Abstract Central skull base osteomyelitis has an infective pathology located in the deep‐seated regions of the skull base, close to critical neurovascular structures. The disease has significant morbidity and mortality risks associated with it especially if early specific management is not initiated. The diagnostic and therapeutic challenges are in identifying the causative organisms and administering specific antimicrobial therapy on a long‐term basis. The routine nasopharyngeal...
Fri Aug 07, 2020 17:29
Related Articles Posterior semi-circular canal electrode misplacement in Goldenhar's syndrome. Cochlear Implants Int. 2020 Aug 06;:1-5 Authors: Castellino A, Rayamajhi P, Kurkure R, Kameswaran M Abstract Literature documents the incidence of electrode misplacement within the range of 0.2% to 5.8% with the superior SCC as the most common site, followed by the vestibule. In this report, we present the finding of electrode misplacement in...
Sun Aug 09, 2020 14:53
Background and Objectives Non‐invasive skin tightening devices have become a safe and non‐invasive treatment for patients with skin laxity of the upper arm. The efficacy of microfocused ultrasound with visualization (MFU‐V) in skin tightening had been demonstrated in several studies. This study aimed to evaluate the efficacy and safety of MFU‐V in treating skin laxity of the upper arm using different treatment protocols. Study Design/Materials and Methods Thirty patients with upper arm laxity...
Sat Aug 08, 2020 14:18
Background and Objectives While optical imaging is a useful technique to quantitate morphological differences and treatment effects, comparative investigations of the various techniques are lacking. This study aimed at evaluating intermethod agreement, reliability, and technical limitations of wide‐field microscopy (WFM), reflectance confocal microscopy (RCM), and optical coherence tomography (OCT) for morphometry by assessing fractionally ablated nail tissue. Study Design/Materials and Methods...
Sat Aug 08, 2020 14:17
Background and Objectives To compare the efficacy of autologous platelet‐rich plasma (PRP), ablative fractional carbon dioxide (FCO2) laser, and their combination in the treatment of atrophic acne scars, both clinically and immuno‐histopathologically. Study Design/Materials and Methods Sixty patients were randomly divided into three equal groups. Group 1 received intradermal PRP injection sessions. Group 2 received FCO2 laser sessions. Group 3 received FCO2 laser followed by intradermal PRP...
Sat Aug 08, 2020 14:16
Extended-spectrum beta-lactamase (ESBL)-producing Gram-negative bacteria have become a serious threat to global health. Their rapid spread is associated with high mortality due to ineffective antibiotic treatm...
Sat Aug 08, 2020 03:00
Hand sanitisers are urgently needed in the time of COVID-19, and as a result of shortages, some people have resorted to making their own formulations, including the repurposing of distilleries. We wish to high...
Sat Aug 08, 2020 03:00
Set‐up of the laboratory experiment. Trials were four minutes during which behavioral reactions were recorded and categorized. Abstract Predator odors such as urine and feces are known to elicit antipredator behaviors in prey including avoidance, fear, and curiosity. We measured how wild brown mouse lemurs (Microcebus rufus ) responded to odors of mammalian, avian, and snake predators as well as nonpredator controls. The first experiment took place under controlled conditions in a laboratory...
Sat Aug 08, 2020 22:00
Abstract Background Long‐term changes in masticatory function, oral health‐related quality of life (OHRQoL), and prosthetic complications in implant‐retained mandibular overdenture (IMO) wearers as a function of bone atrophy require detailed investigations. Objective Investigating the evolution of masticatory function, OHRQoL, and prosthetic occurrences of IMO wearers according to mandibular bone atrophy over 3 years of usage. Methods This study evaluated 26 IMO wearers after 2 and...
Sat Aug 08, 2020 21:08
Abstract Background There is a balance between adipogenic and osteogenic differentiation of human adipose‐derived stem cells (hASCs). It is essential to explore the mechanism of hASCs lineage commitment. In our previous study, UNC‐5 netrin receptor B (UNC5B) was identified as a positive regulator for osteogenesis. Objective To further explore the potential roles and mechanisms of UNC5B during adipogenic differentiation, and to provide a new method to regulate adipogenesis and osteogenesis...
