Cancers, Vol. 12, Pages 698: Carbon-Ion Beam Irradiation Alone or in Combination with Zoledronic acid Effectively Kills Osteosarcoma Cells Cancers doi: 10.3390/cancers12030698 Authors: Eun Ho Kim Mi-Sook Kim Akihisa Takahashi Masao Suzuki Guillaume Vares Akiko Uzawa Akira Fujimori Tatsuya Ohno Sei Sai Osteosarcoma (OSA) is the most common malignant bone tumor in children and adolescents. The overall five-year survival rate for all bone cancers is...
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Cancers, Vol. 12, Pages 697: Oxaliplatin-Induced DHX9 Phosphorylation Promotes Oncogenic Circular RNA CCDC66 Expression and Development of Chemoresistance Cancers doi: 10.3390/cancers12030697 Authors: Ya-Chi Lin Ya-Shan Yu Hui-Hsuan Lin Kuei-Yang Hsiao Circular RNA (circRNA), generated through backsplicing in which the downstream splice donor joins the upstream splice acceptor, is a novel class of RNA molecules. Our previous study found that a novel oncogenic circRNA—consisting...
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Abstract Infertility affects 10% of reproductive-age women and is extremely heterogeneous in etiology. The genetic contribution to female infertility is incompletely understood, and involves chromosomal and single-gene defects. Our aim in this study is to decipher single-gene causes in infertile women in whom endocrinological, anatomical, and chromosomal causes have been excluded. Our cohort comprises women with recurrent pregnancy loss and no offspring from spontaneous pregnancies...
Sat Mar 14, 2020 02:00
Related ArticlesHypokalemia but not Hyperkalemia is Associated with Recurrences of Ventricular Tachyarrhythmias in ICD Recipients. Clin Lab. 2020 Mar 01;66(3): Authors: Schupp T, Behnes M, Zworowsky MV, Kim SH, Weidner K, Rusnak J, Kuche P, Müller J, Barth C, Reiser L, Taton G, Reichelt T, Ellguth D, Engelke N, Bollow A, Kittel M, Bertsch T, Mashayekhi K, Borggrefe M, Akin I Abstract BACKGROUND: Only few data evaluating the prognostic impact of blood-derived...
Sat Mar 14, 2020 07:19
Related ArticlesPlatelet and Monocyte Activity Markers and Mortality in Patients with End-Stage Renal Disease. Clin Lab. 2020 Mar 01;66(3): Authors: Gergei I, Kälsch T, März W, Krämer BK, Kälsch AI Abstract BACKGROUND: The association of platelet and monocyte activity markers with long-term mortality was assessed in hemodialysis (HD) patients. METHODS: In 41 HD patients (25 male, 16 female), surface expression of CD40L and CD62P on platelets,...
Sat Mar 14, 2020 07:19
Related ArticlesDiagnostic Value of miR-34a in Bone Marrow Mononuclear Cells of Acute Myeloid Leukemia Patients. Clin Lab. 2020 Mar 01;66(3): Authors: Liu X, Li H Abstract BACKGROUND: The current study aims to analyze the expression of miR-34a in bone marrow mononuclear cells (BMMCs) of acute myeloid leukemia (AML) patients and its possible role in the development of leukemia. METHODS: Real-time fluorescent quantitative PCR was used to detect...
Sat Mar 14, 2020 07:19
Related ArticlesPreparation of In-House Quality Control Human Serum for Urea and its Use in Clinical Chemistry. Clin Lab. 2020 Mar 01;66(3): Authors: Haile B, Bikila D, Tewabe H, Wolde M Abstract BACKGROUND: Quality control materials play a vital role in the laboratory internal and external quality assessment program. However, Ethiopia and other developing countries are challenged by the unavailability and high cost of commercial control material. Therefore,...
Sat Mar 14, 2020 07:19
Diagnostic Accuracy of the Mean Platelet Volume in the Prediction of Upper Urinary Tract Infections.
Related ArticlesDiagnostic Accuracy of the Mean Platelet Volume in the Prediction of Upper Urinary Tract Infections. Clin Lab. 2020 Mar 01;66(3): Authors: Gökçe Ş, Kurugöl Z Abstract BACKGROUND: The studies have reported that mean platelet volume may be a marker in the discrimination of upper and lower urinary tract infections. We investigated whether the mean platelet volume was a reliable indicator in upper and lower urinary tract infections. ...
