Outline of RSK3 regulatory mechanism via p‐RIP3/p‐MLKL in OGD‐induced RGC‐5 necroptosis, which suggested that RSK3 might work as an upstream regulator of RIP3 phosphorylation during RGC‐5 necroptosis. Abstract Receptor‐interacting protein 3 (RIP3) plays an important role in the necroptosis signaling pathway. Our previous studies have shown that the RIP3/mixed lineage kinase domain‐like protein (MLKL)‐mediated necroptosis occurs in retinal ganglion cell line 5 (RGC‐5) following oxygen‐glucose deprivation...
Fri Mar 13, 2020 21:20
This article describes longitudinal ethnographic research conducted between 1985 and 2010 in contiguous rural hamlets—pseudonymously, Manioc Hill—in the commune of Fond-des-Blancs in southern Haiti. I focus on three interrelated critiques of Manioc Hill residents about three faith-based nongovernmental organizations (NGOs) established during the 1980s to deliver education and health services, and critiques directed at those member of the Haitian diaspora returning to Manioc Hill during my research...
Fri Mar 13, 2020 21:00
Abstract Although continuous researches are going on for the discovery of new chemotherapeutic agents, resistance to these anticancer agents has made it really difficult to reach the fruitful results. There are many causes for this resistance that are being studied by the researchers across the world, but still, success is far because there are several factors that are going along unattended or have been studied less. Drug-metabolizing enzymes (DMEs) are one of these factors,...
Fri Mar 13, 2020 02:00
Abstract Purpose The limitation of surgery, radiotherapy and chemotherapy in the treatment of cancer and the rise of the application of nanomaterials in the field of biomedicine have promoted the application of various nanomaterials in the combination of radiotherapy and chemotherapy in the treatment of cancer. To improve the efficiency of cancer treatment, the multifunctional nanocomposites MGO/FU-MI (MGO/FU-MI NCs) were used for combination...
Fri Mar 13, 2020 02:00
Abstract Background The addition of everolimus to exemestane therapy significantly improves progression-free survival in postmenopausal patients with hormone-receptor (HR)-positive HER2-negative endocrine-resistant breast cancer. However, the safety profile of this schedule still might be optimized. Methods Patients included in the BALLET trial were...
Fri Mar 13, 2020 02:00
Abstract When Adolf Hitler annexed Austria to the German Reich in 1938, the famous Jewish oral pathologist Bernhard Gottlieb was in great distress. The Viennese university teacher immediately lost his employment and teaching authority and was forced to emigrate. While Gottlieb’s exceptional scientific position in oral pathology is well documented, the complex implications of his deprivation of rights and forced emigration in the Third Reich have so far received...
Fri Mar 13, 2020 02:00
Publication date: May 2020Source: Journal of Human Evolution, Volume 142Author(s): Grégoire Boulinguez-Ambroise, Anthony Herrel, Emmanuelle Pouydebat
Fri Mar 13, 2020 19:37
Publication date: April 2020Source: Journal of Human Evolution, Volume 141Author(s): Luke D. Fannin, Debbie Guatelli-Steinberg, Elise Geissler, Paul E. Morse, Paul J. Constantino, W. Scott McGraw
Fri Mar 13, 2020 19:37
Vaginal cuff dehiscence is a rare but potentially grave complication after total hysterectomy. Abdominal or pelvic contents are at risk of evisceration through the vaginal opening. It is associated with signif...
Mon Mar 09, 2020 02:00
ObjectivesPneumoconiosis prevalence and severity among US coal miners has been increasing for the past 20 years. An examination of the current approaches to primary and secondary prevention efforts is warranted. One method of secondary prevention is the Mine Safety and Health Administration-administered part 90 option programme where US coal miners with radiographic evidence of pneumoconiosis can exercise their right to be placed in a less dusty area of the mine. This study focuses on characterising...
Fri Mar 13, 2020 18:00
Dear Editor,We read with great interest the editorial by Reynolds and Blanc1 on "forging effective surveillance for work-related lung disease". On its 30th anniversary, the authors cleverly looked at initial objectives of Surveillance of Work-related and Occupational Respiratory Disease (SWORD) programme and how these objectives have been met over the last three decades.There is one point that we would like to add to what Reynolds and Blanc1 wrote about SWORD. This is the potential to globalise the...
