Objectives: Sociodemographic disparities in lung cancer prevalence, treatment options offered, and outcomes have been well documented. In stage I non–small cell lung cancer (NSCLC), the standard of care is surgical resection. This study explores disparities in surgical recommendations in stage I NSCLC, when surgery is considered curative. Materials and Methods: Patients diagnosed with primary stage I NSCLC from 2007 to 2016 were identified from the Surveillance, Epidemiology, and End...
Fri Jul 17, 2020 03:00
Thu Jul 23, 2020 15:51
British Journal of Cancer, Published online: 24 July 2020; doi:10.1038/s41416-020-1005-5Comment on: “UGT2B17 modifies drug response in chronic lymphocytic leukaemia”
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British Journal of Cancer, Published online: 24 July 2020; doi:10.1038/s41416-020-0992-6Progesterone receptor membrane component 1 promotes the growth of breast cancers by altering the phosphoproteome and augmenting EGFR/PI3K/AKT signalling
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British Journal of Cancer, Published online: 24 July 2020; doi:10.1038/s41416-020-0988-2Phase 1 safety and pharmacodynamic study of lenalidomide combined with everolimus in patients with advanced solid malignancies with efficacy signal in adenoid cystic carcinoma
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British Journal of Cancer, Published online: 24 July 2020; doi:10.1038/s41416-020-1006-4Reply to Comment on “UGT2B17 modifies drug response in chronic lymphocytic leukaemia”
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British Journal of Cancer, Published online: 23 July 2020; doi:10.1038/s41416-020-1000-xReflections on the upsurge of virtual cancer conferences during the COVID-19 pandemic
Thu Jul 23, 2020 03:00
Thu Jul 23, 2020 03:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Fri Jul 17, 2020 10:00
Background The goal of this study was to evaluate the morphology, immunoprofile, and management of renal oncocytoma (RO), hybrid oncocytic tumor (HOT), and chromophobe renal cell carcinoma (ChRCC). Methods Forty‐seven cases of RO, 7 cases of HOT, and 25 cases of ChRCC were included in the study. Tissue microarrays were prepared for immunohistochemical evaluation. Results Large sheets of cells with transverse vessels, and higher nuclear grade were seen more often in ChRCC than in RO or...
Wed Jul 22, 2020 16:53
Background The US American Society of Colposcopy and Cervical Pathology guidelines for cervical cancer screening have been largely adopted worldwide. Pooled high‐risk human papillomavirus (hrHPV) testing has been routinely used to risk‐stratify women who have atypical squamous cells of undetermined significance (ASC‐US) cytology. However, it has been reported that there are distinguished differences in the distribution of hrHPV genotypes between the Chinese and American populations. Methods...
Wed Jul 22, 2020 16:53
Abstract The effectiveness of current chemotherapies for cancer is gradually progressing; however, achieving a complete cure with chemotherapy is still difficult and has been the main goal for the treatment of advanced cancer. Drug resistance is one of the issues in cancer therapy; therefore, an increasing number of investigations regarding drug resistance have focused on the characteristics of cancer cells themselves. However, the interaction between the tumor microenvironment (TME) and cancer...
Thu Jul 23, 2020 17:59
Abstract This study examined the outcomes of recent confirmatory randomized controlled trials (RCTs) in phase 3 that were initiated between 2005 and 2017 for oncological drugs in the United States and identified several factors that were associated with the success of RCTs. Our regression analysis showed that studies with progression‐free survival or response rate as primary endpoint were more likely to succeed than studies with overall survival (odds ratio (OR)=2.94 and 6.23, respectively). The...
Thu Jul 23, 2020 20:54
Abstract On the 24th of April 2019, a symposium on Pediatric pharmacokinetics and dose predictions was held as a satellite meeting to the 10th Juvenile Toxicity Symposium. This symposium brought together scientists from academia, industry and clinical research organizations with the aim to update each other on the current knowledge on pediatric drug development. Through more knowledge on specific ontogeny profiles of drug metabolism and transporter proteins, integrated into physiologically based...
Thu Jul 23, 2020 20:54
Abstract The absorption, metabolism, and excretion (AME) profiles of KD101, currently under clinical development to treat obesity, were assessed in humans using accelerator mass spectrometry (AMS) after a single oral administration of KD101 at 400 mg and a microdose of 14C‐KD101 at ~35.2 μg with a total radioactivity of 6.81 kBq. The mean total recovery of administered radioactivity was 85.2% with predominant excretion in the urine (78.0%). The radio‐chromatographic metabolite profiling showed that...