Sat Mar 14, 2020 07:19
Related ArticlesNeonatal Iron: Factors Influencing its Level and Associated Complications - a Review Article. Clin Lab. 2020 Mar 01;66(3): Authors: Getu S, Shiferaw E, Melku M Abstract BACKGROUND: Iron is an essential micronutrient which plays a significant role, particularly vital for early brain growth and function. Maternal iron condition influences the iron status of neonates since iron transferred from the mother is the only source for fetal iron....
Sat Mar 14, 2020 07:19
Related ArticlesData Mining the Prognostic Biomarkers: miRNAs Targeting the Chemotherapeutic Agent 5-Fluorouracil in Colon Cancer. Clin Lab. 2020 Mar 01;66(3): Authors: Wu XX, Huang XL, Lin XR, Li YL, Chen YH, Huang ZM Abstract BACKGROUND: Colon cancer is one of the most common and has the highest mortality rate in the world. MicroRNAs (miRNAs) as potential biomarkers play crucial roles in diagnosis, prognosis, and drug-response prediction of colon cancer....
Sat Mar 14, 2020 07:19
Related ArticlesDiagnostic Value of Peripheral Blood miR-148a-3p in Patients with Liver Injury After Hepatectomy Under General Anesthesia with Propofol. Clin Lab. 2020 Mar 01;66(3): Authors: Chen Y, Duan J Abstract BACKGROUND: The current study aims to evaluate the correlation between peripheral blood miR-148a-3p level in patients with liver injury after hepatectomy under general anesthesia with propofol, thereby evaluating whether circulating miR-148a-3p...
Sat Mar 14, 2020 07:19
Related ArticlesSignificance of Lymphocyte Count, Monocyte Count, and Lymphocyte-To-Monocyte Ratio in Predicting Molecular Response in Patients with Chronic Myeloid Leukemia: a Single-Centre Experience. Clin Lab. 2020 Mar 01;66(3): Authors: Pepedil-Tanrikulu F, Buyukkurt N, Korur A, Sariturk C, Aytan P, Boga C, Ozdogu H, Kozanoglu I Abstract BACKGROUND: Chronic myeloid leukemia (CML) is a disease resulting from BCR-ABL gene fusion. It is possible to...
Sat Mar 14, 2020 07:19
Related ArticlesMolecular Typing of Campylobacter jejuni and Campylobacter coli of Human Strains Isolated in Turkey Over an Eight-Year Period. Clin Lab. 2020 Mar 01;66(3): Authors: Ilktac M, Ongen B Abstract BACKGROUND: Campylobacter spp. is one of the leading causes of bacterial foodborne infections worldwide. In this study, we aimed to investigate the genetic diversity of 341 Campylobacter strains isolated in Turkey. METHODS: Campylobacter...
Sat Mar 14, 2020 07:19
Related ArticlesIdentification of Amoxicillin Crystals in Urine: a Case Report. Clin Lab. 2020 Mar 01;66(3): Authors: Fanelli A, Rapi S, Dugheri S, Bonari A, Milletti E, Cappelli G, Mucci N, Arcangeli G Abstract BACKGROUND: The case concerns a 30-year-old woman in the 24th week of pregnancy presenting to the medical emergency room with fever and abdominal pain. Urine sediment microscopy revealed the presence of unknown needle-shaped crystals. ...
Sat Mar 14, 2020 07:19
Related ArticlesSevere Anaphylaxis During Allogeneic Hematopoietic Stem Cell Transplantation in a Patient with Aplastic Anemia: Case Report of Individualized Pharmaceutical Care and Literature Review. Clin Lab. 2020 Mar 01;66(3): Authors: Peng H, Ji D, Ren S, Zou D, Li F, Huang R Abstract BACKGROUND: Cyclosporine injection is usually applied in allogeneic hematopoietic stem cell transplantation (Allo-HSCT) during induction phase. Anaphylaxis to cyclosporine...
