Abstract Background Uterus manipulation is a lengthy and tedious task that is usually performed by a human assistant during laparoscopic hysterectomy. Note that the performance of the assistant may decrease with time. Moreover, under this approach, the primary surgeon does not have direct control over the uterus position. He/she can only verbally request the assistant to place it on a particular configuration. Methods A robotic system composed of a 3 degrees‐of‐freedom uterine positioner...
Fri Mar 13, 2020 23:57
Abstract Background Accurate autonomous marker detection and measurement is essential for high precision anatomical registration. The measurement should be in real‐time, accurate, and robust to the varied conditions of the operation theatre. Methods The purpose is to design and implement a robust real‐time algorithm to measure the coordinates of the point on the marker for robot‐based autonomous registration and surgery. The algorithm is built in two parts based on the recursive...
Fri Mar 13, 2020 23:57
Therapeutic agents that target both tumor cell and vascular endothelial cell may achieve additional anti-tumor efficacy, particularly in lung cancer due to the critical roles of angiogenesis during lung cancer progression and metastasis. In this work, we showed that pitavastatin, a novel cholesterol-lowering drug, potently inhibited lung cancer cells and angiogenesis. This was achieved by the induction of apoptosis and inhibition of proliferation of lung cancer cells and human lung tumor-associated...
Fri Mar 13, 2020 23:52
Leucine proline-enriched proteoglycan 1 has been extensively explored because of its protective function in cell homeostasis and correlation with osteogenesis imperfect. Human osteosarcoma is the most common primary malignant tumor of bone with multiple and complex genomic aberrations. However, the functional role of leucine proline-enriched proteoglycan 1 is still unknown in osteosarcoma. Thus we performed this study to explain the leucine proline-enriched proteoglycan 1 effect in osteosarcoma....
Fri Mar 13, 2020 23:52
The aim of this study was to probe the influence of microRNA-301b (miR-301b) in esophageal cancer pathogenesis. Based on the data acquired from The Cancer Genome Atlas database, we found that miR-301b was highly expressed in esophageal cancer tissues and high expression of miR-301b was related to worse prognosis in patients with esophageal cancer. Quantitative real-time PCR revealed that the expression of miR-301b was higher in all examined esophageal cancer cell lines (ECA109, KY-SE150, TE-1, and...
Fri Mar 13, 2020 23:52
Successive infusion of natural killer cells is increasingly being explored as a treatment for cancer patients. The inadequate homing of natural killer cells into the tumor site resulted in the poor efficacy of natural killer cells on solid tumors. For the adoptive transfer of tumor-directed natural killer cell has been proved effective, it is hypothesized that there must be more association between the tumor-produced chemokines and the natural killer cells-expressed chemokine receptors. Increased...
Fri Mar 13, 2020 23:52
Antitumor potential of a 1,4-dihydropyridine derivative (DHP-8) has been successfully studied previously in a number of cancer cell lines including the human melanoma cells, A375. In order to validate its anticancer activity, DMBA induced tumor in Swiss Albino mice was considered for this study. DMBA causes skin carcinoma in murine systems and is an important in vivo model for evaluating the efficacy of any new chemical entity against skin cancer. Topical administration of DHP-8 at the dose rate...
Fri Mar 13, 2020 23:52
Metformin, a medication widely used in the treatment of type 2 diabetes mellitus, has a possible antitumor effect in type 2 diabetes mellitus patients. MicroRNA-7 is a significant microRNA in non-small cell lung cancer. Metformin has an inhibitory effect on lung cancer and regulates the expression of certain microRNAs, but there is no report connecting metformin with microRNA-7 in lung cancer. Thus, we used qPCR to measure microRNA-7 expression in A549 non-small cell lung cancer cells treated with...
Fri Mar 13, 2020 23:52
Long noncoding RNAs (lncRNAs) are a group of non–protein-coding transcripts exceeding 200 nucleotides in length, which are emerging as key players in various fundamental biological processes. Furthermore, it is increasingly recognized that mutation and dysregulation of lncRNAs contribute importantly to a variety of human diseases, particularly human cancers. Previous studies have revealed that altered lncRNAs have a close association with tumorigenesis, metastasis, prognosis and diagnosis of cancers....
Fri Mar 13, 2020 23:52
A class of substituted quinolines (PQs) acts as a gap junction enhancer with the ability to increase the gap junctional intercellular communication in breast cancer cells. This study examined the effect of a combinational treatment of PQs and the antineoplastic drug paclitaxel in a xenograft animal model. Mice were implanted with estradiol-17ß (1.7 mg/pellet) before the injection of 1 × 107 T47D breast cancer cells subcutaneously into the inguinal region of mammary fat pad. Animals were treated intraperitoneally...
Fri Mar 13, 2020 23:52
Resistance to cisplatin (DDP) remains a major obstacle in the control of gastric cancer (GC) progression. A previous study revealed that microRNA-21 (miR-21) contributes to DDP resistance in GC cells via the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway. The aim of the current study was to explore the mechanisms underlying the cytoprotective function of miR-21. In this study, DDP-resistant GC cells were obtained by continuous exposure of human gastric adenocarcinoma cells to increasing...
