Related Articles Posttranscriptional control of intestinal epithelium homeostasis by RNA-binding protein HuR. Sheng Li Xue Bao. 2020 Jun 25;72(3):325-335 Authors: Liu X, Xiao L, Wang JY Abstract The mammalian intestinal epithelium is a rapidly self-renewing tissue in the body and directly interfaces with a wide array of luminal noxious contents and microorganisms. Homeostasis of the intestinal epithelium is preserved through well-controlled...
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Related Articles Cell death of intestinal epithelial cells in intestinal diseases. Sheng Li Xue Bao. 2020 Jun 25;72(3):308-324 Authors: Subramanian S, Geng H, Tan XD Abstract Gut injury continues to be the devastating and unpredictable critical illness associated with increased cell death of intestinal epithelial cells (IECs). The IECs, immune system and microbiome are the interrelated entities to maintain normal intestinal homeostasis and barrier...
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Related Articles [Effect of L-cysteine on colonic motility and the underlying mechanism]. Sheng Li Xue Bao. 2020 Jun 25;72(3):299-307 Authors: Quan XJ, Zou BC, Qin B, Dai F, Luo HS, Wang JH Abstract The purpose of the present study is to investigate the effect of L-cysteine on colonic motility and the underlying mechanism. Immunohistochemical staining and Western blot were used to detect the localization of the H2S-generating enzymes cystathionine-β-synthase...
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Related Articles [Perinatal antibiotics exposure causes increase in serum 5-hydroxytryptamine level as well as changes in behavior and gastrointestinal motility in the male offspring in mice]. Sheng Li Xue Bao. 2020 Jun 25;72(3):285-298 Authors: Zou YY, Wu XY, Shu L, Ji PL, Gong HS, Rong WF Abstract The current study was aimed to investigate the potential effects of perinatal exposure to therapeutic dose of penicillin and cefixime on the cognitive...
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Related Articles [A calcium-sensing receptor polymorphism at E942K promotes the proliferation of gastric cancer cells via Ca2+ and ERK1/2 pathways]. Sheng Li Xue Bao. 2020 Jun 25;72(3):274-284 Authors: Zhang YB, DU C, Lu C, Dong H, Wu XL Abstract The study was designed to investigate the effects and mechanism of a calcium-sensing receptor (CaSR) polymorphism at E942K on the proliferation of gastric cancer cells. Single nucleotide polymorphisms...
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Related Articles Na+-K+-2Cl- symporter contributes to γ-aminobutyric acid-evoked excitation in rat enteric neurons. Sheng Li Xue Bao. 2020 Jun 25;72(3):263-273 Authors: Liu S, Zheng L, Neitzel K, Ji T, Ren W, Qu MH Abstract Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter in the adult central nervous system (CNS), however, it causes excitation in the immature CNS neurons. The shift from GABA-induced depolarization to hyperpolarization...
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Treatment recommendations for chronic obstructive pulmonary disease (COPD) involve a stepwise approach, in which treatments are added as necessary to control symptoms and reduce or eliminate exacerbations, with an additional goal of reducing mortality from the disease. Triple therapy with an…
Wed Jun 24, 2020 03:00
This case report aims to increase awareness of the diagnosis of laryngeal cleft in adult patients and discuss treatment options.
Wed Jun 24, 2020 03:00
Practitioners in the field of voice are often faced with patients who are ‘dysphonic’, but who do not have identifiable abnormalities of the vocal tract structures or any neural or hormonal alteration affecting the phonatory function. For lack of better nomenclature describing the origin of the disorder, this group of patients has been labeled as having ‘non-organic’ or ‘functional’ dysphonia. ‘Non-organic’ only states what the dysphonia is not, and ‘functional’ does not have any etiological implication.
Wed Jun 24, 2020 03:00
Deferasirox (DFX) is an oral iron-chelating agent and classified into class II of the Biopharmaceutics Classification System. Low bioavailability of the drug due to insufficient solubility in physiological fluids is the main drawback of DFX. The idea of the current study was to explore the potential of solid dispersion (SD) as an effective method to improve the dissolution rate of DFX in pellets. The SDs were made by the solvent evaporation technique using polyethylene glycol 4000 (PEG 4000) and...