Thu Jul 23, 2020 20:53
Abstract Interest in drug development for rare diseases has expanded dramatically since the Orphan Drug Act was passed in 1983, with 40% of new drug approvals in 2019 targeting orphan indications. However, limited quantitative understanding of natural history and disease progression hinders progress and increases the risks associated with rare disease drug development. Use of international data standards can assist in data harmonization and enable data exchange, integration into larger datasets,...
Thu Jul 23, 2020 20:53
Abstract To develop a novel pharmacogenetic genotyping panel, a multidisciplinary team evaluated available evidence and selected 29 genes implicated in interindividual drug response variability, including 130 sequence variants and additional copy number variants (CNVs). Of the 29 genes, 11 had guidelines published by the Clinical Pharmacogenetics Implementation Consortium. Targeted genotyping and CNV interrogation were accomplished by multiplex single‐base extension using the MassARRAY® platform...
Thu Jul 23, 2020 20:53
Abstract The use of digital health products has gained considerable interest as a new way to improve therapeutic research and development. While these products are being adopted by various industries and stakeholders, their incorporation in clinical trials has been slow due to a disconnect between the promises of digital products and potential risks in using these new technologies in the absence of regulatory support. The Foundation for the National Institutes of Health (FNIH) Biomarkers Consortium...
Thu Jul 23, 2020 20:51
Abstract Pediatric intensive care unit (PICU) patients are exposed to multiple medications and are at high risk for adverse drug reactions. Pharmacogenomic (PGx) testing could help decrease their risk of adverse reactions. Although whole blood is preferred for PGx testing, blood volume in this population is often limited. However, for patients on mechanical ventilation, tracheal secretions are abundant, frequently suctioned, and discarded. Thus, the aim of this pilot study was to determine if tracheal...
Thu Jul 23, 2020 20:51
Abstract Heart failure (HF) causes pathological changes in multiple organs, thus affecting the pharmacokinetics of drugs. The aim of this study was to investigate the pharmacokinetics of candesartan in HF patients while examining significant covariates and their related impact on estimated clearance using a population pharmacokinetics (Pop‐PK) modeling approach. Data from a prospective, multicenter study were used. Modeling and simulations were conducted using Nonlinear Mixed‐Effects Modeling (NONMEM)...
Thu Jul 23, 2020 20:51
Abstract Metformin may act renoprotective prior to kidney transplantation by reducing ischemia‐reperfusion injury (IRI). This study examined whether metformin pre‐ and postconditioning during ex vivo normothermic machine perfusion (NMP) of rat and porcine kidneys affect IRI. In the rat study, saline or 300 mg/kg metformin was administered orally twice the day before nephrectomy. After 15 min warm ischemia, kidneys were preserved with static cold storage for 24h. Thereafter, 90 min of NMP was performed...
Thu Jul 23, 2020 20:47
Publication date: September 2020Source: European Journal of Cancer, Volume 136Author(s): Laetitia Callec, Audrey Lardy-Cleaud, Lea Guerrini-Rousseau, Claire Alapetite, Laure Vignon, Pascal Chastagner, Didier Frappaz, Cecile Faure-Conter
Thu Jul 23, 2020 16:15
Publication date: Available online 23 July 2020Source: European Journal of Surgical OncologyAuthor(s): Quang Van Le, Duy Quoc Ngo, Toan Duc Tran, Quy Xuan Ngo
Thu Jul 23, 2020 16:03
ABSTRACT Biliary tract cancers have dismal prognoses even when cytotoxic chemotherapy is administered. There is an unmet need to develop precision treatment approaches using comprehensive genomic profiling. A total of 121 patients with biliary tract cancers were analyzed for circulating‐tumor DNA (ctDNA) and/or tissue‐based tumor DNA (tissue‐DNA) using clinical‐grade next‐generation sequencing: 71 patients (59%) had ctDNA; 90 (74%), tissue‐DNA; and 40 (33%), both. Efficacy of targeted therapeutic...
Thu Jul 23, 2020 14:52
Abstract Although receptor status included estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) of the primary breast tumors was related to the prognosis of breast cancer patients, little information is yet available on whether patient management and survival are impacted by receptor conversion in breast cancer metastases. Using data from the nation‐wide multicenter clinical epidemiology study of advanced breast cancer in China (NCT03047889), we...
Thu Jul 23, 2020 14:51
Abstract Hepatocellular carcinoma (HCC) is highly resistant to anticancer therapy and novel therapeutic strategies are needed. Chronotherapy may become a promising approach because it may improve the efficacy of antimitotic radiation and chemotherapy by considering timing of treatment. To date little is known about time‐of‐day dependent changes of proliferation and DNA damage in HCC. Using transgenic c‐myc/ transforming growth factor (TGFα) mice as HCC animal model we immunohistochemically demonstrated...
