Related Articles Kynurenine and Tetrahydrobiopterin Pathways Crosstalk in Pain Hypersensitivity. Front Neurosci. 2020;14:620 Authors: Staats Pires A, Tan VX, Heng B, Guillemin GJ, Latini A Abstract Despite the identification of molecular mechanisms associated with pain persistence, no significant therapeutic improvements have been made. Advances in the understanding of the molecular mechanisms that induce pain hypersensitivity will allow the...
Thu Jul 23, 2020 18:56
Related Articles Investigation of Electrically Evoked Auditory Brainstem Responses to Multi-Pulse Stimulation of High Frequency in Cochlear Implant Users. Front Neurosci. 2020;14:615 Authors: Saeedi A, Hemmert W Abstract We investigated the effects of electric multi-pulse stimulation on electrically evoked auditory brainstem responses (eABRs). Multi-pulses with a high burst rate of 10,000 pps were assembled from pulses of 45-μs phase duration....
Thu Jul 23, 2020 18:56
Related Articles Associations of [18F]-APN-1607 Tau PET Binding in the Brain of Alzheimer's Disease Patients With Cognition and Glucose Metabolism. Front Neurosci. 2020;14:604 Authors: Lu J, Bao W, Li M, Li L, Zhang Z, Alberts I, Brendel M, Cumming P, Lu H, Xiao Z, Zuo C, Guan Y, Zhao Q, Rominger A Abstract Molecular imaging of tauopathies is complicated by the differing specificities and off-target binding properties of available radioligands...
Thu Jul 23, 2020 18:56
Related Articles Adolescent Vulnerability to Heightened Emotional Reactivity and Anxiety After Brief Exposure to an Obesogenic Diet. Front Neurosci. 2020;14:562 Authors: Vega-Torres JD, Azadian M, Rios-Orsini RA, Reyes-Rivera AL, Ontiveros-Angel P, Figueroa JD Abstract Background: Emerging evidence demonstrates that diet-induced obesity disrupts corticolimbic circuits underlying emotional regulation. Studies directed at understanding how obesity...
Thu Jul 23, 2020 18:56
Related Articles Risk of invasive prostate cancer and prostate cancer death in relatives of patients with prostatic borderline or in situ neoplasia: A nationwide cohort study. Cancer. 2020 Jul 22;: Authors: Xu X, Fallah M, Tian Y, Mukama T, Sundquist K, Sundquist J, Brenner H, Kharazmi E Abstract BACKGROUND: The question of whether having a family history of prostatic borderline or in situ neoplasia (PBISN) is associated with an increased...
Thu Jul 23, 2020 19:20
Related Articles The Adoption of Radiomics and machine learning improves the diagnostic processes of women with Ovarian MAsses (the AROMA pilot study). J Ultrasound. 2020 Jul 21;: Authors: Chiappa V, Bogani G, Interlenghi M, Salvatore C, Bertolina F, Sarpietro G, Signorelli M, Castiglioni I, Raspagliesi F Abstract PURPOSE: To develop and evaluate the performance of a radiomic and machine learning model applied to ultrasound images in predicting...
Thu Jul 23, 2020 19:20
Related Articles Characterizations of Cancer Gene Mutations in Chinese Metastatic Breast Cancer Patients. Front Oncol. 2020;10:1023 Authors: Tao Z, Li T, Feng Z, Liu C, Shao Y, Zhu M, Gong C, Wang B, Cao J, Wang L, Du Y, Lizaso A, Li B, Zhang J, Hu X Abstract Background: Breast cancer (BC) is a type of disease with high heterogeneity. Molecular profiling, by revealing the intrinsic nature of its various subtypes, has extensively improved...
Thu Jul 23, 2020 19:20
Related Articles Novel Potential Biomarkers Associated With Epithelial to Mesenchymal Transition and Bladder Cancer Prognosis Identified by Integrated Bioinformatic Analysis. Front Oncol. 2020;10:931 Authors: Wang C, Yang Y, Yin L, Wei N, Hong T, Sun Z, Yao J, Li Z, Liu T Abstract Bladder cancer (BC) is one of the most common malignancies in terms of incidence and recurrence worldwide. The aim of this study was to identify novel prognostic...
