T-cell recognizable p53 hotspot mutations offer opportunities for immunotherapy and immune monitoring. Recognition of p53 mutations by peripheral blood CD8 and CD4 T lymphocytes has been revealed. See related article by Malekzadeh et al., p. 1267
Fri Mar 13, 2020 15:05
Publication date: Available online 13 March 2020Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Matthew Rawls, Jenny Thiele, Daniel E. Adams, Lisa M. Steacy, Anne K. Ellis
Fri Mar 13, 2020 15:13
Related ArticlesEffect of UV radiation and altitude characteristics on the functional traits and leaf optical properties in Saxifraga hostii at the alpine and montane sites in the Slovenian Alps. Photochem Photobiol Sci. 2020 Feb 19;19(2):180-192 Authors: Trošt Sedej T, ErznoŽnik T, Rovtar J Abstract UV radiation affects the biochemical, physiological and morphological responses of plants. The effect is most pronounced at high altitude, such as alpine...
Fri Mar 13, 2020 15:09
Abstract Background Obstructive sleep apnea (OSA) often coexists with atrial fibrillation (AF) and makes the course of AF worse. The negative impact of OSA on AF may be due to atrial stretch, hypoxia, hypertension, obesity, fibrosis, and inflammation. Several mediators are thought to be responsible for this correlation, among them adipokines such as visfatin. This study aimed to assess the association between visfatin concentrations...
Fri Mar 13, 2020 02:00
Related Articles[Effect of acupuncture at the anterior oblique parietotemporal line on gray matter remodeling in patients with hemiplegia of cerebral infarction]. Zhen Ci Yan Jiu. 2020 Feb 25;45(2):141-7 Authors: Lang Y, Li KS, Yang JY, Cui FY, Bai W, Liang CX Abstract OBJECTIVE: To observe the intervention effect of acupuncture at the anterior oblique parietotemporal line on gray matter remodeling in patients with hemiplegia of cerebral infarction based...
Fri Mar 13, 2020 14:56
Abstract The objective of this study was to evaluate the effect of continuous positive airway pressure treatment on pulse wave velocity and blood pressure in patients with type 2 diabetes and obstructive sleep apnea. A randomized controlled study was performed, including 72 patients with type 2 diabetes and newly diagnosed obstructive sleep apnea recruited from outpatient clinics at three Danish hospitals. The patients were randomized to continuous positive airway pressure for 12 weeks or no continuous...
Fri Mar 13, 2020 14:51
Abstract Sleep is a pillar of health, alongside adequate nutrition and exercise. Problems with sleep are common and often treatable. Twenty years ago, UK medical school education on sleep disorders had a median teaching time of 15 min; we investigate whether education on sleep disorders has improved. This is a cross‐sectional survey, including time spent on teaching sleep medicine, subtopics covered and forms of assessment. Thirty‐four medical degree courses in the UK were investigated via a questionnaire....
Fri Mar 13, 2020 14:51
Fri Mar 13, 2020 14:51
Abstract Adverse childhood experiences (ACEs) can have long‐term impacts on a person's mental health, which extend into adulthood. There is a high prevalence of ACEs among service members. Further, service members also report frequently experiencing disrupted sleep. We hypothesized that disrupted sleep may serve a mechanistic function connecting ACEs to functional impairment and poorer mental health. In a cross‐sectional sample (n = 759), we found evidence for an indirect effect of ACEs on mental...
Fri Mar 13, 2020 14:51
Fri Mar 13, 2020 14:51
Publication date: June 2020Source: International Immunopharmacology, Volume 83Author(s): Ningchao Du, Li Song, Yang Li, Tingting Wang, Qinghua Fang, Jiaxin Ou, Kutty Selva Nandakumar
Fri Mar 13, 2020 14:46
Publication date: May 2020Source: International Immunopharmacology, Volume 82Author(s): Sergei A. Grando, Michael Rigas, Alex Chernyavsky
Fri Mar 13, 2020 14:46
Publication date: May 2020Source: International Immunopharmacology, Volume 82Author(s): Maryam Kamarehei, Sina Pejman, Sussan Kaboudanian Ardestani, Hamid Zahednasab, Masoumeh Firouzi, Mohammad Hossein Harirchian
Fri Mar 13, 2020 14:46
Abstract Objectives To obtain radicular measurements of two separate mesiobuccal (MB) root canals in maxillary first molars using micro-computed tomography (μCT) with customized software. Materials and methods Human maxillary first molar MB roots (N = 36) with two separate canals (MB1, MB2) and apical foramina were scanned by μCT and analyzed with Kappa2...
