Related Articles The Role of Liquid Biopsies in Pediatric Brain Tumors. J Neuropathol Exp Neurol. 2020 Aug 07;: Authors: Tang K, Gardner S, Snuderl M Abstract Early detection and serial therapeutic monitoring for pediatric brain tumors are essential for diagnosis and therapeutic intervention. Currently, neuropathological diagnosis relies on biopsy of tumor tissue and surgical intervention. There is a great clinical need for less invasive methods...
Sun Aug 09, 2020 14:26
Related Articles Risk of Second Primary Malignancies in Colon Cancer Patients Treated With Colectomy. Front Oncol. 2020;10:1154 Authors: Zhang B, Guo K, Zheng X, Sun L, Shen M, Ruan S Abstract Background: Second primary malignancy (SPM) attracts a growing attention. However, the clinical features of colon cancer (CC) survivors with SPMs are not clear and could help guide clinicians to develop a better surveillance strategy. Methods: We reviewed...
Sun Aug 09, 2020 14:26
Related Articles Lanreotide Induces Cytokine Modulation in Intestinal Neuroendocrine Tumors and Overcomes Resistance to Everolimus. Front Oncol. 2020;10:1047 Authors: Sciammarella C, Luce A, Riccardi F, Mocerino C, Modica R, Berretta M, Misso G, Cossu AM, Colao A, Vitale G, Necas A, Fedacko J, Galdiero M, Correale P, Faggiano A, Caraglia M, Capasso A, Grimaldi A Abstract Somatostatin analogs mantain their major role in the treatment of patients...
Sun Aug 09, 2020 14:26
Related Articles Community economic factors influence outcomes for patients with primary malignant glioma. Neurooncol Pract. 2020 Jul;7(4):453-460 Authors: Bower A, Hsu FC, Weaver KE, Yelton C, Merrill R, Wicks R, Soike M, Hutchinson A, McTyre E, Laxton A, Tatter S, Cramer C, Chan M, Lesser G, Strowd RE Abstract Background: Community economics and other social health determinants influence outcomes in oncologic patient populations. We sought...
Sun Aug 09, 2020 14:26
Related Articles Immune Checkpoint Inhibitor-Induced Myasthenia Gravis. Front Neurol. 2020;11:634 Authors: Huang YT, Chen YP, Lin WC, Su WC, Sun YT Abstract The development of immune checkpoint inhibitors (ICIs) has been a major breakthrough in cancer immunotherapy. The increasing use of ICIs has led to the discovery of a broad spectrum of immune-related adverse events (irAEs). Immune-related myasthenia gravis (irMG) is a rare but life-threatening...
Sun Aug 09, 2020 14:26
Related Articles Refractory Metastatic Colorectal Cancer: Current Challenges and Future Prospects. Cancer Manag Res. 2020;12:5819-5830 Authors: Lam M, Lum C, Latham S, Tipping Smith S, Prenen H, Segelov E Abstract Despite advances, patients with metastatic colorectal cancer (mCRC) still have poor long-term survival. Identification of molecular subtypes is important to guide therapy through standard treatment pathways and holds promise for the...
Sun Aug 09, 2020 14:26
Related Articles Urokinase Plasminogen Activator Receptor (uPAR) PET/MRI of Prostate Cancer for Non-invasive Evaluation of Aggressiveness: a Prospective Phase II Clinical Trial Comparing with Gleason Score. J Nucl Med. 2020 Aug 06;: Authors: Fosbøl MØ, Kurbegovic S, Johannesen HH, Røder MA, Hansen AE, Mortensen J, Loft A, Petersen PM, Madsen J, Brasso K, Kjaer A Abstract The aim of this study was to evaluate the correlation between uptake of...
Sun Aug 09, 2020 14:26
Related Articles Caring and living with Prader-Willi syndrome in Italy: integrating children, adults and parents' experiences through a multicentre narrative medicine research. BMJ Open. 2020 Aug 06;10(8):e036502 Authors: Ragusa L, Crinò A, Grugni G, Reale L, Fiorencis A, Licenziati MR, Faienza MF, Wasniewska M, Delvecchio M, Franzese A, Rutigliano I, Fusilli P, Corica D, Campana G, Greco D, Chiarito M, Sacco M, Toscano S, Marini MG Abstract ...