Thu Jul 23, 2020 19:20
Related Articles The use of cardiovascular magnetic resonance as an early non-invasive biomarker for cardiotoxicity in cardio-oncology. Cardiovasc Diagn Ther. 2020 Jun;10(3):610-624 Authors: Burrage MK, Ferreira VM Abstract Contemporary cancer therapy has resulted in significant survival gains for patients. However, many current and emerging cancer therapies have an associated risk of cardiotoxicity, either acutely or later in life. Regular...
Thu Jul 23, 2020 19:20
Related Articles Maintenance therapies in metastatic pancreatic cancer: present and future with a focus on PARP inhibitors. Ther Adv Med Oncol. 2020;12:1758835920937949 Authors: Hammel P, Vitellius C, Boisteau É, Wisniewski M, Colle E, Hilmi M, Dengremont C, Granier S, Turpin A, de Mestier L, Neuzillet C Abstract Metastatic pancreatic ductal adenocarcinomas (PDACs) are now more effectively controlled using chemotherapy combinations such...
Thu Jul 23, 2020 19:20
Related Articles Precision Detection Technology: Equipping Precision Oncology with Wings. J Oncol. 2020;2020:9068121 Authors: Bai R, Lv Z, Chen X, Guo H, Bai L, Tian H, Li W, Cui J Abstract In recent years, precision medical detection techniques experienced a rapid transformation from low-throughput to high-throughput genomic sequencing, from multicell promiscuous detection to single-cell precision sequencing. The emergence of liquid biopsy...
Thu Jul 23, 2020 19:20
Related Articles Immune checkpoint inhibitors for treatment of advanced gastric or gastroesophageal junction cancer: Current evidence and future perspectives. Chin J Cancer Res. 2020 Jun;32(3):287-302 Authors: Zhang Z, Xie T, Zhang X, Qi C, Shen L, Peng Z Abstract Despite the application of conventional therapies, the prognosis of advanced gastric cancer (GC) or gastroesophageal junction cancer (GEJC) is still poor. In recent years, immune...
Thu Jul 23, 2020 19:20
Related Articles Cognitive Impact of Calorie Restriction: A Narrative Review. J Am Med Dir Assoc. 2020 Jul 18;: Authors: Yu Q, Zou L, Kong Z, Yang L Abstract The impairment of cognitive function can cause substantial emotional and financial burdens. A recent global increasing trend in cognitive impairment and associated disorders has been observed, which will continue to grow as the population ages rapidly. As a nonpharmaceutical approach,...
Thu Jul 23, 2020 19:20
Related Articles Assessment of outcomes and novel immune biomarkers in metaplastic breast cancer: a single institution retrospective study. World J Surg Oncol. 2020 Jan 14;18(1):11 Authors: Morgan E, Suresh A, Ganju A, Stover DG, Wesolowski R, Sardesai S, Noonan A, Reinbolt R, VanDeusen J, Williams N, Cherian MA, Li Z, Young G, Palettas M, Stephens J, Liu J, Luff A, Ramaswamy B, Lustberg M Abstract BACKGROUND: Metaplastic breast cancer remains...
Thu Jul 23, 2020 19:20
Related Articles Addition of Bevacizumab to First-Line Palliative Chemotherapy in Patients with Metastatic Small Bowel Adenocarcinoma: A Population-Based Study. Target Oncol. 2019 12;14(6):699-705 Authors: Legué LM, van Erning FN, Bernards N, Lemmens VEPP, de Hingh IHJT, Creemers GJ Abstract BACKGROUND: Data about the use and effectiveness of targeted therapy in metastatic small bowel adenocarcinoma (SBA) are scarce. OBJECTIVE: The...