Wed Jun 24, 2020 16:50
Wed Jun 24, 2020 16:50
The present paper reviewed publications on the nematocidal activity of edible mushrooms (EM) and their potential use as sustainable tools for the control of parasitic nematodes affecting agriculture and livestock industry. Nematodes are organisms living in the soil and animals’ guts where they may live as parasites severely affecting economically important crops and farm animals, thus causing economic losses to worldwide agriculture. Traditionally, parasitic nematodes have been controlled using commercial...
Wed Jun 24, 2020 11:05
Pathogenic bacteria are recognized as a major cause of foodborne diseases in humans, globally, with negative impact on the economy of each country. The aim of the present review was to obtain a comprehensive understanding about the frequency of isolation, diversity, and antimicrobial susceptibility profile of the six major foodborne pathogenic bacteria in food matrices and food processing environment, in Romania. In this regard, results of relevant epidemiological studies, published during the last...
Wed Jun 24, 2020 10:50
Lonicera japonica is a traditional Chinese herbal medicine with antioxidation, anti-inflammatory, antibacterial, and immunoregulation functions. A method to isolate polysaccharides from Lonicera japonica (LJP) has been reported previously by our group. We also reported previously that LJP was consisted of 6 types of monosaccharides and had the characteristic absorption of typical polysaccharides. In this study, we investigated the protective effect of LJP on cardiomyocytes of mice injured by hydrogen...
Wed Jun 24, 2020 09:50
Aims. Hypoxic exposure improves glucose metabolism. We investigated to validate the hypothesis that carbohydrate (CHO) oxidation could increase in mice exposed to severe hypoxic conditions. Methods. Seven-week-old male ICR mice () were randomly divided into two groups: the control group (CON) was kept in normoxic condition (fraction of inspired ) and the hypoxia group (HYP) was exposed to hypoxic condition (fraction of inspired , ≈altitude of 4,300 m). The CON group was pair-fed with the HYP group....
Wed Jun 24, 2020 09:35
Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus (DM). Schwann cell (SC) apoptosis contributes to the occurrence and development of DPN. Effective drugs to prevent SC apoptosis are required to relieve and reverse peripheral nerve injury caused by DM. Oltipraz [4-methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione], an agonist of nuclear factor erythroid derived-2-related factor 2 (Nrf2), exerts strong effect against oxidative stress in animal models or clinical patients...
Wed Jun 24, 2020 09:20
Background. Hepatocellular carcinoma (HCC) is characterized by increased mortality and poor prognosis. We aimed to identify potential prognostic markers by weighted gene coexpression network analysis (WGCNA), to assist clinical outcome prediction and improve treatment decisions for HCC patients. Methods. Prognosis-related gene modules were first established by WGCNA. Venn diagrams obtained intersection genes of module genes and differentially expressed genes. The Kaplan-Meier overall survival curves...
Wed Jun 24, 2020 08:50
Leishmania spp. proteases have been proposed as virulence factors contributing to adaptive success these parasites to the mammalian hosts. Since these enzymes are poorly studied in naturally infected dogs, this work aims to show the differences in metalloprotease and cysteine proteases gene expression in ear edge skin of dogs naturally infected by Leishmania (Leishmania) infantum. A cohort of dogs () naturally infected by L. (L.) infantum was clinically classified as asymptomatic, oligosymptomatic,...
Wed Jun 24, 2020 08:50
Background. Cervical squamous cell carcinoma (CSCC) is the main pathological type of cervical cancer, accounting for 80%–85% of cervical cancer. Owing to concurrent chemoradiotherapy (CCRT) resistance in a subset of CSCC patients, the treatment response is often unsatisfactory. Identifying predictors and therapeutic targets related to cisplatin-based CCRT resistance in CSCC is critical. Methods. We reanalyzed GSE56363, an mRNA dataset from the GEO database with 21 patients with locally advanced CSCC,...
Wed Jun 24, 2020 06:20
Earthlike planets are out there, hidden in our technological blind spots. ( NASA's Goddard Space Flight Center Conceptual Image Lab/)In 2009, the Kepler space telescope constantly watched over some 200,000 stars in our corner of the Milky Way. It was looking for where life might exist—by pinpointing small, rocky planets in the temperate zones of warm, yellow suns, and figuring out just how special Earth is in the grand scheme of things. While the mission revolutionized the study of exoplanets, those...
