IJMS, Vol. 21, Pages 5233: Induced Periosteum-Mimicking Membrane with Cell Barrier and Multipotential Stromal Cell (MSC) Homing Functionalities International Journal of Molecular Sciences doi: 10.3390/ijms21155233 Authors: Heather E. Owston Katrina M. Moisley Giuseppe Tronci Stephen J. Russell Peter V. Giannoudis Elena Jones The current management of critical size bone defects (CSBDs) remains challenging and requires multiple surgeries. To reduce the number of surgeries,...
Thu Jul 23, 2020 03:00
IJMS, Vol. 21, Pages 5226: Whole-Genome-Based Survey for Polyphyletic Serovars of Salmonella enterica subsp. enterica Provides New Insights into Public Health Surveillance International Journal of Molecular Sciences doi: 10.3390/ijms21155226 Authors: Zhiqiu Yin Jiaheng Liu Binghai Du Hai-Hua Ruan Yi-Xin Huo Yuhui Du Jianjun Qiao Serotyping has traditionally been considered the basis for surveillance of Salmonella, but it cannot distinguish distinct lineages sharing...
Thu Jul 23, 2020 03:00
IJMS, Vol. 21, Pages 5232: Molecular Targets, Pathways, and Therapeutic Implications for Hepatocellular Carcinoma International Journal of Molecular Sciences doi: 10.3390/ijms21155232 Authors: Jun Gong Jeremy Chuang May Cho Kyra Toomey Andrew Hendifar Daneng Li Hepatocellular carcinoma (HCC) represents one of the leading causes of cancer mortality worldwide. While significant advances have been made for the treatment of advanced hepatocellular carcinoma in the past few...
Thu Jul 23, 2020 03:00
IJMS, Vol. 21, Pages 5224: Potential Anti-COVID-19 Therapeutics that Block the Early Stage of the Viral Life Cycle: Structures, Mechanisms, and Clinical Trials International Journal of Molecular Sciences doi: 10.3390/ijms21155224 Authors: Rami A. Al-Horani Srabani Kar Kholoud F. Aliter The ongoing pandemic of coronavirus disease-2019 (COVID-19) is being caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The disease continues to present significant challenges...
Thu Jul 23, 2020 03:00
IJMS, Vol. 21, Pages 5227: Extracellular Nucleotides Selectively Induce Migration of Chondrocytes and Expression of Type II Collagen International Journal of Molecular Sciences doi: 10.3390/ijms21155227 Authors: Marcin Szustak Edyta Gendaszewska-Darmach The migration of chondrocytes from healthy to injured tissues is one of the most important challenges during cartilage repair. Additionally, maintenance of the chondrogenic phenotype remains another limitation, especially during monolayer...
Thu Jul 23, 2020 03:00
IJMS, Vol. 21, Pages 5219: Cell-Based Therapeutic Approaches for Cystic Fibrosis International Journal of Molecular Sciences doi: 10.3390/ijms21155219 Authors: Pascal Duchesneau Thomas K. Waddell Golnaz Karoubi Cystic Fibrosis (CF) is a chronic autosomal recessive disease caused by defects in the cystic fibrosis transmembrane conductance regulator gene (CFTR). Cystic Fibrosis affects multiple organs but progressive remodeling of the airways, mucus accumulation, and chronic inflammation...
Thu Jul 23, 2020 03:00
IJMS, Vol. 21, Pages 5223: Primary Humoral Immune Deficiencies: Overlooked Mimickers of Chronic Immune-Mediated Gastrointestinal Diseases in Adults International Journal of Molecular Sciences doi: 10.3390/ijms21155223 Authors: Ida Judyta Malesza Michał Malesza Iwona Krela-Kaźmierczak Aleksandra Zielińska Eliana B. Souto Agnieszka Dobrowolska Piotr Eder In recent years, the incidence of immune-mediated gastrointestinal disorders, including celiac disease (CeD) and inflammatory...
Thu Jul 23, 2020 03:00
IJMS, Vol. 21, Pages 5221: The Effect of Novel 7-methyl-5-phenyl-pyrazolo[4,3-e]tetrazolo[4,5-b][1,2,4]triazine Sulfonamide Derivatives on Apoptosis and Autophagy in DLD-1 and HT-29 Colon Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms21155221 Authors: Agnieszka Gornowicz Anna Szymanowska Mariusz Mojzych Krzysztof Bielawski Anna Bielawska The discovery of cytotoxic drugs is focused on designing a compound structure that directly affects cancer cells...
