LINC00152 promotes hepatocellular carcinoma progression by regulating PI3k/Akt/mTOR signaling pathway through miR-139/PIK3CA

LINC00152 promotes hepatocellular carcinoma progression by regulating PI3k/Akt/mTOR signaling pathway through miR-139/PIK3CA: Hepatocellular carcinoma (HCC) ranks as the fifth most common cancer worldwide, and is the primary histological subtype of liver cancer with high incidence and poor prognosis. Recently, numerous long non-coding RNAs (lncRNAs) have been reported to be associated with the tumorigenesis of HCC, however, the underlying mechanisms of LINC00152 action in HCC are poorly understood. Herein, we identified a significant up-regulation of LINC00152 both in HCC tissues and cell lines. Functional studies showed that knockdown of LINC00152 inhibited cell proliferation, migration, and invasion, but promoted cell apoptosis, indicating its oncogenic functions in HCC tumorigenesis.