Πέμπτη 23 Ιουλίου 2020


ALCOHOL; +110 new citations
110 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: ALCOHOL These pubmed results were generated on 2020/07/23PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Alcohol
Thu Jul 23, 2020 20:51
A chemical biology approach to identifying molecular pathways associated with aging
Abstract The understanding of how aging contributes to dementia remains obscure. To address this problem, a chemical biology approach was used employing CAD031, an Alzheimer’s disease (AD) drug candidate identified using a discovery platform based upon phenotypic screens that mimic toxicities associated with the aging brain. Since CAD031 has therapeutic efficacy when fed to old symptomatic transgenic AD mice, the chemical biology hypothesis is that it can be used to determine the...
GeroScience
Thu Jul 23, 2020 03:00
Biomarkers of senescence in non-human primate adipose depots relate to aging
Abstract Forty-three female African green monkeys (Chlorocebus aethiops sabaeus) were selected to represent young adult to advanced geriatric ages (7–24 years) to exhibit a wide range of obesity status (8–53% body fat) and diverse metabolic syndrome criteria such as diabetes, dyslipidemia, and hypertension. Subcutaneous and visceral adipose tissues were collected and evaluated for the presence of senescence cells in both whole tissue and single-cell isolates from subcutaneous sources,...
GeroScience
Thu Jul 23, 2020 03:00
human homeostasis; +39 new citations
39 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human homeostasis These pubmed results were generated on 2020/07/23PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Human homeostasis
Thu Jul 23, 2020 19:11
human physiology; +114 new citations
114 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human physiology These pubmed results were generated on 2020/07/23PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Human physiology
Thu Jul 23, 2020 21:31
medical science; +2984 new citations
2984 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: medical science These pubmed results were generated on 2020/07/23PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Medical Science
Thu Jul 23, 2020 20:44
Long-distance learning could help us democratize education
Kids with all different skin colors need to see teachers from underrepresented groups. (August de Richelieu from Pexels/)This story originally featured on Working Mother.“We moved here for the schools.” It’s a popular refrain of suburban families wealthy enough to afford the high real-estate taxes that go toward funding well-rated public schools but not wealthy enough, or not interested, to send their kids to private school. The result: Because Black parents earn 40 percent less than non-Hispanic...
Popular Science
03:00
Geologists say Venus has enough active volcanoes to form a ‘Ring of Fire’
A volcano named Sapas Mons dominates this computer-generated view of the surface of Venus. (NASA/JPL/)In many ways—size, density, chemical make-up—Venus is Earth’s fiery twin. Sure, this radiation-bombarded, sulfuric-acid-raining, blistering hellscape of a planet is hardly a haven of habitability like our home. But the longstanding hypothesis that Venus, like the Earth, is a volcanically active planet, is backed by new evidence. Researchers have identified three dozen features on Venus that appear...
Popular Science
00:00
Leagues scramble to replace the roar of the crowd as pro sports return
Fenway without fans cussing in the stands? Get used to it. (Veronica Benavides/Unsplash/)It’s going to be a good while before fans can pack the bleachers and seats at sporting events again. But as teams mount their summer comebacks in empty arenas and stadiums, some leagues have found alternative ways to keep viewers from suffering awkward silences during the action. Here’s what you can expect to hear when you tune into pro games, starting this week.SoccerReturn date: Already back, but the quarterfinals...
Popular Science
00:48
Pole saws to keep trees healthy
For some extra reach. ( David Vig via Unsplash/)If you want to keep your trees healthy and looking their best, it’s important to occasionally prune older or damaged branches. A great tool for this is a pole saw. Essentially, pole saws are chainsaws attached extendable rods and designed to cut thicker branches.Pole saws can be powered by gas, an electrical outlet, or rechargeable batteries. Gas-powered tools are best for larger jobs, with longer run-times and more power for branches up to 12 inches...
Popular Science
Thu Jul 23, 2020 20:29
Face masks with valves don’t stop COVID-19 from spreading
Mask valves might make you breathe a little easier, but when it comes to fighting COVID, wearing one is a bad move. (Unsplash/)Follow all of PopSci’s COVID-19 coverage here, including tips on cleaning groceries, ways to tell if your symptoms are just allergies, and a tutorial on making your own mask.When shopping for face masks to prevent the spread of COVID-19, you don’t need to look for bells and whistles. Masks with breathing valves, in particular, are being marketed as a better option than plain...
Popular Science
Thu Jul 23, 2020 19:00
The four best ways to cook a burger
Think you're good at cooking burgers now? You might be even better after you read this. (Zac Cain/Unsplash/)This story was originally featured on Saveur.Whether you’ve got a single skillet or a fully stocked kitchen—or perhaps you’re just itching to light that new grill—there is a burger method that’s right for you. Below, we break down the best ways to cook burgers on the stovetop, in a toaster oven, over the grill, even how to steam the patties. Once you’ve mastered your preferred method, check...
