Medicine by Alexandros G. Sfakianakis

For humans navigating without vision, navigation depends upon the layout of mechanically contacted ground surfaces

Abstract Navigation can be haptically guided. In specific, tissue deformations arising from both limb motions during locomotion (i.e., gait patterns) and mechanical interactions between the limbs and the environment can convey information, detected by the haptic perceptual system, about how the body is moving relative to the environment. Here, we test hypotheses concerning the properties of mechanically contacted environments relevant to navigation of this kind. We studied blindfolded...

Understanding motor control in health and disease: classic single ( n = 1) observations

Sat Mar 14, 2020 02:00

Abstract The field of neuroscience is increasingly dominated by a preferred use of big data, where analysis of large numbers has become an essential area of development. We here draw attention to the importance of smaller numbers, and more specifically, to the historical and continued importance of detailed and judiciously performed studies in single healthy volunteers or single patients with a unique clinical presentation, as an important approach to study normal functions of...

Faster recognition of graspable targets defined by orientation in a visual search task

Sat Mar 14, 2020 02:00

Abstract Peri-hand space is the area surrounding the hand. Objects within this space may be subject to increased visuospatial perception, increased attentional prioritization, and slower attentional disengagement compared to more distal objects. This may result from kinesthetic and visual feedback about the location of the hand that projects from the reach and grasp networks of the dorsal visual stream back to occipital visual areas, which in turn, refines cortical visual processing...

Fri Mar 13, 2020 02:00

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Healthcare utilization and productivity loss in glioma patients and family caregivers: the impact of treatable psychological symptoms

Abstract Background Gliomas are associated with significant healthcare burden, yet reports of costs are scarce. While many costs are unavoidable there may be treatable symptoms contributing to higher costs. We describe healthcare and societal costs in glioma patients at high risk for depression and their family caregivers, and explore relationships between costs and treatable symptoms. ...

Reciprocal control of ADAM17/EGFR/Akt signaling and miR-145 drives GBM invasiveness

Sat Mar 14, 2020 02:00

Abstract Introduction Glioblastoma multiforme (GBM) is one of the most devastating brain malignancies worldwide and is considered to be incurable. However, the mechanisms underlying its aggressiveness remain unclear. Methods The expression of ADAM17 in tissue samples was detected by immunohistochemistry. Knockdown and rescue experiments were used to...

Correction to: Super selective intra‑arterial cerebral infusion of modern chemotherapeutics after blood–brain barrier disruption: where are we now, and where we are going

Fri Mar 13, 2020 02:00

The name of author Jason A. Ellis was missing in the intial online publication, and there was a typo in the sixth author's first name. The original article has been corrected.

Fri Mar 13, 2020 02:00

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Effect of sodium and calcium on polysaccharide production and the activities of enzymes involved in the polysaccharide synthesis of Lentinus edodes

Lentinan is a Lentinus edodes secondary metabolite that can regulate human immune function, but yields are low. Here, the effects of Ca2+ and Na+ on L. edodes lentinan content were investigated. Metal ion concent...

Production and identification of monoclonal antibodies and development of a sandwich ELISA for detection of the H3-subtype avian influenza virus antigen

Sat Mar 14, 2020 02:00

The H3 subtype of avian influenza virus (AIV) is widespread in avian species and is frequently isolated in surveillance projects; thus, we have developed a more effective diagnostic approach of a monoclonal an...

Probiotics mitigating subclinical necrotic enteritis (SNE) as potential alternatives to antibiotics in poultry

Sat Mar 14, 2020 02:00

Subclinical necrotic enteritis (SNE) caused by Clostridium perfringens (CP), is an important disease in chickens, which causes huge economic losses by damaging the intestinal mucosa, decreasing digestion and abso...

Diversity of active root-associated methanotrophs of three emergent plants in a eutrophic wetland in northern China

Sat Mar 14, 2020 02:00

Root-associated aerobic methanotrophs play an important role in regulating methane emissions from the wetlands. However, the influences of the plant genotype on root-associated methanotrophic structures, espec...

The influence of a swab type on the results of point-of-care tests

Sat Mar 14, 2020 02:00

Most point-of-care tests (POCT) use swabs for sampling and/or for applying a sample on the test. A variety of swabs differing in tip materials is commercially available. Different tip materials have different ...