Thu Jul 23, 2020 03:00
IJMS, Vol. 21, Pages 5222: lncRNA_Mdeep: An Alignment-Free Predictor for Distinguishing Long Non-Coding RNAs from Protein-Coding Transcripts by Multimodal Deep Learning International Journal of Molecular Sciences doi: 10.3390/ijms21155222 Authors: Xiao-Nan Fan Shao-Wu Zhang Song-Yao Zhang Jin-Jie Ni Long non-coding RNAs (lncRNAs) play crucial roles in diverse biological processes and human complex diseases. Distinguishing lncRNAs from protein-coding transcripts is a fundamental...
Thu Jul 23, 2020 03:00
IJMS, Vol. 21, Pages 5218: Investigation of Strand-Selective Interaction of SNA-Modified siRNA with AGO2-MID International Journal of Molecular Sciences doi: 10.3390/ijms21155218 Authors: Yukiko Kamiya Yuuki Takeyama Tomonari Mizuno Fuminori Satoh Hiroyuki Asanuma Small interfering RNA (siRNA) has been recognized as a powerful gene-silencing tool. For therapeutic application, chemical modification is often required to improve the properties of siRNA, including its nuclease...
Thu Jul 23, 2020 03:00
IJMS, Vol. 21, Pages 5220: The Association of Free Fatty Acids and Eicosanoids with the Severity of Depressive Symptoms in Stroke Patients International Journal of Molecular Sciences doi: 10.3390/ijms21155220 Authors: Dariusz Kotlega Agnieszka Zembron-Lacny Monika Golab-Janowska Przemyslaw Nowacki Malgorzata Szczuko The study was designed to demonstrate the relationship of free fatty acids (FFAs) and eicosanoids levels with the severity of depressive symptoms in stroke. The...
Thu Jul 23, 2020 03:00
IJMS, Vol. 21, Pages 5217: Characteristics of Circular RNA Expression Profiles of Porcine Granulosa Cells in Healthy and Atretic Antral Follicles International Journal of Molecular Sciences doi: 10.3390/ijms21155217 Authors: Li Meng Katja Teerds Jian Tao Hengxi Wei Marcel Jaklofsky Zhihong Zhao Yaodi Liang Li Li Chi Chiu Wang Shouquan Zhang Circular RNAs (circRNAs) are thought to play essential roles in multiple biological processes, including apoptosis, an...
Thu Jul 23, 2020 03:00
IJMS, Vol. 21, Pages 5215: A Tissue-Engineered Human Psoriatic Skin Model to Investigate the Implication of cAMP in Psoriasis: Differential Impacts of Cholera Toxin and Isoproterenol on cAMP Levels of the Epidermis International Journal of Molecular Sciences doi: 10.3390/ijms21155215 Authors: Mélissa Simard Sophie Morin Geneviève Rioux Rachelle Séguin Estelle Loing Roxane Pouliot Pathological and healthy skin models were reconstructed using similar culture conditions according...
Thu Jul 23, 2020 03:00
IJMS, Vol. 21, Pages 5216: Cx43 in Neural Progenitors Promotes Glioma Invasion in a 3D Culture System International Journal of Molecular Sciences doi: 10.3390/ijms21155216 Authors: Kanika Khosla Christian C. Naus Wun Chey Sin The environment that envelops the cancer cells intimately affects the malignancy of human cancers. In the case of glioma, an aggressive adult brain cancer, its high rate of recurrence after total resection is responsible for a poor prognosis. Connexin43 (Cx43)...
Thu Jul 23, 2020 03:00
IJMS, Vol. 21, Pages 5214: Gut Microbiota Metabolites in NAFLD Pathogenesis and Therapeutic Implications International Journal of Molecular Sciences doi: 10.3390/ijms21155214 Authors: Jiezhong Chen Luis Vitetta Gut microbiota dysregulation plays a key role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) through its metabolites. Therefore, the restoration of the gut microbiota and supplementation with commensal bacterial metabolites can be of therapeutic benefit against...
Thu Jul 23, 2020 03:00
IJMS, Vol. 21, Pages 5209: The Role of the RNA-Binding Protein Family MEX-3 in Tumorigenesis International Journal of Molecular Sciences doi: 10.3390/ijms21155209 Authors: Simon Jasinski-Bergner André Steven Barbara Seliger The muscle excess 3 (MEX-3) protein was first identified in Caenorhabditis elegans (C. elegans), and its respective homologues were also observed in vertebrates, including humans. It is a RNA-binding protein (RBP) with an additional ubiquitin E3 ligase function,...
