Δευτέρα 16 Μαρτίου 2020


The combined effect of host and food availability on optimized parasitoid life history traits based on a three‐dimensional trade‐off surface
Abstract The reproductive success of many insects is considered to be limited by two main factors: the availability of mature eggs to lay (termed egg limitation) and the time to locate suitable hosts (termed time limitation). High host density in the environment is likely to enhance oviposition opportunities, thereby selecting for higher investment in egg supply. In contrast, a shortage of food (e.g., sugar sources) is likely to increase the risk of time limitation, thereby selecting for higher...
Journal of Evolutionary Biology
Sun Mar 15, 2020 04:32
Temporally consistent species differences in parasite infection but no evidence for rapid parasite‐mediated speciation in Lake Victoria cichlid fish
Abstract Parasites may have strong eco‐evolutionary interactions with their hosts. Consequently, they may contribute to host diversification. The radiation of cichlid fish in Lake Victoria provides a good model to study the role of parasites in the early stages of speciation. We investigated patterns of macroparasite infection in a community of 17 sympatric cichlids from a recent radiation and 2 older species from 2 non‐radiating lineages, to explore the opportunity for parasite‐mediated speciation....
Journal of Evolutionary Biology
Fri Mar 13, 2020 17:48
Delimitation of five astome ciliate species isolated from the digestive tube of three ecologically different groups of lumbricid earthworms, using the internal transcribed spacer region and the hypervariable D1/D2 region of the 28S rRNA gene
Various ecological groups of earthworms very likely constitute sharply isolated niches that might permit speciation of their symbiotic ciliates, even though no distinct morphological features appear to be reco...
Most Recent Articles: BMC Evolutionary Biology
Sat Mar 14, 2020 02:00
Genus level molecular phylogeny of Aegisthidae Gisbrecht, 1893 (Copepoda: Harpacticoida) reveals morphological adaptations to deep-sea and plagic habitats
The family Aegisthidae is known as typical component of deep-sea hyperbenthic waters that gradually colonized other marine environments. The phylogenetic relationships within this family have been examined her...
Most Recent Articles: BMC Evolutionary Biology
Sat Mar 14, 2020 02:00
Intraspecific and interspecific investigations of skeletal DNA methylation and femur morphology in primates
Abstract Objectives Epigenetic mechanisms influence the development and maintenance of complex phenotypes and may also contribute to the evolution of species–specific phenotypes. With respect to skeletal traits, little is known about the gene regulation underlying these hard tissues or how tissue‐specific patterns are associated with bone morphology or vary among species. To begin exploring these topics, this study evaluates one epigenetic mechanism, DNA methylation, in skeletal tissues from...
American Journal of Physical Anthropology
Sun Mar 15, 2020 01:34
A chomped chimp: New evidence of tooth marks on an adult chimpanzee (Pan troglodytes verus)
Abstract Objectives To describe and interpret previously unreported marks on the dry cranium of an adult chimpanzee (Pan troglodytes verus) from Côte d'Ivoire at the Smithsonian's National Museum of Natural History (USNM 450071). Materials and Methods All marks on the cranium were documented and assessed through physical examination of the specimen, photography, micro‐computed tomography (micro‐CT), and 3D laser scanning. Pits and punctures were measured with digital calipers...
American Journal of Physical Anthropology
Sun Mar 15, 2020 01:34
Mandibular corpus shape is a taxonomic indicator in extant hominids
Abstract Objectives The aim of this study is to understand whether the shape of three sub‐regions of the mandibular corpus (the alveolar arch, corpus at M1 and posterior symphysis) are useful for making taxonomic assessments at the genus and species levels in extant hominids. Materials and Methods We use data taken from 3D surface scans of the mandibular corpus of seven extant hominid taxa: Gorilla gorilla gorilla, Gorilla beringei graueri, Homo sapiens, Pan paniscus, Pan troglodytes...
American Journal of Physical Anthropology
Sat Mar 14, 2020 10:59
Mandibular symphyseal fusion in fossil primates: Insights from correlated patterns of jaw shape and masticatory function in living primates
Abstract Objectives Variation in primate masticatory form and function has been extensively researched through both morphological and experimental studies. As a result, symphyseal fusion in different primate clades has been linked to either the recruitment of vertically directed balancing‐side muscle force, the timing and recruitment of transversely directed forces, or both. This study investigates the relationship between jaw muscle activity patterns and morphology in extant primates to make...