Popular Science
Thu Jul 23, 2020 16:00
Cereal accessories for hard-core breakfasters
Eat your breakfast exactly how you like it. (Freestocks via Unsplash/)Sometimes when you look a little closer at what you thought was a good relationship, you start to see problems that you’ve ignored so frequently, you’ve forgotten there might be a solution. Take cereal and milk, for instance. When cow, almond, or oat milk enters the equation, the relationship doesn’t feel so light and sweet. Will you ever get the satisfying crunch you crave, or will your bowl continue to dissolve into a slurry...
Popular Science
Thu Jul 23, 2020 15:24
There’s a dangerous virus brewing in pigs—but there’s no need to panic yet
Viruses grow and evolve in many animal hosts, and pigs allow them to become especially dangerous. (Unsplash/)We first learned about COVID-19 when headlines proclaimed that the virus was already spreading like wildfire amongst humans. But what if there was a way to catch these viruses before they become efficiently transmissible between humans? In a study published last month in Proceedings of the National Academy of Sciences, scientists presented a way to do just that. By closely surveying the movements...
Popular Science
Thu Jul 23, 2020 13:00
Intake of Sugar-Sweetened and Low-Calorie Sweetened Beverages and Risk of Cardiovascular Disease: A Meta-Analysis and Systematic Review.
Related Articles Intake of Sugar-Sweetened and Low-Calorie Sweetened Beverages and Risk of Cardiovascular Disease: A Meta-Analysis and Systematic Review. Adv Nutr. 2020 Jul 22;: Authors: Yin J, Zhu Y, Malik V, Li X, Peng X, Zhang FF, Shan Z, Liu L Abstract The long-term associations between the consumption of sugar-sweetened beverages (SSBs) and low-calorie sweetened beverages (LCSBs) with cardiovascular diseases (CVDs) remains inconsistent....
pubmed: "adv nutr"[jour]
Thu Jul 23, 2020 20:12
A hydraulic model of cardiovascular physiology and pathophysiology embedded into a computer-based teaching system for student training in laboratory courses.
Related Articles A hydraulic model of cardiovascular physiology and pathophysiology embedded into a computer-based teaching system for student training in laboratory courses. Adv Physiol Educ. 2020 Sep 01;44(3):423-429 Authors: Christ A, Barowsky D, Gekle M, Thews O Abstract Functional understanding of the different parts of the cardiovascular system is essential for an insight into pathomechanisms of numerous diseases. During training cardiovascular...
pubmed: "adv physiol educ"[j...
Thu Jul 23, 2020 20:16
Using online decision trees to support students' self-efficacy in the laboratory.
Related Articles Using online decision trees to support students' self-efficacy in the laboratory. Adv Physiol Educ. 2020 Sep 01;44(3):430-435 Authors: McLean S, Meadows KN, Heffernan A, Campbell N Abstract Failed experiments are a common occurrence in research, yet many undergraduate science laboratories rely on established protocols to ensure students are able to obtain results. While it is logistically challenging to facilitate students'...
pubmed: "adv physiol educ"[j...
Thu Jul 23, 2020 20:16
Understanding preload and preload reserve within the conceptual framework of a limited range of possible left ventricular end-diastolic volumes.
Related Articles Understanding preload and preload reserve within the conceptual framework of a limited range of possible left ventricular end-diastolic volumes. Adv Physiol Educ. 2020 Sep 01;44(3):414-422 Authors: Peverill RE Abstract Preload has been variously defined, but if there is to be a direct relationship with activity of the Frank-Starling mechanism in its action to increase the force and extent of contraction, preload must directly...
pubmed: "adv physiol educ"[j...
Thu Jul 23, 2020 20:16
A student practical to conceptualize the importance of Poiseuille's law and flow control in the cardiovascular system.
Related Articles A student practical to conceptualize the importance of Poiseuille's law and flow control in the cardiovascular system. Adv Physiol Educ. 2020 Sep 01;44(3):436-443 Authors: Holmes AP, Ray CJ, Kumar P, Coney AM Abstract The laboratory practical reported here is based in Poiseuille's law and utilizes low-cost laboratory consumable items, thereby making it easy to deploy in any teaching laboratory. In the practical, students take...
pubmed: "adv physiol educ"[j...
Thu Jul 23, 2020 20:16
A perfect confluence of physiology and morphology: discovery of the transverse tubular system and inward spread of activation in skeletal muscle.
