Pneumocystis jirovecii is recognized as an opportunistic pathogen in immunosuppressed patients. We report a case of severe Pneumocystis pneumonia (PCP) in an infant with acquired combined immunodeficiency secondary to maternal chemotherapy exposure during the second and third trimesters of pregnancy. The infant required cardiorespiratory support with veno-venous extracorporeal membrane oxygenation (VV-ECMO) for severe respiratory failure. This case highlights the potential for severe acquired immunodeficiency...
04:20
Objective: To compare functional hearing preservation (HP) with a slim perimodiolar array (SPA) and a slim lateral wall array (SLW) in cochlear implantation (CI). Study Design: Retrospective chart review. Setting: Tertiary referral center. Patients: All adult, post-lingual CI recipients with serviceable preoperative hearing serially implanted with SPA or SLW electrodes from July 2015 through July 2018. Interventions: Cochlear implantation. Main Outcome...
Fri Mar 13, 2020 02:00
Introduction: Three-dimensional (3D) tools have played a significant role in advancing anatomical knowledge, in simulation and clinical practice in Otology. Technology is evolving at a rapid rate with new applications being reported at an overwhelming pace. It is important to continuously review new applications, assess emerging trends, and identify challenges to innovation so clinical translation progresses in an efficient and evidenced-based manner. Methods: A review of 20 years of...
Fri Mar 13, 2020 02:00
Introduction: This study aimed to investigate the association between candidate genetic variants and audiometric measures of noise-induced hearing loss (NIHL) in young musicians. Methods: The study analyzed a database by Phillips et al. (Feasibility of a bilateral 4000–6000 Hz notch as a phenotype for genetic association analysis. Int J Audiol 2015;54:645–52.) which included behavioral hearing thresholds, distortion-product otoacoustic emissions (DPOAE), tympanometric, and genetic data...
Fri Mar 13, 2020 02:00
A high‐fat diet alters the gut microbial community in conventionally raised mice, leading to an increase in Gram‐positive Firmicutes. This increase in Gram‐positive bacteria is likely associated with increased lipoteichoic acid (LTA). LTA induces enteric neuropathy, which is associated with increased neuroinflammation and oxidative stress in the gastrointestinal tracts of mice fed a high‐fat diet. Abstract Background High‐fat diet, microbial alterations and lipopolysaccharide (LPS) are thought...
Sat Mar 14, 2020 15:57
Hierarchical opioid use (non vs mild‐moderate vs moderate‐severe) was associated with decreasing proportions of patients with no physiological abnormality on testing (40.2% vs 38.1% vs 29.2%) and increasing proportions with both delayed whole‐gut transit and rectal sensorimotor dysfunction (16.6% vs 17.5% vs 28.5%). Abstract Background Opioid use has reached epidemic proportions. In contrast to the known effect of opioids on gut transit, the effect on rectal sensorimotor function has not been...
Sat Mar 14, 2020 15:57
Manometric response of the gastric to jejunal regions in the fasted and fed states . Abstract Background High‐resolution manometric studies below the stomach are rare due to technical limitations of traditional manometry catheters. Consequently, specific motor patterns and their impact on gastric and small bowel function are not well understood. High‐resolution manometry was used to record fed‐state motor patterns in the antro‐jejunal segment and relate these to fasting motor function. ...
Sat Mar 14, 2020 15:57
During the straight leg raise (SLR) maneuver during high resolution manometry (HRM), intra‐abdominal pressure transmits into the intra‐thoracic cavity when the esophagogastric junction (EGJ) is physiologically disrupted, particularly with large hiatus hernias (type 3 EGJ). SLR is therefore a simple provocative test to evaluate integrity of the EGJ barrier during HRM. Abstract Background Straight leg raise (SLR) while supine increases intra‐abdominal pressure. We hypothesized that elevations...
Fri Mar 13, 2020 16:32
In addition to the vascular changes occurring in the spinal cord following spinal trauma, gastrointestinal vascular permeability is also increased contributing to reduced intestinal function. An intravenous administration of Ang‐1, a vascular stabilizing protein, reduces vascular leakage and improves intestinal contractile activity. Abstract Background Gastrointestinal (GI) dysfunction is observed clinically after spinal cord injury (SCI) and contributes to the diminished long‐term quality of...
