Related ArticlesTumor-Associated Macrophages: Recent Insights and Therapies. Front Oncol. 2020;10:188 Authors: Zhou J, Tang Z, Gao S, Li C, Feng Y, Zhou X Abstract Macrophages, which have functions of engulfing and digesting foreign substances, can clear away harmful matter, including cellular debris and tumor cells. Based on the condition of the internal environment, circulating monocytes give rise to mature macrophages, and when they are recruited...
Fri Mar 13, 2020 12:53
Related ArticlesChange of Pathological Type to Metaplastic Squamous Cell Carcinoma of the Breast During Disease Recurrence: Case Report and Literature Review. Front Oncol. 2020;10:32 Authors: Guo T, Chen Z, Xu J, Zhang Y Abstract Background: Metaplastic squamous cell carcinoma (SCC) of the breast is a rare and heterogeneous group of primary breast malignancies. The etiology, pathogenesis, and proper treatment for this kind rare breast cancer are still...
Fri Mar 13, 2020 12:53
Related ArticlesMicroRNA-34 expression in gingival crevicular fluid correlated with orthodontic tooth movement. Angle Orthod. 2020 Mar 12;: Authors: Zhang B, Yang L, Zheng W, Lin T Abstract OBJECTIVES: To explore the expression of miR-34a and its effect on expression of matrix metalloproteinases (MMPs) during orthodontic tooth movement (OTM). MATERIALS AND METHODS: Twenty patients, age 12-18 years old, who underwent orthodontic treatment were...
Fri Mar 13, 2020 14:51
ObjectiveTo examine the association between exposures to psychosocial work stressors and mortality in a nationally representative Australian working population sample. Methods18 000 participants from the Household, Income and Labour Dynamics in Australia survey with self-reported job demands, job control, job security and fair pay psychosocial work stressors exposures at baseline were followed for up to 15 waves. Cox proportional hazards regression models were used to examine the association between...
Fri Mar 13, 2020 11:00
ObjectivesThis study examined predictors of lung cancer mortality, beyond age and smoking, among construction workers employed at US Department of Energy (DOE) sites to better define eligibility for low-dose CT (LDCT) lung cancer screening. MethodsPredictive models were based on 17 069 workers and 352 lung cancer deaths. Risk factors included age, gender, race/ethnicity, cigarette smoking, years of trade or DOE work, body mass index (BMI), chest X-ray results, spirometry results, respiratory symptoms,...
Fri Mar 13, 2020 11:00
ObjectiveThe objective of the study was to examine the effects of occupational exposure to diisononyl phthalate (DINP) on serum testosterone levels in male workers. MethodsFrom 2015 to 2018, 97 male workers were recruited from six French factories in the plastics industry. In a short longitudinal study, changes over 3 days in the level of total or free serum testosterone and DINP exposure were measured. DINP exposure was measured by urinary biomonitoring: mono-4-methyl-7-oxo-octyl phthalate (OXO-MINP),...
Fri Mar 13, 2020 11:00
ObjectivesSince 2000 the European Industrial Minerals Association’s Dust Monitoring Programme (IMA-DMP) has systematically collected respirable dust and respirable quartz measurements from 35 companies producing industrial minerals. The IMA-DMP initiative allowed for estimating overall temporal trends in exposure concentrations for the years 2002–2016 and for presenting these trends by type of mineral produced, by jobs performed and by time of enrolment into the DMP. MethodsApproximately 32 000...
Fri Mar 13, 2020 11:00
ObjectiveThe objective of this study was to evaluate the association between occupational exposure to solvents and cognitive performance in middle-aged and early-ageing participants, taking into account the working environment. MethodsIn the French Cohorte des consultants des Centres d'examens de santé (CONSTANCES) cohort, 41 854 participants aged 45–69 years completed a self-reported, lifetime occupational exposure questionnaire. Exposure to solvents (gasoline for hand washing, trichloroethylene,...
Fri Mar 13, 2020 11:00
ObjectivesTo investigate how a standard ceiling mounted light-emitting diode (LED)-based bright light intervention affected alertness and neurobehavioural performance during three consecutive simulated night shifts, and timing of circadian rhythm after the shifts. MethodsTwenty seven participants (20 females, 21.4±2.1 years; mean±SD) worked three consecutive night shifts (23:00–07:00) under a full-spectrum (4000 K) bright light (900 lx) and a standard light (90 lx) condition in a counterbalanced...