Radiotherapy and Oncology

Thu Mar 12, 2020 02:00

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Methodological concerns for investigating the effects of mid-treatment break of stereotactic body radiotherapy (SBRT) for hepatocellular carcinoma (HCC)

Publication date: Available online 13 March 2020Source: Radiotherapy and OncologyAuthor(s): Yuichi Kibe, Atsuya Takeda

Radiotherapy and Oncology

Sat Mar 14, 2020 17:12

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Survival of patients with advanced metastatic melanoma: The impact of MAP kinase pathway inhibition and immune checkpoint inhibition - Update 2019

Publication date: May 2020Source: European Journal of Cancer, Volume 130Author(s): Selma Ugurel, Joachim Röhmel, Paolo A. Ascierto, Jürgen C. Becker, Keith T. Flaherty, Jean J. Grob, Axel Hauschild, James Larkin, Elisabeth Livingstone, Georgina V. Long, Paul Lorigan, Grant A. McArthur, Antoni Ribas, Caroline Robert, Lisa Zimmer, Dirk Schadendorf, Claus Garbe

Comparison of survival between primary debulking surgery and neoadjuvant chemotherapy for stage III/IV ovarian, tubal and peritoneal cancers in phase III randomised trial

Sat Mar 14, 2020 16:52

Publication date: May 2020Source: European Journal of Cancer, Volume 130Author(s): Takashi Onda, Toyomi Satoh, Gakuto Ogawa, Toshiaki Saito, Takahiro Kasamatsu, Toru Nakanishi, Tomonori Mizutani, Kazuhiro Takehara, Aikou Okamoto, Kimio Ushijima, Hiroaki Kobayashi, Kei Kawana, Harushige Yokota, Masashi Takano, Hiroyuki Kanao, Yoh Watanabe, Kaichiro Yamamoto, Nobuo Yaegashi, Toshiharu Kamura, Hiroyuki Yoshikawa

Diagnosing deficits in quality of life and providing tailored therapeutic options: Results of a randomised trial in 220 patients with colorectal cancer

Sat Mar 14, 2020 16:52

Publication date: May 2020Source: European Journal of Cancer, Volume 130Author(s): Monika Klinkhammer-Schalke, Brunhilde Steinger, Michael Koller, Florian Zeman, Alois Fürst, Julia Gumpp, Robert Obermaier, Pompiliu Piso, Patricia Lindberg-Scharf, Annegret Altendorfer, Christina Apel, Vladimir Arcybasov, Markus Artner, Olga Arzberger, Erwin Bambl, Martin Bauer, Irmengard Begemann, Norbert Bloos, Maximilian Bock, Brigitte Böhmer

Locoregional recurrence risk after neoadjuvant chemotherapy: A pooled analysis of nine prospective neoadjuvant breast cancer trials

Sat Mar 14, 2020 16:52

Publication date: May 2020Source: European Journal of Cancer, Volume 130Author(s): Gustavo Werutsky, Michael Untch, Claus Hanusch, Peter A. Fasching, Jens-Uwe Blohmer, Sabine Seiler, Carsten Denkert, Hans Tesch, Christian Jackisch, Bernd Gerber, Andreas Schneeweiss, Theresa Link, David Krug, Jens Huober, Kerstin Rhiem, Thorsten Kühn, Valentina Vladimirova, Valentina Nekljudova, Sibylle Loibl

Re: A multicentre retrospective cohort study of ovarian germ cell tumours: Evidence for chemotherapy de-escalation and alignment of paediatric and adult practice

Sat Mar 14, 2020 16:52

Publication date: Available online 13 March 2020Source: European Journal of CancerAuthor(s): Farzana Pashankar, A. Lindsay Frazier

Improved survival in patients with head and neck cancer treated in higher volume centres: A population-based study in Belgium

Sat Mar 14, 2020 16:52

Publication date: May 2020Source: European Journal of Cancer, Volume 130Author(s): Roos Leroy, Geert Silversmit, Sabine Stordeur, Cindy De Gendt, Leen Verleye, Viki Schillemans, Isabelle Savoye, Liesbet Van Eycken, Philippe Deron, Marc Hamoir, Jan Vermorken, Vincent Grégoire, Sandra Nuyts