Sun Aug 09, 2020 14:26
Related Articles The functional epigenetic landscape of aberrant gene expression in molecular subgroups of newly diagnosed multiple myeloma. J Hematol Oncol. 2020 Aug 06;13(1):108 Authors: Choudhury SR, Ashby C, Tytarenko R, Bauer M, Wang Y, Deshpande S, Den J, Schinke C, Zangari M, Thanendrarajan S, Davies FE, van Rhee F, Morgan GJ, Walker BA Abstract BACKGROUND: Multiple Myeloma (MM) is a hematological malignancy with genomic heterogeneity...
Sun Aug 09, 2020 14:26
Related Articles Pediatric Oncology Clinical Trials and Collaborative Research in Africa: Current Landscape and Future Perspectives. JCO Glob Oncol. 2020 Aug;6:1264-1275 Authors: van Heerden J, Zaghloul M, Neven A, de Rojas T, Geel J, Patte C, Balagadde-Kambugu J, Hesseling P, Tchintseme F, Bouffet E, Hessissen L, SIOP Africa Abstract PURPOSE: Adequate clinical services have yet to be established in the majority of African countries, where childhood...
Sun Aug 09, 2020 14:26
Related Articles Reliance on Self-Medication Increase Delays in Diagnosis and Management of GI Cancers: Results From Nepal. JCO Glob Oncol. 2020 Aug;6:1258-1263 Authors: Dulal S, Paudel BD, Wood LA, Neupane P, Shah A, Acharya B, Shilpakar R, Acharya SC, Karn A, Poudel B, Thapa RR, Acharya A, Martin MG Abstract PURPOSE: Patients with GI cancers in Nepal often present with advanced disease and poor outcomes. The purpose of the study was to determine...
Sun Aug 09, 2020 14:26
Related Articles Review of Radium-223 and Metastatic Castration-Sensitive Prostate Cancer. Cancer Biother Radiopharm. 2020 Aug 06;: Authors: Dandapani SV, Wong J, Twardowski P Abstract Background: Radium-223 is approved for treatment of bone metastases in metastatic castration-resistant prostate cancer (mCRPC). After the ALSYMPCA trial showed overall survival benefit with the addition of radium-223 to standard of care in mCRPC in 2013, there...
Sun Aug 09, 2020 14:26
Related Articles FOXD2-AS1 promotes migration and invasion of head and neck squamous cell carcinoma and predicts poor prognosis. Future Oncol. 2020 Aug 07;: Authors: Zhang L, Bo H, Chen T, Li Q, Huan Y, Zhang S Abstract Aim: To investigate the role of long noncoding RNA FOXD2-AS1 in head and neck squamous cell carcinoma (HNSCC). Materials & methods: The expression and clinical significance of FOXD2-AS1 were analyzed using data from public...
Sun Aug 09, 2020 14:26
Related Articles Analysis of epigenetic aging in vivo and in vitro: Factors controlling the speed and direction. Exp Biol Med (Maywood). 2020 Aug 06;:1535370220947015 Authors: Matsuyama M, Søraas A, Yu S, Kim K, Stavrou EX, Caimi PF, Wald D, deLima M, Dahl JA, Horvath S, Matsuyama S Abstract IMPACT STATEMENT: Aging is associated with DNA methylation (DNAm) changes. Recent advancement of the whole-genome DNAm analysis technology allowed scientists...
Sun Aug 09, 2020 14:26
Related Articles Physioxia enhances T cell development ex vivo from human hematopoietic stem and progenitor cells. Stem Cells. 2020 Aug 05;: Authors: Shin D, Huang X, Gil CH, Aljoufi A, Ropa J, Broxmeyer HE Abstract Understanding physiologic T cell development from hematopoietic stem (HSCs) and progenitor cells (HPCs) is essential for development of improved hematopoietic cell transplantation (HCT) and emerging T-cell therapies. Factors in the...