American Journal of Physical Anthropology
Sat Mar 14, 2020 10:59
Issue Information – Table of Contents
American Journal of Physical Anthropology
Fri Mar 13, 2020 10:28
Cover & Editorial Board
American Journal of Physical Anthropology
Fri Mar 13, 2020 10:28
Imprint cytology of histiocytic sarcoma manifesting as a retroperitoneal mass: A valuable aid for frozen section diagnosis
Abstract Histiocytic sarcoma (HS) is a comparatively rare hematolymphoid neoplasm. Differential diagnosis of this entity has generally been proven to be so difficult that extensive immunohistochemical staining is required to confirm its presence. We herein present a case of HS manifesting as a retroperitoneal mass in which imprint cytology (IC) contributed to the diagnosis. A 77‐year‐old man was referred for the evaluation of a colonic tubulovillous polypoid lesion. Preoperative imaging revealed...
Diagnostic Cytopathology
Sun Mar 15, 2020 01:24
Noninvasive follicular thyroid neoplasm with papillary‐like nuclear features and the risk of malignancy in The Bethesda System for the Reporting of Thyroid Cytopathology
Abstract Introduction The Bethesda System for the Reporting of Thyroid Cytopathology (TBSRTC) is used to categorize and diagnose thyroid nodules by fine needle aspiration biopsy (FNAB). Each category in TBSRTC is associated with an estimated risk of malignancy (ROM). A subset of noninvasive encapsulated follicular variant of papillary thyroid carcinoma (niEFVPTC) was reclassified as a nonmalignant tumor: noninvasive follicular thyroid neoplasm with papillary‐like nuclear features (NIFTP)....
Diagnostic Cytopathology
Sat Mar 14, 2020 11:06
Cepstral Measures to Analyze Vocal Fatigue in Individuals With Hyperfunctional Voice Disorder
Cepstral measures are sensitive to slightest deviance in voice quality. Vocal fatigue is an initial symptom of a voice disorder. This study aimed (1) to assess the correlation of vocal fatigue and cepstral measures and (2) to identify a measure for analyzing voice change due to vocal fatigue in individuals with hyperfunctional voice disorders.
Journal of Voice
Sat Mar 14, 2020 02:00
Associations between Teachers’ Posture, Muscle Tension and Voice Complaints
The interaction between muscle tension, posture, and vocal use is very complex as clinical research suggests that abnormal laryngeal posture can be associated with muscle adaptive changes, although specific evidence concerning body posture and voice disorders has been lacking. Thus, the aim of this study was to verify if there were differences in posture, muscle tension and voice between teachers with and without voice complaints.
Journal of Voice
Sat Mar 14, 2020 02:00
Classification of Voice Disorders Using a One-Dimensional Convolutional Neural Network
Auditory-perceptual voice analysis is a standard method for quantifying pathological voice quality, but perceptual ratings are based on subjective evaluations and therefore may vary among examiners. Although many acoustic metrics have been studied for potential use in the objective evaluation of pathological voices, the interpretation of acoustic metrics in individual cases is difficult and the technique is not widely used by clinicians. The aim of this study was to establish standardized methods...
Journal of Voice
Fri Mar 13, 2020 02:00
Combined Use Of Cytology, P16 Immunostaining And Genotyping For Triage Of Women Positive For High Risk Human Papillomavirus At Primary Screening
HPV testing is very sensitive for primary cervical screening but has low specificity. Triage tests which improve specificity but maintain high sensitivity are needed. Women enrolled in the experimental arm of phase 2 of the NTCC randomised controlled cervical screening trial were tested for high risk human papillomavirus (hrHPV) and referred to colposcopy if positive. hrHPV positive women also had HPV genotyping (by PCR with GP5+/GP6+ primers and reverse line blotting), immunostaining for p16 overexpression...