Related Articles A perfect confluence of physiology and morphology: discovery of the transverse tubular system and inward spread of activation in skeletal muscle. Adv Physiol Educ. 2020 Sep 01;44(3):402-413 Authors: Rall JA Abstract By early 1954, there existed a plausible model of muscle contraction called the sliding filament model. In addition, the nature of muscle excitation was understood. Surprisingly, the link between the membrane excitation...
pubmed: "adv physiol educ"[j...
Thu Jul 23, 2020 20:16
The "Gut Game": an active methodology to teach digestive physiology.
Related Articles The "Gut Game": an active methodology to teach digestive physiology. Adv Physiol Educ. 2020 Sep 01;44(3):444-447 Authors: de Campos RP, Viero VP, Medeiros NM, Marcondes FK, Montrezor LH, Porawski M, Gutierrez LLP PMID: 32697150 [PubMed - in process]
pubmed: "adv physiol educ"[j...
Thu Jul 23, 2020 20:16
Graph-based prediction of Protein-protein interactions with attributed signed graph embedding.
Related Articles Graph-based prediction of Protein-protein interactions with attributed signed graph embedding. BMC Bioinformatics. 2020 Jul 21;21(1):323 Authors: Yang F, Fan K, Song D, Lin H Abstract BACKGROUND: Protein-protein interactions (PPIs) are central to many biological processes. Considering that the experimental methods for identifying PPIs are time-consuming and expensive, it is important to develop automated computational methods...
pubmed: "bmc bioinformatics"...
Thu Jul 23, 2020 22:05
A robust nonlinear low-dimensional manifold for single cell RNA-seq data.
Related Articles A robust nonlinear low-dimensional manifold for single cell RNA-seq data. BMC Bioinformatics. 2020 Jul 21;21(1):324 Authors: Verma A, Engelhardt BE Abstract BACKGROUND: Modern developments in single-cell sequencing technologies enable broad insights into cellular state. Single-cell RNA sequencing (scRNA-seq) can be used to explore cell types, states, and developmental trajectories to broaden our understanding of cellular heterogeneity...
pubmed: "bmc bioinformatics"...
Thu Jul 23, 2020 22:05
A student-led curriculum framework for homeless and vulnerably housed populations.
Related Articles A student-led curriculum framework for homeless and vulnerably housed populations. BMC Med Educ. 2020 Jul 21;20(1):232 Authors: Hashmi SS, Saad A, Leps C, Gillies-Podgorecki J, Feeney B, Hardy C, Falzone N, Archibald D, Hoang T, Bond A, Wang J, Alkhateeb Q, Penney D, DiFalco A, Pottie K Abstract BACKGROUND: Medical student demands for competency based homeless health education is increasing. Indeed, humans living homeless is...
pubmed: "bmc med educ"[jour]
Thu Jul 23, 2020 21:34
Determinants and risk factors of gastroenteritis in the general population, a web-based cohort between 2014 and 2017 in France.
Related Articles Determinants and risk factors of gastroenteritis in the general population, a web-based cohort between 2014 and 2017 in France. BMC Public Health. 2020 Jul 21;20(1):1146 Authors: Ecollan M, Guerrisi C, Souty C, Rossignol L, Turbelin C, Hanslik T, Colizza V, Blanchon T Abstract BACKGROUND: Although it is rarely fatal in developed countries, acute gastroenteritis (AGE) still induces significant morbidity and economic costs. The...
pubmed: "bmc public health"[...
Thu Jul 23, 2020 20:04
Correction to: Cross-cultural validation of the motivation to change lifestyle and health behaviours for dementia risk reduction scale in the Dutch general population.
Related Articles Correction to: Cross-cultural validation of the motivation to change lifestyle and health behaviours for dementia risk reduction scale in the Dutch general population. BMC Public Health. 2020 Jul 21;20(1):1147 Authors: Joxhorst T, Vrijsen J, Niebuur J, Smidt N Abstract An amendment to this paper has been published and can be accessed via the original article. PMID: 32693784 [PubMed - in process]
pubmed: "bmc public health"[...
Thu Jul 23, 2020 20:04
Modification of Cellular Ion Transport by the Ha-ras Oncogene: Steps towards Malignant Transformation.
Related Articles Modification of Cellular Ion Transport by the Ha-ras Oncogene: Steps towards Malignant Transformation. Cell Physiol Biochem. 1996;6(5):245-270 Authors: Markus R, Ewald W Abstract Expression of the transforming Ha-ras oncogene in NIH 3T3 fibroblasts (+ras cells) results in growth-factor-independent proliferation, breakdown of actin stress fiber network and increase in intracellular pH and cell volume due to activation of the...
pubmed: "cell physiol bioche...