Fri Mar 13, 2020 02:00
Fri Mar 13, 2020 09:22
Fri Mar 13, 2020 13:36
Related ArticlesThe efficacy of microphone directionality in improving speech recognition in noise for three commercial cochlear-implant systems. Cochlear Implants Int. 2020 Mar 11;:1-7 Authors: Sivonen V, Willberg T, Aarnisalo AA, Dietz A Abstract Objectives: To investigate the effect of fixed and adaptive microphone directionality on speech reception threshold (SRT) in noise when compared to omnidirectional mode in unilateral cochlear-implant (CI)...
Fri Mar 13, 2020 14:05
Publication date: Available online 12 March 2020Source: Clinical NeurophysiologyAuthor(s): PM. Rossini, R. Di Iorio, F. Vecchio, M. Anfossi, C. Babiloni, M. Bozzali, AC. Bruni, SF. Cappa, J. Escudero, FJ. Fraga, P. Giannakopoulos, B. Guntekin, G. Logroscino, C. Marra, F. Miraglia, F. Panza, F. Tecchio, A. Pascual-Leone, B. Dubois
Fri Mar 13, 2020 14:04
Publication date: Available online 12 March 2020Source: Clinical NeurophysiologyAuthor(s): T.W.P. Janssen, K. Geladé, M. Bink, R. van Mourik, J.W.R. Twisk, A. Maras, J. Oosterlaan
Fri Mar 13, 2020 14:04
Publication date: Available online 12 March 2020Source: Clinical NeurophysiologyAuthor(s): Zachary T. Irwin, Mohammad Z. Awad, Christopher L. Gonzalez, Arie Nakhmani, J. Nicole Bentley, Thomas A. Moore, Kenneth G. Smithson, Barton L. Guthrie, Harrison C. Walker
Fri Mar 13, 2020 14:04
Publication date: Available online 12 March 2020Source: Clinical NeurophysiologyAuthor(s): Mamede de Carvalho, Michael Swash
Fri Mar 13, 2020 14:04
Publication date: Available online 12 March 2020Source: Clinical NeurophysiologyAuthor(s): Stefan B. Rowny, Monica T. Ly, Luke Kluisza, Lindsey Casal-Roscum, Joan Prudic, Chi-Ming Chen
Fri Mar 13, 2020 14:04
Related ArticlesMiddle age, a key time point for changes in birdsong and human voice. Behav Neurosci. 2020 Mar 12;: Authors: Badwal A, Borgstrom M, Samlan RA, Miller JE Abstract Voice changes caused by natural aging and neurodegenerative diseases are prevalent in the aging population and diminish quality of life. Most treatments involve behavioral interventions that target the larynx because of a limited understanding of central brain mechanisms. The...
Fri Mar 13, 2020 13:58
Related ArticlesSolitary Fibrous Tumor of the Larynx-CO2 Laser Excision With Arterial Embolization. Ear Nose Throat J. 2020 Feb;99(2):119-121 Authors: Hong YT, Hong KH PMID: 32162550 [PubMed - in process]
Fri Mar 13, 2020 13:58
Related ArticlesCDK4/6 inhibitors in P16/HPV16-negative squamous cell carcinoma of the head and neck. Eur Arch Otorhinolaryngol. 2020 Mar 11;: Authors: Billard-Sandu C, Tao YG, Sablin MP, Dumitrescu G, Billard D, Deutsch E Abstract PURPOSE: Addition of CDK4/6 inhibitors to a variety of established treatments in squamous cell carcinoma of the head and neck (SCCHN) has the potential to improve responses to other therapies and may help overcome treatment...