International Journal of Cancer
Sun Mar 15, 2020 00:18
Erratum
International Journal of Cancer
Sun Mar 15, 2020 00:18
Proteasome inhibitors and Smac mimetics cooperate to induce cell death in Diffuse Large B‐cell Lymphoma by stabilizing NOXA and triggering mitochondrial apoptosis
Copy number gains and increased expression levels of cellular Inhibitor of Apoptosis protein (cIAP)1 and cIAP2 have been identified in primary diffuse large B‐cell lymphoma (DLBCL) tissues. Smac (second mitochondria‐derived activator of caspases) mimetics were designed to antagonize IAP proteins. However, since their effect as single agents is limited, combination treatment represents a strategy for their clinical development. Therefore, we investigated the Smac mimetic BV6 in combination with proteasome...
International Journal of Cancer
Sat Mar 14, 2020 09:23
Invited commentary ‐ WHO classification of tumors: How should tumours be classified? Expert consensus, systematic reviews or both?
International Journal of Cancer
Sat Mar 14, 2020 09:23
Reply to Comments on: Lifestyles and Myeloproliferative Neoplasms with Special Reference to Coffee Consumption
International Journal of Cancer
Sat Mar 14, 2020 09:23
Effectiveness of Sorafenib Dose Modifications on Treatment Outcome of Hepatocellular Carcinoma: Analysis in Real‐Life Settings
Controlling adverse events through dose reduction can enhance drug adherence and treatment response. Currently, there is no guide for sorafenib dosing. The aim of this study was to evaluate whether sorafenib dosing could affect treatment outcomes. A total of 782 hepatocellular carcinoma (HCC) patients treated with sorafenib were evaluated for sorafenib dosing and its modifications via medical records at baseline and regular followed‐up. Study outcomes included progression‐free survival (PFS), overall...
International Journal of Cancer
Sat Mar 14, 2020 09:23
Ovarian cancer derived copy number alterations signatures are prognostic in chemoradiotherapy treated head and neck squamous cell carcinoma
DNA copy number alterations (CNA) are frequent in cancer and recently developed CNA signatures revealed their value in molecular tumor stratification for patient prognosis and platinum resistance prediction in ovarian cancer. Head and neck squamous cell carcinoma (HNSCC) are also characterized by high CNA numbers. In this study, we determined CNA in 173 HPV‐negative HNSCC from a Dutch multicenter cohort by low‐coverage whole genome sequencing and tested the prognostic value of seven cancer derived...
International Journal of Cancer
Sat Mar 14, 2020 09:23
High Impact Physical Activity and Bone Health of Lower Extremities in Childhood Cancer Survivors: A Cross‐sectional Study of SURfit
Childhood cancer survivors (CCS) are at risk of reduced bone health and premature osteoporosis. As physical activity with high impact loading (IL‐PA) is known to promote bone health, we compared bone densitometry and microstructure between groups of CCS who performed different amounts of physical activities in their daily life. We used baseline data of a single‐centre PA trial including 161 CCS from the Swiss Childhood Cancer Registry, aged <16 at diagnosis, ≥16 at study, and ≥ 5 years since diagnosis....
International Journal of Cancer
Sat Mar 14, 2020 09:23
Major multi‐level molecular divergence between THP‐1 cells from different biorepositories
The THP‐1 cell line is broadly used as a model for acute myeloid leukemia (AML) with MLL fusion and to study monocyte differentiation and function. We studied THP‐1 cells obtained from two major biorepositories. The two cell lines were closely related with a percentage match of short tandem repeat (STR) profiles ranging from 93.75% to 100%, depending on the algorithm used. Nevertheless, we found that the two cell lines presented discordant HLA type, cytogenetic aberrations and AML‐related gene expression...
International Journal of Cancer
Fri Mar 13, 2020 10:34
Role of Cellular, Molecular, and Tumor Microenvironment in Hepatocellular Carcinoma: Possible Targets and Future Directions in the Regorafenib Era
Hepatocellular carcinoma (HCC) remains as one of the major causes of cancer‐related mortality, despite the recent development of new therapeutic options. Regorafenib, an oral multikinase inhibitor, is the first systemic therapy that has a survival benefit for patients with advanced HCC that have a poor response to sorafenib. Even though regorafenib has been approved by the FDA, the clinical trial for regorafenib treatment does not show significant improvement in overall survival. The impaired efficacy...