Thu Jul 23, 2020 21:35
The expanding role of CDR1-AS in the regulation and development of cancer and human diseases.
Related Articles The expanding role of CDR1-AS in the regulation and development of cancer and human diseases. J Cell Physiol. 2020 Jul 22;: Authors: Azari H, Mousavi P, Karimi E, Sadri F, Zarei M, Rafat M, Shekari M Abstract CircRNAs are a superabundant and highly conserved group of noncoding RNAs (ncRNAs) that are characterized by their high stability and integrity compared with linear forms of ncRNAs. Recently, their critical role in gene...
pubmed: "j cell physiol"[jou...
Thu Jul 23, 2020 21:31
Osthole interacts with an ER-mitochondria axis and facilitates tumor suppression in ovarian cancer.
Related Articles Osthole interacts with an ER-mitochondria axis and facilitates tumor suppression in ovarian cancer. J Cell Physiol. 2020 Jul 22;: Authors: Bae H, Lee JY, Song J, Song G, Lim W Abstract Osthole is a natural coumarin found in a variety of plants and has been reported to have diverse biological functions, including antimicrobial, antiviral, immunomodulatory, and anticancer effects. Here, we investigated the natural derivative osthole...
pubmed: "j cell physiol"[jou...
Thu Jul 23, 2020 21:31
The Hippo in the room: Targeting the Hippo signalling pathway for osteosarcoma therapies.
Related Articles The Hippo in the room: Targeting the Hippo signalling pathway for osteosarcoma therapies. J Cell Physiol. 2020 Jul 22;: Authors: Rothzerg E, Ingley E, Mullin B, Xue W, Wood D, Xu J Abstract Osteosarcoma (OS) is a primary malignant bone tumour which usually occurs in children and adolescents. OS is primarily a result of chromosomal aberrations, a combination of acquired genetic changes and, hereditary, resulting in the dysregulation...
pubmed: "j cell physiol"[jou...
Thu Jul 23, 2020 21:31
COVID-19 and olfactory dysfunction: A possible associative approach towards neurodegenerative diseases.
Related Articles COVID-19 and olfactory dysfunction: A possible associative approach towards neurodegenerative diseases. J Cell Physiol. 2020 Jul 22;: Authors: Mahalaxmi I, Kaavya J, Mohana Devi S, Balachandar V Abstract The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent of novel coronavirus 2019 (COVID-19), has kept the globe in disquiets due to its severe life-threatening conditions. The most common symptoms...
pubmed: "j cell physiol"[jou...
Thu Jul 23, 2020 21:31
Virodhamine, an endocannabinoid, induces megakaryocyte differentiation by regulating MAPK activity and function of mitochondria.
Related Articles Virodhamine, an endocannabinoid, induces megakaryocyte differentiation by regulating MAPK activity and function of mitochondria. J Cell Physiol. 2020 Jul 22;: Authors: Sharma DS, Raghuwanshi S, Kovuru N, Dahariya S, Gautam DK, Paddibhatla I, Gutti RK Abstract Endocannabinoids are well-known regulators of neurotransmission by activating the cannabinoid (CB) receptors. Endocannabinoids are being used extensively for the treatment...
pubmed: "j cell physiol"[jou...
Thu Jul 23, 2020 21:31
Reply to C Fabiansen et al.
Related Articles Reply to C Fabiansen et al. J Nutr. 2019 Dec 01;149(12):2265-2266 Authors: McDonald CM, Ackatia-Armah RS, Doumbia S, Brown KH PMID: 32696062 [PubMed - in process]
pubmed: "j nutr"[jour]
Thu Jul 23, 2020 19:11
Adaptation to Low Carbohydrate High Fat diet is rapid but impairs endurance exercise metabolism and performance despite enhanced glycogen availability.
Related Articles Adaptation to Low Carbohydrate High Fat diet is rapid but impairs endurance exercise metabolism and performance despite enhanced glycogen availability. J Physiol. 2020 Jul 22;: Authors: Burke LM, Whitfield J, Heikura IA, Ross MLR, Tee N, Forbes SF, Hall R, McKay AKA, Wallett AM, Sharma AP Abstract KEY POINTS: Brief (5-6 d) adaptation to LCHF in elite athletes increased exercise fat oxidation to rates previously observed with...
pubmed: "j physiol"[jour]
Thu Jul 23, 2020 22:14
Lessons from neuronal HIF1a: understanding its role in ventilatory acclimatization to hypoxia.
Related Articles Lessons from neuronal HIF1a: understanding its role in ventilatory acclimatization to hypoxia. J Physiol. 2020 Jul 22;: Authors: Khuu MA PMID: 32697343 [PubMed - as supplied by publisher]
pubmed: "j physiol"[jour]
Thu Jul 23, 2020 22:14
Intracranial pressure and visual acuity: the final frontier?