Thu Aug 06, 2020 22:44
Abstract Background Psychosocial wellbeing is an important determinant for patients` oral health‐related quality of life (OHRQoL). Psychosocial Impact (PI), together with the dimensions Oral Function, Orofacial Pain, and Orofacial Appearance, have been proposed to cover the different areas of OHRQoL. Objective The objective of the study was to collect further scientific support for the new four‐dimensional structure of OHRQoL. This study is one out of a series of four and focuses on the...
Thu Aug 06, 2020 18:22
Abstract Dispersal is well recognised as a major driver of evolutionary processes in local populations. Nevertheless, dispersal abilities should also be perceived as a life history trait, being subject to evolutionary changes in response to various drivers. Empirical studies investigating these drivers rarely consider that they may influence male and female dispersal differently. The purpose of our study was to document intersexual differences in density‐dependent emigration from local habitat patches....
Sat Aug 08, 2020 18:21
Abstract Reproductive interference (costly interspecific sexual interactions) are well‐understood to promote divergence in mating‐relevant traits (i.e. reproductive character displacement: RCD), but it can also reduce population growth, eventually leading to local extinction of one of the species. The ecological and evolutionary processes driven by reproductive interference can interact with each other. These interactions are likely to influence whether the outcome is co‐existence or extinction,...
Thu Aug 06, 2020 11:04
Abstract To assess the difference in smile esthetic impact of Coronally Advanced Flap (CAF) with or without the adjunct of a collagen matrix (CMX) used as root coverage procedures. Subjects with esthetic demands showing multiple upper gingival recessions of at least 2 mm, without interproximal attachment loss and cervical abrasion no more than 1 mm were recruited and randomized to CAF plus CMX or CAF alone. The Smile Esthetic Index (SEI) was adopted to quantify the quality of...
Sun Aug 09, 2020 03:00
Abstract To investigate the effect of benzalkonium chloride (BAC) addition to ethylenediaminetetraacetic acid (EDTA) on transforming growth factor-β1 (TGF-β1) release, as well as attachment and proliferation of dental pulp stem cells (DPSCs) on dentin. A total of standard 268 human dentin disks were prepared and immersed in 1.5% sodium hypochlorite (NaOCl) for 5 min. The disks were rinsed with distilled water and randomly divided into seven groups. In control group, the disks...
Fri Aug 07, 2020 03:00
Many animals rely heavily on olfaction to navigate their environment. Among rodents, olfaction is crucial for a wide range of social behaviors. The vomeronasal olfactory system in particular plays an important...
Sat Aug 08, 2020 03:00
Convergent and parallel evolution provide unique insights into the mechanisms of natural selection. Some of the most striking convergent and parallel (collectively recurrent) amino acid substitutions in proteins ...
Sat Aug 08, 2020 03:00
Was there a mid-Cenozoic vertebrate extinction and recovery event in Madagascar and, if so, what are its implications for the evolution of lemurs? The near lack of an early and mid-Cenozoic fossil record on Ma...
Sat Aug 08, 2020 03:00
Abstract Rationale Opioid abuse remains a serious public health problem. The pseudoirreversible mu opioid receptor antagonist methocinnamox (MCAM) might be useful for treating opioid abuse and overdose. Because endogenous opioid systems can modulate cognition and decision-making, it is important to evaluate whether long-term blockade of mu opioid receptors by MCAM adversely impacts complex operant behavior involving memory. ...
Sun Aug 09, 2020 03:00
Abstract Rationale The amygdala is a key brain structure to study in relation to cannabis use as reflected by its high-density of cannabinoid receptors and functional reactivity to processes relevant to drug use. Previously, we identified a correlation between cannabis use in early adolescence and amygdala hyper-reactivity to angry faces (Spechler et al. 2015). Objectives ...