Sat Mar 14, 2020 07:19
Related ArticlesA Rapid Quantitative Chemiluminescence Immunoassay for Vitamin B12 in Human Serum. Clin Lab. 2020 Mar 01;66(3): Authors: Chen X, Ren F, Xu J, Yu Z, Lin X, Bai Z, Gong F Abstract BACKGROUND: Vitamin B12 is very important for the human body. Early diagnosis of vitamin B12 deficiency is essential because it is associated with many problems such as fatigue, lethargy, depression, poor memory, breathlessness, headaches, pale skin, mania, psychosis,...
Sat Mar 14, 2020 07:19
Related ArticlesConcerning Fiedler S. A. et al.: Evaluation of the in vitro Function of Platelet Concentrates from Pooled Buffy Coats or Apheresis. Transfus Med Hemother 2020. Clin Lab. 2020 Mar 01;66(3): Authors: Wolny M, Knabbe C, Birschmann I PMID: 32162879 [PubMed - as supplied by publisher]
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Related ArticlesImplementation of an Affordable Method for MPS Diagnosis from Urine Screening to Enzymatic Confirmation: Results of a Pilot Study in Morocco. Clin Lab. 2020 Mar 01;66(3): Authors: Fdil N, Sabir ES, Ezoubeiri A, Elqadiry R, Daoudi A, Lalaoui A, Fouad A, Rada N, Slitine N, Bennaoui F, Bourrahouat A, Saab IA, Boualy B, Karim A, Andrade F, González-Lamuňo D, Aldámiz-Echevarria L, Bouskraoui M Abstract BACKGROUND: Rapid and accurate diagnosis...
Sat Mar 14, 2020 07:19
Related ArticlesPlatelet miR-587 may be Used as a Potential Biomarker for Diagnosis of Patients with Acute Coronary Syndrome. Clin Lab. 2020 Mar 01;66(3): Authors: Qiu H, Zhang Y, Zhao Q, Jiang H, Yan J, Liu Y Abstract BACKGROUND: The current study aims to investigate the expression of miR-587 in platelets of patients with acute coronary syndrome (ACS) and its correlation with the severity of coronary artery disease. METHODS: One hundred thirty-nine...
Sat Mar 14, 2020 07:19
Related ArticlesBacteremia Caused by Turicella otitidis in a Patient with Diffuse Large B-Cell Lymphoma. Clin Lab. 2020 Mar 01;66(3): Authors: Li D, Shan W, Dai C, Kan J, Li M, Yin M Abstract BACKGROUND: Invasive Gram-positive bacilli infections are commonly encountered in immunocompromised patients. In this paper, we report a bacteremia caused by Turicella otitidis in a patient with diffuse large B-cell lymphoma. METHODS: Bacteria was identified...
Sat Mar 14, 2020 07:19
Related ArticlesD-Dimer Assay May Guide LMWH Treatment in Repeated Biochemical Pregnancy Losses in Women with Positive Antiphospholipid Antibody. Clin Lab. 2020 Mar 01;66(3): Authors: Bao SH, Frempong ST, Ruan JL Abstract BACKGROUND: Do D-dimer levels influence the pregnancy outcomes after treatment with low molecular weight heparin (LMWH) in women of recurrent miscarriage (RM), repeated biochemical pregnancy losses (BPL), and a positive test for antiphospholipid...
Sat Mar 14, 2020 07:19
Related ArticlesResistance Trends Among 1,294 Nosocomial Acinetobacter baumannii Strains from a Tertiary General Hospital in China, 2014 - 2017. Clin Lab. 2020 Mar 01;66(3): Authors: He S, Li Z, Yang Q, Quan M, Zhao L, Hong Z Abstract BACKGROUND: To analyze the difference of the antibiotic resistance of Acinetobacter baumannii (A. baumannii) isolated from our hospital between 2014 and 2017. METHODS: We retrospectively evaluated the patients...
Sat Mar 14, 2020 07:19
Related ArticlesDetection of HPV DNA in Esophageal Lesions: a Cross-Sectional Study. Clin Lab. 2020 Mar 01;66(3): Authors: Dinc B, Altay-Kocak A, Aydog G, Kuran S, Akoglu M, Ozkan S, Bozdayi G Abstract BACKGROUND: Several studies have documented human papillomavirus (HPV) in extra-cervical tumors. We aimed to detect HPV type 16 and HPV other than type 16 (OT-16) DNA in esophageal papilloma and esophagus squamous cell carcinoma (ESCC) samples and to compare...
