, Abhidha ShahNeurology India 2020 68(7):66-71 The authors review the anatomy of the pituitary gland on the basis of cadaver dissection studies and anatomy of dural relationships of pituitary tumors and its extensions on the basis of a 35-year-old experience of surgically treating pituitary tumors. Perfect understanding of anatomical correlates and nuances of pituitary tumor surgery is essential to achieve satisfactory surgical results. The pituitary gland is located...
Wed Jun 24, 2020 00:00
Joseph W Quillin, Nelson M OyesikuNeurology India 2020 68(7):134-136 Even in ideal circumstances, the performance of safe and effective endoscopic transsphenoidal pituitary surgery requires complicated orchestration of care amongst multiple medical and surgical teams in the preoperative, intraoperative, and postoperative settings. The current COVID-19 pandemic further complicates this highly orchestrated effort. Healthcare systems around the globe are working to adapt to the rapidly changing...
Wed Jun 24, 2020 00:00
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