Thu Jul 23, 2020 03:00
IJMS, Vol. 21, Pages 5213: The In Vitro Effect of Prostaglandin E2 and F2α on the Chemerin System in the Porcine Endometrium during Gestation International Journal of Molecular Sciences doi: 10.3390/ijms21155213 Authors: Kamil Dobrzyn Marta Kiezun Ewa Zaobidna Katarzyna Kisielewska Edyta Rytelewska Marlena Gudelska Grzegorz Kopij Kinga Bors Karolina Szymanska Barbara Kaminska Tadeusz Kaminski Nina Smolinska Chemerin belongs to the group of adipocyte-derived...
Thu Jul 23, 2020 03:00
IJMS, Vol. 21, Pages 5212: Early-Life Maternal Deprivation Predicts Stronger Sickness Behaviour and Reduced Immune Responses to Acute Endotoxaemia in a Pig Model International Journal of Molecular Sciences doi: 10.3390/ijms21155212 Authors: Roberto Brückmann Margret Tuchscherer Armin Tuchscherer Ulrike Gimsa Ellen Kanitz Early-life adversity may have programming effects on neuroendocrine and immune adaptation mechanisms in humans and socially living animals. Using a pig model,...
Thu Jul 23, 2020 03:00
IJMS, Vol. 21, Pages 5210: Unusual Occurrence of Two Bona-Fide CCA-Adding Enzymes in Dictyostelium discoideum International Journal of Molecular Sciences doi: 10.3390/ijms21155210 Authors: Lieselotte Erber Anne Hoffmann Jörg Fallmann Monica Hagedorn Christian Hammann Peter F. Stadler Heike Betat Sonja Prohaska Mario Mörl Dictyostelium discoideum, the model organism for the evolutionary supergroup of Amoebozoa, is a social amoeba that, upon starvation, undergoes...
Thu Jul 23, 2020 03:00
IJMS, Vol. 21, Pages 5211: Pt-, Rh-, Ru-, and Cu-Single-Wall Carbon Nanotubes Are Exceptional Candidates for Design of Anti-Viral Surfaces: A Theoretical Study International Journal of Molecular Sciences doi: 10.3390/ijms21155211 Authors: Aref Aasi Sadegh M Aghaei Matthew D. Moore Balaji Panchapakesan As SARS-CoV-2 is spreading rapidly around the globe, adopting proper actions for confronting and protecting against this virus is an essential and unmet task. Reactive oxygen species...
Thu Jul 23, 2020 03:00
IJMS, Vol. 21, Pages 5207: Tumor-Associated Macrophages in Osteosarcoma: From Mechanisms to Therapy International Journal of Molecular Sciences doi: 10.3390/ijms21155207 Authors: Francesca Cersosimo Silvia Lonardi Giulia Bernardini Brian Telfer Giulio Eugenio Mandelli Annalisa Santucci William Vermi Emanuele Giurisato Osteosarcomas (OSs) are bone tumors most commonly found in pediatric and adolescent patients characterized by high risk of metastatic progression and...
Thu Jul 23, 2020 03:00
IJMS, Vol. 21, Pages 5208: ROS Homeostasis in Abiotic Stress Tolerance in Plants International Journal of Molecular Sciences doi: 10.3390/ijms21155208 Authors: Kalaivani K. Nadarajah Climate change-induced abiotic stress results in crop yield and production losses. These stresses result in changes at the physiological and molecular level that affect the development and growth of the plant. Reactive oxygen species (ROS) is formed at high levels due to abiotic stress within different organelles,...
Thu Jul 23, 2020 03:00
IJMS, Vol. 21, Pages 5206: The Background K+ Channel TRESK in Sensory Physiology and Pain International Journal of Molecular Sciences doi: 10.3390/ijms21155206 Authors: Alba Andres-Bilbe Aida Castellanos Anna Pujol-Coma Gerard Callejo Nuria Comes Xavier Gasull TRESK belongs to the K2P family of potassium channels, also known as background or leak potassium channels due to their biophysical properties and their role regulating membrane potential of cells. Several studies...
Thu Jul 23, 2020 03:00
IJMS, Vol. 21, Pages 5205: HLA-B*44 and C*01 Prevalence Correlates with Covid19 Spreading across Italy International Journal of Molecular Sciences doi: 10.3390/ijms21155205 Authors: Pierpaolo Correale Luciano Mutti Francesca Pentimalli Giovanni Baglio Rita Emilena Saladino Pierpaolo Sileri Antonio Giordano The spread of COVID-19 is showing huge, unexplained, differences between northern and southern Italy. We hypothesized that the regional prevalence of specific class...