Thu Jul 23, 2020 19:20
Related Articles Outcomes After Urgent Thyroidectomy Following Rapid Control of Thyrotoxicosis in Graves' Disease are Similar to Those After Elective Surgery in Well-Controlled Disease. World J Surg. 2019 12;43(12):3051-3058 Authors: Ali A, Debono M, Balasubramanian SP Abstract BACKGROUND: Surgery for Graves' disease (GD) is usually performed after adequate control with medical treatment. Occasionally, rapid pre-operative optimization is required....
Thu Jul 23, 2020 19:20
Related Articles Lapatinib Activates the Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 Pathway in HepG2 Cells. Front Pharmacol. 2020;11:944 Authors: Roos NJ, Aliu D, Bouitbir J, Krähenbühl S Abstract The receptor tyrosine kinase inhibitor lapatinib, indicated to treat patients with HER2-positive breast cancer in combination with capecitabine, can cause severe hepatotoxicity. Lapatinib is further associated with...
Thu Jul 23, 2020 20:44
Related Articles Effectiveness of second-line anti-HER2 treatment in HER2-positive metastatic breast cancer patients previously treated with trastuzumab: A real-world study. Chin J Cancer Res. 2020 Jun;32(3):361-369 Authors: Zhao W, Bian L, Wang T, Zhang S, Li J, Xu F, Jiang Z Abstract Objective: Several studies have demonstrated different benefits for patients whose disease progressed despite previous trastuzumab treatment. Due to limited real-world...
Thu Jul 23, 2020 20:44
Related Articles Evaluation of Myelin Radiotracers in the Lysolecithin Rat Model of Focal Demyelination: Beware of Pitfalls! Contrast Media Mol Imaging. 2019;2019:9294586 Authors: Zhang M, Hugon G, Bouillot C, Bolbos R, Langlois JB, Billard T, Bonnefoi F, Li B, Zimmer L, Chauveau F Abstract The observation that amyloid radiotracers developed for Alzheimer's disease bind to cerebral white matter paved the road to nuclear imaging of myelin in...
Thu Jul 23, 2020 11:17
Related Articles Making Sense of the Noise: Toward Rational Treatment for Obstructive Sleep Apnea. Am J Respir Crit Care Med. 2020 Jul 22;: Authors: Kezirian EJ, Simmons M, Schwab RJ, Cistulli P, Li KK, Weaver EM, Goldberg AN, Malhotra A Abstract There has been a recent surge in the number of potential alternative therapies that have been proposed and marketed for adults with OSA. This Perspective finds that many of these alternatives do not...
Thu Jul 23, 2020 19:44
Related Articles Prevalence and associated factors in community-dwelling subjects - a population-based study. Rev Assoc Med Bras (1992). 2020 Jun;66(6):830-837 Authors: Cruz R, Garcia-Rosa M, Faria C Abstract OBJECTIVES To assess the prevalence of nocturia and identify factors associated with it in a community-dwelling population. METHODS A cross-sectional study was conducted in subjects aged 45 years or more and registered with a Family Doctor...
Thu Jul 23, 2020 19:44
Related Articles Translation and cultural adaptation of the Sleep Apnea Clinical Score for use in Brazil. J Bras Pneumol. 2020;46(5):e20190230 Authors: Lapas VSC, Faria AC, Rufino RL, Costa CHD Abstract OBJECTIVE: To translate the Sleep Apnea Clinical Score (SACS) into Brazilian Portuguese and adapt it to the cultural setting, validating it for use as a screening method for polysomnography and as a tool to quantify the risk of obstructive sleep...
Thu Jul 23, 2020 19:44
Related Articles Postoperative outcomes in patients with treatment-emergent central sleep apnea: a case series. J Anesth. 2020 Jul 21;: Authors: Barman RA, Fields AR, Eells AJ, Kouri I, Mansukhani MP, Gali B, Sprung J, Weingarten TN Abstract PURPOSE: Treatment-emergent central sleep apnea (TECSA) is a central sleep-related breathing disorder, characterized by either the persistence or emergence of central sleep apnea during the initiation of...