Fri Mar 13, 2020 11:00
ObjectivesTo establish normative reference values for work ability in healthy Australian adults using the Work Ability Score and investigate the association of physical performance factors. MethodsThe Work Ability Score was collected from 720 participants aged 18–101 years from the 1000 Norms Project. Physical performance was evaluated by assessing isometric strength of 13 muscle groups; flexibility of six joints; and 11 functional measures categorised as gross motor, fine motor and balance tasks....
Fri Mar 13, 2020 11:00
IntroductionThis study estimated the prevalence of spirometry-defined airflow obstruction and coal workers’ pneumoconiosis (CWP) among never-smoking coal miners participating in the National Institute for Occupational Safety and Health (NIOSH) Coal Workers’ Health Surveillance Program (CWHSP). MethodsData were from working miners screened by a CWHSP mobile unit who had valid spirometry and chest radiography results. Spirometry-defined airflow obstruction was determined when the ratio of forced...
Fri Mar 13, 2020 11:00
ObjectiveThis study evaluated the relationship between brain and other central nervous system cancer (‘CNS cancer’) and exposures at two semiconductor and electronic module manufacturing facilities and at a storage device manufacturing facility. MethodsThe case–control study, nested in a cohort of 126 836 employees, compared 120 CNS cancer cases and 1028 matched controls with respect to employment in 10 process groups and estimated cumulative exposure to 31 known or possible carcinogens. ResultsCNS...
Fri Mar 13, 2020 11:00
Objective2,4-Dichlorophenoxyacetic acid (2,4-D) is a herbicide that is commonly used commercially, agriculturally and residentially worldwide. There is concern about its potential for carcinogenicity based on studies in laboratory animals demonstrating the potential for induction of oxidative stress. We conducted a longitudinal biomarker study of 31 pesticide applicators in Kansas who heavily applied 2,4-D and 34 non-applicator controls. MethodsWe used multivariable generalised linear mixed-effect...
Fri Mar 13, 2020 11:00
L'articolo Differences and similarities between Severe Acute Respiratory Syndrome (SARS)-CoronaVirus (CoV) and SARS-CoV-2. Would a rose by another name smell as sweet? sembra essere il primo su European Review.
Fri Mar 13, 2020 11:59
An outbreak of a novel coronavirus disease-19 (nCoV-19) infection began in December 2019 in Wuhan, China, and now involved the whole word. Several health workers have been infected in different countries. We report the case of a young man with documented nCoV-19 infection evaluated with lung ultrasound and discuss potential applications of lung ultrasound in this setting. Lung ultrasound allowed the identification of nCoV-19 infection at bed-side. Moreover, lung ultrasound can have several other...
Fri Mar 13, 2020 11:59
OBJECTIVE: To assess the value of the simultaneous application of ultrasound and sialendoscopy (US+SE) in several salivary gland diseases not caused either by sialolithiasis or by tumours. PATIENTS AND METHODS: US+SE are routinely used in patients with inflammatory, obstructive, and other non-tumorous major salivary gland diseases. In patients in whom US and SE as single investigation tools were not conclusive or not useful in the management of several non-sialolithiasis-related conditions (stenoses,...
Fri Mar 13, 2020 12:00
Related ArticlesThe predominance of seafood allergy in Vietnamese adults: Results from the first population-based questionnaire survey. World Allergy Organ J. 2020 Mar;13(3):100102 Authors: Le TTK, Tran TTB, Ho HTM, Vu ATL, McBryde E, Lopata AL Abstract Background: Food allergy (FA) is a serious, costly and growing health problem worldwide. FA occurs in both children and adults; however, there is a paucity of information on FA prevalence and its...
Fri Mar 13, 2020 12:29
Related ArticlesSinonasal cancer: an overview of the emerging subtypes. J Laryngol Otol. 2020 Mar 12;:1-6 Authors: Virk JS, Chan J, Dimitrov L, Williamson A, Sandison A, Weir J, Clarke P Abstract BACKGROUND: Advances in immunohistochemistry have spearheaded major developments in our understanding and classification of sinonasal tumours. In the last decade, several new distinct histopathological entities of sinonasal cancer have been characterised. ...