Sat Mar 14, 2020 07:19
Related ArticlesThe Performance of Nesfatin-1 in Distinguishing Irritable Bowel Syndrome Presenting Predominantly with Diarrhea from Celiac Disease. Clin Lab. 2020 Mar 01;66(3): Authors: Karatay E, Gül-Utku Ö, Aksoy N Abstract BACKGROUND: We hypothesized that nesfatin-1, an anti-inflammatory peptide, could be used as a non-invasive diagnostic tool in the identification of celiac disease (CD) and irritable bowel syndrome presenting predominantly with...
Sat Mar 14, 2020 07:19
Related ArticlesThe Relationship between Erythrocyte Sedimentation Rate and Erythrocyte Sedimentation/Red Blood Cell Ratio and Disease Activity in Systemic Lupus Erythematosus. Clin Lab. 2020 Mar 01;66(3): Authors: Xiao LJ, Liu JL, Pan NN, Cui SJ, He HH, Ren TY, Lan X, Li Q, Zhou YW Abstract BACKGROUND: The treatment options of systemic lupus erythematosus (SLE) patients in active and inactive phases are very different clinically, and the prognosis of...
Sat Mar 14, 2020 07:19
Related ArticlesThe Total Testing Process of Intra-Operative Parathyroid Hormone. A Narrative Review. Clin Lab. 2020 Mar 01;66(3): Authors: Stenner E, Sandic S, Dobrinja C, Ruscio M, Bernardi S Abstract BACKGROUND: Primary hyperparathyroidism (pHPT) is a common endocrine disorder, due to an excessive secretion of parathyroid hormone (PTH) from one or more parathyroid gland(s), where the only cure remains surgery. The surgical approach has become less...
Sat Mar 14, 2020 07:19
Related ArticlesAssociation of CXCR4 Expression and Clinical Outcome in Different Subsets of De Novo Acute Myeloid Leukemia Patients. Clin Lab. 2020 Mar 01;66(3): Authors: Rady AS, Badawy RH, Gamal BME, Darwish AD, Aziz RSA, Gammal ME, Goweda RA Abstract BACKGROUND: Acute myeloid leukemia is a heterogeneous group of diseases characterized by the uncontrolled proliferation of hematopoietic stem cells (HSCs) and progenitor cells with a reduced capacity...
Sat Mar 14, 2020 07:19
Related ArticlesAge-Adapted Prostate Cancer Gene 3 Score Interpretation - Suggestions for Clinical Use. Clin Lab. 2020 Mar 01;66(3): Authors: Hennenlotter J, Neumann T, Alperowitz S, Wagner V, Hohneder A, Bedke J, Stenzl A, Todenhöfer T, Rausch S Abstract BACKGROUND: The prostate cancer antigen 3 (PCA3) gene urine assay is established for biopsy decision in case of prostate cancer (PC) suspicion. Recent findings pointed to an age dependence of PCA3,...
Sat Mar 14, 2020 07:19
Related ArticlesThe Serum Tumor Markers in Combination for Clinical Diagnosis of Lung Cancer. Clin Lab. 2020 Mar 01;66(3): Authors: Wu H, Wang Q, Liu Q, Zhang Q, Huang Q, Yu Z Abstract BACKGROUND: To explore the clinical value of combined detection of serum tumor markers in lung cancer, including carcinoembryonic antigen (CEA), carbohydrate antigen 15-3 (CA15-3), cytokeratin 19 fragment (CYFRA 21-1), neuron specific enolase (NSE), and squamous carcinoma...
Sat Mar 14, 2020 07:19
Related ArticlesPrognostic Value of Hematological Inflammatory Markers in Patients with Pleural Effusion Due to Heart Failure. Clin Lab. 2020 Mar 01;66(3): Authors: Garcia-Pachon E, Soler-Sempere MJ, Cerda-Guilabert P, Zamora-Molina L, Baeza-Martinez C, Grau-Delgado J, Padilla-Navas I Abstract BACKGROUND: Pleural effusions due to heart failure are associated with a high 1-year mortality. Several hematological parameters have been shown to provide prognostic...