Outcomes of metastatic non-rhabdomyosarcoma soft tissue sarcomas (NRSTS) treated within the BERNIE study: a randomised, phase II study evaluating the addition of bevacizumab to chemotherapy

Fri Mar 13, 2020 16:05

Publication date: May 2020Source: European Journal of Cancer, Volume 130Author(s): Andrea Ferrari, Johannes H.M. Merks, Julia C. Chisholm, Daniel Orbach, Bernadette Brennan, Soledad Gallego, Max M. van Noesel, Kieran McHugh, Rick R. van Rijn, Mark N. Gaze, Helene Martelli, Christophe Bergeron, Nadege Corradini, Veronique Minard-Colin, Gianni Bisogno, Birgit Geoerger, Hubert N. Caron, Gian Luca De Salvo, Michela Casanova

Concomitant intake of abiraterone acetate and food to increase pharmacokinetic exposure: real life data from a therapeutic drug monitoring programme

Fri Mar 13, 2020 16:05

Publication date: May 2020Source: European Journal of Cancer, Volume 130Author(s): Stefanie L. Groenland, Merel van Nuland, Andries M. Bergman, Jeantine M. de Feijter, Vincent O. Dezentje, Hilde Rosing, Jos H. Beijnen, Alwin D.R. Huitema, Neeltje Steeghs, Dutch Pharmacology Oncology Group (DPOG)

Guidelines for time-to-event end-point definitions in adjuvant randomised trials for patients with localised colon cancer: Results of the DATECAN initiative

Fri Mar 13, 2020 16:05

Publication date: May 2020Source: European Journal of Cancer, Volume 130Author(s): Romain Cohen, Dewi Vernerey, Carine Bellera, Aurélia Meurisse, Julie Henriques, Xavier Paoletti, Benoît Rousseau, Steven Alberts, Thomas Aparicio, Ioannis Boukovinas, Sharlene Gill, Richard M. Goldberg, Axel Grothey, Tetsuya Hamaguchi, Timothy Iveson, Rachel Kerr, Roberto Labianca, Sara Lonardi, Jeffrey Meyerhardt, James Paul

Korean red ginseng for cancer-related fatigue in colorectal cancer patients with chemotherapy: A randomised phase III trial

Fri Mar 13, 2020 16:05

Publication date: May 2020Source: European Journal of Cancer, Volume 130Author(s): Jin Won Kim, Sae Won Han, Jae Yong Cho, Ik-Joo Chung, Jong Gwang Kim, Kyung Hee Lee, Keon Uk Park, Sun Kyung Baek, Sang Cheul Oh, Myung Ah Lee, Doyeun Oh, Byoungyong Shim, Joong Bae Ahn, Dongbok Shin, Jae Won Lee, Yeul Hong Kim

The 2016–2019 ImmunoTOX assessment board report of collaborative management of immune-related adverse events, an observational clinical study

Fri Mar 13, 2020 16:05

Publication date: May 2020Source: European Journal of Cancer, Volume 130Author(s): Jean-Marie Michot, Ariane Lappara, Jérôme Le Pavec, Audrey Simonaggio, Michael Collins, Eléonora De Martin, François-Xavier Danlos, Samy Ammari, Cécile Cauquil, Stéphane Ederhy, Emmanuel Barreau, Rakiba Belkhir, Amandine Berdelou, Julien Lazarovici, Philippe Chanson, Hassan Izzedine, Andrei Seferian, Christine Le Pajolec, Capucine Baldini, Patricia Martin-Romano

Latest Results for Review of Philosophy and Psychology

Fri Mar 13, 2020 16:05

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Normality: a Two-Faced Concept

Abstract Consider how we evaluate how normal an object is. On the dual-nature hypothesis, a normality evaluation depends on the object’s goodness (how good do you think it is?) and frequency (how frequent do you think it is?). On the single-nature hypothesis, the evaluation depends solely on either frequency or goodness. To assess these hypotheses, I ran four experiments. Study 1 shows that normality evaluations vary with both the goodness and the frequency assessment of the object....