Fri Mar 13, 2020 12:19
Related ArticlesBalancing Rules with Common Sense in the Protection of Human Subjects. J Dermatolog Treat. 2020 Mar 12;:1-2 Authors: Svoboda SA, Balogh EA, Feldman SR PMID: 32162573 [PubMed - as supplied by publisher]
Fri Mar 13, 2020 14:17
Related ArticlesEnhanced Multiple Instance Representation Using Time-Frequency Atoms in Motor Imagery Classification. Front Neurosci. 2020;14:155 Authors: Collazos-Huertas D, Caicedo-Acosta J, Castaño-Duque GA, Acosta-Medina CD Abstract Selection of the time-window mainly affects the effectiveness of piecewise feature extraction procedures. We present an enhanced bag-of-patterns representation that allows capturing the higher-level structures of brain...
Fri Mar 13, 2020 12:09
Related Articles"Defining the Independence of the Liver Circadian Clock" & "BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis". Front Neurosci. 2020;14:107 Authors: Rotinen M PMID: 32161519 [PubMed]
Fri Mar 13, 2020 12:09
Related ArticlesHerb-drug interactions: a mechanistic approach. Drug Chem Toxicol. 2020 Mar 12;:1-10 Authors: Sharma AK, Kapoor VK, Kaur G Abstract In India, traditional herbal medicines have been an essential part of therapy for the last centuries. However, a large portion of the general populace is using these therapies in combination with allopathy lacking a proper understanding of possible interactions (synergistic or antagonistic) between the herbal...
Fri Mar 13, 2020 12:07
Non-infectious scleritis is a potentially sight-threatening condition in which the sclera, the white outer layer of the eye, becomes inflamed. Whilst scleritis can be infective, the majority of cases are due t...
Thu Mar 12, 2020 02:00
As systematic reviews’ limited coverage of the medical literature necessitates decision-making based on unsystematic review, we investigated a possible advantage of systematic review (aside from dataset size a...
Mon Mar 09, 2020 02:00
Journal Name: Biological ChemistryIssue: Ahead of print
Fri Mar 13, 2020 12:06
Related ArticlesSaline Solution Irrigation of the Bile Duct after Stone Removal Reduces the Recurrence of Common Bile Duct Stones. Tohoku J Exp Med. 2020;250(3):173-179 Authors: Endo R, Satoh A, Tanaka Y, Shimoda F, Suzuki K, Takahashi K, Okata H, Hiramoto K, Kimura O, Asonuma S, Umemura K, Shimosegawa T Abstract Common bile duct (CBD) stone is a relatively common but potentially life-threatening disease. Endoscopic sphincterotomy (EST) has been performed...
Fri Mar 13, 2020 12:05
Post-Traumatic West Syndrome due to Abusive Head Trauma in Two Infants with Different Brain Imaging Findings. Tohoku J Exp Med. 2020;250(3):167-171 Authors: Takeda R, Kobayashi S, Kamioka N, Hamajima N, Muramatsu K, Suzuki S Abstract Abusive head trauma (AHT), commonly known as shaken baby syndrome, is a cranial injury of infants and young children. AHT is an important cause of morbidity and mortality in young children, particularly those younger than...
Fri Mar 13, 2020 12:05
Fri Mar 13, 2020 11:57
Seed survival is of great importance for the performance of plant species and it is strongly affected by post-dispersal seed removal by either different animals such as granivorous species and secondary dispersers or abiotic conditions such as wind or water. The success of post-dispersal seed removal depends on seed specific traits including seed size, the presence of coats or elaiosomes, the mode of seed dispersion, and on the habitat in which seeds happen to arrive. In the present study we asked...
Fri Mar 13, 2020 02:00
Background This study assesses the feasibility of using machine learning methods such as Random Forests (RF), Artificial Neural Networks (ANN), Support Vector Regression (SVR) and Self-Organizing Feature Maps (SOM) to identify and determine factors associated with hypertensive patients’ adherence levels. Hypertension is the medical term for systolic and diastolic blood pressure higher than 140/90 mmHg. A conventional medication adherence scale was used to identify patients’ adherence...
Fri Mar 13, 2020 02:00
Using an out-of-body paradigm, the present study provided further empirical evidence for the theory of embodied time by suggesting that the body-self plays a key role in time judgments. Looking through virtual reality glasses, the participants saw the arm of a mannequin instead of their own arm. They had to judge the duration of the interval between two (perceived) touches applied to the mannequin’s body after a series of strokes had been viewed being made to the mannequin and tactile strokes had...