Related Articles Intracranial pressure and visual acuity: the final frontier? J Physiol. 2020 Jul 22;: Authors: Steele A, Boulet LM, Tymko MM PMID: 32697333 [PubMed - as supplied by publisher]
pubmed: "j physiol"[jour]
Thu Jul 23, 2020 22:14
What determines blood viscosity at the highest city in the world?
Related Articles What determines blood viscosity at the highest city in the world? J Physiol. 2020 Jul 22;: Authors: Cabrales PA, Govender K, Williams AT PMID: 32697332 [PubMed - as supplied by publisher]
pubmed: "j physiol"[jour]
Thu Jul 23, 2020 22:14
Is bilateral corticospinal connectivity impaired in patients with chronic obstructive pulmonary disease?
Related Articles Is bilateral corticospinal connectivity impaired in patients with chronic obstructive pulmonary disease? J Physiol. 2020 Jul 22;: Authors: Cabibel V, Héraud N, Perrey S, Oliver N, Alexandre F, Varray A Abstract KEY POINTS: During moderate and high levels of quadriceps force production, the ipsilateral motor cortex is concomitantly activated with the contralateral motor cortex throughout the corpus callosum to generate the motor...
pubmed: "j physiol"[jour]
Thu Jul 23, 2020 22:14
The beneficial O2 paradox: hyperoxia-enhanced neurocognition and vigilance during reduction in global cerebral blood flow.
Related Articles The beneficial O2 paradox: hyperoxia-enhanced neurocognition and vigilance during reduction in global cerebral blood flow. J Physiol. 2020 Jul 22;: Authors: Dean JB PMID: 32697328 [PubMed - as supplied by publisher]
pubmed: "j physiol"[jour]
Thu Jul 23, 2020 22:14
AnnotatorJ: an ImageJ plugin to ease hand-annotation of cellular compartments.
Related Articles AnnotatorJ: an ImageJ plugin to ease hand-annotation of cellular compartments. Mol Biol Cell. 2020 Jul 22;:mbcE20020156 Authors: Hollandi R, Diósdi Á, Hollandi G, Moshkov N, Horváth P Abstract AnnotatorJ combines single-cell identification with deep learning and manual annotation. Cellular analysis quality depends on accurate and reliable detection and segmentation of cells so that the subsequent steps of analyses e.g. expression...
pubmed: "mol biol cell"[jour...
Thu Jul 23, 2020 19:52
Scribble, Lgl1, and myosin II form a complex in vivo to promote directed cell migration.
Related Articles Scribble, Lgl1, and myosin II form a complex in vivo to promote directed cell migration. Mol Biol Cell. 2020 Jul 22;:mbcE19110657 Authors: Abedrabbo M, Ravid S Abstract Scribble (Scrib) and Lgl1 are conserved polarity proteins that play important roles in different forms of cell polarity. The roles of Scrib and Lgl1 in apical-basal cell polarity has been studied extensively, but little is known about their roles in the cell...
pubmed: "mol biol cell"[jour...
Thu Jul 23, 2020 19:52
PCH-2TRIP13 regulates spindle checkpoint strength.
Related Articles PCH-2TRIP13 regulates spindle checkpoint strength. Mol Biol Cell. 2020 Jul 22;:mbcE20050310 Authors: Défachelles L, Russo AE, Nelson CR, Bhalla N Abstract Spindle checkpoint strength is dictated by the number of unattached kinetochores, cell volume and cell fate. We show that the conserved AAA-ATPase, PCH-2/TRIP13, which remodels the checkpoint effector Mad2 from an active conformation to an inactive one, controls checkpoint...
pubmed: "mol biol cell"[jour...
Thu Jul 23, 2020 19:52
The Borealin Dimerization Domain Interacts with Sgo1 to Drive Aurora B-mediated Spindle Assembly.
Related Articles The Borealin Dimerization Domain Interacts with Sgo1 to Drive Aurora B-mediated Spindle Assembly. Mol Biol Cell. 2020 Jul 22;:mbcE20050341 Authors: Bonner MK, Haase J, Saunders H, Gupta H, Li BI, Kelly AE Abstract The Chromosomal Passenger Complex (CPC), which includes the kinase Aurora B, is a master regulator of meiotic and mitotic processes that ensure the equal segregation of chromosomes. Sgo1 is thought to play a major...
pubmed: "mol biol cell"[jour...
Thu Jul 23, 2020 19:52
WAVE1 and WAVE2 have distinct and overlapping roles in controlling actin assembly at the leading edge.