Latest Results for Review of Philosophy and Psychology

Sat Mar 14, 2020 02:00

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Inguinal Extrusion of a Ventriculoperitoneal Shunt: A Case Report

Publication date: Available online 14 March 2020Source: World NeurosurgeryAuthor(s): Jacob Mazza, Michael G. Brandel, Jeffrey A. Steinberg, Hoi Sang U

Intraspinal Iliac Venous Stent Migration with Lumbar Nerve Root Compression

Sat Mar 14, 2020 16:22

Publication date: May 2020Source: World Neurosurgery, Volume 137Author(s): Mélissa Di Santo, Asmae Belhaj, Benoit Rondelet, Thierry Gustin

Epidermoid Cyst of the Lumbar Spine After Lumbar Puncture: A Clinical, Radiographic, and Pathologic Correlation

Fri Mar 13, 2020 14:24

Publication date: May 2020Source: World Neurosurgery, Volume 137Author(s): Vincent Dodson, Neil Majmundar, Leroy R. Sharer, John L. Gillick

Vasospasm Following Hemispherectomy: A Case Report of a Novel Complication

Fri Mar 13, 2020 14:24

Publication date: May 2020Source: World Neurosurgery, Volume 137Author(s): Amr Morsi, Andres Maldonado, Dennis Lal, Ahsan N.V. Moosa, Elia Pestana-Knight, William Bingaman

Cavernous-Carotid Fistula Presenting with Intracerebral Hemorrhage in the Absence of Ocular Symptoms

Fri Mar 13, 2020 14:24

Publication date: May 2020Source: World Neurosurgery, Volume 137Author(s): Nikolaos Mouchtouris, Michael J. Lang, Anthony Stefanelli, William Hirsch, Stavropoula Tjoumakaris, M. Reid Gooch, Robert Rosenwasser, Pascal M. Jabbour

Endoscopic Endonasal Approach to Foramen Magnum Meningioma: Two-Dimensional Surgical Video

Fri Mar 13, 2020 14:24

Publication date: May 2020Source: World Neurosurgery, Volume 137Author(s): Raíssa Mansilla, Daniel Monte Serrat Prevedello, Lázaro de Lima, Ricardo L. Carrau, José Alberto Landeiro

Inverse National Trends in Decompressive Craniectomy versus Endovascular Thrombectomy for Stroke

Fri Mar 13, 2020 14:24

Publication date: Available online 13 March 2020Source: World NeurosurgeryAuthor(s): Nicolas K. Khattar, Beatrice Ugiliweneza, Enzo M. Fortuny, Shawn W. Adams, Kimberly S. Meyer, Mayur Sharma, Dengzhi Wang, Thomas R. Chandler, Maxwell Boakye, Robert F. James, Dale Ding

Fri Mar 13, 2020 14:24

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Cannabis & ENT: State certification—An expanding yet unregulated system

Publication date: Available online 13 March 2020Source: American Journal of OtolaryngologyAuthor(s): William L. Valentino, Brian J. McKinnon

Laser tongue debridement for oral malodor—A novel approach to halitosis

Sat Mar 14, 2020 16:19

Publication date: Available online 13 March 2020Source: American Journal of OtolaryngologyAuthor(s): Yosef P. Krespi, Victor Kizhner, Karen A. Wilson, Alina Sivriver, Samuel Low, Yalda Khosravi, Paul Stoodley

The semicircular canal function tests contribute to identifying unilateral idiopathic sudden sensorineural hearing loss with vertigo

Sat Mar 14, 2020 16:19

Publication date: Available online 13 March 2020Source: American Journal of OtolaryngologyAuthor(s): Ruirui Guan, Zhu Zhao, Xiaotao Guo, Jingwu Sun

Drainage of a petrous apex cholesterol granuloma through an infracochlear approach

Sat Mar 14, 2020 16:19

Publication date: Available online 13 March 2020Source: American Journal of OtolaryngologyAuthor(s): Maurizio Falcioni, Giovanni Pepe

The prevalence and clinical characteristics of vestibular schwannoma among patients treated as sudden sensorineural hearing loss: A 10-year retrospective study in southern China

Fri Mar 13, 2020 19:33

Publication date: Available online 12 March 2020Source: American Journal of OtolaryngologyAuthor(s): Weiqiang Yang, Xueshuang Mei, Xiaoling Li, Yaqi Zhou, Jiatao Zhong, Hongyu Liu, Lu Li, Hongyi Hu