Sat Aug 08, 2020 03:00
Abstract Rationale and objective The adenosine A(2A) receptor forms a mutually inhibitory heteromer with the dopamine D2 receptor, and A(2A) agonists decrease D2 signaling. This study analyzed whether an adenosine A(2A) agonist would alleviate deficits in sensorimotor gating and increases in cyclic-AMP response element binding protein (CREB) in the nucleus accumbens (NAc) in the neonatal quinpirole model of schizophrenia (SZ). ...
Sat Aug 08, 2020 03:00
Abstract Rationale Atypical dopamine (DA) transport blockers such as modafinil and its analogs may be useful for treating motivational symptoms of depression and other disorders. Previous research has shown that the DA depleting agent tetrabenazine can reliably induce motivational deficits in rats, as evidenced by a shift towards a low-effort bias in effort-based choice tasks. This is consistent with human studies showing that people with...
Fri Aug 07, 2020 03:00
Abstract Rationale and objectives Alcohol use disorder (AUD) and post-traumatic stress disorder (PTSD) often occur comorbidly. While the incidence of these disorders is increasing, there is little investigation into the interacting neural mechanisms between these disorders. These studies aim to identify cognitive deficits that occur as a consequence of fear and ethanol exposure, implement a novel pharmaceutical intervention, and determine...
Fri Aug 07, 2020 03:00
Lactobacillus rhamnosus p75 protein with peptidoglycan hydrolase (PGH) activity is one of the key molecules exhibiting anti-apoptotic and cell-protective activity for human intestinal epithelial cells. In this st...
Sat Aug 08, 2020 03:00
Summary Purpose Programmed cell death 1 (PD-1), which is upregulated under the continuous induction of the tumor microenvironment, causes chimeric antigen receptor (CAR)-T cell hypofunction via interaction with programmed death ligand 1 (PD-L1). This study aimed to construct CAR-T cells that are resistant to PD-1 inhibition to improve the effect of CAR-T cells in solid tumors. Methods We constructed a type of dual-function CAR-T cell that targets tumor-associated antigen c-Met...
Sat Aug 08, 2020 03:00
Summary Purpose. A phase I study of intraperitoneal paclitaxel (ip PTX) combined with gemcitabine (GEM) plus nab-paclitaxel (nab-PTX) (GnP) was conducted to determine the maximum tolerated dose (MTD) and the recommended dose (RD) in pancreatic cancer patients with peritoneal metastasis in first-line setting. Methods. Based on the 3 + 3 dose-escalation model, ip PTX, GEM and nab-PTX were administered at doses of 20 or 30 mg/m2, 800 or 1000 mg/m2 and 100 or 125 mg/m2 (level 1, 2...
Sat Aug 08, 2020 03:00
Summary Neuroblastoma (NB) is the most common extracranial solid tumor in children. Under various treatments, some patients still have a poor prognosis. Hence, it is necessary to find new valid targets for NB therapy. In this study, a comprehensive bioinformatic analysis was used to identify differentially expressed genes (DEGs) between NB and control cells, and to select hub genes associated with NB. GSE66586 and GSE78061 datasets were downloaded from the Gene Expression Omnibus...
Sat Aug 08, 2020 03:00
Summary T cells play crucial roles in the antitumour immune response. However, their dysfunction leads to inefficient tumour eradication. New members of the B7 family have moved to the fore of cancer research because of their involvement in T cell-mediated immune escape and tumorigenesis. Recently, bispecific antibodies (Bi-Abs) have become attractive because of their ability to activate T cells to target tumours. In this study, we examined the expression of new B7 family members...
Fri Aug 07, 2020 03:00
Summary Naringenin (NG) is a natural antioxidant flavonoid which is isolated from citrus fruits, and has been reported to inhibit colon cancer proliferation. However, the effects of NG treatment on glioma remain to be elucidated. The present study aimed to explore the effects of NG on glioma in vitro and in vivo. Also, the interactions between NG and APO2 ligand (APO2L; also known as tumor necrosis factor-related apoptosis-inducing ligand) were investigated in glioma. A synergistic...
Fri Aug 07, 2020 03:00
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