Δευτέρα, 16 Μαρτίου 2020


A Collaborative Robotic Uterine Positioning System for Laparoscopic Hysterectomy: Design and Experiments
Abstract Background Uterus manipulation is a lengthy and tedious task that is usually performed by a human assistant during laparoscopic hysterectomy. Note that the performance of the assistant may decrease with time. Moreover, under this approach, the primary surgeon does not have direct control over the uterus position. He/she can only verbally request the assistant to place it on a particular configuration. Methods A robotic system composed of a 3 degrees‐of‐freedom uterine positioner...
The International Journal of Medical Robotics and Computer Assisted Surgery
Fri Mar 13, 2020 23:57
Robust Marker Detection and High Precision Measurement for Real‐Time Anatomical Registration using Taguchi Method
Abstract Background Accurate autonomous marker detection and measurement is essential for high precision anatomical registration. The measurement should be in real‐time, accurate, and robust to the varied conditions of the operation theatre. Methods The purpose is to design and implement a robust real‐time algorithm to measure the coordinates of the point on the marker for robot‐based autonomous registration and surgery. The algorithm is built in two parts based on the recursive...
The International Journal of Medical Robotics and Computer Assisted Surgery
Fri Mar 13, 2020 23:57
Cholesterol-lowering drug pitavastatin targets lung cancer and angiogenesis via suppressing prenylation-dependent Ras/Raf/MEK and PI3K/Akt/mTOR signaling
Therapeutic agents that target both tumor cell and vascular endothelial cell may achieve additional anti-tumor efficacy, particularly in lung cancer due to the critical roles of angiogenesis during lung cancer progression and metastasis. In this work, we showed that pitavastatin, a novel cholesterol-lowering drug, potently inhibited lung cancer cells and angiogenesis. This was achieved by the induction of apoptosis and inhibition of proliferation of lung cancer cells and human lung tumor-associated...
Anti-Cancer Drugs - Current Issue
Fri Mar 13, 2020 23:52
Upregulated LEPRE1 correlates with poor outcome and its knockdown attenuates cells proliferation, migration and invasion in osteosarcoma
Leucine proline-enriched proteoglycan 1 has been extensively explored because of its protective function in cell homeostasis and correlation with osteogenesis imperfect. Human osteosarcoma is the most common primary malignant tumor of bone with multiple and complex genomic aberrations. However, the functional role of leucine proline-enriched proteoglycan 1 is still unknown in osteosarcoma. Thus we performed this study to explain the leucine proline-enriched proteoglycan 1 effect in osteosarcoma....
Anti-Cancer Drugs - Current Issue
Fri Mar 13, 2020 23:52
MicroRNA-301b and its target gene synaptosome-associated protein 91 as important modulators in esophageal cancer: functional experiments
The aim of this study was to probe the influence of microRNA-301b (miR-301b) in esophageal cancer pathogenesis. Based on the data acquired from The Cancer Genome Atlas database, we found that miR-301b was highly expressed in esophageal cancer tissues and high expression of miR-301b was related to worse prognosis in patients with esophageal cancer. Quantitative real-time PCR revealed that the expression of miR-301b was higher in all examined esophageal cancer cell lines (ECA109, KY-SE150, TE-1, and...
Anti-Cancer Drugs - Current Issue
Fri Mar 13, 2020 23:52
Overexpressed CXCR4 and CCR7 on the surface of NK92 cell have improved migration and anti-tumor activity in human colon tumor model
Successive infusion of natural killer cells is increasingly being explored as a treatment for cancer patients. The inadequate homing of natural killer cells into the tumor site resulted in the poor efficacy of natural killer cells on solid tumors. For the adoptive transfer of tumor-directed natural killer cell has been proved effective, it is hypothesized that there must be more association between the tumor-produced chemokines and the natural killer cells-expressed chemokine receptors. Increased...
Anti-Cancer Drugs - Current Issue
Fri Mar 13, 2020 23:52
Anticancer activity of a 1,4-dihydropyridine in DMBA-induced mouse skin tumor model
Antitumor potential of a 1,4-dihydropyridine derivative (DHP-8) has been successfully studied previously in a number of cancer cell lines including the human melanoma cells, A375. In order to validate its anticancer activity, DMBA induced tumor in Swiss Albino mice was considered for this study. DMBA causes skin carcinoma in murine systems and is an important in vivo model for evaluating the efficacy of any new chemical entity against skin cancer. Topical administration of DHP-8 at the dose rate...