Sat Aug 08, 2020 14:17
Related Articles Irinotecan and temozolomide chemotherapy in paediatric and adult populations with relapsed Ewing Sarcoma. Clin Transl Oncol. 2020 Aug 05;: Authors: Salah S, To YH, Khozouz O, Ismail T, Yaser S, Alnsour A, Shahin O, Sultan I, Abuhijlih R, Halalsheh H, Abuhijla F, Lewin J Abstract BACKGROUND: Irinotecan and temozolomide (IT) is a widely used regimen for relapsed Ewing sarcoma (ES), although studies are largely limited to paediatric...
Sat Aug 08, 2020 14:17
Related Articles Why contact tracing efforts have failed to curb COVID-19 transmission in much of the U.S. Clin Infect Dis. 2020 Aug 06;: Authors: Clark E, Chiao EY, Amirian ES Abstract By late April 2020, public discourse in the U.S. had shifted toward the idea of using more targeted case-based mitigation tactics (e.g., contact tracing) to combat COVID-19 transmission while allowing for the safe "re-opening" of society, in an effort to reduce...
Sat Aug 08, 2020 14:17
Related Articles Advance care planning in Asian culture. Jpn J Clin Oncol. 2020 Aug 06;: Authors: Cheng SY, Lin CP, Chan HY, Martina D, Mori M, Kim SH, Ng R Abstract Ageing has been recognized as one of the most critically important health-care issues worldwide. It is relevant to Asia, where the increasing number of older populations has drawn attention to the paramount need for health-care investment, particularly in end-of-life care. The advocacy...
Sat Aug 08, 2020 14:17
Related Articles Inconsistencies in assessment of pain endpoints in radiotherapy for painful tumors: Analysis of original articles in the Green and Red Journals. Clin Transl Radiat Oncol. 2020 Sep;24:111-115 Authors: Saito T, Shikama N, Yorozu A, Kubota H, Murotani K, Yamaguchi K, Oya N, Nakamura N Abstract Background and purpose: Consistent assessment of the pain response is essential for adequately comparing treatment efficacy between studies....
Sat Aug 08, 2020 14:17
Related Articles Current State of Target Treatment in BRAF Mutated Melanoma. Front Mol Biosci. 2020;7:154 Authors: Tanda ET, Vanni I, Boutros A, Andreotti V, Bruno W, Ghiorzo P, Spagnolo F Abstract Incidence of melanoma has been constantly growing during the last decades. Although most of the new diagnoses are represented by thin melanomas, the number of melanoma-related deaths in 2018 was 60,712 worldwide (Global Cancer Observatory, 2019)....
Sat Aug 08, 2020 14:17
Related Articles Ferroptosis in Acute Central Nervous System Injuries: The Future Direction? Front Cell Dev Biol. 2020;8:594 Authors: Shen L, Lin D, Li X, Wu H, Lenahan C, Pan Y, Xu W, Chen Y, Shao A, Zhang J Abstract Acute central nervous system (CNS) injuries, such as stroke, traumatic brain injury (TBI), and spinal cord injury (SCI) present a grave health care challenge worldwide due to high morbidity and mortality, as well as limited clinical...
Sat Aug 08, 2020 14:17
Related Articles Current Management and Progress in Radiotherapy for Small Cell Lung Cancer. Front Oncol. 2020;10:1146 Authors: Tjong MC, Mak DY, Shahi J, Li GJ, Chen H, Louie AV Abstract Radiotherapy (RT) and chemotherapy continue to be widely utilized in small cell lung cancer (SCLC) management. In most limited stage (LS)-SCLC cases, the standard initial therapy remains concurrent chemoradiotherapy (CRT), typically with an etoposide and platinum-based...
Sat Aug 08, 2020 14:17
Related Articles The Influence of Pre-Existing Beta-Blockers Use on Survival Outcomes in HER2 Positive Advanced Breast Cancer: Pooled Analysis of Clinical Trial Data. Front Oncol. 2020;10:1130 Authors: Modi ND, Tan JQE, Rowland A, Koczwara B, Kichenadasse G, McKinnon RA, Wiese MD, Sorich MJ, Hopkins AM Abstract Introduction: Beta-blockers (BB) are commonly used to manage cardiovascular disease and may have benefits in controlling complications...