Sat Mar 14, 2020 07:19
Related ArticlesPlasma YKL-40: a Potential Biomarker for Tumor Invasion in Esophageal Cancer. Clin Lab. 2020 Mar 01;66(3): Authors: Huang R, Yao J, Ding X, Liu J, Fan C, Duan H, Ye H Abstract BACKGROUND: YKL-40, a chitinase-like glycoprotein has been identified as a candidate tumor marker. The current study evaluated the clinical significance of plasma YKL-40 in esophageal cancer patients. METHODS: We enrolled 127 esophageal cancer patients,...
Sat Mar 14, 2020 07:19
Related ArticlesMolecular Analysis of the Antibiotic Resistant NDM-1 Gene in Clinical Isolates of Enterobacteriaceae. Clin Lab. 2020 Mar 01;66(3): Authors: Ejaz H, Alzahrani B, Hamad MFS, Abosalif KOA, Junaid K, Abdalla AE, Elamir MYM, Aljaber NJ, Hamam SSM, Younas S Abstract BACKGROUND: The emergence of the New Dehli metallo-beta-lactamase (NDM) gene in Enterobacteriaceae is responsible for multidrug resistance responsible for severe infections and...
Sat Mar 14, 2020 07:19
Related ArticlesMean Platelet Volume/Platelet Count Ratio as a Predictor of 3-Month Mortality in HBV-Related Decompensated Cirrhosis Patients. Clin Lab. 2020 Mar 01;66(3): Authors: Ding QM, Zhou WQ, Mao WL, Zhang JF Abstract BACKGROUND: Hepatitis B virus (HBV)-associated decompensated cirrhosis (HBV-DeCi) has a high mortality rate if liver transplantation is not performed. The study aimed to evaluate the association between the mean platelet volume to...
Sat Mar 14, 2020 07:19
Related ArticlesProcalcitonin (PCT) Improves the Accuracy and Sensitivity of Dyspnea, Eosinopenia, Consolidation, Acidemia and Atrial Fibrillation (DECAF) Score in Predicting AECOPD Patients Admission to ICU. Clin Lab. 2020 Mar 01;66(3): Authors: Chen Y, Li LIQ, Ge YL, Hu XY, Zhang Q, Zhang HF, Li WQ, Zhang S, Zhu XY, Zhang JB Abstract BACKGROUND: The score of Dyspnea, Eosinopenia, Consolidation, Acidemia and Atrial Fibrillation (DECAF) can be used to...
Sat Mar 14, 2020 07:19
Related ArticlesThe Trend of ripk1/ripk3 and mlkl Mediated Necroptosis Pathway in Patients with Different Stages of Prostate Cancer as Promising Progression Biomarkers. Clin Lab. 2020 Mar 01;66(3): Authors: Heidaryan F, Bamehr H, Babaabasi B, Imamverdi A, Mohammadzadeh N, Khalili A Abstract BACKGROUND: Programmed cell death is critical to maintain tissue homeostasis. Necroptosis, as well as apoptosis, has been considered as another form of regulated...
Sat Mar 14, 2020 07:19
Related ArticlesRole of Pernicious Anemia in Patients Admitted to Internal Medicine with Vitamin B12 Deficiency and Oral Replacement Therapy as a Treatment Option. Clin Lab. 2020 Mar 01;66(3): Authors: Harmandar FA, Dolu S, Çekin AH Abstract BACKGROUND: To determine the role of vitamin B12 deficiency in pernicious anemia and the efficacy of oral vitamin B12 replacement therapy given regardless of the etiology, and to compare the endoscopic and pathological...
Sat Mar 14, 2020 07:19
AbstractWe sense fat by its texture and smell, but it is still unknown whether we also taste fat despite evidence of both candidate receptors and distinct fat-taste sensations. One major reason fat is still not recognised as a basic taste quality is that we first need to demonstrate its underlying neural activity. To investigate such neural fat-taste activation, we recorded evoked responses to commercial cow milk products with 0.1 %, 4 %, and 38 % fat via high-density electroencephalography (EEG)...
Sat Mar 14, 2020 02:00
Future Oncology, Ahead of Print.
Fri Mar 13, 2020 13:12
Future Oncology, Ahead of Print.
Fri Mar 13, 2020 12:23
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