Anti-Cancer Drugs - Current Issue
Fri Mar 13, 2020 23:52
Metformin mediated microRNA-7 upregulation inhibits growth, migration, and invasion of non-small cell lung cancer A549 cells
Metformin, a medication widely used in the treatment of type 2 diabetes mellitus, has a possible antitumor effect in type 2 diabetes mellitus patients. MicroRNA-7 is a significant microRNA in non-small cell lung cancer. Metformin has an inhibitory effect on lung cancer and regulates the expression of certain microRNAs, but there is no report connecting metformin with microRNA-7 in lung cancer. Thus, we used qPCR to measure microRNA-7 expression in A549 non-small cell lung cancer cells treated with...
Anti-Cancer Drugs - Current Issue
Fri Mar 13, 2020 23:52
The role of long noncoding RNAs in regulating invasion and metastasis of malignant tumors
Long noncoding RNAs (lncRNAs) are a group of non–protein-coding transcripts exceeding 200 nucleotides in length, which are emerging as key players in various fundamental biological processes. Furthermore, it is increasingly recognized that mutation and dysregulation of lncRNAs contribute importantly to a variety of human diseases, particularly human cancers. Previous studies have revealed that altered lncRNAs have a close association with tumorigenesis, metastasis, prognosis and diagnosis of cancers....
Anti-Cancer Drugs - Current Issue
Fri Mar 13, 2020 23:52
Combinational treatment of gap junction enhancers and paclitaxel attenuates mammary tumor growth
A class of substituted quinolines (PQs) acts as a gap junction enhancer with the ability to increase the gap junctional intercellular communication in breast cancer cells. This study examined the effect of a combinational treatment of PQs and the antineoplastic drug paclitaxel in a xenograft animal model. Mice were implanted with estradiol-17ß (1.7 mg/pellet) before the injection of 1 × 107 T47D breast cancer cells subcutaneously into the inguinal region of mammary fat pad. Animals were treated intraperitoneally...
Anti-Cancer Drugs - Current Issue
Fri Mar 13, 2020 23:52
miR-21 modulates cisplatin resistance of gastric cancer cells by inhibiting autophagy via the PI3K/Akt/mTOR pathway
Resistance to cisplatin (DDP) remains a major obstacle in the control of gastric cancer (GC) progression. A previous study revealed that microRNA-21 (miR-21) contributes to DDP resistance in GC cells via the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway. The aim of the current study was to explore the mechanisms underlying the cytoprotective function of miR-21. In this study, DDP-resistant GC cells were obtained by continuous exposure of human gastric adenocarcinoma cells to increasing...
Anti-Cancer Drugs - Current Issue
Fri Mar 13, 2020 23:52
Combination treatment of bicalutamide and curcumin has a strong therapeutic effect on androgen receptor-positive triple-negative breast cancers
Triple-negative breast cancers account for approximately 15–20% of breast cancer patients. Due to lack of expression of estrogen receptor, PR and human epidermal growth factor receptor 2 in triple-negative breast cancers, there are no targeted therapies available for these cancers. Therefore, a major research priority is to find potential therapeutic targets. Androgen receptor is present in 80–90% of all breast cancers, including 55% of estrogen receptor-α–negative cancers and 12%–35% of triple-negative...
Anti-Cancer Drugs - Current Issue
Fri Mar 13, 2020 23:52
Clinical efficacy of irinotecan plus raltitrexed chemotherapy in refractory esophageal squamous cell cancer
Our retrospective study assessed the efficacy and safety of irinotecan plus raltitrexed in esophageal squamous cell cancer (ESCC) patients who were previously treated with multiple systemic therapies. Between January 2016 and December 2018, records of 38 ESCC patients who underwent irinotecan plus raltitrexed chemotherapy after at least one line of chemotherapy were reviewed. Efficacy assessment was performed every two cycles according to the RECIST version 1.1. A total of 95 cycles of chemotherapy...