Fri Mar 13, 2020 23:52
Triple-negative breast cancers account for approximately 15–20% of breast cancer patients. Due to lack of expression of estrogen receptor, PR and human epidermal growth factor receptor 2 in triple-negative breast cancers, there are no targeted therapies available for these cancers. Therefore, a major research priority is to find potential therapeutic targets. Androgen receptor is present in 80–90% of all breast cancers, including 55% of estrogen receptor-α–negative cancers and 12%–35% of triple-negative...
Fri Mar 13, 2020 23:52
Our retrospective study assessed the efficacy and safety of irinotecan plus raltitrexed in esophageal squamous cell cancer (ESCC) patients who were previously treated with multiple systemic therapies. Between January 2016 and December 2018, records of 38 ESCC patients who underwent irinotecan plus raltitrexed chemotherapy after at least one line of chemotherapy were reviewed. Efficacy assessment was performed every two cycles according to the RECIST version 1.1. A total of 95 cycles of chemotherapy...
Fri Mar 13, 2020 23:52
Gastric cancer (GC) is lethal and there is an urgent need for improved understanding of this disease. Recent studies have reported that microRNAs (miRNAs) play increasingly important roles in the regulation of GC. In this study, we explored the target genes and effects of miR-7641 in GC. Our data showed that high miR-7641 expression was associated with low expression of ARID1A in GC tissue. miR-7641 expression promoted GC cell proliferation and colony formation. Luciferase reporter assay results...
Fri Mar 13, 2020 23:52
Bromodomain-containing protein 7 (BRD7) is a member of the bromodomain-containing protein family. Previous studies suggest that BRD7 is predominantly localized in the nucleus, wherein it functions as a transcriptional regulator. Several lines of evidence imply a tumour suppressor function for BRD7. However, the importance of BRD7 in the pathogenesis of breast cancer is not well understood. We have investigated the expression, CpG island methylation and subcellular localization of BRD7 in breast cancer...
Fri Mar 13, 2020 23:52
Journal of Neurotrauma, Ahead of Print.
Wed Mar 11, 2020 09:00
Journal of Neurotrauma, Ahead of Print.
Wed Mar 11, 2020 09:00
Journal of Neurotrauma, Ahead of Print.
Wed Mar 11, 2020 09:00
Journal of Neurotrauma, Ahead of Print.
Wed Mar 11, 2020 09:00
Journal of Neurotrauma, Ahead of Print.
Wed Mar 11, 2020 09:00
Journal of Neurotrauma, Ahead of Print.
Wed Mar 11, 2020 09:00
Journal of Neurotrauma, Ahead of Print.
Wed Mar 11, 2020 09:00
Journal of Neurotrauma, Ahead of Print.
Wed Mar 11, 2020 09:00
Abstract Kosakonia radicincitans GXGL-4A, a free-living nitrogen-fixing (NF) bacterial strain isolated from maize (Zea mays L.) roots was found to have ability to degrade aromatic hydrocarbons. In this study, we describe the main morphological characteristics of bacterium, aromatic hydrocarbon-degrading capability, and the complete genome of K. radicincitans GXGL-4A. The genome is consisted of only one 5,687,681 bp linear chromosome with a G + C content of 53.96%. The strain has...
Fri Mar 13, 2020 02:00
Abstract A Gram-negative, aerobic, non-motile, rod-shaped, floc-forming, and non-spore-forming bacterium, designated as NLF-7-7T, was isolated from the biofilm of a sample collected from a livestock wastewater treatment plant in Nonsan, Republic of Korea. Strain NLF-7-7T, forms a visible floc and grows in the flocculated state. Cells of strain NLF-7-7T grew optimally at pH 6.5 and 30 °C and in the presence of 0.5% (w/v) NaCl. Phylogenetic analysis based on 16S rRNA gene sequences...
Fri Mar 13, 2020 02:00
Writing in the heady days of new antibiotics and immunizations, esteemed microbiologists Macfarlane Burnet and David White predicted in 1972 that "the most likely forecast about the future of infectious diseases is that it will be very dull." They acknowledged that there was always a risk of "some…
Thu Mar 12, 2020 02:00
Recognizing that patients prioritize convenient and inexpensive care, Duffy and Lee recently asked whether in-person visits should become the second, third, or even last option for meeting patient needs. Previous work has specifically described the potential for using telemedicine in disasters and…
Wed Mar 11, 2020 02:00
Thyroid, Volume 30, Issue 3, Page 443-450, March 2020.
Wed Mar 11, 2020 09:00
Thyroid, Ahead of Print.
Wed Mar 11, 2020 09:00
Thyroid, Volume 30, Issue 3, Page 351-354, March 2020.
Wed Mar 11, 2020 09:00
Thyroid, Ahead of Print.
Wed Mar 11, 2020 09:00
Thyroid, Volume 30, Issue 3, Page 355-356, March 2020.
Wed Mar 11, 2020 09:00
Thyroid, Ahead of Print.
Wed Mar 11, 2020 09:00
Thyroid, Volume 30, Issue 3, Page 380-388, March 2020.
Wed Mar 11, 2020 09:00
Thyroid, Volume 30, Issue 3, Page 347-348, March 2020.
Wed Mar 11, 2020 09:00
Thyroid, Ahead of Print.
Wed Mar 11, 2020 09:00
Thyroid, Ahead of Print.
Wed Mar 11, 2020 09:00
Thyroid, Volume 30, Issue 3, Page 425-431, March 2020.
Wed Mar 11, 2020 09:00
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