International Journal of Cancer
Fri Mar 13, 2020 10:34
Association between chronic pancreatitis and pancreatic cancer: a ten‐year retrospective study of endoscopically treated and surgical patients
Pancreatic cancer (PC) has a poor prognosis. Chronic pancreatitis (CP) associates with high morbidity and mortality, and serves as a risk factor for PC. This study aimed to assess the association between endoscopically treated CP patients and PC, and to establish the rate of CP among patients undergoing surgery for pancreatic ductal adenocarcinoma (PDAC). We retrospectively analyzed 458 CP patients undergoing endoscopic treatment (ET) between 2000 and 2010 and 349 PDAC patients undergoing pancreatic...
International Journal of Cancer
Fri Mar 13, 2020 10:34
Cryptic aberrations may allow more accurate prognostic classification of patients with myelodysplastic syndromes and clonal evolution
ABSTRACT The karyotype of bone‐marrow cells at the time of diagnosis is one of the most important prognostic factors in patients with myelodysplastic syndromes (MDS). In some cases, the acquisition of additional genetic aberrations (clonal evolution, CE) associated with clinical progression may occur during the disease. We analyzed a cohort of 469 MDS patients using a combination of molecular cytogenomic methods to identify cryptic aberrations and to assess their potential role in CE. We confirmed...
Genes, Chromosomes and Cancer
Sun Mar 15, 2020 00:02
Variant WWTR1 Gene Fusions in Epithelioid Hemangioendothelioma ‐ A Genetic Subset Associated with Cardiac Involvement
ABSTRACT The genetic hallmark of epithelioid hemangioendothelioma (EHE) is a recurrent WWTR1‐CAMTA1 fusion, which is present in most cases bearing a conventional histology. A subset of cases is characterized by a distinct morphology and harbors instead a YAP1‐TFE3 fusion. Nevertheless, isolated cases lack these canonical fusions and remain difficult to classify. Triggered by an index case of a left atrial mass in a 76‐year‐old female with morphologic features typical of EHE, but which showed an...
Genes, Chromosomes and Cancer
Sat Mar 14, 2020 11:59
Identification of a t(X;17)(q28;q21) generating a KANSL1‐MTCP1 gene fusion leading to dysregulated expression of MTCP1 in acute myeloid leukemia
Abstract Chromosomal translocations and generating fusion genes are closely associated with disease initiation and progression in acute myeloid leukemia (AML). In this study, we identified a novel t(X;17)(q28;q21) chromosomal rearrangement in a patient with acute monocytic leukemia. Using RNA‐sequencing, we identified a KANSL1‐MTCP1 and a KANSL1‐CMC4 fusion gene. 5’‐UTR sequences of the KANSL1 gene were found to become fused upstream of the coding sequence (CDS) region of the MTCP1 and CMC4 genes,...
Genes, Chromosomes and Cancer
Fri Mar 13, 2020 19:56
Comparison of Different Colorectal Cancer With Liver Metastases Models Using Six Colorectal Cancer Cell Lines
Abstract At present, modeling methods of colorectal cancer with liver metastases have significant limitations. Here, we established orthotopic and ectopic hepatic metastases models using six colorectal cancer cell lines to choose an ideal animal model for studying colorectal cancer growth and liver metastases. Luciferin-expressing six colorectal cancer cell lines were used to induce animal models of colorectal cancer with liver metastases by intra-splenic injection or implantation...
Pathology & Oncology Research
Sat Mar 14, 2020 02:00
Total Tumor Volume Should be Considered as an Important Prognostic Factor for Synchronous Multiple Gastric Cancer Patients with Curative Gastrectomy
Abstract Synchronous multiple gastric cancer (SMGC) was a special type of gastric cancer with relatively low incidence. This article was designed to demonstrate that the total tumor volume (TTV) should be treated as an important prognostic factor in SMGC patients with curative gastrectomy. This study retrospective analyzed 140 SMGC patients who received curative gastrectomy between December 2004 and December 2014 in our hospital. Clinicopathological features, preoperative evaluation,...
Pathology & Oncology Research
Fri Mar 13, 2020 02:00
Tight Junction-Related CLDN5 and CLDN6 Genes, and Gap Junction-Related GJB6 and GJB7 Genes Are Somatically Mutated in Gastric and Colorectal Cancers
Abstract Tight junction and gap junction are major cell junctions that play important roles in cellular communication and structural integrity. Alterations of these junctions are known to be involved in cancer pathogenesis. Claudins and connexins are major tight and gap junction proteins, but genetic alterations of these genes have not been reported in gastric (GC) and colorectal cancers (CRC) with microsatellite instability (MSI). Claudin genes CLDN5 and CKDN6, and connexin genes...