Anti-Cancer Drugs - Current Issue
Fri Mar 13, 2020 23:52
miR-7641 depletion suppresses proliferation of gastric cancer cells by targeting ARID1A
Gastric cancer (GC) is lethal and there is an urgent need for improved understanding of this disease. Recent studies have reported that microRNAs (miRNAs) play increasingly important roles in the regulation of GC. In this study, we explored the target genes and effects of miR-7641 in GC. Our data showed that high miR-7641 expression was associated with low expression of ARID1A in GC tissue. miR-7641 expression promoted GC cell proliferation and colony formation. Luciferase reporter assay results...
Anti-Cancer Drugs - Current Issue
Fri Mar 13, 2020 23:52
Expression and subcellular localization of the bromodomain-containing protein 7 is a prognostic biomarker in breast cancer
Bromodomain-containing protein 7 (BRD7) is a member of the bromodomain-containing protein family. Previous studies suggest that BRD7 is predominantly localized in the nucleus, wherein it functions as a transcriptional regulator. Several lines of evidence imply a tumour suppressor function for BRD7. However, the importance of BRD7 in the pathogenesis of breast cancer is not well understood. We have investigated the expression, CpG island methylation and subcellular localization of BRD7 in breast cancer...
Anti-Cancer Drugs - Current Issue
Fri Mar 13, 2020 23:52
Unsupervised Machine Learning Reveals Novel Traumatic Brain Injury Patient Phenotypes with Distinct Acute Injury Profiles and Long-Term Outcomes
Journal of Neurotrauma, Ahead of Print.
Journal of Neurotrauma
Wed Mar 11, 2020 09:00
Alterations in Plasma microRNA and Protein Levels in War Veterans with Chronic Mild Traumatic Brain Injury
Journal of Neurotrauma, Ahead of Print.
Journal of Neurotrauma
Wed Mar 11, 2020 09:00
Interobserver Agreement for the Computed Tomography Severity Grading Scales for Acute Traumatic Brain Injury
Journal of Neurotrauma, Ahead of Print.
Journal of Neurotrauma
Wed Mar 11, 2020 09:00
The Cerebral Thrombin System Is Activated after Intracerebral Hemorrhage and Contributes to Secondary Lesion Growth and Poor Neurological Outcome in C57Bl/6 Mice
Journal of Neurotrauma, Ahead of Print.
Journal of Neurotrauma
Wed Mar 11, 2020 09:00
Cumulative Influence of Inflammatory Response Genetic Variation on Long-Term Neurobehavioral Outcomes after Pediatric Traumatic Brain Injury Relative to Orthopedic Injury: An Exploratory Polygenic Risk Score
Journal of Neurotrauma, Ahead of Print.
Journal of Neurotrauma
Wed Mar 11, 2020 09:00
Comparison of Four Quality of Life Inventories for Patients with Traumatic Brain Injuries and Orthopedic Injuries
Journal of Neurotrauma, Ahead of Print.
Journal of Neurotrauma
Wed Mar 11, 2020 09:00
Interventions to Optimize Spinal Cord Perfusion in Patients with Acute Traumatic Spinal Cord Injuries: A Systematic Review
Journal of Neurotrauma, Ahead of Print.
Journal of Neurotrauma
Wed Mar 11, 2020 09:00
Trajectories and Predictors of Clinician-Determined Recovery after Child Concussion
Journal of Neurotrauma, Ahead of Print.
Journal of Neurotrauma
Wed Mar 11, 2020 09:00
Complete Genome Sequence of Kosakonia radicincitans GXGL-4A, a Nitrogen-Fixing Bacterium with Capability to Degrade TEX
Abstract Kosakonia radicincitans GXGL-4A, a free-living nitrogen-fixing (NF) bacterial strain isolated from maize (Zea mays L.) roots was found to have ability to degrade aromatic hydrocarbons. In this study, we describe the main morphological characteristics of bacterium, aromatic hydrocarbon-degrading capability, and the complete genome of K. radicincitans GXGL-4A. The genome is consisted of only one 5,687,681 bp linear chromosome with a G + C content of 53.96%. The strain has...