Thu Jul 23, 2020 14:50
Abstract Tumor microenvironment‐mechanics greatly affect tumor‐cell characteristics such as invasion and proliferation. We and others have previously shown that following chemotherapy, tumor cells shed more extracellular vesicles (EVs), leading to tumor growth and even spread, via angiogenesis and the mobilization of specific bone marrow derived cells contributing to metastasis. However, physical, mechanobiological, and mechanostructural changes at pre‐metastatic sites that may support tumor cell...
Thu Jul 23, 2020 14:50
Abstract We assessed the frequency that oncology drugs approved by the US Food and Drug Administration (FDA) based on a single arm study when there is already evidence of existing and available treatments. For this, we conducted a retrospective cross‐sectional analysis of FDA approved oncology drugs, based on a single arm study. All FDA announcements for all oncology drugs approved from May 2014 through June 2019 on a single‐arm trial were included. We then performed a systematic search in PubMed,...
Thu Jul 23, 2020 14:49
Abstract Antibodies targeting the human epidermal growth factor receptor (EGFR ) are used for the treatment of RAS wild‐type metastatic colorectal cancer. A significant proportion of patients remains unresponsive to this therapy. Here, we performed a reverse phase protein array‐based (phospho)protein analysis of 63 KRAS , NRAS , BRAF and PIK3CA wild‐type metastatic CRC tumours. Responses of tumours to anti‐EGFR therapy with cetuximab were recorded in patient‐derived xenograft (PDX) models. Unsupervised...
Thu Jul 23, 2020 14:48
Long non-coding RNA H19 was demonstrated to be significantly correlated with tumor metastasis. However, the specific functions of H19 in colorectal cancer (CRC) metastasis and the underlying mechanism are stil...
Wed Jul 22, 2020 03:00
Exosomal microRNAs (miRNAs or miRs) from bone marrow-derived mesenchymal stem cells (UCMSCs) have emerged as promising therapeutic strategies for cancer treatment. The current study aimed to elucidate the unde...
Wed Jul 22, 2020 03:00
Abstract Purpose Diffuse midline gliomas are rare midline CNS malignancies that primarily affect children but can also affect adults. While radiation is standard treatment, prognosis remains fatal. Furthermore, due to its sensitive anatomic location, many physicians have been reluctant to perform biopsies without potential for improved prognosis. However, recent advancements in molecular-targeted therapeutics have encouraged greater...
Thu Jul 23, 2020 03:00
Abstract Objective The great heterogeneity of meningiomas is challenging and we need to distinguish relevant subgroups. Spheno-orbital osteomeningiomas (SOOM) constitute a clinically specific entity, with slow-growing benign osteo-meningiomatous tumors, which recur after surgery in one fourth of cases. Neurosurgical daily practice, supported by the literature, shows that the vast majority of patients with SOOM are women, and we explored...
Thu Jul 23, 2020 03:00
Abstract Follicular lymphoma (FL) is an indolent, B-cell, non-Hodgkin’s lymphoma with varying cytological appearance and clinical behavior. The genetic hallmark of FL is the t(14;18) translocation, and as a germinal center derived entity it is also characterized by somatic hypermutation of the immunoglobulin heavy chain (IgH) gene. In an attempt to correlate this molecular signature with the cytological grading of FL, we have analyzed the IgH variable (IgVH), regions in all cytological...
Thu Jul 23, 2020 03:00
The assessment of organ motion is a crucial feature for prostate stereotactic body radiotherapy (SBRT). Rectal spacer may represent a helpful device in order to outdistance rectal wall from clinical target, bu...
Wed Jul 22, 2020 03:00
Chronic encapsulated intracerebral hematomas (CEIHs) are a rare, late complication of radiosurgery for intracranial AVM. We present 5 cases treated mostly by surgical excision and review the literature.
Wed Jul 22, 2020 03:00
Patient-specific quality assurance (QA) of high precision radiotherapy, such as intensity modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT), is an important step in treatment plan verification [1,2]. In general, the plan complexity relates to uncertainties in radiotherapy [3] and is defined as consisting of a large number of small and irregularly shaped beam segments created by a multi-leaf collimator (MLC). To assure the delivery accuracy of IMRT and VMAT, the American Association...
Thu Jul 23, 2020 03:00
Abstract Introduction Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase protein frequently overexpressed in cancer and has been linked to an increase in the stem cell population of tumors, resistance to therapy, and metastatic spread. Pharmacological FAK inhibition in pancreatic cancer has received increased attention over the last few years, either alone or in combination with other therapeutics including chemotherapy and...
Thu Jul 23, 2020 03:00
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