Fri Mar 13, 2020 16:32
Unitron launched its newest platform, Discover Next, which delivers speech and environmental cues that enable hearing aid wearers to understand the deeper meaning of words in both quiet and noisy environments. The company's smallest lithium-ion receiver-in-the-canal (RIC) MoxiTM Move R joins the product family with hassle-free technology that lasts all day and delivers easy connections to all kinds of favorite tech.The number one need of hearing instrument wearers is to hear better in noisy environments.1...
Fri Mar 13, 2020 14:00
Unitron launched its newest platform, Discover Next, which delivers speech and environmental cues that enable hearing aid wearers to understand the deeper meaning of words in both quiet and noisy environments. The company's smallest lithium-ion receiver-in-the-canal (RIC) MoxiTM Move R joins the product family with hassle-free technology that lasts all day and delivers easy connections to all kinds of favorite tech.The number one need of hearing instrument wearers is to hear better in noisy environments.1...
Fri Mar 13, 2020 14:00
By Marion Burgess After years of preparation, the International Year of Sound 2020 (IYS 2020) was formally launched on January 31, 2020, at the Grand Amphithéâtre of Sorbonne University in Paris, France. The IYS 2020 is an initiative of the International Commission for Acoustics (ICA) with the mission to highlight the importance of sound in all aspects of life on earth. It aims to enhance people’s understanding of sound-related issues at the international level. Sound is an integral part of culture...
Wed Mar 11, 2020 16:39
Related ArticlesTreatment and new progress of neonatal hypoxic-ischemic brain damage. Histol Histopathol. 2020 Mar 13;:18214 Authors: Yang L, Zhao H, Cui H Abstract Neonatal hypoxic ischemia (HI) results in different extents of brain damage, and immature brain tissue is particularly sensitive to the stimulation of HI. Hypoxic-ischemic brain damage (HIBD) is a common and serious nervous system disease in neonates, for both full-term infants and preterm...
Sat Mar 14, 2020 15:42
Related ArticlesDiversity of mucins in labial glands of infants. Histol Histopathol. 2020 Mar 12;:18213 Authors: Stoeckelhuber M, Kesting MR, Loeffelbein DJ, Schmitz C, Wolff KD Abstract Mucins as highly glycosylated proteins comprise multiple functions like protection, homeostasis, immune defense, cell signaling. Various epithelial tissues including glandular structures express different specific mucin types. We investigated labial salivary glands in...
Fri Mar 13, 2020 15:53
Background. Preeclampsia is a major cause of pregnancy-related maternal, fetal, and neonatal morbidities and mortalities. We aimed to review the effect of maternal preeclampsia on the hematological profile of newborns in the Qatari population. Methods. In this case-control study, we reviewed data and complete blood count results of neonates born to Qatari women diagnosed of preeclampsia in 2017 in comparison with data of a control group. Statistical analysis was done using unpaired -test, chi-square...
Sat Mar 14, 2020 08:05
Background and Aim. Myeloid-derived suppressor cells (MDSCs) have attracted attention due to their important role in tumor immune escape. Several studies have investigated the involvement of MDSCs into hepatocellular carcinoma (HCC); however, due to the difference of MDSC phenotype, patient types, and sample source among the studies, the results were inconsistent and controversial. The present study aimed to confirm the expression and clinical significance of MDSCs in HBV-related HCC patients. Methods....
Sat Mar 14, 2020 05:20
Purposes. Cervical cancer (CC) is one of the highest frequently occurred malignant gynecological tumors with high rates of morbidity and mortality. Here, we aimed to identify significant genes associated with poor outcome. Materials and methods. Differentially expressed genes (DEGs) between CC tissues and normal cervical tissues were picked out by GEO2R tool and Venn diagram software. Database for Annotation, Visualization and Integrated Discovery (DAVID) was performed to analyze gene ontology (GO)...
Sat Mar 14, 2020 04:50
Nanosecond pulsed electric field (nsPEF) has emerged as a promising tool for hepatocellular carcinoma ablation recently. However, little is known about how nsPEF affects liver regeneration while being applied to eliminate liver lesions. Besides, the impact of nsPEF ablation on liver function should also be taken into consideration in the process. In this paper, we study the impact of nsPEF ablation on liver function by the measurement of serum levels of AST and ALT as well as liver regeneration and...