Thu Jul 23, 2020 19:44
Related Articles Consequences and Solutions for the Impact of Communication Impairment on Noninvasive Ventilation Therapy for Acute Respiratory Failure: A Focused Review. Crit Care Explor. 2020 Jun;2(6):e0121 Authors: Wong AI, Cheung PC, Happ MB, Gay PC, Collop NA Abstract Objectives: With over 2 million cases of acute respiratory failure in the United States per year, noninvasive ventilation has become a leading treatment modality, often supplanting...
Thu Jul 23, 2020 19:44
Related Articles Effects of CPAP on Blood Pressure and Sympathetic Activity in Patients With Diabetes Mellitus, Chronic Kidney Disease, and Resistant Hypertension. CJC Open. 2020 Jul;2(4):258-264 Authors: Ruzicka M, Knoll G, Leenen FHH, Leech J, Aaron SD, Hiremath S Abstract Background: Patients with obstructive sleep apnea (OSA) have increased sympathetic activity and frequently also have resistant hypertension (HTN). Treatment of OSA with...
Thu Jul 23, 2020 19:44
Related Articles Obstructive sleep apnea versus central sleep apnea: prognosis in systolic heart failure. Cardiovasc Diagn Ther. 2020 Jun;10(3):396-404 Authors: Hetland A, Vistnes M, Haugaa KH, Liland KH, Olseng M, Edvardsen T Abstract Background: In chronic heart failure (CHF), obstructive sleep apnea (OSA) and Cheyne-Stokes respiration (CSR) are associated with increased mortality. The present study aimed to evaluate the prognostic effect...
Thu Jul 23, 2020 19:44
Related Articles Alternative Approaches to Adenotonsillectomy and Continuous Positive Airway Pressure (CPAP) for the Management of Pediatric Obstructive Sleep Apnea (OSA): A Review. Sleep Disord. 2020;2020:7987208 Authors: Rana M, August J, Levi J, Parsi G, Motro M, DeBassio W Abstract Continuous positive airway pressure (CPAP) is considered first-line treatment in the management of pediatric patients without a surgically correctible cause of...
Thu Jul 23, 2020 19:44
Related Articles Plasma Homocysteine and Autonomic Nervous Dysfunction: Association and Clinical Relevance in OSAS. Dis Markers. 2020;2020:4378505 Authors: Liu L, Wu Q, Yan H, Zheng X, Zhou Q Abstract Objective: Elevated plasma homocysteine (Hcy) is an independent risk factor for cardiovascular diseases, but the precise mechanism of Hcy in cardiovascular disease remains elusive. This study is aimed at evaluating the association between Hcy levels...
Thu Jul 23, 2020 19:44
Related Articles RFC1 repeat expansion in Japanese patients with late-onset cerebellar ataxia. J Hum Genet. 2020 Jul 21;: Authors: Tsuchiya M, Nan H, Koh K, Ichinose Y, Gao L, Shimozono K, Hata T, Kim YJ, Ohtsuka T, Cortese A, Takiyama Y Abstract Recently, the expansion of an intronic AAGGG repeat in the replication factor C subunit 1 (RFC1) gene was reported to cause cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS). In...
Thu Jul 23, 2020 19:44
Related Articles Restarting CPAP Therapy for Sleep Apnea After a Previous Failure. Respir Care. 2020 Jul 21;: Authors: Avellan-Hietanen H, Maasilta P, Bachour A Abstract BACKGROUND: About one third of patients fail their first CPAP trial due to several factors. Despite its clinical importance, data on the success of CPAP re-initiation are scarce. METHODS: Of the 6,231 patients referred to our sleep unit for sleep apnea, we included...
Thu Jul 23, 2020 19:44
Related Articles Acute Pulmonary Edema in Healthy Subjects. Aerosp Med Hum Perform. 2020 Aug 01;91(8):662-668 Authors: Marabotti C, Cialoni D, Pingitore A Abstract INTRODUCTION: Healthy individuals may present with acute pulmonary edema when exposed to extreme environments (high-altitude or deep diving) or while performing strenuous exercises. Recent data support the hypothesis that these forms of acute pulmonary edema might be due to a limited...