Related Articles WAVE1 and WAVE2 have distinct and overlapping roles in controlling actin assembly at the leading edge. Mol Biol Cell. 2020 Jul 22;:mbcE19120705 Authors: Tang Q, Schaks M, Koundinya N, Yang C, Pollard LW, Svitkina TM, Rottner K, Goode BL Abstract SCAR/WAVE proteins and Arp2/3 complex assemble branched actin networks at the leading edge. Two isoforms of SCAR/WAVE, WAVE1 and WAVE2, reside at the leading edge, yet it has remained...
pubmed: "mol biol cell"[jour...
Thu Jul 23, 2020 19:52
Lipid sponge droplets as programmable synthetic organelles.
Related Articles Lipid sponge droplets as programmable synthetic organelles. Proc Natl Acad Sci U S A. 2020 Jul 21;: Authors: Bhattacharya A, Niederholtmeyer H, Podolsky KA, Bhattacharya R, Song JJ, Brea RJ, Tsai CH, Sinha SK, Devaraj NK Abstract Living cells segregate molecules and reactions in various subcellular compartments known as organelles. Spatial organization is likely essential for expanding the biochemical functions of synthetic...
pubmed: "proc natl acad sci ...
Thu Jul 23, 2020 22:04
Long-range intramolecular allostery and regulation in the dynein-like AAA protein Mdn1.
Related Articles Long-range intramolecular allostery and regulation in the dynein-like AAA protein Mdn1. Proc Natl Acad Sci U S A. 2020 Jul 21;: Authors: Mickolajczyk KJ, Olinares PDB, Niu Y, Chen N, Warrington SE, Sasaki Y, Walz T, Chait BT, Kapoor TM Abstract Mdn1 is an essential mechanoenzyme that uses the energy from ATP hydrolysis to physically reshape and remodel, and thus mature, the 60S subunit of the ribosome. This massive (>500...
pubmed: "proc natl acad sci ...
Thu Jul 23, 2020 22:04
Autonomics: In search of a foundation for next-generation autonomous systems.
Related Articles Autonomics: In search of a foundation for next-generation autonomous systems. Proc Natl Acad Sci U S A. 2020 Jul 21;: Authors: Harel D, Marron A, Sifakis J Abstract The potential benefits of autonomous systems are obvious. However, there are still major issues to be dealt with before developing such systems becomes a commonplace engineering practice, with accepted and trustworthy deliverables. We argue that a solid, evolving,...
pubmed: "proc natl acad sci ...
Thu Jul 23, 2020 22:04
QnAs with David Harel.
Related Articles QnAs with David Harel. Proc Natl Acad Sci U S A. 2020 Jul 21;: Authors: Azar B PMID: 32694209 [PubMed - as supplied by publisher]
pubmed: "proc natl acad sci ...
Thu Jul 23, 2020 22:04
Thermodynamic energetics underlying genomic instability and whole-genome doubling in cancer.
Related Articles Thermodynamic energetics underlying genomic instability and whole-genome doubling in cancer. Proc Natl Acad Sci U S A. 2020 Jul 21;: Authors: Remacle F, Graeber TG, Levine RD Abstract Genomic instability contributes to tumorigenesis through the amplification and deletion of cancer driver genes. DNA copy number (CN) profiling of ensembles of tumors allows a thermodynamic analysis of the profile for each tumor. The free energy...
pubmed: "proc natl acad sci ...
Thu Jul 23, 2020 22:04
Gene coexpression patterns predict opiate-induced brain-state transitions.
Related Articles Gene coexpression patterns predict opiate-induced brain-state transitions. Proc Natl Acad Sci U S A. 2020 Jul 21;: Authors: Brynildsen JK, Mace KD, Cornblath EJ, Weidler C, Pasqualetti F, Bassett DS, Blendy JA Abstract Opioid addiction is a chronic, relapsing disorder associated with persistent changes in brain plasticity. Reconfiguration of neuronal connectivity may explain heightened abuse liability in individuals with a...
pubmed: "proc natl acad sci ...
Thu Jul 23, 2020 22:04
Allosteric deactivation of PIFs and EIN3 by microproteins in light control of plant development.
Related Articles Allosteric deactivation of PIFs and EIN3 by microproteins in light control of plant development. Proc Natl Acad Sci U S A. 2020 Jul 21;: Authors: Wu Q, Kuang K, Lyu M, Zhao Y, Li Y, Li J, Pan Y, Shi H, Zhong S Abstract Buried seedlings undergo dramatic developmental transitions when they emerge from soil into sunlight. As central transcription factors suppressing light responses, PHYTOCHROME-INTERACTING FACTORs (PIFs) and ETHYLENE-INSENSITIVE...
pubmed: "proc natl acad sci ...