Sat Aug 08, 2020 14:17
Related Articles Potential Zoonotic Origins of SARS-CoV-2 and Insights for Preventing Future Pandemics Through One Health Approach. Cureus. 2020 Jun 30;12(6):e8932 Authors: Konda M, Dodda B, Konala VM, Naramala S, Adapa S Abstract Coronavirus disease 2019 (COVID-19) is an emerging infectious disease that has resulted in a global pandemic and is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Zoonotic diseases are infections...
Sat Aug 08, 2020 14:17
Related Articles Brain Metastases from Ovarian Cancer: Current Evidence in Diagnosis, Treatment, and Prognosis. Cancers (Basel). 2020 Aug 04;12(8): Authors: Borella F, Bertero L, Morrone A, Gambella A, Bovetti M, Cosma S, Carosso A, Katsaros D, Gemmiti S, Preti M, Valabrega G, Scotto G, Cassoni P, Benedetto C Abstract With this review, we provide the state of the art concerning brain metastases (BMs) from ovarian cancer (OC), a rare condition....
Sat Aug 08, 2020 14:17
Related Articles A comprehensive DNA panel next generation sequencing approach supporting diagnostics and therapy prediction in neurooncology. Acta Neuropathol Commun. 2020 Aug 05;8(1):124 Authors: Lorenz J, Rothhammer-Hampl T, Zoubaa S, Bumes E, Pukrop T, Kölbl O, Corbacioglu S, Schmidt NO, Proescholdt M, Hau P, Riemenschneider MJ Abstract Recent updates in the classification of central nervous system (CNS) tumors have increased the need for...
Sat Aug 08, 2020 14:17
Related Articles Aptamers: a novel targeted theranostic platform for pancreatic ductal adenocarcinoma. Radiat Oncol. 2020 Aug 05;15(1):189 Authors: Li Q, Maier SH, Li P, Peterhansl J, Belka C, Mayerle J, Mahajan UM Abstract Pancreatic ductal adenocarcinoma (PDAC) is an extremely challenging disease with a high mortality rate and a short overall survival time. The poor prognosis can be explained by aggressive tumor growth, late diagnosis, and...
Sat Aug 08, 2020 14:17
Related Articles Healthcare providers perspectives on compassion training: a grounded theory study. BMC Med Educ. 2020 Aug 05;20(1):249 Authors: Sinclair S, Hack TF, McClement S, Raffin-Bouchal S, Chochinov HM, Hagen NA Abstract BACKGROUND: There is little concrete guidance on how to train current and future healthcare providers (HCPs) in the core competency of compassion. This study was undertaken using Straussian grounded theory to address...
Sat Aug 08, 2020 14:17
Related Articles Smoking cessation and survival among people diagnosed with non-metastatic cancer. BMC Cancer. 2020 Aug 05;20(1):726 Authors: Barnett TE, Lu Y, Gehr AW, Ghabach B, Ojha RP Abstract BACKGROUND: We aimed to estimate the effects of smoking cessation on survival among people diagnosed with cancer. METHODS: We used data from a Comprehensive Community Cancer Program that is part of a large urban safety-net hospital system....
Sat Aug 08, 2020 14:17
Related Articles Cholangiocarcinoma: investigations into pathway-targeted therapies. Expert Rev Anticancer Ther. 2020 Aug 06;: Authors: Ntanasis-Stathopoulos I, Tsilimigras DI, Gavriatopoulou M, Schizas D, Pawlik TM Abstract INTRODUCTION: Cholangiocarcinoma refers to malignant disease of the biliary tract and accounts for 3% of all gastrointestinal tumors. Surgical intervention is currently the only potentially curative strategy for cholangiocarcinoma....
Sat Aug 08, 2020 14:17
Related Articles Making the case for EGFR TKI sequencing in EGFR mutation-positive NSCLC: a GioTag study US patient analysis. Future Oncol. 2020 Aug 06;: Authors: Feinberg B, Halmos B, Gucalp R, Tang W, Moehring B, Hochmair MJ Abstract Aim: To assess time-to-treatment failure (TTF) in US patients with epidermal growth factor receptor (EGFR) mutation-positive non-small-cell lung cancer (NSCLC) who received sequential afatinib-osimertinib treatment...