Fri Mar 13, 2020 13:58
Related Articles[The influence of age on the score of reflux symptom index scale and reflux finding score scale in the diagnosis of pharyngeal and laryngeal reflux]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020 Feb;34(2):170-172 Authors: Qi Z, Zhang Y, Su R, Niu R, Liu C Abstract Objective:The aim of this study is to determine the accuracy of RSI and RFS in the diagnosis of hypopharyngeal reflux （LPR）, the scores of RSI and RFS were compared...
Fri Mar 13, 2020 13:58
Related Articles[Voice analysis of early glottic carcinoma treated by carbon dioxide laser]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020 Feb;34(2):162-165 Authors: Pan X, Wang J, Xiao Y Abstract Objective:The aim of this study is to investigate the effect of CO2 laser cordectomy on the voice of early glottic carcinoma. Method:A retrospective analysis of 40 patients who underwent CO2 laser treatment early glottis preoperative clinical data...
Fri Mar 13, 2020 13:58
Nature Communications, Published online: 13 March 2020; doi:10.1038/s41467-020-15192-1The secretion of blood coagulation factor V and factor VIII (FV and FVIII) are driven by secretion factors ERGIC-53 and MCDF2. Here, the authors report a 10 amino acid motif from FVIII that can enhance secretion of another glycoprotein erythropoietin (EPO).
Fri Mar 13, 2020 02:00
Nature Communications, Published online: 13 March 2020; doi:10.1038/s41467-020-15154-7Description of non-equilibrium phase transitions is problematic, due to the absence of suitable free energy landscapes. Here, the authors experimentally show delayed photon condensation and timing jitter in a dye-filled microcavity, modelled by a non-equilibrium extension of the free-energy landscape.
Fri Mar 13, 2020 02:00
Nature Communications, Published online: 13 March 2020; doi:10.1038/s41467-020-15119-wMicroglia perform important supporting roles for neurons in the brain. Here, the authors show that microglia clear neuron-derived α-synuclein through selective autophagy (synucleinphagy) to prevent accumulation of misfolded α-synuclein and subsequent neurodegeneration in a mouse model of disease.
Fri Mar 13, 2020 02:00
Nature Communications, Published online: 13 March 2020; doi:10.1038/s41467-020-15166-3Synthetic biological pattern formation is challenging to engineer due to theoretical complexity and practical limitations. Here, the authors introduce a cell-in-the-loop approach in which cells interact through in silico signaling.
Fri Mar 13, 2020 02:00
Nature Communications, Published online: 13 March 2020; doi:10.1038/s41467-020-15185-0Nucleosome organization has been suggested to affect local mutation rates in the genome. Here, the authors analyse data on >300,000 human de novo mutations and high-resolution nucleosome maps and provide evidence that nucleosome positioning stability modulates germline mutation rate variation across the human genome.
Fri Mar 13, 2020 02:00
Nature Communications, Published online: 13 March 2020; doi:10.1038/s41467-020-15173-4Fgf4 is a critical signal driving embryonic stem cell (ESC) exit from pluripotency and differentiation. Here the authors identify EPHA2 as a target of FGF4 signalling in ESCs, and show that EPHA2-EFNA1 signalling promotes pluripotent gene expression and suppresses commitment through repression of ERK1/2 activation.
Fri Mar 13, 2020 02:00
Nature Communications, Published online: 13 March 2020; doi:10.1038/s41467-020-15121-2Previous studies implicate the hippocampal–amygdala pathway in contextual fear conditioning, in which animals learn to associate a neutral context with an aversive stimulus and display fear responses to dangerous situations. Here the authors show that selective strengthening of hippocampal–amygdala pathway contributes to encoding adaptive fear memory for threat-predictive context.
Fri Mar 13, 2020 02:00
Nature Communications, Published online: 13 March 2020; doi:10.1038/s41467-020-15081-7The emergence of multidrug resistance (MDR) in bacteria represents a global threat to human health. Here, Cazares et al. identify a family of MDR megaplasmids carrying large arrays of antibiotic resistance genes in Pseudomonas strains from various sources, including P. aeruginosa clinical isolates.
Fri Mar 13, 2020 02:00
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