Fri Mar 13, 2020 18:00
Onjisaponin B (OB) is the main active ingredient of the traditional Chinese medicinal herb polygala, which is effective against neurodegenerative disorders. However, the target of OB is currently unknown. Neuroinflammation and oxidative stress are both risk factors for the pathogenesis and progression of Parkinson’s disease (PD). Here, we used a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced subacute mouse model of PD to explore the efficacy and neuroprotective mechanism of OB in PD....
Thu Mar 12, 2020 02:00
Protecting neurons from neurotoxicity is a job mainly performed by astrocytes through glutamate uptake and potassium buffering. These functions are aided principally by the Kir4.1 inwardly rectifying potassium channels located in the membrane of astrocytes. Astrocytes grown in hyperglycemic conditions have decreased levels of Kir4.1 potassium channels as well as impaired potassium and glutamate uptake. Previous studies performed in a human corneal epithelial cell injury model demonstrated a mechanism...
Thu Mar 12, 2020 02:00
Progranulin (PGRN) is a glycoprotein that is widely expressed among organs, including the central nervous system. PGRN insufficiency is involved in various neurodegenerative disorders such as frontotemporal dementia, Alzheimer’s disease, and neuronal ceroid lipofuscinosis. One of the major causes of neuronal damage is hyperactivation of the cerebrum triggered by upregulation of excitatory systems. In the present study, we examined the possible involvement of PGRN in modulating excitability of the...
Thu Mar 12, 2020 02:00
It has been found that hypothalamus helps to control aging, and hypothalamus-driven programmatic aging is associated with nuclear factor-κB (NF-κB)-mediated decrease of gonadotropin-releasing hormone (GnRH). However, the molecular mechanism(s) underlying aging-associated hypothalamic GnRH decline are largely unknown. Forkhead box O (FOXO), a family of transcription factors, has been demonstrated to be associated with aging. GnRH neuronal cell line GT1-7 was used in this study to determine whether...
Thu Mar 12, 2020 02:00
Ischemic stroke damages the blood-brain barrier (BBB), which leads to brain edema and increases the risk of intracranial hemorrhage. Proteasome inhibition has been found to protect the BBB against cerebral ischemia by suppressing neuroinflammation-mediated matrix metalloproteases-9 (MMP-9) activation. We recently showed that ginsenoside Rd (Rd), a major active ingredient of Panax ginseng, could suppress proteasome-mediated inflammation and be efficient for treating ischemic stroke but downstream...
Thu Mar 12, 2020 02:00
Hippocampal complement C3 might contribute to cognitive impairment induced by anesthesia and surgery
Postoperative cognitive dysfunction is a well-recognized complication after major surgery in the elderly, but its pathophysiological mechanism is not fully understood. In the present study, we used liquid chromatography-tandem mass spectrometry combined with tandem mass tags to identify differentially expressed proteins and perform further functional studies on protein of interest. Here, we showed that hippocampal complement C3 was significantly upregulated after surgery, which was accompanied by...
Thu Mar 12, 2020 02:00
The gamma-aminobutyric acid (GABA)-shift hypothesis proposes that GABA agonist action is excitatory early in development and transitions to an inhibitory role later in life. In experiment 1, the nonspecific GABA agonist, valproic acid (VPA), was administered to pregnant C57BL/6 mice on embryonic day 13. Fetal and maternal brains were harvested 2 h post-VPA exposure and assayed for nuclear factor erythroid 2-related factor 2 (NRF2) and H3 expression through western blot analysis. In experiment 2,...
Thu Mar 12, 2020 02:00
Autophagy and neurogenesis play a pivotal role in maintaining cellular homeostasis of neurons in the brain. Endurance exercise (EXE) serves as a potent regulator of both autophagy and neurogenesis in the hippocampus of the brain; however, the underlying molecular mechanisms of the dual expression remains unclear. Thus, we examined the signaling pathways of EXE-induced autophagy and neurogenesis-associated protein expression in the hippocampus. C57BL/6 male mice (10 weeks old) were randomly divided...