Sat Aug 08, 2020 14:17
Related Articles Radiogenomics: bridging imaging and genomics. Abdom Radiol (NY). 2019 06;44(6):1960-1984 Authors: Bodalal Z, Trebeschi S, Nguyen-Kim TDL, Schats W, Beets-Tan R Abstract From diagnostics to prognosis to response prediction, new applications for radiomics are rapidly being developed. One of the fastest evolving branches involves linking imaging phenotypes to the tumor genetic profile, a field commonly referred to as "radiogenomics."...
Sat Aug 08, 2020 14:17
Related Articles Immunotherapy-based combination strategies for advanced urothelial cancer: A long quest. Cancer. 2020 Aug 05;: Authors: Khaki AR, Agarwal N, Pal SK, Grivas P Abstract LAY SUMMARY: Despite longer survival with immune checkpoint inhibitors targeting programmed cell death protein 1 (PD-1)/programmed cell death-ligand 1 (PD-L1), metastatic urothelial carcinoma remains lethal. There is an unmet need to further improve the efficacy...
Fri Aug 07, 2020 14:16
Effect of functional variant rs11466313 on breast cancer susceptibility and TGFB1 promoter activity.
Related Articles Effect of functional variant rs11466313 on breast cancer susceptibility and TGFB1 promoter activity. Breast Cancer Res Treat. 2020 Aug 05;: Authors: Zhou YT, Zheng LY, Wang YJ, Yang L, Xie YT, Panda I, Tian XX, Fang WG Abstract PURPOSE: This study aimed to investigate whether genetic polymorphisms in TGFB1 contribute to breast cancer (BC) susceptibility, and explore the mechanism of action. METHODS: A total of 7 tagging...
Fri Aug 07, 2020 14:16
Related Articles In situ vaccination with laser interstitial thermal therapy augments immunotherapy in malignant gliomas. J Neurooncol. 2020 Aug 05;: Authors: Shin DH, Melnick KF, Tran DD, Ghiaseddin AP Abstract INTRODUCTION: Laser interstitial thermal therapy (LITT) remains a promising advance in the treatment of primary central nervous system malignancies. As indications for its use continue to expand, there has been growing interest in its...
Fri Aug 07, 2020 14:16
Related Articles Systemic therapy for metastatic renal cell carcinoma in the first-line setting: a systematic review and network meta-analysis. Cancer Immunol Immunother. 2020 Aug 05;: Authors: Mori K, Mostafaei H, Miura N, Karakiewicz PI, Luzzago S, Schmidinger M, Bruchbacher A, Pradere B, Egawa S, Shariat SF Abstract PURPOSE: Management of metastatic renal cell cancer (mRCC) has undergone a paradigm shift with immune-checkpoint inhibitors...
Fri Aug 07, 2020 14:16
Related Articles Molecular profiling of non-small cell lung cancer. PLoS One. 2020;15(8):e0236580 Authors: Forsythe ML, Alwithenani A, Bethune D, Castonguay M, Drucker A, Flowerdew G, French D, Fris J, Greer W, Henteleff H, MacNeil M, Marignani P, Morzycki W, Plourde M, Snow S, Xu Z Abstract Lung cancer is generally treated with conventional therapies, including chemotherapy and radiation. These methods, however, are not specific to cancer cells...
Fri Aug 07, 2020 14:16
Related Articles Novel Therapies Potentially Available for Pediatric B-Cell Non-Hodgkin Lymphoma. J Natl Compr Canc Netw. 2020 Aug;18(8):1125-1134 Authors: Harker-Murray PD, Pommert L, Barth MJ Abstract Burkitt lymphoma, diffuse large B-cell lymphoma (DLBCL), and primary mediastinal B-cell lymphoma are the most common aggressive pediatric mature B-cell non-Hodgkin lymphomas (B-NHLs). Despite excellent survival with current chemotherapy regimens,...
Fri Aug 07, 2020 14:16
Related Articles Lung cancer management: monitoring and treating resistance development in third generation EGFR TKIs. Expert Rev Anticancer Ther. 2020 Aug 05;: Authors: Franceschini D, Rossi S, Loi M, Chiola I, Piccoli F, Lutman FR, Finocchiaro G, Toschi L, Santoro A, Scorsetti M Abstract INTRODUCTION: Patients treated with third generation EGFR TKIs will develop resistance to treatment at a certain point. Early detection of resistance occurrence...
Fri Aug 07, 2020 14:16
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