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Trust us. We know the type! (Sam Albury via Unsplash/)Finding the right keyboard can be a daunting task, with so many brands and functionalities available. Regardless of your preference or use case—be it a board for every day work, one that is suited to travel, or a first time mechanical keyboard purchase—we’ve got the best choices.An office workhorse. (Amazon/)Logitech has long been a leading name in computer accessories, and their master series solidifies that title. The MX Keys can connect to...
Wed Jun 24, 2020 23:42
Always have the option to bundle up. ( Autri Taheri via Unsplash/)When you’re not in a rush, a road trip is a perfect way to enjoy the journey from point A to point B. Whether you’re camping at night, sleeping in your van, or finding other lodging along the way, a blanket is a must for those cold nights and for staying comfortable during the day. We’ve considered factors like coziness, durability, water resistance, and odor resistance. Here are some of the best we’ve found.A classic choice from an...
Wed Jun 24, 2020 23:39
There a few snakes to be wary of when exploring with a four-legged buddy in the US: rattlesnakes, copperheads, coral snakes, and water moccasins. (Rachel Baskerville/Unsplash/)This story originally featured on Field & Stream.A lot of us who go West—meaning to the Dakotas and beyond—to chase pheasants and other upland birds find ourselves hunting in some toasty weather. And the toastier the temperature in that part of the world, the more active rattlesnakes are likely to be. This is a relatively...
Wed Jun 24, 2020 23:00
Scorching heat is more than just an inconvenience (Johannes Plenio/Pexels/)It’s virtually certain that 2020 will be on the top five list of hottest years on record for the planet, according to atmospheric scientists at the National Oceanic and Atmospheric Administration. In a briefing, NOAA officials announced their three-month outlook for this summer, with above average temperatures expected across almost all of the United States. The likelihood of excessive heat is highest in the West and Northeast.What’s...
Wed Jun 24, 2020 21:00
Yes, it's possible everyone knows exactly how many times you've listened to the same sad song on a loop since you broke up with your ex. (Oleg Magni/Unsplash/)In our modern age, you can’t be too careful when it comes to protecting your privacy online. That means knowing exactly what you’re sharing on the web, and with whom.Even if you think you know what you’ve put out there and what you haven’t, it’s important to check once in a while. You might be posting out personal information without even realizing...
Wed Jun 24, 2020 19:13
Improve your sound. ( John Hult via Unsplash/)Until the introduction of transistor amplifiers in the 1940s, tube circuits were the gold standard in audio amplification. Tubes are still commonly found today in high-end stereo receivers, instrument amplifiers, and microphone preamps largely because of both their prevalence in recorded musical history as well as the pleasing warmth and depth that they impart to otherwise plain audio signals. If you work with audio in any capacity, from live to studio...
Wed Jun 24, 2020 18:08
Add some smarts to your kitchen. (Christian Mackie via Unsplash/)There are endless options for kitchen appliances, and most tend to take up a large chunk of counter space even if they only perform one task. If you really want to improve your kitchen, it pays to invest in a few tools that will make your life easier. Some of these are multipurpose, so essentially function as multiple devices, and others make the cooking and cleaning process more accessible, more pleasant, and fun.Prepare warm soup...
Wed Jun 24, 2020 18:02
Capt. Carlos Espino (call sign "Loko"), foreground, walks towards a B-52 for a training flight out of Barksdale Air Force Base on March 10th. (Rob Verger /)Just before 9 a.m. on a blue-sky Louisiana morning, a giant gray B-52 bomber gradually lifts off the tarmac with some 190,000 pounds of fuel on board, a trail of dark exhaust behind it.A few seconds later, there’s a small glitch: One of the aircraft’s landing gear legs—the rear one on the left—decides to stay down. The rest fold up, as they should....
Wed Jun 24, 2020 17:50
A view of the Sahara dust plume taken on June 18, 2020 (NASA Worldview/)Expansive dust clouds arise from the sun-baked Sahara each year, making the 5,000-mile journey across the Atlantic Ocean to the southern United States. While these dust plumes tend to stay intact while traveling across the ocean, they typically diffuse by the time they hit the Caribbean. But this year, things are different.This month’s dust cloud is more resilient than usual—its dust is so opaque and thick that it can be clearly...
Wed Jun 24, 2020 17:07
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