Sat Mar 14, 2020 04:50
Long noncoding RNAs (lncRNAs) are a class of noncoding RNAs that modulate gene expression, thereby participating in the regulation of various cellular processes. However, it is not clear about the expression and underlying mechanism of lncRNAs in irradiation-induced DNA damage response. In the present study, we performed integrative analysis of lncRNA-mRNA expression profile in human lymphocytes irradiated with ultraviolet-C (UVC). The results showed that exposure to UVC irradiation dose-dependently...
Fri Mar 13, 2020 09:05
Introduction. Morphea (or localized scleroderma) is an inflammatory, immune-mediated disease of unknown etiology. It is characterized by excessive collagen deposition that leads to hardening of the dermis, subcutaneous tissues, or both. Morphea is associated with cosmetic and functional impairment, which might affect the patients’ quality of life (QoL). Objective. The aim of the study was to evaluate QoL in patients suffering from morphea. Material and Methods. Sixty-five patients with morphea were...
Fri Mar 13, 2020 08:50
Antibiotic resistance including the emergence of multidrug resistant microbes has become a public health crisis. In this study, we analyzed the antibiotic resistance genes (ARGs) in the urinary metagenome of the kidney transplant and healthy subjects using metagenomic shotgun sequencing. Our data suggest an increased abundance of antibiotic resistance genes in the kidney transplant subjects. In addition, the antibiotic resistance genes identified in the transplant subjects were predominantly composed...
Fri Mar 13, 2020 08:35
The determination of Cd, Co, Cr, Cu, Fe, Na, Zn, and Pb by inductively coupled plasma-optical emission spectrometry (ICP OES) was performed on dry matter and decoctions of the medicinal plants Cordia salicifolia, Chiococca alba (L.) Hitchc., and Echites peltata used as an appetite suppressant and diuretic in Brazil. The accuracy of the measurements was analyzed by the spike recovery test. Results showed that the concentration of these seven metals (Cd, Co, Cr, Cu, Fe, Na, and Zn) in dry plant samples...
Fri Mar 13, 2020 08:20
A full-length cDNA encoding digestive lipase (SmDL) was cloned from the pancreas of the smooth-hound (Mustelus mustelus). The obtained cDNA was 1350 bp long encoding 451 amino acids. The deduced amino acid sequence has high similarity with known pancreatic lipases. Catalytic triad and disulphide bond positions are also conserved. According to the established phylogeny, the SmDL was grouped with those of tuna and Sparidae lipases into one fish digestive lipase cluster. The recently purified enzyme...
Fri Mar 13, 2020 07:50
This study reports the potential of the endophytic fungi identified as a Fusarium oxysporum to produce gibberellic acid (GA3). The GA3 production was confirmed by high performance liquid chromatography. To improve the production of this phytohormone under solid state fermentation (SSF), successive optimization strategies were used. Firstly, Plackett-Burman design was applied for screening medium components and culture condition. Under the optimized condition, GA3 yield (7.14 g/kg) was 2.62-fold higher...
Fri Mar 13, 2020 07:05
Paratuberculosis, a chronic and sometimes fatal disease of ruminants, is caused by Mycobacterium avium subsp. paratuberculosis (MAP). In this study, we examined paratuberculosis cases among 2–4-year-old dairy cows at farms in Shandong Province, China. Paratuberculosis cases were diagnosed based on clinical symptoms, pathological autopsy, and histopathological inspection. Characteristics of paratuberculosis in the affected dairy cattle included poor body condition, persistent diarrhea, subcutaneous...
Fri Mar 13, 2020 06:50
Background. The study examines the mediation effect of safety knowledge in causal the relationship between Occupational Health and Safety Management Frameworks (OHSMF) and occupational injuries and workplace accidents in the Ghanaian Oil and Gas Industry. The study explores different dimensions of occupational health and safety management systems, workplace accidents, and occupational injuries. The study adopted a cross-sectional survey design. A total of 699 respondents through a convenience and...
Fri Mar 13, 2020 05:05
Several different methods exist for reconstructing the mandibular body and ramus defect with the use of a free vascularized fibula flap, but none have adequately addressed the long-term mechanical stability and osseointegration. The aim of this study is to compare the biomechanics of different surgical methods and to investigate the best approach for reconstructing the mandibular body and ramus defect. Five finite element models based on different reconstructive methods were simulated. Stress, strain,...
Fri Mar 13, 2020 04:50
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