Latest Results for Current Microbiology
Fri Mar 13, 2020 02:00
Comamonas flocculans sp. nov., a Floc-Forming Bacterium Isolated from Livestock Wastewater
Abstract A Gram-negative, aerobic, non-motile, rod-shaped, floc-forming, and non-spore-forming bacterium, designated as NLF-7-7T, was isolated from the biofilm of a sample collected from a livestock wastewater treatment plant in Nonsan, Republic of Korea. Strain NLF-7-7T, forms a visible floc and grows in the flocculated state. Cells of strain NLF-7-7T grew optimally at pH 6.5 and 30 °C and in the presence of 0.5% (w/v) NaCl. Phylogenetic analysis based on 16S rRNA gene sequences...
Latest Results for Current Microbiology
Fri Mar 13, 2020 02:00
History in a Crisis — Lessons for Covid-19
Writing in the heady days of new antibiotics and immunizations, esteemed microbiologists Macfarlane Burnet and David White predicted in 1972 that "the most likely forecast about the future of infectious diseases is that it will be very dull." They acknowledged that there was always a risk of "some…
The New England Journal of Medicine: Search Results in Health Policy and Reform
Thu Mar 12, 2020 02:00
Virtually Perfect? Telemedicine for Covid-19
Recognizing that patients prioritize convenient and inexpensive care, Duffy and Lee recently asked whether in-person visits should become the second, third, or even last option for meeting patient needs. Previous work has specifically described the potential for using telemedicine in disasters and…
The New England Journal of Medicine: Search Results in Health Policy and Reform
Wed Mar 11, 2020 02:00
Evaluation of Iodine Nutritional Status Among Pregnant Women in China
Thyroid, Volume 30, Issue 3, Page 443-450, March 2020.
liebertpub1
Wed Mar 11, 2020 09:00
Recombinant Human Thyrotropin Worsens Renal Cortical Perfusion and Renal Function in Patients After Total Thyroidectomy Due to Differentiated Thyroid Cancer
Thyroid, Ahead of Print.
liebertpub1
Wed Mar 11, 2020 09:00
Shifting Trends and Informed Decision-Making in the Management of Graves' Disease
Thyroid, Volume 30, Issue 3, Page 351-354, March 2020.
liebertpub1
Wed Mar 11, 2020 09:00
Nomogram Based on Shear-Wave Elastography Radiomics Can Improve Preoperative Cervical Lymph Node Staging for Papillary Thyroid Carcinoma
Thyroid, Ahead of Print.
liebertpub1
Wed Mar 11, 2020 09:00
The “APCs” of PTCs: Adenomatous Polyposis Syndrome and the Thyroid
Thyroid, Volume 30, Issue 3, Page 355-356, March 2020.
liebertpub1
Wed Mar 11, 2020 09:00
Future Meetings
Thyroid, Volume 30, Issue 3, Page 469-470, March 2020.
liebertpub1
Wed Mar 11, 2020 09:00
AIBx, Artificial Intelligence Model to Risk Stratify Thyroid Nodules
Thyroid, Ahead of Print.
liebertpub1
Wed Mar 11, 2020 09:00
Thyroid Carcinomas That Occur in Familial Adenomatous Polyposis Patients Recurrently Harbor Somatic Variants in APC, BRAF, and KTM2D
Thyroid, Volume 30, Issue 3, Page 380-388, March 2020.
liebertpub1
Wed Mar 11, 2020 09:00
American Thyroid Association Satellite Symposium: Personalized Approach to Thyroid Disorders, Friday, March 27, 2020, 1:00 PM–5:30 PM, Moscone Convention Center, San Francisco, California
Thyroid, Volume 30, Issue 3, Page 347-348, March 2020.
liebertpub1
Wed Mar 11, 2020 09:00
Risk Stratification of Pediatric Patients with Differentiated Thyroid Cancer: Is Total Thyroidectomy Necessary for Patients at Any Risk?
Thyroid, Ahead of Print.
liebertpub1
Wed Mar 11, 2020 09:00
Preoperative and Postoperative Risk Stratification of Thyroid Papillary Microcarcinoma: A Comparative Study Between Kuma Criteria and 2015 American Thyroid Association Guidelines Risk Stratification
Thyroid, Ahead of Print.
liebertpub1
Wed Mar 11, 2020 09:00
The Presence of Hürthle Cells Does Not Increase the Risk of Malignancy in Most Bethesda Categories in Thyroid Fine-Needle Aspirates
Thyroid, Volume 30, Issue 3, Page 425-431, March 2020.
liebertpub1
Wed Mar 11, 2020 09:00

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