Thu Jul 23, 2020 19:44
Related Articles Ictal Central Apnea (ICA) may be a useful semiological sign in invasive epilepsy surgery evaluations. Epilepsy Res. 2019 10;156:106164 Authors: Lacuey N, Hupp NJ, Hampson J, Lhatoo S Abstract INTRODUCTION: Ictal central apnea (ICA) occurs in up to 44% focal seizures (temporal > extratemporal) and precedes scalp electrographic (EEG) seizure onset in 54% of them. Central apnea can be elicited by electrical stimulation of mesial...
Thu Jul 23, 2020 19:44
Related Articles Uncertainty Evaluation in Measurement of the Personal dose Equivalent at Nine Individual Monitoring Services in Asia and the Pacific Region. Radiat Prot Dosimetry. 2020 Jul 22;: Authors: Rizk C, Askounis P, Okyar HB, Sangau JK, Baradaran S, Al Fares E, Shah BR, Munkhtsetseg B, Mitrayon L, Rathnayake M, Ali M Abstract This paper presents the results of the evaluation of the uncertainty in measurement of the personal dose...
Thu Jul 23, 2020 22:05
Related Articles Characterization of Exposure to Electromagnetic Emissions from Public Mobile Systems Using the Time-Averaged and Integral-Based Measure. Radiat Prot Dosimetry. 2020 Jul 22;: Authors: Šuka D, Pejović P, Simić-Pejović M Abstract Since radio frequency (RF) signals from public mobile systems are stochastic and exhibit large temporal variations, the results of measurements, typically E field measurements, are time dependent...
Thu Jul 23, 2020 22:05
Related Articles Toward National CT Diagnostic Reference Levels in the United Arab Emirates: A Multicenter Review of CT Dose Index and Dose Area Product. Radiat Prot Dosimetry. 2020 Jul 22;: Authors: Abuzaid MM, Elshami W, El Serafi A, Hussien T, McConnell JR, Tekin HO Abstract This multicenter study evaluated computed tomography dose index volume (CTDIvol) and dose length product (DLP) to contribute to establishing computed tomography...
Thu Jul 23, 2020 22:05
Related Articles Strabismus Surgery in Thyroid-Associated Ophthalmopathy; Surgical Outcomes and Surgical Dose Responses. J Binocul Vis Ocul Motil. 2020 Jul 21;:1-7 Authors: Akbari M, Bayat R, Mirmohammadsadeghi A, Mahmoudzadeh R, Eshraghi B, Salabati M Abstract PURPOSE: To investigate the success rate and surgical dose responses in strabismus surgery of thyroid-associated ophthalmopathy (TAO). METHODS: Thirty-three patients (26...
Thu Jul 23, 2020 20:32
Related Articles 125I radioactive seed localization for non-palpable lesions in breast cancer. Rev Esp Med Nucl Imagen Mol. 2019 Nov - Dec;38(6):343-347 Authors: Sánchez Sánchez R, González Jiménez AD, Rebollo Aguirre AC, Mendoza Arnau I, Menjón Beltrán S, Vergara Alcaide ME, Osorio Ceballos JL, Llamas Elvira JM Abstract AIM: Marking of non-palpable breast lesions with 125I radioactive seeds is an alternative to the use of the surgical wire....
Thu Jul 23, 2020 20:32
Related Articles The coracoglenoid notch: anatomy and clinical significance. Surg Radiol Anat. 2020 Jul 21;: Authors: Strnad T, Bartoníček J, Naňka O, Tuček M Abstract INTRODUCTION: The superior surface of the anatomical neck is presented in the classification of scapular fractures as a 2-cm-long structure, which does not correspond to reality. This issue has not yet been adequately addressed in the literature. The aim of the study was...
Thu Jul 23, 2020 21:30
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