Thu Jul 23, 2020 03:00
IJMS, Vol. 21, Pages 5204: Oxidized Oligosaccharides Stabilize Rehydrated Sea Cucumbers against High-Temperature Impact International Journal of Molecular Sciences doi: 10.3390/ijms21155204 Authors: Jingyi Liu Yanan Xu Tianhang Xia Changhu Xue Li Liu Pengtao Chang Dongfeng Wang Xun Sun Small-molecule crosslinkers could diffuse into and stabilize protein hydrogels without damaging their appearance, but they are absent from the food industry due to the high safety...
Thu Jul 23, 2020 03:00
JCDD, Vol. 7, Pages 27: Early Embryonic Expression of AP-2α Is Critical for Cardiovascular Development Journal of Cardiovascular Development and Disease doi: 10.3390/jcdd7030027 Authors: Amy-Leigh Johnson Jürgen E. Schneider Timothy J. Mohun Trevor Williams Shoumo Bhattacharya Deborah J. Henderson Helen M. Phillips Simon D. Bamforth Congenital cardiovascular malformation is a common birth defect incorporating abnormalities of the outflow tract and aortic arch arteries,...
Thu Jul 23, 2020 03:00
JCM, Vol. 9, Pages 2362: Rapid Phenotype-Driven Gene Sequencing with the NeoSeq Panel: A Diagnostic Tool for Critically Ill Newborns with Suspected Genetic Disease Journal of Clinical Medicine doi: 10.3390/jcm9082362 Authors: María José de Castro Emiliano González-Vioque Sofía Barbosa-Gouveia Enrique Salguero Segundo Rite Olalla López-Suárez Alejandro Pérez-Muñuzuri María-Luz Couce New genomic sequencing techniques have shown considerable promise in the field of...
Thu Jul 23, 2020 03:00
JCM, Vol. 9, Pages 2360: Efficacy of Modified Treat-and-Extend Aflibercept Regimen for Macular Edema Due to Branch Retinal Vein Occlusion: 1-Year Prospective Study Journal of Clinical Medicine doi: 10.3390/jcm9082360 Authors: Yusuke Arai Hidenori Takahashi Satoru Inoda Shinichi Sakamoto Xue Tan Yuji Inoue Satoko Tominaga Hidetoshi Kawashima Yasuo Yanagi Purpose: To assess the efficacy and safety of a modified treat-and-extend (mTAE) regimen of aflibercept for...
Thu Jul 23, 2020 03:00
JCM, Vol. 9, Pages 2361: Platelet Functions during Extracorporeal Membrane Oxygenation. Platelet–Leukocyte Aggregates Analyzed by Flow Cytometry as a Promising Tool to Monitor Platelet Activation Journal of Clinical Medicine doi: 10.3390/jcm9082361 Authors: Mansour Roussel Gaussem Nédelec-Gac Pontis Flécher Bachelot-Loza Gouin-Thibault Extracorporeal membrane oxygenation (ECMO) is an extracorporeal circulation used to manage patients with severe circulatory...
Thu Jul 23, 2020 03:00
JCM, Vol. 9, Pages 2349: Mitochondrial DNA: Hotspot for Potential Gene Modifiers Regulating Hypertrophic Cardiomyopathy Journal of Clinical Medicine doi: 10.3390/jcm9082349 Authors: Parisa K. Kargaran Jared M. Evans Sara E. Bodbin James G. W. Smith Timothy J. Nelson Chris Denning Diogo Mosqueira Hypertrophic cardiomyopathy (HCM) is a prevalent and untreatable cardiovascular disease with a highly complex clinical and genetic causation. HCM patients bearing similar sarcomeric...
Thu Jul 23, 2020 03:00
JCM, Vol. 9, Pages 2359: Endothelial Dysfunction in Chronic Kidney Disease, from Biology to Clinical Outcomes: A 2020 Update Journal of Clinical Medicine doi: 10.3390/jcm9082359 Authors: Roumeliotis Mallamaci Zoccali The vascular endothelium is a dynamic, functionally complex organ, modulating multiple biological processes, including vascular tone and permeability, inflammatory responses, thrombosis, and angiogenesis. Endothelial dysfunction is a threat to the integrity of...