Pathology & Oncology Research
Fri Mar 13, 2020 02:00
PBX1 Increases the Radiosensitivity of Oesophageal Squamous Cancer by Targeting of STAT3
Abstract The radioresistance of oesophageal squamous cell carcinoma (OSCC) is a critical factor leading to a poor prognosis among patients. The expression of PBX1 is abnormally high in a broad range of human tissues, and this gene plays a key role in tumour proliferation. This research intended to explore the radiosensitization of OSCC by silencing PBX1. The OSCC cell lines KYSE450 and KYSE150 were subjected to PBX1 silencing and/or irradiation (IR). Cell proliferation, colony...
Pathology & Oncology Research
Fri Mar 13, 2020 02:00
The cytokine network in the pathogenesis of major depressive disorder. Close to translation?
Publication date: Available online 13 March 2020Source: Autoimmunity ReviewsAuthor(s): Maria Cristina Petralia, Emanuela Mazzon, Paolo Fagone, Maria Sofia Basile, Vittorio Lenzo, Maria Catena Quattropani, Santo Di Nuovo, Klaus Bendtzen, Ferdinando Nicoletti
Autoimmunity Reviews
Sat Mar 14, 2020 22:41
Precision medicine in the care of rheumatoid arthritis: Focus on prediction and prevention of future clinically-apparent disease
Publication date: Available online 12 March 2020Source: Autoimmunity ReviewsAuthor(s): Michael Mahler, Laura Martinez-Prat, Jeffrey A. Sparks, Kevin D. Deane
Autoimmunity Reviews
Fri Mar 13, 2020 14:57
Severe infections in patients with anti-neutrophil cytoplasmic antibody-associated vasculitides receiving rituximab: A meta-analysis
Publication date: Available online 12 March 2020Source: Autoimmunity ReviewsAuthor(s): Clémence Thery-Casari, Romain Euvrard, Sabine Mainbourg, Stéphane Durupt, Quitterie Reynaud, Isabelle Durieu, Alexandre Belot, Hervé Lobbes, Natalia Cabrera, Jean-Christophe Lega
Autoimmunity Reviews
Fri Mar 13, 2020 14:57
Personalized medicine in rheumatoid arthritis: How immunogenicity impacts use of TNF inhibitors
Publication date: Available online 12 March 2020Source: Autoimmunity ReviewsAuthor(s): Caterina Bodio, Claudia Grossi, Francesca Pregnolato, Ennio Giulio Favalli, Martina Biggioggero, Antonio Marchesoni, Antonella Murgo, Matteo Filippini, Paola Migliorini, Roberto Caporali, Raffaele Pellerito, Francesco Ciccia, Piercarlo Sarzi-Puttini, Federico Perosa, Giuseppe Paolazzi, Ivana Hollan, Klaus Bendzten, Pier Luigi Meroni, Maria Orietta Borghi
Autoimmunity Reviews
Fri Mar 13, 2020 14:57
Cell-type-specific role of CHK2 in mediating DNA damage-induced G2 cell cycle arrest
Oncogenesis, Published online: 13 March 2020; doi:10.1038/s41389-020-0219-yCell-type-specific role of CHK2 in mediating DNA damage-induced G2 cell cycle arrest
Oncogenesis - nature.com science feeds
Fri Mar 13, 2020 02:00
Cell-type-specific role of CHK2 in mediating DNA damage-induced G2 cell cycle arrest
Oncogenesis - nature.com science feeds
Fri Mar 13, 2020 02:00

The long non-coding RNA PIK3CD-AS2 promotes lung adenocarcinoma progression via YBX1-mediated suppression of p53 pathway
Oncogenesis, Published online: 12 March 2020; doi:10.1038/s41389-020-0217-0The long non-coding RNA PIK3CD-AS2 promotes lung adenocarcinoma progression via YBX1-mediated suppression of p53 pathway
Oncogenesis - nature.com science feeds
Thu Mar 12, 2020 02:00

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