Fri Mar 13, 2020 02:00
An accurate depiction of the genetic relationship, the development of core collection, and genome-wide association analysis (GWAS) are key for the effective exploitation and utilization of genetic resources. Here, genotyping-by-sequencing (GBS) was used to characterize 415 tea accessions mostly collected from the Guizhou region in China. A total of 30,282 high-quality SNPs was used to estimate the genetic relationships, develop core collections, and perform GWAS. We suggest 198 and 148 accessions...
Fri Mar 13, 2020 02:00
Trihelix transcription factors play multiple roles in plant growth, development and various stress responses. In this study, we identified 71 trihelix family genes in the soybean genome. These trihelix genes were located at 19 out of 20 soybean chromosomes unevenly and were classified into six distinct subfamilies: GT-1, GT-2, GTγ, SIP1, SH4 and GTδ. The gene structure and conserved functional domain of these trihelix genes were similar in the same subfamily but diverged between different subfamilies....
Fri Mar 13, 2020 02:00
Background CDK8/CycC complex has kinase activity towards the carboxyterminal domain of RNA polymerase II, and contributes to the regulation of transcription via association with the mediator complex. Different human malignancies, mainly colorectal and gastric cancers, were produced as a result of overexpression of CDK8/CycC in the mediator complex. Therefore, CDK8/CycC complex represents as a cancer oncogene and it has become a potential target for developing CDK8/CycC modulators....
Fri Mar 13, 2020 02:00
In this study, we analyzed differences in the enzyme activities and transcriptomes of embryogenic and non-embryogenic calli to gain insights for improving the success of tissue culture-based breeding. A total of 2,856 differentially expressed genes (DEGs; 1,632 up-regulated and 1,224 down-regulated) were identified based on RNA sequencing and verified by reverse transcription quantitative polymerase chain reaction. Gene set enrichment analysis revealed that many of the up-regulated DEGs in embryogenic...
Fri Mar 13, 2020 02:00
Lung cancer is the most common malignant tumor, accounting for 25% of cancer-related deaths and 14% of new cancers worldwide. Lung adenocarcinoma is the most common type of pulmonary cancer. Although there have been some improvements in the traditional therapy of lung cancer, the outcome and prognosis of patients remain poor. Lung cancer is the leading cause of cancer-related deaths worldwide, with 1.8 million new cases being diagnosed each year. Precision medicine based on genetic alterations is...
Fri Mar 13, 2020 02:00
The recent introduction in a tropical agricultural environment of a weedy open-habitat plant (Solanum myriacanthum) and subsequent host range expansion of a common forest-edge butterfly (Mechanitis menapis) onto that plant provides an opportunity to examine reconfiguration of tritrophic networks in human-impacted landscapes. The objectives of this study were (1) determine if the caterpillars on the exotic host are more or less limited by plant defenses (bottom-up forces) and if they experience enemy...
Fri Mar 13, 2020 02:00
Abstract Immunotherapy has revolutionized cancer treatment for several hematologic and solid organ malignancies; however, pancreatic cancer remains unresponsive to conventional immunotherapies. Several characteristics of pancreatic cancer present challenges to successful treatment with immunotherapy, including its aggressive biology, poor immunogenicity, and abundant desmoplastic stroma which can impede effector T cell infiltration and promote an immunosuppressive microenvironment. In this review,...
Fri Mar 13, 2020 11:39
Introduction: The Intelligibility in Context Scale (ICS) is a parent-report scale by which parents can rate their child’s functional speech intelligibility according to seven different communicative partners. Translations, linguistic adaptations, and psychometric and norming data for ICS have been achieved in different languages. Objective: To evaluate the psychometric properties of the Italian version of the ICS (ICS-I) in terms of internal consistency, test-retest reliability, criterion validity...
Fri Mar 13, 2020 11:02
New England Journal of Medicine, Ahead of Print.
Thu Mar 12, 2020 06:01
New England Journal of Medicine, Ahead of Print.
Thu Mar 12, 2020 06:00
New England Journal of Medicine, Ahead of Print.
Thu Mar 12, 2020 06:00
Abstract Purpose To assess estradiol (E2) and progesterone levels during ovarian stimulation determined by third-generation (Gen III) and second-generation (Gen II) Elecsys® immunoassays. Methods E2 and progesterone concentrations were measured using Elecsys® Gen III and Gen II immunoassays, and progesterone concentrations on the day of ovulation triggering...
Fri Mar 13, 2020 02:00
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