Thu Jul 23, 2020 22:04
A single-cell Raman-based platform to identify developmental stages of human pluripotent stem cell-derived neurons.
Related Articles A single-cell Raman-based platform to identify developmental stages of human pluripotent stem cell-derived neurons. Proc Natl Acad Sci U S A. 2020 Jul 21;: Authors: Hsu CC, Xu J, Brinkhof B, Wang H, Cui Z, Huang WE, Ye H Abstract Stem cells with the capability to self-renew and differentiate into multiple cell derivatives provide platforms for drug screening and promising treatment options for a wide variety of neural diseases....
pubmed: "proc natl acad sci ...
Thu Jul 23, 2020 22:04
Exoplanet secondary atmosphere loss and revival.
Related Articles Exoplanet secondary atmosphere loss and revival. Proc Natl Acad Sci U S A. 2020 Jul 21;: Authors: Kite ES, Barnett MN Abstract The next step on the path toward another Earth is to find atmospheres similar to those of Earth and Venus-high-molecular-weight (secondary) atmospheres-on rocky exoplanets. Many rocky exoplanets are born with thick (>10 kbar) H2-dominated atmospheres but subsequently lose their H2; this process has...
pubmed: "proc natl acad sci ...
Thu Jul 23, 2020 22:04
FOXO transcription factors activate alternative major immediate early promoters to induce human cytomegalovirus reactivation.
Related Articles FOXO transcription factors activate alternative major immediate early promoters to induce human cytomegalovirus reactivation. Proc Natl Acad Sci U S A. 2020 Jul 21;: Authors: Hale AE, Collins-McMillen D, Lenarcic EM, Igarashi S, Kamil JP, Goodrum F, Moorman NJ Abstract Human progenitor cells (HPCs) support human cytomegalovirus (HCMV) latency, and their differentiation along the myeloid lineage triggers cellular cues that drive...
pubmed: "proc natl acad sci ...
Thu Jul 23, 2020 22:04
Biocement stabilization of an experimental-scale artificial slope and the reformation of iron-rich crusts.
Related Articles Biocement stabilization of an experimental-scale artificial slope and the reformation of iron-rich crusts. Proc Natl Acad Sci U S A. 2020 Jul 21;: Authors: Levett A, Gagen EJ, Zhao Y, Vasconcelos PM, Southam G Abstract Novel biotechnologies are required to remediate iron ore mines and address the increasing number of tailings (mine waste) dam collapses worldwide. In this study, we aimed to accelerate iron reduction and oxidation...
pubmed: "proc natl acad sci ...
Thu Jul 23, 2020 22:04
Διαβήτης: Τι να αυξήσουμε στη διατροφή μας για να τον κρατήσουμε μακριά μας
Μια μικρή αύξηση της κατανάλωσης φρούτων, λαχανικών και δημητριακών ολικής άλεσης μπορεί να μειώσει τον κίνδυνο εμφάνισης διαβήτη τύπου 2 σύμφωνα με τα συμπεράσματα δύο νέων πρόσφατων μελετών, μια αμερικανικής και μιας και μιας ευρωπαϊκής. Τα ευρήματα δεν προκαλούν εντύπωση μεν, αλλά είναι αρκούντως τεκμηριωμένα δεδομένου ότι οι παρατηρήσεις βασίστηκαν σε μετρήσεις βάσει  βιοδεικτών και όχι σε απαντήσεις των συμμετεχόντων σε ερωτηματολόγια. Οι διαιτολόγοι συνιστούν να καταναλώνουμε φρέσκα φρούτα...
Επιστημονικές Εξελίξεις – ygeiamou | Το αξιόπιστο site για την Υγεία, τη Διατροφή και την Ευεξία
Thu Jul 23, 2020 12:39
Νόσος Αλτσχάιμερ: Δέκα παράγοντες που αυξάνουν τον κίνδυνο και πώς να τους αντιμετωπίσετε
Υπάρχουν τουλάχιστον δέκα παράγοντες κινδύνου που φαίνεται να παίζουν σημαντικό ρόλο στην πιθανότητα ενός ατόμου να εκδηλώσει νόσο Αλτσχάιμερ. Αλλά ομάδα ερευνητών υποστηρίζει ότι υπάρχουν μέτρα που μπορούν να ληφθούν προληπτικά και να αποτρέψουν την εκδήλωση της νευροεκφυλιστικής πάθησης, σύμφωνα με άρθρο που δημοσιεύουν στο Journal of Neurology, Neurosurgery & Psychiatry. Η διεθνής επιστημονική ομάδα με επικεφαλής τον καθηγητή Jin-Tai Yu από το Πανεπιστήμιο της Κίνας αξιολόγησε δημοσιευμένα...