Thu Mar 12, 2020 02:00
Publication date: Available online 13 March 2020Source: Journal of Neuroscience MethodsAuthor(s): Nicole Thompson, Enrico Ravagli, Svetlana Mastitskaya, Francesco Iacoviello, Kirill Aristovich, Justin Perkins, Paul R Shearing, David Holder
Fri Mar 13, 2020 18:17
Publication date: Available online 12 March 2020Source: Journal of Neuroscience MethodsAuthor(s): Amir Ziafati, Ali Maleki
Fri Mar 13, 2020 18:17
Publication date: Available online 12 March 2020Source: Journal of Neuroscience MethodsAuthor(s): Gerhard S. Drenthen, Walter H. Backes, Albert P. Aldenkamp, R. Jeroen Vermeulen, Sylvia Klinkenberg, Jacobus F.A. Jansen
Fri Mar 13, 2020 18:17
Analytical ChemistryDOI: 10.1021/acs.analchem.9b04181
Fri Mar 13, 2020 06:00
Atherothrombosis is a leading cause of cardiovascular mortality and morbidity worldwide. The underlying mechanisms of atherothrombosis comprise plaque disruption and subsequent thrombus formation. Arterial thrombi are thought to mainly comprise aggregated platelets as a result of high blood velocity. However, thrombi that develop on disrupted plaques comprise not only aggregated platelets, but also large amounts of fibrin, because plaques contain large amount of tissue factor that activate the coagulation...
Fri Mar 13, 2020 17:58
Nasal irrigations (NI) are increasingly used as an over-the-counter adjunctive treatment for allergic rhinitis (AR), but clinical studies on their effectiveness are limited.
Fri Mar 13, 2020 02:00
3D printing is already used in medicine in many applications, but there’s still a great deal that custom-built implants could offer to patients. Bioinks, the materials from which bespoke implants can printed, may be the most important focus of research aimed at expanding the use of additive manufacturing, another term for 3D printing, in medicine. Typically, bio-compatible inks have to be developed for a specific application, but researchers at ETH Zurich in Switzerland report on a new ink...
Fri Mar 13, 2020 17:26
Abstract Esculetin, a coumarin derivative from various natural plants, has an anti-inflammatory property. In the present study, we examined if esculetin has any salutary effects against lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. Acute lung injury (ALI) was induced via the intratracheal administration of LPS, and esculetin (20 and 40 mg/kg) was given intraperitoneally 30 min before LPS challenge. After 6 h of LPS...
Fri Mar 13, 2020 02:00
Publication date: Available online 13 March 2020Source: Dental MaterialsAuthor(s): Nicoleta Ilie, David C Watts
Fri Mar 13, 2020 17:29
Fri Mar 13, 2020 02:00
Abstract CT colonography (CTC) is the radiological examination of choice for the diagnosis of colorectal neoplasia. Faecal tagging is considered a mandatory part of bowel preparation. However, the colonic mucosa, obscured by tagged residue, is not accessible to endoluminal 3D views and requires time-consuming 2D evaluation. Electronic cleansing (EC) software algorithms can overcome this limitation by digitally subtracting tagged residue from the colonic lumen. Ideally, this...
Fri Mar 13, 2020 02:00
Publication date: Available online 13 March 2020Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): A. Quast, P. Santander, J. Trautmann, N. Moser, H. Schliephake, P. Meyer-Marcotty
Fri Mar 13, 2020 17:08
Publication date: Available online 13 March 2020Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): J.P.J. Dings, M.A. Vijverberg, M.K.S. Hol, D.J.O. Ulrich, A.F.J. de Haan, G.W. Verhage-Damen, M.T.P. de Clonie Maclennan-Naphausen, I.J. Kruyt, H. Ghaeminia, G.B. Bruekers-Schipper, K.J.A.O. Ingels, G.J. Dicker, G.J. Meijer, M.A.W. Merkx
Fri Mar 13, 2020 17:08
Inhibition of ABC transporters is considered the most effective way to circumvent multidrug resistance (MDR). In the present study, we evaluated the MDR modulatory potential of ERK5-IN-1, a potent extracelluar...
Thu Mar 12, 2020 02:00
Condition: Solid Tumor, AdultInterventions: Combination Product: TTX-030, budigalimab and mFOLFOX6; Combination Product: TTX-030, budigalimab and docetaxel; Combination Product: TTX-030 and mFOLFOX6; Combination Product: TTX-030 and budigalimabSponsors: Tizona Therapeutics, Inc; AbbVieNot yet recruiting
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