Thu Jul 23, 2020 03:00
JCM, Vol. 9, Pages 2358: Brain Stimulation in Eating Disorders: State of the Art and Future Perspectives Journal of Clinical Medicine doi: 10.3390/jcm9082358 Authors: Duriez Bou Khalil Chamoun Maatoug Strumila Seneque Gorwood Courtet Guillaume The management of eating disorders (EDs) is still difficult and few treatments are effective. Recently, several studies have described the important contribution of non-invasive brain stimulation (repetitive transcranial...
Thu Jul 23, 2020 03:00
JCM, Vol. 9, Pages 2353: Clinical Response and Changes of Cytokines and Zonulin Levels in Patients with Diarrhoea-Predominant Irritable Bowel Syndrome Treated with Bifidobacterium Longum ES1 for 8 or 12 Weeks: A Preliminary Report Journal of Clinical Medicine doi: 10.3390/jcm9082353 Authors: Gian Paolo Caviglia Alessandra Tucci Rinaldo Pellicano Sharmila Fagoonee Chiara Rosso Maria Lorena Abate Antonella Olivero Angelo Armandi Ester Vanni Giorgio Maria Saracco Elisabetta...
Thu Jul 23, 2020 03:00
JCM, Vol. 9, Pages 2352: Prevention and Management of CMV Infections after Liver Transplantation: Current Practice in German Transplant Centers Journal of Clinical Medicine doi: 10.3390/jcm9082352 Authors: Cornelius Engelmann Martina Sterneck Karl Heinz Weiss Silke Templin Steffen Zopf Gerald Denk Dennis Eurich Johann Pratschke Johannes Weiss Felix Braun Martin-Walter Welker Tim Zimmermann Petra Knipper Dirk Nierhoff Thomas Lorf Elmar Jäckel Hans-Michael...
Thu Jul 23, 2020 03:00
JCM, Vol. 9, Pages 2351: Gender Differences in Association between Air Pollution and Daily Mortality in the Capital of the Green Lungs of Poland–Population-Based Study with 2,953,000 Person-Years of Follow-Up Journal of Clinical Medicine doi: 10.3390/jcm9082351 Authors: Łukasz Kuźma Krzysztof Struniawski Szymon Pogorzelski Hanna Bachórzewska-Gajewska Sławomir Dobrzycki (1) Introduction: air pollution is considered to be one of the main risk factors for public health. According...
Thu Jul 23, 2020 03:00
JCM, Vol. 9, Pages 2350: Adaptive Designs: Lessons for Inflammatory Bowel Disease Trials Journal of Clinical Medicine doi: 10.3390/jcm9082350 Authors: Ferdinando D'Amico Silvio Danese Laurent Peyrin-Biroulet In recent decades, scientific research has considerably evolved in the field of inflammatory bowel diseases (IBD) and clinical studies have become increasingly complex, including new outcomes, different study populations, and additional techniques of re-randomization and centralized...
Thu Jul 23, 2020 03:00
JCM, Vol. 9, Pages 2356: Reduced Recovery Capacity after Major Trauma in the Elderly: Results of a Prospective Multicenter Registry-Based Cohort Study Journal of Clinical Medicine doi: 10.3390/jcm9082356 Authors: Freigang Müller Ernstberger Kaltenstadler Bode Pfeifer Alt Baumann Aims: Considering the worldwide trend of an increased lifetime, geriatric trauma is moving into focus. Trauma is a leading cause of hospitalization, leading to disability and mortality....
Thu Jul 23, 2020 03:00
JCM, Vol. 9, Pages 2355: Feasibility of Using the Epidural Space Detecting Device (EPI-DetectionTM) for Interlaminar Cervical Epidural Injection Journal of Clinical Medicine doi: 10.3390/jcm9082355 Authors: Kang Park Kim Kim Kim Jeon Kim Shin Cervical epidural injection (CEI), which is widely used for the treatment of cervical radiculopathy, sometimes has been associated with post-operative complications. Recently, EPI-DetectionTM, which detects the negative...
Thu Jul 23, 2020 03:00
JCM, Vol. 9, Pages 2354: Allogeneic Stem Cell Transplantation in Relapsed/Refractory Multiple Myeloma Treatment: Is It Still Relevant? (Running Title: The Role of Salvage alloSCT in MM) Journal of Clinical Medicine doi: 10.3390/jcm9082354 Authors: Hyunkyung Park Ja Min Byun Sung-Soo Yoon Youngil Koh Dong-Yeop Shin Junshik Hong Inho Kim Background: Despite offering an attractive option, the role of allogeneic stem cell transplantation (alloSCT) for treatment of multiple...
Thu Jul 23, 2020 03:00
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