Επιστημονικές Εξελίξεις – ygeiamou | Το αξιόπιστο site για την Υγεία, τη Διατροφή και την Ευεξία
Thu Jul 23, 2020 09:20
Καρκίνος στομάχου και οισοφάγου: Ο παράγοντας που αυξάνει πάνω από 40% τον κίνδυνο νόσου
Ο κίνδυνος εμφάνισης ορισμένων μορφών καρκίνου του οισοφάγου και του στομάχου φαίνεται ότι αυξάνεται για όσους έχουν ιστορικό σοβαρής περιοδοντικής νόσου υποστηρίζει νέα έρευνα Οι άνθρωποι με περιοδοντική νόσο (δηλαδή προχωρημένη μορφή ουλίτιδας σε σημείο που τα δόντια να χάνουν τη στήριξή τους και να πέφτουν) μπορεί να έχουν υψηλότερο κίνδυνο εμφάνισης ορισμένων μορφών καρκίνου σύμφωνα με τα συμπεράσματα έρευνας που δημοσιεύθηκε στο Gut. Οι ερευνητές  της Σχολής Δημόσιας Υγείας Chan του Πανεπιστημίου...
Επιστημονικές Εξελίξεις – ygeiamou | Το αξιόπιστο site για την Υγεία, τη Διατροφή και την Ευεξία
Thu Jul 23, 2020 08:55
Το αντιικό μπαχαρικό που μπορεί να καταπολεμήσει τη γαστρεντερίτιδα
«Θανάσιμος εχθρός» του ιού της γαστρεντερίτιδας θα μπορούσε να αποδειχθεί ο κουρκουμάς, το ευρέως διαδεδομένο μπαχαρικό που προέρχεται από την Ασία, όπως προκύπτει από τα προκαταρκτικά ευρήματα νέας εργαστηριακής μελέτης που δημοσιεύεται στις σελίδες του Journal of General Virology. Η κουρκουμίνη, το φυσικό συστατικό που περιέχει ο κουρκουμάς, εμφανίστηκε να εμποδίζει τη μετάδοση ή ακόμη και να σκοτώνει τα σωματίδια ενός ιού που προσβάλει το γαστρεντερικό σύστημα σε χοίρους και προκαλεί διάρροια,...
Επιστημονικές Εξελίξεις – ygeiamou | Το αξιόπιστο site για την Υγεία, τη Διατροφή και την Ευεξία
Thu Jul 23, 2020 08:40
Πίεση: Ο τρόπος να την κρατήσουμε υπό έλεγχο ακόμη και σε αυτή την ατμόσφαιρα
Οι άνθρωποι που ασκούνται τακτικά τείνουν να έχουν χαμηλότερο κίνδυνο ανάπτυξης υψηλής αρτηριακής πίεσης, ακόμα και όταν ζουν σε περιοχές όπου η ατμοσφαιρική ρύπανση βρίσκεται σε σχετικά υψηλά επίπεδα, σύμφωνα με μία νέα έρευνα που δημοσιεύθηκε στο Circulation. Οι ερευνητές από το Πανεπιστήμιο της Κίνας μελέτησαν περισσότερους από 140.000 μη υπερτασικούς ενήλικες στην Ταϊβάν και τους παρακολούθησαν για περίπου πέντε χρόνια, κατηγοριοποιώντας τα επίπεδα εβδομαδιαίας σωματικής δραστηριότητάς τους...
Επιστημονικές Εξελίξεις – ygeiamou | Το αξιόπιστο site για την Υγεία, τη Διατροφή και την Ευεξία
Thu Jul 23, 2020 08:20
Κορωνοϊός: Ανακαλύφθηκαν φυσικά αντισώματα που εξουδετερώνουν τον ιό
Αμερικανοί ερευνητές ανακοίνωσαν ότι κατάφεραν να απομονώσουν ισχυρά εξουδετερωτικά αντισώματα από ασθενείς με νόσο COVID-19, τα οποία μπορούν να καταστείλουν τον νέο κορωνοϊό. Η επιστημονική ομάδα του Ιατρικού Κέντρου Irving στο Πανεπιστήμιο Κολούμπια απομόνωσαν τα πολύτιμα αυτά αντισώματα από ασθενείς με σοβαρής μορφής νόσο COVID-19, υποστηρίζοντας ότι μέχρι σήμερα δείχνουν να είναι τα ικανότερα να εξουδετερώσουν τον SARS-CoV-2. Σύμφωνα με τους ειδικούς, τα αντισώματα αυτά μπορούν να παραχθούν...
Επιστημονικές Εξελίξεις – ygeiamou | Το αξιόπιστο site για την Υγεία, τη Διατροφή και την Ευεξία
Thu Jul 23, 2020 08:05

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